Entry
Name
3-dehydroshikimate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
3-dehydroshikimate hydro-lyase
Reaction(IUBMB)
3-dehydro-shikimate = 3,4-dihydroxybenzoate + H2O [RN:
R01627 ]
Reaction(KEGG)
Substrate
3-dehydro-shikimate
Product
Comment
Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.
History
EC 4.2.1.118 created 2009
Pathway
ec01053 Biosynthesis of siderophore group nonribosomal peptides
ec01110 Biosynthesis of secondary metabolites
Orthology
K09483 3-dehydroshikimate dehydratase
K15652 3-dehydroshikimate dehydratase
Genes
PALR : HGI30_15360 HGI30_17840
CCHL : FPL14_04840 FPL14_24360
» show all
Taxonomy
Reference
Authors
Fox DT, Hotta K, Kim CY, Koppisch AT
Title
The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.
Journal
Reference
Authors
Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH
Title
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.118