KEGG   ENZYME: 4.2.1.107
Entry
EC 4.2.1.107                Enzyme                                 
Name
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase;
46 kDa hydratase 2;
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming]
Reaction(IUBMB)
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O [RN:R04813]
Reaction(KEGG)
R04813;
(other) R04809
Substrate
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA [CPD:C15614]
Product
(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA [CPD:C05460];
H2O [CPD:C00001]
Comment
This enzyme forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity. The enzyme is involved in the beta-oxidation of the cholesterol side chain in the cholic-acid-biosynthesis pathway.
History
EC 4.2.1.107 created 2005
Pathway
ec00120  Primary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K12405  (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
Genes
HSA3295(HSD17B4)
PTR462019(HSD17B4)
PPS100981028(HSD17B4)
GGO101129538(HSD17B4)
PON100448539(HSD17B4)
NLE100590035(HSD17B4)
MCC698369(HSD17B4)
MCF102123675(HSD17B4)
CSAB103244395(HSD17B4)
CATY105590649(HSD17B4)
PANU101004327(HSD17B4)
TGE112625827(HSD17B4)
RRO104654581(HSD17B4)
RBB108529825(HSD17B4)
TFN117065971(HSD17B4)
PTEH111530208(HSD17B4)
CJC100390100(HSD17B4)
SBQ101036776(HSD17B4)
CSYR103262046
MMUR105872240
OGA100966879(HSD17B4)
MMU15488(Hsd17b4)
MCAL110284447(Hsd17b4)
MPAH110332881(Hsd17b4)
RNO79244(Hsd17b4)
MCOC116087150(Hsd17b4)
CGE103161104(Hsd17b4)
PLEU114694768(Hsd17b4)
NGI103745113(Hsd17b4)
HGL101713520(Hsd17b4)
CPOC100379226(Hsd17b4)
CCAN109674145
DORD105985471(Hsd17b4)
DSP122101973(Hsd17b4)
OCU100346781(HSD17B4)
OPI101530287(HSD17B4)
TUP102468828(HSD17B4)
CFA474630(HSD17B4)
VVP112932403(HSD17B4)
VLG121494637(HSD17B4)
AML100471749(HSD17B4)
UMR103670554(HSD17B4)
UAH113261629(HSD17B4)
UAR123790430(HSD17B4)
ELK111158891
LLV125100000
MPUF101683185(HSD17B4)
ORO101385731(HSD17B4)
EJU114209435(HSD17B4)
ZCA113928790(HSD17B4)
MLX118016560(HSD17B4)
FCA101091840(HSD17B4)
PYU121010581(HSD17B4)
PBG122486641(HSD17B4)
PTG102968873(HSD17B4)
PPAD109278892(HSD17B4)
AJU106975089(HSD17B4)
HHV120240242(HSD17B4)
BTA493643(HSD17B4)
BOM102268517(HSD17B4)
BBUB102412917(HSD17B4)
CHX102172142(HSD17B4)
OAS101114519(HSD17B4)
ODA120864671(HSD17B4)
CCAD122440074(HSD17B4)
SSC397574(HSD17B4)
CFR102508317(HSD17B4)
CBAI105082053(HSD17B4)
CDK105104293(HSD17B4)
VPC102537534(HSD17B4)
LVE103084787(HSD17B4)
OOR101282963(HSD17B4)
DLE111183342(HSD17B4)
PCAD102996127(HSD17B4)
PSIU116751686(HSD17B4)
ECB100034046(HSD17B4)
EPZ103548315(HSD17B4)
EAI106833039(HSD17B4)
MYB102240475(HSD17B4)
MYD102767159(HSD17B4)
MMYO118656167(HSD17B4)
MLF102425700(HSD17B4)
MNA107530713(HSD17B4)
PKL118703106(HSD17B4)
HAI109374101(HSD17B4)
DRO112315031(HSD17B4)
SHON118975196(HSD17B4)
AJM119051192(HSD17B4)
PDIC114494306(HSD17B4)
PHAS123818113(HSD17B4)
MMF118642891(HSD17B4)
RFQ117024890(HSD17B4)
PALE102887000(HSD17B4)
PGIG120590862(HSD17B4)
PVP105290860(HSD17B4)
RAY107511154(HSD17B4)
TOD119243559(HSD17B4)
SARA101542842(HSD17B4)
LAV100659299(HSD17B4)
TMU101356123
DNM101423884(HSD17B4)
MDO100028098(HSD17B4)
GAS123235791(HSD17B4)
SHR100932771(HSD17B4)
PCW110202743(HSD17B4)
OAA100081754(HSD17B4)
GGA395785(HSD17B4)
PCOC116234067(HSD17B4)
CJO107306670(HSD17B4)
NMEL110389447(HSD17B4)
APLA101791118(HSD17B4)
ACYG106048362(HSD17B4)
AFUL116500754(HSD17B4)
TGU100218226(HSD17B4)
LSR110479177(HSD17B4)
SCAN103821465(HSD17B4)
PMOA120512524(HSD17B4)
OTC121332706(HSD17B4)
PRUF121362562(HSD17B4)
GFR102036502(HSD17B4)
FAB101807233(HSD17B4)
PHI102109547(HSD17B4)
PMAJ107216347(HSD17B4)
CCAE111941198(HSD17B4)
CCW104690497(HSD17B4)
ETL114056305(HSD17B4)
ZAB102062238(HSD17B4)
FPG101917400(HSD17B4)
FCH102058406(HSD17B4)
CLV102095771(HSD17B4)
EGZ104122491(HSD17B4)
NNI104014571(HSD17B4)
ACUN113489653(HSD17B4)
TALA104363287(HSD17B4)
PADL103912347(HSD17B4)
ACHC115336530(HSD17B4)
AROW112978041(HSD17B4)
NPD112958912(HSD17B4)
DNE112992405
ASN102371766(HSD17B4)
AMJ102571005(HSD17B4)
CPOO109323436(HSD17B4)
GGN109297318(HSD17B4)
PSS102451304(HSD17B4)
CPIC101945395(HSD17B4)
TST117879364(HSD17B4)
CABI116836212(HSD17B4)
MRV120408024(HSD17B4)
ACS100558484(hsd17b4)
PVT110084344(HSD17B4)
SUND121921111(HSD17B4)
PBI103063870(HSD17B4)
PMUR107294349(HSD17B4)
TSR106543382(HSD17B4)
PGUT117674677(HSD17B4)
VKO123031365(HSD17B4)
PMUA114606393(HSD17B4)
ZVI118076708(HSD17B4)
GJA107116225(HSD17B4)
XLA444492(hsd17b4.L)
XTR613082(hsd17b4)
NPR108787696(HSD17B4)
RTEM120931986(HSD17B4)
BBUF120992600(HSD17B4)
BGAR122924617(HSD17B4)
DRE393105(hsd17b4)
SANH107703629(hsd17b4)
SGH107571774(hsd17b4)
CAUA113094195 113106903
IPU108265438(hsd17b4)
PHYP113529268(hsd17b4)
SMEO124399595(hsd17b4)
AMEX103046836(hsd17b4)
EEE113571049(hsd17b4)
TRU101062498(hsd17b4)
TNGGSTEN00030945G001
LCO104920820(hsd17b4)
NCC104966339(hsd17b4)
CGOB115013548(hsd17b4)
ELY117252434(hsd17b4)
PLEP121944362(hsd17b4)
SLUC116054060(hsd17b4)
ECRA117944965(hsd17b4)
PFLV114555481(hsd17b4)
GAT120830783(hsd17b4)
PPUG119225552(hsd17b4)
MSAM119891683(hsd17b4)
CUD121509730(hsd17b4)
MZE101482787(hsd17b4)
ONL100706762(hsd17b4)
OAU116310500(hsd17b4)
OLA101159921(hsd17b4)
OML112148954(hsd17b4)
XMA102223774(hsd17b4)
XCO114154573(hsd17b4)
XHE116730397(hsd17b4)
PRET103470095(hsd17b4)
PFOR103141760(hsd17b4)
PLAI106944940(hsd17b4)
PMEI106923064(hsd17b4)
GAF122827419(hsd17b4)
CVG107086311(hsd17b4)
CTUL119798579(hsd17b4)
GMU124877861(hsd17b4)
NFU107394149(hsd17b4)
KMR108233704(hsd17b4)
ALIM106513677(hsd17b4)
NWH119413904(hsd17b4)
AOCE111564685(hsd17b4)
POV109637138(hsd17b4)
SSEN122769476(hsd17b4)
HHIP117768550(hsd17b4)
LCF108882142(hsd17b4)
SDU111230866(hsd17b4)
SLAL111645149(hsd17b4)
XGL120805559(hsd17b4)
HCQ109526033(hsd17b4)
BPEC110167024(hsd17b4)
MALB109956607(hsd17b4)
SASA106585849(hsd17b4)
OTW112247069(hsd17b4)
OMY110525264(hsd17b4)
OGO124034633(hsd17b4)
ONE115111275(hsd17b4)
SALP111974039(hsd17b4)
SNH120045172(hsd17b4)
ELS105014609(hsd17b4)
SFM108938133(hsd17b4)
PKI111856620(hsd17b4)
AANG118206736(hsd17b4)
LOC102697531(hsd17b4)
PSPA121302596(hsd17b4) 121316706
ARUT117427495 117973220
LCM102356548(HSD17B4)
CMK103181119(hsd17b4)
BFO118409354
BBEL109480804
CIN100187421
SCLV120338122
SPU581580
DMEDmel_CG3415(Mfe2)
DPODpse_GA17436
DMN108161558
DGR6565453
AGAAgaP_AGAP008667
ACOZ120955687
AARA120901803
AAG5568633
AALB109428196
CQUCpipJ_CPIJ001576
CPII120414661
CNS116337519 116349688
AME409986
NVI100123018
CGLO123268667
FAS105272013
DAM107040917
AGIF122847409
TCA663655(17-beta-HD4)
SOY115888404
CSET123306476
AGB108915760
LDC111505860
APLN108736403
PPYR116158989 116159225 116159796 116159821 116176974 116179454
OTU111423793
BMOR101745499
API100167575
DNX107163428
AGS114120233
RMD113555196
DCI103506752 108253294
HHAL106683228
NLU111057072
FOC113212460
CSEC111873091
DPXDAPPUDRAFT_332860
DMK116931070
PVM113818099
PJA122257684
HAME121875772
PCLA123765087
PTRU123518804
HAZT108681612
EAF111696524
DSV119440587
RSAN119387719
VDE111252755
VJA111266535
DFR124493442 124496269
SDM118180496
CELCELE_E04F6.3(maoc-1) CELE_M03A8.1(dhs-28)
CBRCBG_10899(Cbr-dhs-28)
BGT106065027
GAE121385566
HRF124143730
HRJ124264477
CRG105326295
MYI110453744
PMAX117334218
MMER123566556
OSN115209823
NVE5504006
ATEN116294223
XEN124434950
TADTRIADDRAFT_19721
MBRMONBRDRAFT_23152
DDIDDB_G0291247(mfeA)
TETTTHERM_00317440
PCAYFRD00_09620
 » show all
Reference
1  [PMID:9371691]
  Authors
Qin YM, Haapalainen AM, Conry D, Cuebas DA, Hiltunen JK, Novikov DK.
  Title
Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis.
  Journal
Biochem J 328 ( Pt 2):377-82 (1997)
DOI:10.1042/bj3280377
Reference
2  [PMID:8619845]
  Authors
Xu R, Cuebas DA.
  Title
The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids.
  Journal
Biochem Biophys Res Commun 221:271-8 (1996)
DOI:10.1006/bbrc.1996.0585
Reference
3
  Authors
Kinoshita, T., Miyata, M., Ismail, S.M., Fujimoto, Y., Kakinuma, K., Kokawa, N.I. and Morisaki, M.
  Title
Synthesis and determination of stereochemistry of four diastereoisomers at the C-24 and C-25 positions of 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid and cholic acid.
  Journal
Chem Pharm Bull 36:134-141 (1988)
Reference
4
  Authors
Fujimoto, Y., Kinoshita, T., Oya, I., Kakinuma, K., Ismail, S.M., Sonoda, Y., Sato, Y. and Morisaki, M.
  Title
Non-stereoselective conversion of the four diastereoisomers at the C-24 and C-25 positions of 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid and cholic acid.
  Journal
Chem Pharm Bull 36:142-145 (1988)
Reference
5  [PMID:11146090]
  Authors
Kurosawa T, Sato M, Nakano H, Fujiwara M, Murai T, Yoshimura T, Hashimoto T.
  Title
Conjugation reactions catalyzed by bifunctional proteins related to beta-oxidation in bile acid biosynthesis.
  Journal
Steroids 66:107-14 (2001)
DOI:10.1016/S0039-128X(00)00217-8
Reference
6  [PMID:12543708]
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.107
IUBMB Enzyme Nomenclature: 4.2.1.107
ExPASy - ENZYME nomenclature database: 4.2.1.107
BRENDA, the Enzyme Database: 4.2.1.107
CAS: 152787-68-3

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