KEGG   ENZYME: 4.2.1.105
Entry
EC 4.2.1.105                Enzyme                                 

Name
2-hydroxyisoflavanone dehydratase;
2,7,4'-trihydroxyisoflavanone hydro-lyase;
2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Reaction(IUBMB)
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];
(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction(KEGG)
R07317;
(other) R06793 R07723
Substrate
2,4',7-trihydroxyisoflavanone [CPD:C15567];
2,4',5,7-tetrahydroxyisoflavanone [CPD:C12631]
Product
daidzein [CPD:C10208];
H2O [CPD:C00001];
genistein [CPD:C06563]
Comment
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
History
EC 4.2.1.105 created 2004, modified 2013
Pathway
ec00943  Isoflavonoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13258  2-hydroxyisoflavanone dehydratase
Genes
GMX: 547489(HIDH)
GSJ: 114367895
PVU: PHAVU_002G047500g
VRA: 106776973
VAR: 108319923
VUN: 114166941
CCAJ: 109794824
CAM: 101506056
LANG: 109331604
Reference
1
  Authors
Hakamatsuka, T., Mori, K., Ishida, S., Ebizuka, Y and Sankawa, U.
  Title
Purification of 2-hydroxyisoflavanone dehydratase from the cell cultures of Pueraria lobata.
  Journal
Phytochemistry 49:497-505 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.105
IUBMB Enzyme Nomenclature: 4.2.1.105
ExPASy - ENZYME nomenclature database: 4.2.1.105
BRENDA, the Enzyme Database: 4.2.1.105
CAS: 166800-10-8

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