KEGG   ENZYME: 4.2.1.116Help
Entry
EC 4.2.1.116                Enzyme                                 

Name
3-hydroxypropionyl-CoA dehydratase;
3-hydroxypropionyl-CoA hydro-lyase;
3-hydroxypropanoyl-CoA dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
3-hydroxypropanoyl-CoA hydro-lyase
Reaction(IUBMB)
3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O [RN:R03045]
Reaction(KEGG)
Substrate
3-hydroxypropanoyl-CoA [CPD:C05668]
Product
acryloyl-CoA [CPD:C00894];
H2O [CPD:C00001]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA [2].
History
EC 4.2.1.116 created 2009
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K14469  acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15019  3-hydroxypropionyl-coenzyme A dehydratase
Genes
RRS: RoseRS_3202
RCA: Rcas_2930
CAU: Caur_0613
CHL: Chy400_0662
CAG: Cagg_3394
CTM: Cabther_B0610
ZGA: ZOBELLIA_1046(paaF)
CTS: Ctha_1050
TAC: Ta0121
FAC: FACI_IFERC01G0358
FAI: FAD_1277
SSO: SSO0654(paaF-2)
SOL: Ssol_1713
SSOA: SULA_1740
SSOL: SULB_1741
SSOF: SULC_1739
STO: STK_15160
SAI: Saci_1633(paaF)
SID: M164_1479
SII: LD85_1689
SIH: SiH_1448
SIR: SiRe_1359
SIC: SiL_1361
MSE: Msed_2001
MCN: Mcup_0286
AHO: Ahos_1095
NMR: Nmar_1308
NID: NPIRD3C_0817(crt)
NIN: NADRNF5_0652(crt)
NCT: NMSP_0386
NEV: NTE_02211
TAA: NMY3_00896(echA8_1) NMY3_01290(echA8_2)
NCV: NCAV_1488
NBV: T478_1057
NDV: NDEV_0058(crt) NDEV_1640(hpcD)
 » show all
Taxonomy
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
  Sequence
[mse:Msed_2001]
Reference
2  [PMID:19429610]
  Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  Journal
J Bacteriol 191:4572-81 (2009)
DOI:10.1128/JB.00068-09
  Sequence
[mse:Msed_2001]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.116
IUBMB Enzyme Nomenclature: 4.2.1.116
ExPASy - ENZYME nomenclature database: 4.2.1.116
BRENDA, the Enzyme Database: 4.2.1.116

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