KEGG ENZYME: 4.2.1.130

ENZYME: 4.2.1.130

Entry

EC 4.2.1.130                Enzyme

Name

D-lactate dehydratase;
glyoxylase III;
GLO3

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

(R)-lactate hydro-lyase

Reaction(IUBMB)

(R)-lactate = 2-oxopropanal + H2O [RN:R09796]

Reaction(KEGG)

R09796

Substrate

(R)-lactate [CPD:C00256]

Product

2-oxopropanal [CPD:C00546];
H2O [CPD:C00001]

Comment

The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).

History

EC 4.2.1.130 created 2011

Pathway

ec00620

Pyruvate metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K05523

D-lactate dehydratase / protein deglycase

K18881

D-lactate dehydratase

K22211

D-lactate dehydratase

Genes

AJM:

119039118

ATH:	AT2G38860(YLS5) AT3G02720(DJ1D) AT3G54600(DJ1F)

ALY:	9312329 9317686 9318316

CRB:	17887335 17890045 17893619

CSAT:

104712063 104744352 104763889 104778106 104781326 104782338 104785565 104791729 104792699

EUS:	EUTSA_v10010428mg EUTSA_v10016752mg EUTSA_v10021062mg

BRP:	103829987 103864103 103870900

BNA:	106352871 106410448 106446299 106453221

BOE:	106300197 106336900 106343236

RSZ:	108814118 108829307 108834072 108861274

THJ:	104802426 104824175 104824176

CPAP:

110806854 110806863 110813866 110813874 110814769

CIT:

102624325

CIC:	CICLE_v10011868mg

PVY:	116124576 116124585

MINC:

123226441

TCC:	18601214 18613247

GRA:	105788832 105803151

GHI:	107899375 107924031 107924119 107953939

GAB:	108457545 108473525

DZI:	111305823 111306104

EGR:	104423472 104430779 104440084 104443815 104449772 104457091

GMX:	100791599 100795300

GSJ:	114395469 114396507

PVU:	PHAVU_006G085000g

VRA:

106776237

VAR:

108340996

VUN:

114187101

CCAJ:

109799212

APRC:

113848036 113849147

MTR:	MTR_3g064140

CAM:

101494485

LJA:	Lj2g3v2475540.1(Lj2g3v2475540.1) Lj6g3v0353790.1(Lj6g3v0353790.1)

ADU:	107458019 107480995

AIP:	107608055 107631399 110265349

AHF:	112721297 112733795 112767026 112791698

LANG:

109345164 109356078

FVE:	101301721 101313350

RCN:	112192111 112192308

PPER:

109947823 109947861 109947908 109947909 109947911 109948158 109948159 109948160 109948161

PMUM:

103327328 103327330 103327332 103327333 103327424 103327481

PAVI:

110745932 110765119 110765120 110765184

PDUL:

117621064 117621301 117621302 117621303 117621305 117621306 117621307

MDM:	103444254 103444255

PXB:	103933884 103933886

ZJU:	107434701 107434704 107434708

MNT:	21389895 21389896

CSV:

101208672

CMO:

103494789

BHJ:

120091841

MCHA:

111013252

CMAX:

111492880

CMOS:

111452219

CPEP:

111788975

RCU:	8277864 8277865

JCU:	105636128 105649913

HBR:	110631730 110638958

MESC:

110600167 110611415 110621125

POP:	18106498 18106499 7494513 7494515

PEU:	105112048 105112049 105115962 105135277

PALZ:

118030280 118030281 118037144 118037145 118037207 118055032 118055033

JRE:	108988092 108988093

QSU:

112040100

QLO:

115994881

TWL:	119991384 120011282

VVI:

100247956

VRI:	117908173 117912925

SLY:

101263864

SPEN:

107011681

SOT:

102591897

CANN:

107859656

NTA:	107783336 107790977

NSY:

104230336

NTO:

104106699

NAU:

109226966

INI:

109167578

ITR:

116014192

SIND:

105175971

OEU:	111378094 111401220

EGT:

105961840

SSPL:

121783305 121787483

HAN:

110912749

ECAD:

122586804

LSV:	111898934 111898937 111898949

CCAV:

112515269

DCR:	108206713 108218153 108219409

CSIN:

114278313 114322617

BVG:	104891255 104891256

SOE:

110798222

CQI:	110708249 110711117

NNU:	104607008 104609573

MING:

122092034 122094220

TSS:	122645945 122662274

PSOM:

113275281 113298293 113319157 113337787 113350019

NCOL:

116246095 116260524

OSA:	4337361 4350819

DOSA:

Os04t0671700-01(Os04g0671700) Os11t0591550-00(Os11g0591550)

OBR:

102700620

BDI:

100841497

ATS:	109758946 109776890

TDC:	119332470 119337233 119366304

TAES:

123047323 123055126 123148912 123157367 123168374 123190979

TUA:	125522436 125540251

SBI:	8071985 8082591

ZMA:

100280536

SITA:

101752662 101773459

SVS:	117847941 117866484

PVIR:

120642830

PHAI:

112900435 112903033

PDA:

103717548

EGU:	105035496 105035502 105055359 105058906

MUS:

103978686

DCT:

110107083

PEQ:

110033908

AOF:	109836333 109836334

ATR:

18437741

SMO:	SELMODRAFT_271043 SELMODRAFT_271634

PPP:

112287601

APRO:

F751_5969

CME:	CYME_CMB034C

SCE:	YDR533C(HSP31) YMR322C(SNO4) YOR391C(HSP33) YPL280W(HSP32)

SEUB:

DI49_2822 DI49_4808

SPAO:

SPAR_D07060 SPAR_O04900

KLA:	KLLA0_D00682g KLLA0_D00704g

KMX:	KLMA_80019(HSP31)

VPO:	Kpol_1058p1 Kpol_196p3

CGR:	CAGL0C00275g

TBL:	TBLA_0H02460(TBLA0H02460) TBLA_0H02470(TBLA0H02470)

TDL:	TDEL_0F00110(TDEL0F00110)

TGB:	HG536_0H04940

KAF:	KAFR_0C00500(KAFR0C00500) KAFR_0I02470(KAFR0I02470) KAFR_0K01480(KAFR0K01480)

DHA:	DEHA2D00880g DEHA2E03762g DEHA2E17270g DEHA2G01474g

PIC:	PICST_59509

PGU:	PGUG_04657

SPAA:

SPAPADRAFT_51238

LEL:	LELG_02042 LELG_02043 LELG_02044

CAL:	CAALFM_C302610CA(GLX3)

CTP:	CTRG_02436 CTRG_02543

COT:	CORT_0B04350 CORT_0E00590

CDU:	CD36_82570

CTEN:

CANTEDRAFT_115959

YLI:	YALI0C22000g YALI0F00682g

CLU:	CLUG_02395

CLUS:

A9F13_24g00165

SLB:	AWJ20_5029(HSP31)

TMN:	UCRPA7_2911 UCRPA7_307

SSCK:

SPSK_04538

FGR:	FGSG_03354

FPU:	FPSE_04686

FVR:	FVEG_08620

FOX:	FOXG_09865

NHE:	NECHADRAFT_45064 NECHADRAFT_49514

PLJ:	VFPFJ_01550

CFJ:	CFIO01_09832

CHIG:

CH63R_03318 CH63R_06740

PFY:	PFICI_12001

PSCO:

LY89DRAFT_609778

ACT:	ACLA_067030

AOR:	AO090012000129

ANG:	ANI_1_1122094(An11g08940)

AFV:	AFLA_001842

ACHE:

ACHE_70273A

APUU:

APUU_20078S

TMF:	PMAA_010240

TRG:	TRUGW13939_00171

CIM:	CIMG_03805

CPW:	CPC735_005110

URE:	UREG_07480

PBL:	PAAG_07213

PBN:	PADG_11179(PADG_00973)

ABE:

ARB_05407

TVE:

TRV_03863

BGH:	BDBG_02868

BOR:	COCMIDRAFT_9161

NPA:	UCRNP2_9349

SPO:	SPAC11D3.13 SPAC1F7.06 SPAC5H10.02c SPBC947.09 SPCC757.03c

TASA:

A1Q1_00757

MGL:

MGL_4192

ACAN:

ACA1_080640 ACA1_357050

GTT:	GUITHDRAFT_85381

ECO:	b1967(hchA)

ECJ:	JW1950(hchA)

ECD:	ECDH10B_2110(hchA)

EBW:	BWG_1768(hchA)

ECOK:

ECMDS42_1594(hchA)

ECE:	Z3059(yedU)

ECS:	ECs_2705(hchA)

ECF:	ECH74115_2746(hchA)

ETW:	ECSP_2573(hchA)

ELX:	CDCO157_2499

EOI:	ECO111_2546(hchA)

EOH:	ECO103_2215(hchA)

ECOO:

ECRM13514_2522(yedU)

ECOH:

ECRM13516_2449(yedU)

ESL:

O3K_09775

ESO:

O3O_15850

ESM:

O3M_09740

ECK:	EC55989_2193(hchA)

ECG:	E2348C_2078(hchA)

EOK:	G2583_2417(hchA)

ELR:	ECO55CA74_11625

ELH:

ETEC_2067

ECW:	EcE24377A_2198(hchA)

EUN:	UMNK88_2444

ECP:

ECP_1900

ENA:	ECNA114_1913(yedU)

ECOS:

EC958_2231(hchA)

ECV:	APECO1_1002(hchA)

ECOA:

APECO78_13615

ECX:	EcHS_A2068(hchA)

ECM:	EcSMS35_1218(hchA)

ECY:

ECSE_2196

ECR:	ECIAI1_2047(hchA)

ECQ:	ECED1_2232(hchA)

EUM:	ECUMN_2258(hchA)

ECT:	ECIAI39_1090(hchA)

EOC:	CE10_2245(hchA)

EBR:	ECB_01882(yedU)

EBL:	ECD_01882(hchA)

EBD:

ECBD_1680

ECI:	UTI89_C2166(hchA)

EIH:	ECOK1_2080(hchA)

ECZ:	ECS88_2019(hchA)

ECC:	c2385(yedU)

ELO:	EC042_2123(hchA)

ELN:	NRG857_09820

ESE:

ECSF_1816

ECL:	EcolC_1678

EKO:	EKO11_1809

EKF:	KO11_12890(hchA)

EAB:	ECABU_c22250(hchA)

EDH:	EcDH1_1684

EDJ:	ECDH1ME8569_1907(hchA)

ELU:	UM146_07365

ELW:	ECW_m2139(hchA)

ELL:	WFL_10490(hchA)

ELC:	i14_2198(yedU)

ELD:	i02_2198(yedU)

ELP:	P12B_c1056(hchA)

ELF:	LF82_0965(hchA)

ECOL:

LY180_10185

ECOI:

ECOPMV1_02055(hchA)

ECOJ:

P423_10675

EFE:	EFER_1951(hchA)

EAL:	EAKF1_ch4074c(hchA)

EMA:	C1192_02055

ESZ:	FEM44_24790(hchA)

SFL:	SF2014(yedU)

SFX:	S2111(yedU)

SFV:	SFV_2012(yedU)

SFE:	SFxv_2246(hchA)

SFN:

SFy_2882

SFS:

SFyv_2948

SFT:	NCTC1_02190(yedU)

SSN:	SSON_2023(yedU)

SBC:	SbBS512_E0916(hchA)

KPK:	A593_25505

KVD:	KR75_23415

EAE:

EAE_21665

EAR:

CCG29602

KGR:	JJJ10_09865(hchA)

CBRA:

A6J81_03355

PGE:	LG71_03170

YRE:	HEC60_06150(hchA)

PSHI:

SAMEA2665130_1829(hchA)

SMAR:

SM39_2702

SMAC:

SMDB11_2472

SMW:	SMWW4_v1c32350(hchA)

SMAF:

D781_2748

SLQ:	M495_12165

SERF:

L085_12445

SERS:

SERRSCBI_15625

SRZ:	AXX16_2303

SSUR:

ATE40_012695

SURI:

J0X03_07825(hchA)

SENP:

KHA73_15790(hchA)

EAM:	EAMY_3249(yedU)

EAY:	EAM_0353(hchA)

ETA:	ETA_30440(hchA)

EPY:	EpC_32470(hchA)

EPR:	EPYR_03495(yedU)

ERJ:	EJP617_07320(yedU)

PAM:	PANA_1765(hchA)

PLF:	PANA5342_2437(hchA)

PAJ:	PAJ_1107(hchA)

PAQ:	PAGR_g2345

PANT:

PSNIH1_p01785

PER:	LAC65_18005(hchA)

PCOL:

F1325_07900(hchA)

EIC:	NT01EI_2286

ETR:	ETAE_2048(hchA)

ETD:	ETAF_1847(hchA)

ETE:	ETEE_0036(hchA)

ETC:	ETAC_09485

EDW:	QY76_09980

EDL:	AAZ33_10890(hchA)

EHO:	A9798_05955

PATL:

KGI96_03515(hchA)

ASEG:

NCTC10977_00014(hchA)

GAN:	UMN179_01029

APAG:

EIA51_03490(hchA)

AVT:	NCTC3438_00989(hchA)

RPNE:

NCTC8284_03882(hchA)

RHEY:

FEE42_06700(hchA)

SML:

Smlt1840

SMT:

Smal_1576

BUJ:	BurJV3_1624

SMZ:	SMD_1773(hchA)

STEN:

CCR98_08610

STEM:

CLM74_08875

STES:

MG068_08065

SINC:

DAIF1_16630(hchA_1)

SPAQ:

STNY_R16960(hchA)

DJA:	HY57_13100

VCF:	IR04_03875

VCE:	Vch1786_II0573

VCQ:	EN18_02730

VCO:	VC0395_0351

VCR:	VC395_A0912

VCL:	VCLMA_B0650

VTA:	B1336(hchA)

PAE:

PA1135

PAEV:

N297_1175(hchA)

PAEI:

N296_1175(hchA)

PAU:	PA14_49710(yedU)

PAG:	PLES_41841

PAF:	PAM18_3897

PNC:	NCGM2_2007(yedU)

PAEB:

NCGM1900_1460(yedU)

PDK:	PADK2_19995

PSG:	G655_19565

PRP:	M062_06185

PAEP:

PA1S_20210

PAER:

PA1R_gp4748

PAEM:

U769_20085

PAEL:

T223_21385

PAES:

SCV20265_4289

PAEU:

BN889_01209

PAEG:

AI22_13740

PAEC:

M802_1171(hchA)

PAEO:

M801_1175(hchA)

PMK:

MDS_2717

PMOS:

O165_007180

PMOL:

CLJ08_01895

PFN:	HZ99_05485

PFO:	Pfl01_2246(yedU)

PEN:

PSEEN2870

PCZ:	PCL1606_34340

PSW:	LK03_13980

PPV:	NJ69_06010

PSEM:

TO66_13415

PSEC:

CCOS191_3061(hchA)

PGY:	AWU82_15905

PTY:	JWV26_23650(hchA)

PSEP:

C4K39_5532

PXN:	HU772_013190(hchA)

PMUY:

KSS95_14970(hchA)

PMAM:

KSS90_10645(hchA)

PORY:

EJA05_13005(hchA)

PSYA:

AOT82_1858

ACB:

A1S_2765

ABY:	ABAYE0719(hchA)

ABC:	ACICU_03015

ABN:

AB57_3265

ABB:	ABBFA_00703(hchA_1)

ABX:

ABK1_3067

ABZ:	ABZJ_03197(hchA)

ABR:	ABTJ_00698

ABD:	ABTW07_3236(hchA)

ABH:

M3Q_3245

ABAD:

ABD1_27110(hchA)

ABJ:	BJAB07104_03099

ABAB:

BJAB0715_03166

ABAJ:

BJAB0868_03057

ABAZ:

P795_3320

ABK:	LX00_15120

ABAA:

IX88_16995

ABW:	BL01_05395

ABAL:

ABLAC_07170

ACC:	BDGL_002217(hchA)

ANO:	RR32_03570

ALC:	OTEC02_03630

ACAL:

BUM88_15940

ASEI:

I8T81_03705(hchA)

ACD:	AOLE_03385

ACI:	ACIAD1164(hchA)

ACW:	A0J50_03450

AHL:	AHTJS_08160

AJN:	BVL33_10040

AGU:	AS4_33930(hchA)

ADS:	FPL17_04795(hchA)

ABER:

BSR55_16685

AGYL:

FPL18_16850(hchA)

SWD:

Swoo_2968

COLW:

A3Q33_20280

AHA:	AHA_3120(hchA)

AHY:	AHML_16790

AHR:	V428_17395

AHP:	V429_17430

AHJ:	V469_05865

AHH:	RY45_16090

AHI:	VU14_06065

AAJ:	BOQ57_15980

AVO:	AMS64_17855

ADH:	CK627_10160

NEK:	CGZ77_07010

NANI:

NCTC12227_01155(hchA)

NMUS:

H7A79_1958

NDN:	H3L92_07325(hchA)

NAW:	LVJ86_08340(hchA)

KOA:	H3L93_10625(hchA)

PTES:

JQU52_10935(hchA)

USU:	LVJ78_03720(hchA)

REH:	H16_B1347(h16_B1347)

CBW:	RR42_s3366

CCUP:

BKK81_33095

BUR:	Bcep18194_B3049

BCN:

Bcen_5029

BCH:	Bcen2424_5831

BCM:	Bcenmc03_4348

BCJ:	BCAM0131(hchA)

BCEW:

DM40_3483(hchA)

BCEO:

I35_4112(hchA)

BCT:

GEM_5453

BCED:

DM42_5050(hchA)

BLAT:

WK25_19845

BSTG:

WT74_24065

BSTL:

BBJ41_22555

DAC:

Daci_2046

DHK:	BO996_09500

CTT:	CtCNB1_2595

OTK:	C6570_12645

AGR:	AGROH133_14589

SHZ:

shn_04630

BRK:	CWS35_21920

BEL:	BE61_62090

BOI:	BLM15_17500

LNE:	FZC33_14180(hchA)

BID:

Bind_2506

RHJ:	HZY79_03845(hchA)

AALA:

IGS74_02950(hchA)

SDO:	SD1155_04915

RMM:	ROSMUCSMR3_03433

PZH:	CX676_03515

PARO:

CUV01_06400

PAMN:

JCM7685_0332(hchA)

SPAU:

DRN02_015890(hchA)

SECH:

B18_17365

POQ:	KZX46_22355(hchA)

GXY:

GLX_23440

KEU:	S101446_03111(hchA)

AACE:

A0U92_02185

AOY:	EOV40_007355(hchA)

RGI:	RGI145_16655

NEH:	E3E11_03240

SWF:	E3E12_02545

HJO:	AY555_09080

SA0509

SAV:

SAV0551

SAW:

SAHV_0549

SAH:	SaurJH1_0588

SAJ:	SaurJH9_0574

SAM:

MW0506

SAS:

SAS0509

SAR:

SAR0556

SAC:

SACOL0597

SAX:	USA300HOU_0544

SAA:	SAUSA300_0536

SAO:	SAOUHSC_00533

SAE:

NWMN_0513

SAD:

SAAV_0514

SUU:	M013TW_0538(hchA)

SUV:	SAVC_02345

SUE:

SAOV_0586

SUJ:	SAA6159_00505

SUK:	SAA6008_00557

SUC:

ECTR2_505

SUT:	SAT0131_00604

SUQ:	HMPREF0772_12638

SUZ:

MS7_0541

SUD:	ST398NM01_0626

SUX:	SAEMRSA15_04780

SUW:	SATW20_06210

SUG:

SAPIG0626

SUF:	SARLGA251_04870

SAUA:

SAAG_00969

SAUE:

RSAU_000503(hchA)

SAUN:

SAKOR_00537

SAUS:

SA40_0491

SAUU:

SA957_0506

SAUG:

SA268_0504

SAUZ:

SAZ172_0553

SAUT:

SAI1T1_2004220(hchA)

SAUJ:

SAI2T2_1004220(hchA)

SAUK:

SAI3T3_1004220(hchA)

SAUQ:

SAI4T8_1004220(hchA)

SAUV:

SAI7S6_1004210(hchA)

SAUW:

SAI5S5_1004190(hchA)

SAUX:

SAI6T6_1004200(hchA)

SAUY:

SAI8T7_1004210(hchA)

SAUF:

X998_0592

SAB:

SAB0502

SUY:	SA2981_0528

SAUB:

C248_0626

SAUM:

BN843_5440

SAUC:

CA347_567

SAUR:

SABB_00602(hchA)

SAUI:

AZ30_02790

SAUD:

CH52_03000

SAMS:

NI36_02740

SUH:	SAMSHR1132_04950

SWA:	A284_11100

SPAS:

STP1_1532(hchA)

SMUS:

C7J88_05210

SSH:	NCTC13712_00504(hchA)

SSIM:

SAMEA4384339_0498(hchA_1)

GHA:	NCTC10459_00603(hchA)

STRG:

SRT_12400

DPM:	FNV33_01550(hchA)

AIN:

Acin_1683

MYV:	G155_06540

MDX:	BTO20_05165

MFJ:	MFLOJ_00940(hchA)

MPAG:

C0J29_17025

MBRD:

MBRA_12600(hchA)

MSEN:

K3U95_23455(hchA)

MFT:	XA26_13060

MPHU:

MPHO_27630 MPHO_43310(hchA)

MMUC:

C1S78_004555(hchA) C1S78_025650(hchA)

MMAT:

MMAGJ_38750(hchA)

MBOK:

MBOE_23670(hchA)

MFG:	K6L26_07365(hchA)

MAB:

MAB_1932c

MMV:	MYCMA_1003

MABB:

MASS_1920

MABL:

MMASJCM_1942

MCHE:

BB28_10055

MIZ:	BAB75_15755

MSTE:

MSTE_01869

MSAO:

MYCSP_08415

CKP:	ckrop_0392

CFN:	CFAL_02575

DTM:	BJL86_0430

SALS:

SLNWT_1739

SCAD:

DN051_04905

SFY:	GFH48_36620(hchA)

SSEO:

D0Z67_04815(hchA)

SCOE:

CP976_19120

KPL:	KPaMU14_03050

KVR:	CIB50_0000892(hchA_2)

RAMA:

IDM48_09825(hchA)

RKR:	I6G21_04740(hchA)

DAY:	FV141_02565(hchA)

YIM:	J5M86_11355(hchA)

SERJ:

SGUI_2126

BCAU:

I6G59_10525(hchA)

NRO:	K8W59_06575(hchA)

AMYC:

CU254_23335

PSEE:

FRP1_13125

PSEH:

XF36_09380

PSEQ:

AD006_20805

PECQ:

AD017_00385

PAUT:

Pdca_36460(hchA)

AVC:	NCTC10951_01353(hchA)

EKE:	EK0264_05750(hchA)

ABAS:

ACPOL_6563 ACPOL_6579

STHA:

NCTC11429_04249(hchA)

SSPI:

I6J01_00745(hchA)

SMUI:

I6J00_01400

SSIY:

JVX97_20385

FLL:	EI427_16705(hchA)

FKA:	KM029_25905(hchA)

WIN:

WPG_2158

FBU:	UJ101_01147(hchA)

RAN:	Riean_0767

RAI:

RA0C_1004

RAR:

RIA_1482

RAG:

B739_1117

RAE:

G148_0856

RAT:

M949_1586

EBV:	F0358_13370(hchA)

» show all

Reference

1 [PMID:24302734]

Authors

Hasim S, Hussin NA, Alomar F, Bidasee KR, Nickerson KW, Wilson MA

Title

A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.

Journal

J Biol Chem 289:1662-74 (2014)
DOI:10.1074/jbc.M113.505784

Sequence

[cal:CAALFM_C302610CA]

Reference

2 [PMID:24758716]

Authors

Zhao Q, Su Y, Wang Z, Chen C, Wu T, Huang Y

Title

Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.

Journal

BMC Evol Biol 14:86 (2014)
DOI:10.1186/1471-2148-14-86