KEGG ENZYME: 4.2.1.118

ENZYME: 4.2.1.118

Entry

EC 4.2.1.118                Enzyme

Name

3-dehydroshikimate dehydratase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

3-dehydroshikimate hydro-lyase

Reaction(IUBMB)

3-dehydro-shikimate = 3,4-dihydroxybenzoate + H2O [RN:R01627]

Reaction(KEGG)

R01627

Substrate

3-dehydro-shikimate

Product

3,4-dihydroxybenzoate [CPD:C00230];
H2O [CPD:C00001]

Comment

Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.

History

EC 4.2.1.118 created 2009

Pathway

ec01053

Biosynthesis of siderophore group nonribosomal peptides

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K09483

3-dehydroshikimate dehydratase

K15652

3-dehydroshikimate dehydratase

Genes

RVC:	J9880_12585

PAO:	Pat9b_2424

TCI:	A7K98_19065

XSA:	SB85_14665

XTH:	G4Q83_17865

SLM:	BIZ42_17435

STEM:

CLM74_09120

SINC:

DAIF1_17820(quiC)

SPAQ:

STNY_R17400

DKO:

I596_1177

PPG:	PputGB1_4069

PPW:	PputW619_3862

PPUT:

L483_24900

PPUN:

PP4_12570(quiC)

PSV:	PVLB_18200

PPV:	NJ69_03045

PEZ:	HWQ56_22850

PXA:	KSS93_22595

PQI:	KH389_07630

PPRG:

HU725_016755

PFAK:

KSS94_20020

PWY:	HU734_018785

MAQ:

Maqu_3527

MHC:

MARHY3427

MARJ:

MARI_31170(asbF)

ACB:

A1S_1882

ABM:	ABSDF2013(quiC)

ABY:	ABAYE1683(quiC)

ABC:	ACICU_01992

ABN:

AB57_2216

ABB:	ABBFA_01553(quiC)

ABX:

ABK1_2460

ABZ:	ABZJ_02174

ABR:	ABTJ_01716

ABD:	ABTW07_2204

ABH:

M3Q_2340

ABAD:

ABD1_19030(quiC)

ABJ:	BJAB07104_01746

ABAB:

BJAB0715_02139

ABAJ:

BJAB0868_02131

ABAZ:

P795_7620

ABK:	LX00_10085

ABAU:

IX87_20870

ABAA:

IX88_11585

ABW:	BL01_00635

ABAL:

ABLAC_27550

ACC:	BDGL_001361(quiC)

ANO:	RR32_08445

ALC:	OTEC02_08075

ACAL:

BUM88_10790

ASEI:

I8T81_08340

ACD:	AOLE_08440

ACI:	ACIAD1714(quiC)

AJO:	RZ95_12740

ACW:	A0J50_07800

AHL:	AHTJS_06220

ASOL:

BEN76_04810

AGU:	AS4_11900(quiC)

AUG:

URS_2757

ADS:	FPL17_02770

ABER:

BSR55_05740

ATN:	FM020_09725

ABOU:

ACBO_10070(quiC)

AMAC:

MASE_09730

AMG:	AMEC673_09975

ASP:

AOR13_246

ASQ:	AVL57_17240

AAW:	AVL56_16125

ALE:	AV939_16180

ALZ:	AV940_15935

CATE:

C2869_06580

HMI:	soil367_15790

CELL:

CBR65_18750

MII:	BTJ40_19060

OAI:	OLEAN_C24190

OME:	OLMES_0539

OCE:

GU3_03580

AMIM:

MIM_c35790(quiC)

AMON:

H9L24_09900

AAK:	AA2016_0180

AMIH:

CO731_00653(asbF)

SFH:	SFHH103_01320

EAH:	FA04_19990

RPA:

RPA2386

RPT:

Rpal_2628

RPX:	Rpdx1_3185

NWI:

Nwi_2298

MEA:	Mex_1p4135

MDI:

METDI4727

MEX:

Mext_3763

MCH:

Mchl_4058

MPO:

Mpop_4019

MZA:	B2G69_00630

META:

Y590_18690

METD:

C0214_20940

CMET:

K6K41_17360

AUA:	M673_21075

PSTG:

E8M01_18755

CFH:	C1707_09830

PGA:	PGA1_78p00450

PGL:	PGA2_95p540

PGD:

Gal_04238

LMD:	METH_16715

PARR:

EOJ32_13040

PMAU:

CP157_00998(asbF)

ALI:	AZOLI_p20608

AZM:	DM194_19460

AZZ:	DEW08_01155

SKT:	IGS68_11040

SMUC:

JL100_015615

SROE:

JL101_010055

BAN:	BA_1986(asbF)

BAR:	GBAA_1986(asbF)

BAT:

BAS1843

BAH:	BAMEG_2604(asbF)

BAI:	BAA_2054(asbF)

BAX:	H9401_1883

BANT:

A16_20230

BANR:

A16R_20480

BANS:

BAPAT_1899

BANH:

HYU01_09950

BANV:

DJ46_791(asbF)

BCE:

BC1983

BCZ:	BCE33L1800

BCB:	BCB4264_A1988(asbF)

BCU:	BCAH820_2021(asbF)

BCG:	BCG9842_B3341(asbF)

BCX:	BCA_2048(asbF)

BAL:	BACI_c19600

BCF:

bcf_09775

BTK:	BT9727_1817

BTL:

BALH_1758

BTB:	BMB171_C1770(asbF)

BTT:

HD73_2152

BTHR:

YBT1520_10735

BTHI:

BTK_10875

BTC:	CT43_CH1939(asbF)

BTM:	MC28_1189(asbF)

BTG:	BTB_c20530(asbF)

BTI:

BTG_10030

BTN:	BTF1_07305

BTHT:

H175_ch1965

BTHU:

YBT1518_11045

BTW:	BF38_3200(asbF)

BTHY:

AQ980_20240

BWE:	BcerKBAB4_1849

BWW:	bwei_3030(asbF)

BMYO:

BG05_4000(asbF)

BTY:	Btoyo_4557

BBY:	CY96_09010

BWD:	CT694_10825

BTRO:

FJR70_09665(asbF)

BMOB:

MLA2C4_10105

BNT:	GSN03_09700(asbF)

BWH:	A9C19_17975

BHK:	B4U37_11070

PARH:

I5S86_22055

BCL:

ABC1952

BLE:	BleG1_1615

BPF:	BpOF4_08950(asbF)

BON:	A361_02390

LSP:

Bsph_2958

LFU:	HR49_11820

EXM:	U719_06060

EXU:	ESP131_08455

EACE:

KKI46_06250

BBE:	BBR47_20500

BLR:	BRLA_c008720

BFM:	BP422_05365

BRW:	GOP56_20360

PPOL:

X809_41440

PMS:	KNP414_07050(asbF)

PMQ:	PM3016_6640

PMW:

B2K_33545

PTA:	HPL003_06785

PPEO:

ABE82_25190

PKB:	B4V02_00160

PTRI:

KDC22_17620

PCEL:

HUB94_18025

PALR:

HGI30_15360 HGI30_17840

CCHL:

FPL14_04840 FPL14_24360

SOB:	CSE16_06635

TAER:

GT409_11935

AALG:

AREALGSMS7_02865

MMX:	MmarC6_0487

MMAD:

MMJJ_18570

» show all

Reference

1 [PMID:18975921]

Authors

Fox DT, Hotta K, Kim CY, Koppisch AT

Title

The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.

Journal

Biochemistry 47:12251-3 (2008)
DOI:10.1021/bi801876q

Reference

2 [PMID:18955706]

Authors

Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH

Title

Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.

Journal

Proc Natl Acad Sci U S A 105:17133-8 (2008)
DOI:10.1073/pnas.0808118105

Sequence

[ban:BA_1986]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.118

IUBMB Enzyme Nomenclature:

4.2.1.118

ExPASy - ENZYME nomenclature database:

4.2.1.118

BRENDA, the Enzyme Database:

4.2.1.118

DBGET integrated database retrieval system