KEGG   ENZYME: 4.2.1.118
Entry
EC 4.2.1.118                Enzyme                                 

Name
3-dehydroshikimate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
3-dehydroshikimate hydro-lyase
Reaction(IUBMB)
3-dehydro-shikimate = 3,4-dihydroxybenzoate + H2O [RN:R01627]
Reaction(KEGG)
R01627
Substrate
3-dehydro-shikimate
Product
3,4-dihydroxybenzoate [CPD:C00230];
H2O [CPD:C00001]
Comment
Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.
History
EC 4.2.1.118 created 2009
Pathway
ec01053  Biosynthesis of siderophore group nonribosomal peptides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09483  3-dehydroshikimate dehydratase
K15652  3-dehydroshikimate dehydratase
Genes
PAO: Pat9b_2424
TCI: A7K98_19065
XSA: SB85_14665
SLM: BIZ42_17435
STEM: CLM74_09120
DKO: I596_1177
PPG: PputGB1_4069
PPW: PputW619_3862
PPUT: L483_24900
PPUN: PP4_12570(quiC)
PSV: PVLB_18200
PPV: NJ69_03045
ACB: A1S_1882
ABM: ABSDF2013(quiC)
ABY: ABAYE1683(quiC)
ABC: ACICU_01992
ABN: AB57_2216
ABB: ABBFA_01553(quiC)
ABX: ABK1_2460
ABZ: ABZJ_02174
ABR: ABTJ_01716
ABD: ABTW07_2204
ABH: M3Q_2340
ABAD: ABD1_19030(quiC)
ABJ: BJAB07104_01746
ABAB: BJAB0715_02139
ABAJ: BJAB0868_02131
ABAZ: P795_7620
ABK: LX00_10085
ABAU: IX87_20870
ABAA: IX88_11585
ABW: BL01_00635
ABAL: ABLAC_27550
ACC: BDGL_001361(quiC)
ANO: RR32_08445
ALC: OTEC02_08075
ACAL: BUM88_10790
ACD: AOLE_08440
ACI: ACIAD1714(quiC)
AJO: RZ95_12740
ACW: A0J50_07800
AHL: AHTJS_06220
ASOL: BEN76_04810
AGU: AS4_11900(quiC)
AUG: URS_2757
ADS: FPL17_02770
ABER: BSR55_05740
MAQ: Maqu_3527
MHC: MARHY3427
MARJ: MARI_31170(asbF)
AMAC: MASE_09730
AMG: AMEC673_09975
ASP: AOR13_246
ASQ: AVL57_17240
AAW: AVL56_16125
ALE: AV939_16180
ALZ: AV940_15935
CATE: C2869_06580
HMI: soil367_15790
CELL: CBR65_18750
MII: BTJ40_19060
OAI: OLEAN_C24190
OME: OLMES_0539
OCE: GU3_03580
AMIM: MIM_c35790(quiC)
AAK: AA2016_0180
AMIH: CO731_00653(asbF)
SFH: SFHH103_01320
EAH: FA04_19990
RPA: RPA2386
RPT: Rpal_2628
RPX: Rpdx1_3185
NWI: Nwi_2298
MEA: Mex_1p4135
MDI: METDI4727
MEX: Mext_3763
MCH: Mchl_4058
MPO: Mpop_4019
MZA: B2G69_00630
META: Y590_18690
METD: C0214_20940
AUA: M673_21075
CFH: C1707_09830
PARR: EOJ32_13040
KVL: KVU_1356
KVU: EIO_1898
PGA: PGA1_78p00450
PGL: PGA2_95p540
PGD: Gal_04238
LMD: METH_16715
ALI: AZOLI_p20608
AZM: DM194_19460
AZZ: DEW08_01155
PSTG: E8M01_18755
BAY: RBAM_003390
BAQ: BACAU_0282
BYA: BANAU_0281(asbF)
BAMP: B938_01450
BAML: BAM5036_0298
BAMA: RBAU_0311
BAMN: BASU_0295
BAMB: BAPNAU_0280(frlC1)
BAMT: AJ82_01860
BAMY: V529_03020
BMP: NG74_00319(asbF)
BAO: BAMF_0287(RBAM_003390)
BAZ: BAMTA208_01445
BQL: LL3_00296(prot)
BXH: BAXH7_00299
BQY: MUS_0297
BAMI: KSO_017965
BAMC: U471_02990
BAMF: U722_01745
BSIA: CWD84_20295
BAE: BATR1942_20215
BVM: B9C48_01720
BHT: DIC78_08410
BAN: BA_1986(asbF)
BAR: GBAA_1986(asbF)
BAT: BAS1843
BAH: BAMEG_2604(asbF)
BAI: BAA_2054(asbF)
BAX: H9401_1883
BANT: A16_20230
BANR: A16R_20480
BANS: BAPAT_1899
BANH: HYU01_09950
BANV: DJ46_791(asbF)
BCE: BC1983
BCZ: BCE33L1800
BCB: BCB4264_A1988(asbF)
BCU: BCAH820_2021(asbF)
BCG: BCG9842_B3341(asbF)
BCX: BCA_2048(asbF)
BAL: BACI_c19600
BCF: bcf_09775
BTK: BT9727_1817
BTL: BALH_1758
BTB: BMB171_C1770(asbF)
BTT: HD73_2152
BTHR: YBT1520_10735
BTHI: BTK_10875
BTC: CT43_CH1939(asbF)
BTM: MC28_1189(asbF)
BTG: BTB_c20530(asbF)
BTI: BTG_10030
BTN: BTF1_07305
BTHT: H175_ch1965
BTHU: YBT1518_11045
BTW: BF38_3200(asbF)
BTHY: AQ980_20240
BWE: BcerKBAB4_1849
BWW: bwei_3030(asbF)
BMYO: BG05_4000(asbF)
BTY: Btoyo_4557
BBY: CY96_09010
BWD: CT694_10825
BTRO: FJR70_09665(asbF)
BACP: SB24_08110
BACB: OY17_04360
BWH: A9C19_17975
BHK: B4U37_11070
BACS: AUL54_09115
BCIR: C2I06_01630
BCL: ABC1952
BPF: BpOF4_08950(asbF)
BLE: BleG1_1615
BKW: BkAM31D_09870
BON: A361_02390
LSP: Bsph_2958
LFU: HR49_11820
GRC: GI584_08200
EXM: U719_06060
EXU: ESP131_08455
BBE: BBR47_20500
BLR: BRLA_c008720
BFM: BP422_05365
BRW: GOP56_20360
GYM: GYMC10_3280
PPOL: X809_41440
PMS: KNP414_07050(asbF)
PMQ: PM3016_6640
PMW: B2K_33545
PTA: HPL003_06785
PSAB: PSAB_20060
PPEO: ABE82_25190
PSWU: SY83_22190
PKB: B4V02_00160
PLW: D5F53_14015
PLEN: EIM92_17165
PBK: Back11_14790
SACA: FFV09_02350
AAC: Aaci_2516
AAD: TC41_2813
SOB: CSE16_06635
KEB: GXN75_04985
AUI: APT62_05640
CARN: FPV25_01710
CTHD: CDO33_01315
ANR: Ana3638_20680
CGT: cgR_2454
CGS: C624_12520
CGG: C629_12525
CGJ: AR0_12255
CGQ: CGLAR1_12115
MIM: AKG07_10160
MIP: AXH82_04065
MICR: BMW26_14790
MYL: C3E77_02375
ARR: ARUE_c38300
ARZ: AUT26_17610
ARN: CGK93_20675
ARX: ARZXY2_59
AAU: AAur_3698
PUE: FV140_19235
BFA: Bfae_28960
BRX: BH708_11275
BRV: CFK39_07025
BGG: CFK41_01860
BRZ: CFK38_04020
BSAU: DWV08_12140
BRR: C1N80_04415
PSEI: GCE65_15780
KFL: Kfla_6276
KQI: F1D05_16060
AOI: AORI_3481
AJA: AJAP_21755
AMYB: BKN51_15095
AORI: SD37_18020
PSEA: WY02_06330
PSEH: XF36_08530
PHH: AFB00_27490
SESP: BN6_32940 BN6_83190
LED: BBK82_15560
ACTA: C1701_16005
PLAB: C6361_27315
PLAT: C6W10_29755
PFLA: Pflav_052290
KBS: EPA93_43695
OBT: OPIT5_16430
VBA: IMCC26134_07590
PLH: VT85_20595(asbF_2)
PHM: PSMK_00490
TBE: Trebr_1565
AALG: AREALGSMS7_02865
MMX: MmarC6_0487
MMAD: MMJJ_18570
 » show all
Reference
1  [PMID:18975921]
  Authors
Fox DT, Hotta K, Kim CY, Koppisch AT
  Title
The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.
  Journal
Biochemistry 47:12251-3 (2008)
DOI:10.1021/bi801876q
Reference
2  [PMID:18955706]
  Authors
Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH
  Title
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 105:17133-8 (2008)
DOI:10.1073/pnas.0808118105
  Sequence
[ban:BA_1986]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.118
IUBMB Enzyme Nomenclature: 4.2.1.118
ExPASy - ENZYME nomenclature database: 4.2.1.118
BRENDA, the Enzyme Database: 4.2.1.118

  All links  
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (401)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (249)   
   KEGG MGENES (130)   
   RefGene (20)   
Protein sequence (258)   
   UniProt (163)   
   SWISS-PROT (4)   
   RefSeq(pep) (85)   
   PDBSTR (6)   
DNA sequence (1021)   
   RefSeq(nuc) (682)   
   GenBank (172)   
   EMBL (167)   
3D Structure (1)   
   PDB (1)   
Protein domain (10)   
   InterPro (10)   
All databases (1702)   

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