KEGG   ENZYME: 4.2.1.118
Entry
EC 4.2.1.118                Enzyme                                 
Name
3-dehydroshikimate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
3-dehydroshikimate hydro-lyase
Reaction(IUBMB)
3-dehydro-shikimate = 3,4-dihydroxybenzoate + H2O [RN:R01627]
Reaction(KEGG)
R01627
Substrate
3-dehydro-shikimate
Product
3,4-dihydroxybenzoate [CPD:C00230];
H2O [CPD:C00001]
Comment
Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.
History
EC 4.2.1.118 created 2009
Pathway
ec01053  Biosynthesis of siderophore group nonribosomal peptides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09483  3-dehydroshikimate dehydratase
K15652  3-dehydroshikimate dehydratase
Genes
RVCJ9880_12585
PAOPat9b_2424
TCIA7K98_19065
XSASB85_14665
XTHG4Q83_17865
SLMBIZ42_17435
STEMCLM74_09120
SINCDAIF1_17820(quiC)
SPAQSTNY_R17400
DKOI596_1177
PPGPputGB1_4069
PPWPputW619_3862
PPUTL483_24900
PPUNPP4_12570(quiC)
PSVPVLB_18200
PPVNJ69_03045
PEZHWQ56_22850
PXAKSS93_22595
PQIKH389_07630
PPRGHU725_016755
PFAKKSS94_20020
PWYHU734_018785
MAQMaqu_3527
MHCMARHY3427
MARJMARI_31170(asbF)
ACBA1S_1882
ABMABSDF2013(quiC)
ABYABAYE1683(quiC)
ABCACICU_01992
ABNAB57_2216
ABBABBFA_01553(quiC)
ABXABK1_2460
ABZABZJ_02174
ABRABTJ_01716
ABDABTW07_2204
ABHM3Q_2340
ABADABD1_19030(quiC)
ABJBJAB07104_01746
ABABBJAB0715_02139
ABAJBJAB0868_02131
ABAZP795_7620
ABKLX00_10085
ABAUIX87_20870
ABAAIX88_11585
ABWBL01_00635
ABALABLAC_27550
ACCBDGL_001361(quiC)
ANORR32_08445
ALCOTEC02_08075
ACALBUM88_10790
ASEII8T81_08340
ACDAOLE_08440
ACIACIAD1714(quiC)
AJORZ95_12740
ACWA0J50_07800
AHLAHTJS_06220
ASOLBEN76_04810
AGUAS4_11900(quiC)
AUGURS_2757
ADSFPL17_02770
ABERBSR55_05740
ATNFM020_09725
ABOUACBO_10070(quiC)
AMACMASE_09730
AMGAMEC673_09975
ASPAOR13_246
ASQAVL57_17240
AAWAVL56_16125
ALEAV939_16180
ALZAV940_15935
CATEC2869_06580
HMIsoil367_15790
CELLCBR65_18750
MIIBTJ40_19060
OAIOLEAN_C24190
OMEOLMES_0539
OCEGU3_03580
AMIMMIM_c35790(quiC)
AMONH9L24_09900
AAKAA2016_0180
AMIHCO731_00653(asbF)
SFHSFHH103_01320
EAHFA04_19990
RPARPA2386
RPTRpal_2628
RPXRpdx1_3185
NWINwi_2298
MEAMex_1p4135
MDIMETDI4727
MEXMext_3763
MCHMchl_4058
MPOMpop_4019
MZAB2G69_00630
METAY590_18690
METDC0214_20940
CMETK6K41_17360
AUAM673_21075
PSTGE8M01_18755
CFHC1707_09830
PGAPGA1_78p00450
PGLPGA2_95p540
PGDGal_04238
LMDMETH_16715
PARREOJ32_13040
PMAUCP157_00998(asbF)
ALIAZOLI_p20608
AZMDM194_19460
AZZDEW08_01155
SKTIGS68_11040
SMUCJL100_015615
SROEJL101_010055
BANBA_1986(asbF)
BARGBAA_1986(asbF)
BATBAS1843
BAHBAMEG_2604(asbF)
BAIBAA_2054(asbF)
BAXH9401_1883
BANTA16_20230
BANRA16R_20480
BANSBAPAT_1899
BANHHYU01_09950
BANVDJ46_791(asbF)
BCEBC1983
BCZBCE33L1800
BCBBCB4264_A1988(asbF)
BCUBCAH820_2021(asbF)
BCGBCG9842_B3341(asbF)
BCXBCA_2048(asbF)
BALBACI_c19600
BCFbcf_09775
BTKBT9727_1817
BTLBALH_1758
BTBBMB171_C1770(asbF)
BTTHD73_2152
BTHRYBT1520_10735
BTHIBTK_10875
BTCCT43_CH1939(asbF)
BTMMC28_1189(asbF)
BTGBTB_c20530(asbF)
BTIBTG_10030
BTNBTF1_07305
BTHTH175_ch1965
BTHUYBT1518_11045
BTWBF38_3200(asbF)
BTHYAQ980_20240
BWEBcerKBAB4_1849
BWWbwei_3030(asbF)
BMYOBG05_4000(asbF)
BTYBtoyo_4557
BBYCY96_09010
BWDCT694_10825
BTROFJR70_09665(asbF)
BMOBMLA2C4_10105
BNTGSN03_09700(asbF)
BWHA9C19_17975
BHKB4U37_11070
PARHI5S86_22055
BCLABC1952
BLEBleG1_1615
BPFBpOF4_08950(asbF)
BONA361_02390
LSPBsph_2958
LFUHR49_11820
EXMU719_06060
EXUESP131_08455
EACEKKI46_06250
BBEBBR47_20500
BLRBRLA_c008720
BFMBP422_05365
BRWGOP56_20360
PPOLX809_41440
PMSKNP414_07050(asbF)
PMQPM3016_6640
PMWB2K_33545
PTAHPL003_06785
PPEOABE82_25190
PKBB4V02_00160
PTRIKDC22_17620
PCELHUB94_18025
PALRHGI30_15360 HGI30_17840
CCHLFPL14_04840 FPL14_24360
SOBCSE16_06635
TAERGT409_11935
AALGAREALGSMS7_02865
MMXMmarC6_0487
MMADMMJJ_18570
 » show all
Reference
1  [PMID:18975921]
  Authors
Fox DT, Hotta K, Kim CY, Koppisch AT
  Title
The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.
  Journal
Biochemistry 47:12251-3 (2008)
DOI:10.1021/bi801876q
Reference
2  [PMID:18955706]
  Authors
Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH
  Title
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 105:17133-8 (2008)
DOI:10.1073/pnas.0808118105
  Sequence
[ban:BA_1986]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.118
IUBMB Enzyme Nomenclature: 4.2.1.118
ExPASy - ENZYME nomenclature database: 4.2.1.118
BRENDA, the Enzyme Database: 4.2.1.118

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