| Entry |
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| Name |
o-succinylbenzoate synthase;
o-succinylbenzoic acid synthase;
OSB synthase;
OSBS;
2-succinylbenzoate synthase;
MenC
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate hydro-lyase (2-succinylbenzoate-forming)
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| Reaction(IUBMB) |
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O [RN: R04031]
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| Reaction(KEGG) |
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| Substrate |
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate [CPD: C05817]
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| Product |
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| Comment |
Belongs to the enolase superfamily and requires divalent cations, preferably Mg2+ or Mn2+, for activity. Forms part of the vitamin-K-biosynthesis pathway.
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| History |
EC 4.2.1.113 created 2007
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| Pathway |
| ec00130 | Ubiquinone and other terpenoid-quinone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K02549 | O-succinylbenzoate synthase |
| K14759 | isochorismate synthase / 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / O-succinylbenzoate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Sharma V, Meganathan R, Hudspeth ME. |
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| Title |
Menaquinone (vitamin K2) biosynthesis: cloning, nucleotide sequence, and expression of the menC gene from Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Klenchin VA, Taylor Ringia EA, Gerlt JA, Rayment I. |
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| Title |
Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli. |
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| Journal |
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| Reference |
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| Authors |
Palmer DR, Garrett JB, Sharma V, Meganathan R, Babbitt PC, Gerlt JA. |
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| Title |
Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Thompson TB, Garrett JB, Taylor EA, Meganathan R, Gerlt JA, Rayment I. |
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| Title |
Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Taylor Ringia EA, Garrett JB, Thoden JB, Holden HM, Rayment I, Gerlt JA. |
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| Title |
Evolution of enzymatic activity in the enolase superfamily: functional studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.1.113 |
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