KEGG   ENZYME: 4.2.1.125Help
Entry
EC 4.2.1.125                Enzyme                                 

Name
dammarenediol II synthase;
dammarenediol synthase;
2,3-oxidosqualene (20S)-dammarenediol cyclase;
DDS;
(S)-squalene-2,3-epoxide hydro-lyase (dammarenediol-II forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (dammarenediol-II forming)
Reaction(IUBMB)
dammarenediol II = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O [RN:R09701]
Reaction(KEGG)
Substrate
dammarenediol II [CPD:C19829]
Product
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054];
H2O [CPD:C00001]
Comment
The reaction occurs in the reverse direction.
History
EC 4.2.1.125 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15817  dammarenediol II synthase
Reference
1  [PMID:16962103]
  Authors
Tansakul P, Shibuya M, Kushiro T, Ebizuka Y
  Title
Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng.
  Journal
FEBS Lett 580:5143-9 (2006)
DOI:10.1016/j.febslet.2006.08.044
  Sequence
Reference
2  [PMID:17088293]
  Authors
Han JY, Kwon YS, Yang DC, Jung YR, Choi YE
  Title
Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng.
  Journal
Plant Cell Physiol 47:1653-62 (2006)
DOI:10.1093/pcp/pcl032
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.125
IUBMB Enzyme Nomenclature: 4.2.1.125
ExPASy - ENZYME nomenclature database: 4.2.1.125
BRENDA, the Enzyme Database: 4.2.1.125
CAS: 189354-84-5

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