KEGG   ENZYME: 4.2.1.105
Entry
EC 4.2.1.105                Enzyme                                 
Name
2-hydroxyisoflavanone dehydratase;
2,7,4'-trihydroxyisoflavanone hydro-lyase;
2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Reaction(IUBMB)
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];
(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction(KEGG)
R07317;
(other) R06793 R07723
Substrate
2,4',7-trihydroxyisoflavanone [CPD:C15567];
2,4',5,7-tetrahydroxyisoflavanone [CPD:C12631]
Product
daidzein [CPD:C10208];
H2O [CPD:C00001];
genistein [CPD:C06563]
Comment
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
History
EC 4.2.1.105 created 2004, modified 2013
Pathway
ec00943  Isoflavonoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13258  2-hydroxyisoflavanone dehydratase
Genes
GMX100785409 547489(HIDH)
GSJ114367895 114371837
PVUPHAVU_002G047500g PHAVU_007G054200g
VRA106776973
VAR108319923
VUN114166941 114190838
CCAJ109791254 109794824 109801193 109801222
APRC113870130 113871120
MTRMTR_1g105020 MTR_5g005850
CAM101502005 101506056
LJALj5g3v2057520.1(Lj5g3v2057520.1)
ADU107466945
AIP107617879
AHF112711824 112776333
LANG109331604
QLO115994703
 » show all
Reference
1
  Authors
Hakamatsuka, T., Mori, K., Ishida, S., Ebizuka, Y and Sankawa, U.
  Title
Purification of 2-hydroxyisoflavanone dehydratase from the cell cultures of Pueraria lobata.
  Journal
Phytochemistry 49:497-505 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.105
IUBMB Enzyme Nomenclature: 4.2.1.105
ExPASy - ENZYME nomenclature database: 4.2.1.105
BRENDA, the Enzyme Database: 4.2.1.105
CAS: 166800-10-8

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