KEGG   ENZYME: 4.2.1.116
Entry
EC 4.2.1.116                Enzyme                                 
Name
3-hydroxypropionyl-CoA dehydratase;
3-hydroxypropionyl-CoA hydro-lyase;
3-hydroxypropanoyl-CoA dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
3-hydroxypropanoyl-CoA hydro-lyase
Reaction(IUBMB)
3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O [RN:R03045]
Reaction(KEGG)
R03045
Substrate
3-hydroxypropanoyl-CoA [CPD:C05668]
Product
acryloyl-CoA [CPD:C00894];
H2O [CPD:C00001]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA [2].
History
EC 4.2.1.116 created 2009
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K14469  acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15019  3-hydroxypropionyl-coenzyme A dehydratase
Genes
PZAHU749_011940
ORMHTY61_07290
BQBJ4P68_0034680 J4P68_0034780
RBKE0H22_25265
CAULKCG34_08935
TMDKUV46_06485
CAZTLV780_06945
PALGHFP57_16695
PHAOHF685_04995
SANDH3309_14800
POQKZX46_11635
STELSTAQ_36040 STAQ_38470(crt)
BWHA9C19_11695
BCOHBC6307_13135
PKSIE339_17735
BPFBpOF4_00760
CSUAIM538_10285
ASEDIRT44_18580
SCIBHUG20_01415
SCIAHUG15_02435 HUG15_20660
MSEMGMB29_10605 GMB29_17970
CTHUHUR95_12550
MCUIG8O30_04340
GAJMY490_15215
BBEBBR47_38620
BCHSJNE38_19600
BCOPJD108_08410
ATHEK3F53_12240
CHEBHH215_01750
AACOK1I37_02730
LFBC1X05_11400
PABSJIR001_20550
MSIMMSIM_34110
MSAKMSAS_45100
MBRDMBRA_36960
MHOLK3U96_16025 K3U96_21285
MHERK3U94_12260
MSPGF6B93_09875
MVMMJO54_12195
MPAAMKK62_25435 MKK62_25705
MNED174_05105
MYNMyAD_04995
MPAKMIU77_09260
CCOECETAM_10640(echA4)
NTCKHQ06_31310
RKOJWS14_47335
RGOKYT97_21365
SCADDN051_38405
PSAIC3B54_111272
ASUFMNQ99_17490
THAONI17_008760
TALXFOF52_05410
AMQAMETH_4550(paaG)
AACDLWP59_05945 LWP59_12750
PSEAWY02_09185
PSEQAD006_31800
PECQAD017_28325
RMARGBA65_16170
PARNNBH00_05565 NBH00_06975
RRSRoseRS_3202
RCARcas_2930
CAUCaur_0613
CHLChy400_0662
CAGCagg_3394
PMETG4Y79_13175
CTMCabther_B0610
CVLJ8C06_12460
CHLOJ8C02_11660
GGRHKW67_05055
ZGAZOBELLIA_1046(paaF)
CTSCtha_1050
HALXM0R89_21400
HAKZJ0X25_09315
NAYHYG81_22555
MELUMTLP_03440
TACTa0121
FACFACI_IFERC01G0358
FAIFAD_1277
STOSTK_15160
SOHD1869_08510
SSOSSO0654(paaF-2)
SOLSsol_1713
SSOASULA_1740
SSOLSULB_1741
SSOFSULC_1739
SSHIJ5U23_00433 J5U23_02754
SCASSACC_03270
SAISaci_1633(paaF)
SACNSacN8_07925
SACRSacRon12I_07935
SACSSUSAZ_07730
SISLS215_1590
SIAM1425_1482
SIMM1627_1597
SIDM164_1479
SIYYG5714_1486
SINYN1551_1350
SIILD85_1689
SIHSiH_1448
SIRSiRe_1359
SICSiL_1361
SULABFU36_02775
SULEGFS03_08480
SULOGFS33_00250 GFS33_04315
SULLEWF20_09680
MSEMsed_2001
MEMJMJ1HA_2269
MCNMcup_0286
MHKDFR87_08490
MPRUDFR88_08165
MTENGWK48_03830
MJNMjAS7_0302
AHOAhos_1095
AMANB6F84_09545
ABRIDFR85_09170
ASULDFR86_08230
AAMBD1866_00345
ACIHHS5_24900
SACDHS1genome_0093
SAZOD1868_05545
CSTYKN1_27150
STEPIC006_1372
SAHSHS7_05880
NMRNmar_1308
NIRNSED_07245
NKRNKOR_07370
NIDNPIRD3C_0817(crt)
NINNADRNF5_0652(crt)
NIWNisw_07195
NCLC5F47_07030
NOXC5F49_07025
NUEC5F50_09800
NIPNsoK4_01525
NCTNMSP_0386
NICDSQ20_07975
CSYCENSYa_0166
NGANgar_c21980
NVNNVIE_008340
NEVNTE_02211
TAANMY3_00896(echA8_1) NMY3_01290(echA8_2)
NFNNFRAN_1867(crt)
NCVNCAV_1488
NBVT478_1057
TAHSU86_009010
NIUDSQ19_03120
NDVNDEV_0058(crt) NDEV_1640(hpcD)
 » show all
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
  Sequence
[mse:Msed_2001]
Reference
2  [PMID:19429610]
  Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  Journal
J Bacteriol 191:4572-81 (2009)
DOI:10.1128/JB.00068-09
  Sequence
[mse:Msed_2001]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.116
IUBMB Enzyme Nomenclature: 4.2.1.116
ExPASy - ENZYME nomenclature database: 4.2.1.116
BRENDA, the Enzyme Database: 4.2.1.116

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