Entry
Name
cyclohexyl-isocyanide hydratase;
isonitrile hydratase;
N-cyclohexylformamide hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)
Reaction(IUBMB)
N-cyclohexylformamide = cyclohexyl isocyanide + H2O [RN:
R05771 ]
Reaction(KEGG)
Substrate
N-cyclohexylformamide [CPD:
C11519 ]
Product
Comment
The enzyme from Pseudomonas putida strain N19-2 can also catalyse the hydration of other isonitriles to the corresponding N-substituted formamides. The enzyme has no metal requirements.
History
EC 4.2.1.103 created 2001
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K18199 cyclohexyl-isocyanide hydratase
Genes
EPI : Q3V30_07900 Q3V30_22590
PDIP : KFZ74_20235 KFZ74_20675
PAST : N015_18645 N015_18655
PTOL : I7845_09625 I7845_13770 I7845_13890
PFW : PF1751_v1c19050(inhA)
PPEG : KUA23_10235(inhA) KUA23_15205
PSIV : LZ023_11520 LZ023_35900
CDIZ : CEDIAZO_00144(inhA)
CNC : CNE_BB1p06340 CNE_BB1p06350 CNE_BB1p06390
COX : E0W60_28170 E0W60_30800 E0W60_30825
BUR : Bcep18194_A5986 Bcep18194_C6949
BCEP : APZ15_01180 APZ15_37075
BDF : WI26_12850 WI26_18185
BMEC : WJ16_13640 WJ16_18360
BANN : JFN94_13625 JFN94_18780
BARI : NLX30_15460 NLX30_37835 NLX30_38635
BAEN : L3V59_15305 L3V59_35780 L3V59_41650
BGD : bgla_1g13580 bgla_4p2640
PMEG : FNZ07_17295 FNZ07_18000
PACP : FAZ97_16555 FAZ97_22925
PTX : ABW99_09470 ABW99_09765
BUE : BRPE67_BCDS06360(pfpI)
BGM : CAL15_04620 CAL15_16450
BGV : CAL12_06690 CAL12_26335
ACHR : C2U31_02555 C2U31_23205
ASEL : RAS12_10410 RAS12_24355 RAS12_24365
LIH : L63ED372_02726(inhA)
MESP : C1M53_09140 C1M53_24005
AGT : EYD00_13990 EYD00_23945
AVV : RvVAT039_01740 RvVAT039_pl02010
BPSN : NIK97_17885 NIK97_17890
BRS : S23_30320 S23_40040 S23_56940
BRC : BCCGELA001_07170 BCCGELA001_17850
BRK : CWS35_00885 CWS35_16175 CWS35_22960 CWS35_35285
BOT : CIT37_28250 CIT37_32700
BRQ : CIT40_14000 CIT40_18185
BGZ : XH91_19540 XH91_27890
BSYM : CIT39_13170 CIT39_17535
BEL : BE61_60030 BE61_85190
BSEP : HAP48_0021345 HAP48_0036700 HAP48_0044390
BQB : J4P68_0012710 J4P68_0037910
BAUT : QA635_23700 QA635_36745
BBRA : QA636_24270 QA636_37875
BGK : IC762_05835 IC762_16675
BCOU : IC761_19915 IC761_28065
BPAH : QA639_06750 QA639_20330
BROS : QUH67_15360 QUH67_19375
BRAZ : LRP30_18855 LRP30_41560
BOY : LQG66_03565 LQG66_25465 LQG66_26170 LQG66_26195 LQG66_26260 LQG66_26270
VGO : GJW-30_1_00522(inhA_1)
BVES : QO058_02750 QO058_18735
BOI : BLM15_04605 BLM15_18455
BOSE : RMR04_11910 RMR04_22290
AQI : J5J86_05430 J5J86_05465 J5J86_06935 J5J86_21055
MEA : Mex_1p0926(inh) Mex_1p3533(inh) Mex_1p4818(inh)
MDI : METDI1727(inh) METDI4110(inh) METDI5414(inh)
MEX : Mext_1154 Mext_3318 Mext_4368
MCH : Mchl_1313 Mchl_3642 Mchl_4844
MZA : B2G69_03875 B2G69_13040 B2G69_24145
METQ : MSPGM_10120 MSPGM_32820 MSPGM_44970
MRD : Mrad2831_1653 Mrad2831_3391
META : Y590_04890 Y590_16250
MAQU : Maq22A_c27365(thiJ)
MPHY : MCBMB27_01301 MCBMB27_02881
MEE : DA075_03875 DA075_33305 DA075_33345
METD : C0214_18295 C0214_24205
METX : A3862_14490 A3862_22610
METS : DK389_08825 DK389_09000 DK389_09835 DK389_27220
METI : DK427_05315 DK427_16925
MMES : MMSR116_01165 MMSR116_12260
MIND : mvi_12520 mvi_37970
MTAD : M6G65_09610 M6G65_31555
MECL : CLZ_01245 CLZ_15320 CLZ_21980
MFUJ : ABC766_00765 ABC766_22385
FIL : BN1229_v1_1635(inhA)
FIY : BN1229_v1_1638(inhA)
MBRY : B1812_17210 B1812_17725
MHEY : H2LOC_003240 H2LOC_011360
MPAR : F7D14_14925 F7D14_17980
MIWA : SS37A_02670 SS37A_38110
MTW : CQW49_07215 CQW49_17635 CQW49_21200
MECQ : MSC49_33800 MSC49_37840 MSC49_42390
NOH : G5V57_17685 G5V57_23625
PSTG : E8M01_00590 E8M01_03780 E8M01_24970 E8M01_25820
PAQT : E8L99_10950 E8L99_20970
ACUT : MRB58_05880 MRB58_24380
CCS : CCNA_01858 CCNA_03055
PHB : HYN04_01205 HYN04_09280
TSV : DSM104635_02609(inhA)
PBAE : P8S53_05100 P8S53_05415
SPHI : TS85_18445 TS85_20980
SKR : BRX40_06675 BRX40_06760
SCHY : GVO57_02845 GVO57_10385
SAMI : SAMIE_1007250 SAMIE_1016180 SAMIE_1016210
SFLA : SPHFLASMR4Y_02170(inhA)
PARJ : J4G78_00310 J4G78_11785 J4G78_16785 J4G78_16790
SAND : H3309_06925 H3309_07680
ACIM : GT370_17615 GT370_17640
SRF : LHU95_03515 LHU95_04580
THAC : CSC3H3_01220 CSC3H3_22550 CSC3H3_22625
AVM : JQX13_02040 JQX13_10415
CFUS : CYFUS_000203 CYFUS_000268
SCL : sce6836(thiJ) sce8831
SCU : SCE1572_01610 SCE1572_01695
PAUU : E8A73_029740 E8A73_031165
NON : NOS3756_20200 NOS3756_47790
NPZ : ACX27_21190 ACX27_24270
NCW : NIES2107_49560 NIES2107_63490
NOSU : JYQ62_05815 JYQ62_20765
CALN : NIES2098_29350 NIES2098_32890
TTQ : NIES37_07020 NIES37_46440
ALAX : NIES50_12810 NIES50_40110
» show all
Taxonomy
Reference
Authors
Goda M, Hashimoto Y, Shimizu S, Kobayashi M
Title
Discovery of a novel enzyme, isonitrile hydratase, involved in nitrogen-carbon triple bond cleavage.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.103
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.103