KEGG   ENZYME: 4.2.1.118
Entry
EC 4.2.1.118                Enzyme                                 

Name
3-dehydroshikimate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
3-dehydroshikimate hydro-lyase
Reaction(IUBMB)
3-dehydro-shikimate = 3,4-dihydroxybenzoate + H2O [RN:R01627]
Reaction(KEGG)
R01627
Substrate
3-dehydro-shikimate
Product
3,4-dihydroxybenzoate [CPD:C00230];
H2O [CPD:C00001]
Comment
Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.
History
EC 4.2.1.118 created 2009
Pathway
ec01053  Biosynthesis of siderophore group nonribosomal peptides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09483  3-dehydroshikimate dehydratase
K15652  3-dehydroshikimate dehydratase
Genes
PAO: Pat9b_2424
TCI: A7K98_19065
XSA: SB85_14665
SLM: BIZ42_17435
STEM: CLM74_09120
DKO: I596_1177
PPG: PputGB1_4069
PPW: PputW619_3862
PPUT: L483_24900
PPUN: PP4_12570(quiC)
ACB: A1S_1882
ABM: ABSDF2013(quiC)
ABY: ABAYE1683(quiC)
ABN: AB57_2216
ABB: ABBFA_01553(quiC)
ABX: ABK1_2460
ABH: M3Q_2340
ABAD: ABD1_19030(quiC)
ABAZ: P795_7620
ABAU: IX87_20870
ABAA: IX88_11585
ACC: BDGL_001361(quiC)
ACI: ACIAD1714(quiC)
AGU: AS4_11900(quiC)
AUG: URS_2757
MAQ: Maqu_3527
MHC: MARHY3427
MARJ: MARI_31170(asbF)
AMAC: MASE_09730
ASP: AOR13_246
OCE: GU3_03580
AMIM: MIM_c35790(quiC)
AMIH: CO731_00653(asbF)
RPA: RPA2386
RPT: Rpal_2628
NWI: Nwi_2298
MDI: METDI4727
MEX: Mext_3763
MCH: Mchl_4058
MPO: Mpop_4019
META: Y590_18690
KVL: KVU_1356
KVU: EIO_1898
PGD: Gal_04238
BYA: BANAU_0281(asbF)
BAMP: B938_01450
BAMA: RBAU_0311
BAMN: BASU_0295
BAMB: BAPNAU_0280(frlC1)
BAMT: AJ82_01860
BAMY: V529_03020
BMP: NG74_00319(asbF)
BAO: BAMF_0287(RBAM_003390)
BQL: LL3_00296(prot)
BQY: MUS_0297
BAMI: KSO_017965
BAMC: U471_02990
BAMF: U722_01745
BAN: BA_1986(asbF)
BAR: GBAA_1986(asbF)
BAT: BAS1843
BAH: BAMEG_2604(asbF)
BAI: BAA_2054(asbF)
BANT: A16_20230
BANR: A16R_20480
BANS: BAPAT_1899
BANV: DJ46_791(asbF)
BCE: BC1983
BCB: BCB4264_A1988(asbF)
BCU: BCAH820_2021(asbF)
BCG: BCG9842_B3341(asbF)
BCX: BCA_2048(asbF)
BCF: bcf_09775
BTL: BALH_1758
BTB: BMB171_C1770(asbF)
BTT: HD73_2152
BTHI: BTK_10875
BTC: CT43_CH1939(asbF)
BTM: MC28_1189(asbF)
BTG: BTB_c20530(asbF)
BTI: BTG_10030
BTW: BF38_3200(asbF)
BWW: bwei_3030(asbF)
BMYO: BG05_4000(asbF)
BCL: ABC1952
BPF: BpOF4_08950(asbF)
BACP: SB24_08110
BACB: OY17_04360
LSP: Bsph_2958
PPOL: X809_41440
PMS: KNP414_07050(asbF)
PMW: B2K_33545
PSAB: PSAB_20060
PSWU: SY83_22190
AAC: Aaci_2516
AAD: TC41_2813
CGT: cgR_2454
CGJ: AR0_12255
ARX: ARZXY2_59
AAU: AAur_3698
KFL: Kfla_6276
AOI: AORI_3481
PSEA: WY02_06330
PSEH: XF36_08530
PLH: VT85_20595(asbF_2)
MMAD: MMJJ_18570
 » show all
Reference
1  [PMID:18975921]
  Authors
Fox DT, Hotta K, Kim CY, Koppisch AT
  Title
The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.
  Journal
Biochemistry 47:12251-3 (2008)
DOI:10.1021/bi801876q
Reference
2  [PMID:18955706]
  Authors
Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH
  Title
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 105:17133-8 (2008)
DOI:10.1073/pnas.0808118105
  Sequence
[ban:BA_1986]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.118
IUBMB Enzyme Nomenclature: 4.2.1.118
ExPASy - ENZYME nomenclature database: 4.2.1.118
BRENDA, the Enzyme Database: 4.2.1.118

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