KEGG   ENZYME: 4.2.1.107
Entry
EC 4.2.1.107                Enzyme                                 
Name
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase;
46 kDa hydratase 2;
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming]
Reaction(IUBMB)
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O [RN:R04813]
Reaction(KEGG)
R04813;
(other) R04809
Substrate
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA [CPD:C15614]
Product
(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA [CPD:C05460];
H2O [CPD:C00001]
Comment
This enzyme forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity. The enzyme is involved in the beta-oxidation of the cholesterol side chain in the cholic-acid-biosynthesis pathway.
History
EC 4.2.1.107 created 2005
Pathway
ec00120  Primary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K12405  (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
Genes
HSA3295(HSD17B4)
PTR462019(HSD17B4)
PPS100981028(HSD17B4)
GGO101129538(HSD17B4)
PON100448539(HSD17B4)
NLE100590035(HSD17B4)
HMH116470899(HSD17B4)
MCC698369(HSD17B4)
MCF102123675(HSD17B4)
MTHB126957048
MNI105500031(HSD17B4)
CSAB103244395(HSD17B4)
CATY105590649(HSD17B4)
PANU101004327(HSD17B4)
TGE112625827(HSD17B4)
MLEU105534163(HSD17B4)
RRO104654581(HSD17B4)
RBB108529825(HSD17B4)
TFN117065971(HSD17B4)
PTEH111530208(HSD17B4)
CANG105527387(HSD17B4)
CJC100390100(HSD17B4)
SBQ101036776(HSD17B4)
CIMI108306790(HSD17B4)
CSYR103262046
MMUR105872240
LCAT123648404(HSD17B4)
PCOQ105822547(HSD17B4)
OGA100966879(HSD17B4)
MMU15488(Hsd17b4)
MCAL110284447(Hsd17b4)
MPAH110332881(Hsd17b4)
RNO79244(Hsd17b4)
MCOC116087150(Hsd17b4)
ANU117719952(Hsd17b4)
MUN110539842(Hsd17b4)
CGE103161104(Hsd17b4)
MAUA101827399(Hsd17b4)
PROB127234029(Hsd17b4)
PLEU114694768(Hsd17b4)
MORG121441957 121453615(Hsd17b4)
MFOT126505968
AAMP119815878(Hsd17b4)
NGI103745113(Hsd17b4)
HGL101713520(Hsd17b4)
CPOC100379226(Hsd17b4)
CCAN109674145
DORD105985471(Hsd17b4)
DSP122101973(Hsd17b4)
PLOP125341824(Hsd17b4)
NCAR124986751
MMMA107144783(Hsd17b4)
OCU100346781
OPI101530287(HSD17B4)
TUP102468828(HSD17B4)
GVR103605910(HSD17B4)
CFA474630(HSD17B4)
CLUD112659672(HSD17B4)
VVP112932403(HSD17B4)
VLG121494637(HSD17B4)
NPO129494700(HSD17B4)
AML100471749(HSD17B4)
UMR103670554(HSD17B4)
UAH113261629(HSD17B4)
UAR123790430(HSD17B4)
ELK111158891
LLV125100000
MPUF101683185(HSD17B4)
MNP132027375(HSD17B4)
MLK131832584(HSD17B4)
NVS122916269(HSD17B4)
ORO101385731(HSD17B4)
EJU114209435(HSD17B4)
ZCA113928790(HSD17B4)
MLX118016560(HSD17B4)
NSU110590913(HSD17B4)
LWW102736737(HSD17B4)
FCA101091840(HSD17B4)
PYU121010581(HSD17B4)
PCOO112861741(HSD17B4)
PBG122486641(HSD17B4)
LRUF124515159
PTG102968873(HSD17B4)
PPAD109278892(HSD17B4)
PUC125934835
AJU106975089
HHV120240242(HSD17B4)
BTA493643(HSD17B4)
BOM102268517(HSD17B4)
BBUB102412917(HSD17B4)
BBIS104993366(HSD17B4)
CHX102172142(HSD17B4)
OAS101114519(HSD17B4)
BTAX128050558(HSD17B4)
ODA120864671(HSD17B4)
CCAD122440074(HSD17B4)
MBEZ129558313(HSD17B4)
SSC397574(HSD17B4)
CFR102508317(HSD17B4)
CBAI105082053(HSD17B4)
CDK105104293(HSD17B4)
VPC102537534(HSD17B4)
LVE103084787(HSD17B4)
OOR101282963(HSD17B4)
DLE111183342(HSD17B4)
PCAD102996127(HSD17B4)
PSIU116751686(HSD17B4)
NASI112398657(HSD17B4)
ECB100034046(HSD17B4)
EPZ103548315(HSD17B4)
EAI106833039(HSD17B4)
MYB102240475(HSD17B4)
MYD102767159(HSD17B4)
MMYO118656167(HSD17B4)
MLF102425700(HSD17B4)
PKL118703106(HSD17B4)
EFUS103288694(HSD17B4)
MNA107530713(HSD17B4)
DRO112315031(HSD17B4)
SHON118975196(HSD17B4)
AJM119051192(HSD17B4)
PDIC114494306(HSD17B4)
PHAS123818113(HSD17B4)
MMF118642891(HSD17B4)
PPAM129083880(HSD17B4)
HAI109374101(HSD17B4)
RFQ117024890(HSD17B4)
PALE102887000(HSD17B4)
PGIG120590862(HSD17B4)
PVP105290860(HSD17B4)
RAY107511154(HSD17B4)
TOD119243559(HSD17B4)
SARA101542842(HSD17B4)
LAV100659299(HSD17B4)
TMU101356123
ETF101641151(HSD17B4) 101644420
DNM101423884(HSD17B4)
MDO100028098(HSD17B4)
GAS123235791(HSD17B4)
SHR100932771(HSD17B4)
PCW110202743(HSD17B4)
OAA100081754(HSD17B4)
GGA395785(HSD17B4)
PCOC116234067(HSD17B4)
CJO107306670(HSD17B4)
TPAI128089355(HSD17B4)
LMUT125686634(HSD17B4)
NMEL110389447(HSD17B4)
APLA101791118(HSD17B4)
ACYG106048362(HSD17B4)
CATA118259303(HSD17B4)
AFUL116500754(HSD17B4)
TGU100218226(HSD17B4)
LSR110479177(HSD17B4)
SCAN103821465(HSD17B4)
PMOA120512524(HSD17B4)
OTC121332706(HSD17B4)
PRUF121362562(HSD17B4)
GFR102036502(HSD17B4)
FAB101807233(HSD17B4)
OMA130265187(HSD17B4)
PHI102109547(HSD17B4)
PMAJ107216347(HSD17B4)
CCAE111941198(HSD17B4)
CCW104690497(HSD17B4)
CBRC103611629(HSD17B4)
ETL114056305(HSD17B4)
ZAB102062238(HSD17B4)
ACHL103806159(HSD17B4)
SVG106851983(HSD17B4)
MMEA130577055(HSD17B4)
HRT120765544(HSD17B4)
FPG101917400(HSD17B4)
FCH102058406(HSD17B4)
CLV102095771(HSD17B4)
EGZ104122491(HSD17B4)
NNI104014571(HSD17B4)
PLET104618021(HSD17B4)
ACUN113489653(HSD17B4)
TALA104363287(HSD17B4)
PADL103912347(HSD17B4)
AFOR103897966(HSD17B4)
ACHC115336530(HSD17B4)
HALD104320961(HSD17B4)
HLE104828588(HSD17B4)
AGEN126036470
GCL127027587
CSTI104557391(HSD17B4)
CMAC104480460(HSD17B4)
MUI104541285(HSD17B4)
BREG104629512(HSD17B4)
FGA104069667(HSD17B4)
LDI104348760(HSD17B4)
OHA104339186(HSD17B4)
NNT104407165(HSD17B4)
SHAB115619609(HSD17B4)
DPUB104304758(HSD17B4)
PGUU104458725(HSD17B4)
CPEA104392915(HSD17B4)
AVIT104272741(HSD17B4)
CVF104294213(HSD17B4)
RTD128902269(HSD17B4)
CUCA104061043(HSD17B4)
BRHI104495883(HSD17B4)
AROW112978041(HSD17B4)
NPD112958912(HSD17B4)
TGT104571515(HSD17B4)
DNE112992405
SCAM104150534(HSD17B4)
ASN102371766(HSD17B4)
AMJ102571005(HSD17B4)
CPOO109323436(HSD17B4)
GGN109297318(HSD17B4)
PSS102451304(HSD17B4)
CMY102933522(HSD17B4)
CCAY125636923(HSD17B4)
DCC119855566(HSD17B4)
CPIC101945395(HSD17B4)
TST117879364(HSD17B4)
CABI116836212(HSD17B4)
MRV120408024(HSD17B4)
ACS100558484(hsd17b4)
ASAO132767230(HSD17B4)
PVT110084344(HSD17B4)
SUND121921111(HSD17B4)
PBI103063870(HSD17B4)
PMUR107294349(HSD17B4)
CTIG120316078(HSD17B4)
TSR106543382(HSD17B4)
PGUT117674677(HSD17B4)
APRI131190771(HSD17B4)
PTEX113449307(HSD17B4)
NSS113415957(HSD17B4)
VKO123031365(HSD17B4)
PMUA114606393(HSD17B4)
PRAF128423120(HSD17B4)
ZVI118076708(HSD17B4)
HCG128345823(HSD17B4)
GJA107116225(HSD17B4)
STOW125436558(HSD17B4)
EMC129334456(HSD17B4)
XLA444492(hsd17b4.L)
XTR613082(hsd17b4)
NPR108787696(HSD17B4)
RTEM120931986(HSD17B4)
BBUF120992600(HSD17B4)
BGAR122924617(HSD17B4)
MUO115463217 115463218
GSH117352550(HSD17B4)
DRE393105(hsd17b4)
SANH107703629(hsd17b4)
SGH107571774(hsd17b4)
CAUA113094195 113106903
CGIB127963370
PTET122350586(hsd17b4)
LROH127169979(hsd17b4)
OMC131545625(hsd17b4)
PPRM120475505(hsd17b4)
RKG130072954(hsd17b4)
MAMB125279588(hsd17b4)
CIDE127517328
MASI127414554 127423847
TROS130567576(hsd17b4)
TDW130407013(hsd17b4)
MANU129414969(hsd17b4)
IPU108265438
IFU128607804(hsd17b4)
PHYP113529268(hsd17b4)
SMEO124399595(hsd17b4)
TFD113656214(hsd17b4)
TVC132853239(hsd17b4)
AMEX103046836(hsd17b4)
CMAO118813245(hsd17b4)
EEE113571049(hsd17b4)
CHAR105907549(hsd17b4)
TRU101062498(hsd17b4)
TFS130525784(hsd17b4)
TNGGSTEN00030945G001
LCO104920820(hsd17b4)
NCC104966339(hsd17b4)
TBEN117472759(hsd17b4)
CGOB115013548(hsd17b4)
PGEO117451981(hsd17b4)
GACU117560874
EMAC134873784(hsd17b4)
ELY117252434(hsd17b4)
EFO125890843(hsd17b4)
PLEP121944362(hsd17b4)
SLUC116054060(hsd17b4)
ECRA117944965(hsd17b4)
ESP116689590(hsd17b4)
PFLV114555481(hsd17b4)
GAT120830783(hsd17b4)
PPUG119225552(hsd17b4)
AFB129100775(hsd17b4)
CLUM117736295(hsd17b4)
PSWI130196891
MSAM119891683(hsd17b4)
SCHU122876928(hsd17b4)
CUD121509730(hsd17b4)
ALAT119019193(hsd17b4)
MZE101482787(hsd17b4)
ONL100706762(hsd17b4)
OAU116310500(hsd17b4)
OLA101159921(hsd17b4)
OML112148954(hsd17b4)
CSAI133450638(hsd17b4)
XMA102223774(hsd17b4)
XCO114154573(hsd17b4)
XHE116730397(hsd17b4)
PRET103470095(hsd17b4)
PFOR103141760(hsd17b4)
PLAI106944940(hsd17b4)
PMEI106923064(hsd17b4)
GAF122827419(hsd17b4)
PPRL129366116(hsd17b4)
CVG107086311(hsd17b4)
CTUL119798579(hsd17b4)
GMU124877861(hsd17b4)
NFU107394149(hsd17b4)
KMR108233704(hsd17b4)
ALIM106513677(hsd17b4)
NWH119413904(hsd17b4)
AOCE111564685(hsd17b4)
MCEP125012708(hsd17b4)
POV109637138(hsd17b4)
SSEN122769476(hsd17b4)
HHIP117768550(hsd17b4)
HSP118114529(hsd17b4)
SMAU118313339(hsd17b4)
LCF108882142
SDU111230866(hsd17b4)
SLAL111645149(hsd17b4)
XGL120805559(hsd17b4)
HCQ109526033(hsd17b4)
SSCV125993727
SBIA133499412(hsd17b4)
PEE133399934(hsd17b4)
PTAO133475195(hsd17b4)
BPEC110167024(hsd17b4)
MALB109956607(hsd17b4)
BSPL114861822(hsd17b4)
SJO128365353(hsd17b4)
SASA106585849(hsd17b4)
STRU115164957(hsd17b4)
OTW112247069(hsd17b4)
OMY110525264(hsd17b4)
OGO124034633(hsd17b4)
ONE115111275(hsd17b4)
OKI109875358(hsd17b4)
OKE118370863(hsd17b4)
SALP111974039(hsd17b4)
SNH120045172(hsd17b4)
CCLU121584411(hsd17b4)
ELS105014609(hsd17b4)
SFM108938133(hsd17b4)
PKI111856620(hsd17b4)
AANG118206736(hsd17b4)
LOC102697531(hsd17b4)
PSPA121302596(hsd17b4) 121316706
ARUT117427495 117973220
PSEX120532694(hsd17b4)
LCM102356548(HSD17B4)
CMK103181119(hsd17b4)
CPLA122560645(hsd17b4)
HOC132827888(hsd17b4)
LERI129695811(hsd17b4)
PMRN116938080(HSD17B4)
LRJ133343738(HSD17B4)
BFO118409354
BBEL109480804
CIN100187421
SCLV120338122
SPU115918401 581580
LPIC129262336
AJC117122621
DMEDmel_CG3415(Mfe2)
DER6550509
DSE116802232
DSIDsimw501_GD29376(Dsim_GD29376)
DYADyak_GE17252
DAN6501789
DSR110184585
DPO4815128
DPE6599365
DMN108161558
DWI6648554
DGR6565453
DMODmoj_GI11209
DAZ108619615
DNV108656784
DHE111598829
DVI6636673
CCAT101461807
BOD106614681
BDR105228282
RZE108376746 108381954
AOQ129239714
TDA119668939 119668940 119668942 119668944
MDE101897498
SCAC106092762
LCQ111686897
LSQ119599856
GFS119645347
ECOE129948596
CLON129607664
HIS119648611
AGA1275515
ACOZ120955687
AARA120901803
AMER121597830
ASTE118512713
AFUN125762296
AMOU128305711
AALI118461846
AAG5568633
AALB109428196
CQUCpipJ_CPIJ001576
CPII120414661
CNS116337519
BCOO119084844
AME409986
ACER107999187
ALAB122718722
ADR102672209
AFLR100863446
BIM100745646
BBIF117204816
BVK117231189
BVAN117163388
BTER100648641
BAFF126920772
BPYO122570889
BPAS132906507
FVI122530664
CCAL108626230
OBB114872784
OLG117611985
MGEN117224638
NMEA116425205
SOC105192979
MPHA105839781
AEC105149946
ACEP105621202
HST105188161
DQU106744052
CFO105248091
FEX115245059
LHU105679879
PGC109854791
OBO105280041
PCF106793023
PFUC122520011
VPS122631462
VCRB124426588
VVE124952431
NVI100123018
CSOL105368036
TPRE106659616
LHT122501071
LBD127277949
MDL103579980
CGLO123268667
FAS105272013
DAM107040917
AGIF122847409
CINS118067462
VCAN122416477
CCIN107263397
DSM124411878
NPT124218728
NFB124183016
NLO107228102
NVG124305349
AROA105685765
DPA109536257
SOY115888404
AGRG126743269
CSET123306476
AGB108915760
LDC111505860
NVL108562871
APLN108736403
PPYR116158989 116159225 116159796 116159821 116176974 116179454
OTU111423793
BMOR101745499
BMAN114242087
MSEX115443231
BANY112057966
MJU123875458
NIQ126775080
VCD124537290
MCIX123661344
PMAC106711197
PPOT106102091
PXU106114302
PRAP110991438
PBX123713006
PNAP125062929
ZCE119831635
CCRC123699116
LSIN126971929
HAW110370579
HZE124638194
TNL113504311
SLIU111349601
OFU114351201
PXY105391367
PGW126374557
CFEL113389004
CCRN123300189
API100167575
DNX107163428
AGS114120233
RMD113555196
ACOO126841153
DVT126905328
BTAB109044264
DCI103506752 108253294
CLEC106670504
HHAL106683228
NLU111057072
HVI124355033
MQU128996543
PHUPhum_PHUM414590
FOC113212460
TPAL117645519
CSEC111873091
SGRE126271985 126317089
IEL124169679
FCD110842788
DPXDAPPUDRAFT_332860
DMK116931070
DPZ124349493
PVM113818099
PJA122257684
PCHN125025607
PMOO119577269
HAME121875772
PCLA123765087
CQD128703316
PTRU123518804
ESN126999011
HAZT108681612
EAF111696524
LSM121129872
TCF131879394
PPOI119094250 119094251
DSV119440587
ABRU129955732
UDV129217480
LPOL106463218
HROHELRODRAFT_98504
LGILOTGIDRAFT_157973
PVUL126817343
PCAN112553906
BGT106065027
GAE121385566
HRF124143730
HRJ124264477
CRG105326295
CVN111129331
CANU128175449
OED125649567
MYI110453744
PMAX117334218
MCAF127733788
MMER123566556
RPHI132750164
DPOL127875952
OBI106871734
OSN115209823
NVE5504006
EPA110252238
ATEN116294223
ADF107337999
AMIL114958545
PDAM113684402
SPIS111344377
DGT114523595 114523979
XEN124434950
HMG100208540
HSY130623533
TADTRIADDRAFT_19721
AQU100640903
MBRMONBRDRAFT_23152
SREPTSG_04583
ACANACA1_063620
 » show all
Reference
1  [PMID:9371691]
  Authors
Qin YM, Haapalainen AM, Conry D, Cuebas DA, Hiltunen JK, Novikov DK.
  Title
Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis.
  Journal
Biochem J 328 ( Pt 2):377-82 (1997)
DOI:10.1042/bj3280377
Reference
2  [PMID:8619845]
  Authors
Xu R, Cuebas DA.
  Title
The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids.
  Journal
Biochem Biophys Res Commun 221:271-8 (1996)
DOI:10.1006/bbrc.1996.0585
Reference
3
  Authors
Kinoshita, T., Miyata, M., Ismail, S.M., Fujimoto, Y., Kakinuma, K., Kokawa, N.I. and Morisaki, M.
  Title
Synthesis and determination of stereochemistry of four diastereoisomers at the C-24 and C-25 positions of 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid and cholic acid.
  Journal
Chem Pharm Bull 36:134-141 (1988)
Reference
4
  Authors
Fujimoto, Y., Kinoshita, T., Oya, I., Kakinuma, K., Ismail, S.M., Sonoda, Y., Sato, Y. and Morisaki, M.
  Title
Non-stereoselective conversion of the four diastereoisomers at the C-24 and C-25 positions of 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid and cholic acid.
  Journal
Chem Pharm Bull 36:142-145 (1988)
Reference
5  [PMID:11146090]
  Authors
Kurosawa T, Sato M, Nakano H, Fujiwara M, Murai T, Yoshimura T, Hashimoto T.
  Title
Conjugation reactions catalyzed by bifunctional proteins related to beta-oxidation in bile acid biosynthesis.
  Journal
Steroids 66:107-14 (2001)
DOI:10.1016/S0039-128X(00)00217-8
Reference
6  [PMID:12543708]
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.107
IUBMB Enzyme Nomenclature: 4.2.1.107
ExPASy - ENZYME nomenclature database: 4.2.1.107
BRENDA, the Enzyme Database: 4.2.1.107
CAS: 152787-68-3

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