Entry
Name
3-dehydroshikimate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
3-dehydroshikimate hydro-lyase
Reaction(IUBMB)
3-dehydro-shikimate = 3,4-dihydroxybenzoate + H2O [RN:
R01627 ]
Reaction(KEGG)
Substrate
3-dehydro-shikimate
Product
Comment
Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.
History
EC 4.2.1.118 created 2009
Pathway
ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
ec01053 Biosynthesis of siderophore group nonribosomal peptides
ec01110 Biosynthesis of secondary metabolites
Orthology
K09483 3-dehydroshikimate dehydratase
K15652 3-dehydroshikimate dehydratase
K26400 3-dehydroshikimate dehydratase
Genes
NTE : NEUTE1DRAFT139743(NEUTE1DRAFT_139743)
SSCK : SPSK_00738 SPSK_03395 SPSK_06383
FGR : FGSG_03879 FGSG_05703
FPU : FPSE_06306 FPSE_06597
FVR : FVEG_05966 FVEG_09878
NHE : NECHADRAFT_32792 NECHADRAFT_51252 NECHADRAFT_55795 NECHADRAFT_98157
CFJ : CFIO01_01550 CFIO01_09602
ELA : UCREL1_7070 UCREL1_7617
PFY : PFICI_14925 PFICI_15084
BFU : BCIN_06g00850 BCIN_09g06540
PSCO : LY89DRAFT_590036 LY89DRAFT_680001
GLZ : GLAREA_09761 GLAREA_11529
AFM : AFUA_1G11560 AFUA_3G03510 AFUA_3G14820
ACT : ACLA_024080 ACLA_093830
AOR : AO090038000266 AO090103000429 AO090701000638
ANG : ANI_1_1220184(An04g08090) ANI_1_1304084(An09g03290) ANI_1_1880074(An08g03840)
AFV : AFLA_005157 AFLA_008753 AFLA_013103
ALUC : AKAW2_30244S AKAW2_30652S AKAW2_40379A
ACHE : ACHE_10204A ACHE_30244A ACHE_80024A
APUU : APUU_30067A APUU_31275A APUU_50614A
PCS : Pc12g13180 Pc13g08330 Pc21g12820 Pc22g24620
PDP : PDIP_30910 PDIP_78140
BGH : BDBG_00207 BDBG_07998
PNO : SNOG_10412 SNOG_11437
ZTR : MYCGRDRAFT_67847(QA4)
UMA : UMAG_00025 UMAG_10219
PFP : PFL1_00203 PFL1_00212
RTG : NCTC13098_03101(hpd)
REE : electrica_02127(lly)
KIE : NCTC12125_01190(hpd)
PPG : PputGB1_3362 PputGB1_4069
PPW : PputW619_2225 PputW619_3862
PPUT : L483_10045 L483_24900
PPUN : PP4_12570(quiC) PP4_33440
PPRC : PFLCHA0_c53570(vllY)
PSV : PVLB_10935 PVLB_18200
PPV : NJ69_03045 NJ69_05765
PEZ : HWQ56_22850 HWQ56_25130
PXA : KSS93_17270 KSS93_22595
PQI : KH389_03370 KH389_07630
PPRG : HU725_012975 HU725_016755
PFAK : KSS94_14360 KSS94_20020
PWY : HU734_011295 HU734_018785
PTAE : NCTC10697_00707(hpd_1)
PSIH : LOY51_11835 LOY51_20220
HOL : HORIV_71360 HORIV_71500
HTT : HZS52_05085 HZS52_05175
BPL : BURPS1106A_A0481(hppD)
PLG : NCTC10937_03702(hpd)
PHT : BLM14_17555 BLM14_19960
RHI : NGR_b00190 NGR_b22740
SFH : SFHH103_01320 SFHH103_06820
SFD : USDA257_c21400(melA1) USDA257_c22230(vllY)
SIX : BSY16_4235 BSY16_5040
SAME : SAMCFNEI73_pA0197(hpd) SAMCFNEI73_pC0017(hpd)
SINO : SS05631_b49810 SS05631_b64220
EAH : FA04_19990 FA04_32170
REP : IE4803_CH00102 IE4803_PA00161 IE4803_PD00661
REI : IE4771_CH00102 IE4771_PC00162 IE4771_PE00685
RLU : RLEG12_03540 RLEG12_05885
RPHA : AMC79_PA00327 AMC79_PB00162
RHK : Kim5_CH00101 Kim5_PB00198 Kim5_PD00634
RLN : J0663_21455 J0663_29635
RROS : D4A92_07710 D4A92_21715
RAW : NE851_03425 NE851_34295
NGG : RG540_CH14410 RG540_PA12140
ABAW : D5400_03565 D5400_06995
RBK : E0H22_04410 E0H22_07545
LAP : ACP90_08165 ACP90_08355
PSTG : E8M01_18755 E8M01_24930
PARR : EOJ32_02840 EOJ32_13040
PMAU : CP157_00998(asbF) CP157_03021(hpd_2)
SBIN : SBA_ch2_1470 SBA_ch2_3390
SPYG : YGS_C2P0954 YGS_C2P1150
SROE : JL101_010055 JL101_034840
PARH : I5S86_12590 I5S86_22055
PALR : HGI30_15360 HGI30_17840
CCHL : FPL14_04840 FPL14_24360
RPY : Y013_09925 Y013_14045
SLE : sle_11660(sle_11660)
DCO : SAMEA4475696_0797(lly)
NAQU : ENKNEFLB_00210(hpd_1)
» show all
Taxonomy
Reference
Authors
Fox DT, Hotta K, Kim CY, Koppisch AT
Title
The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.
Journal
Reference
Authors
Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH
Title
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.118