KEGG   ENZYME: 4.2.1.130Help
Entry
EC 4.2.1.130                Enzyme                                 

Name
D-lactate dehydratase;
glyoxylase III;
GLO3
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(R)-lactate hydro-lyase
Reaction(IUBMB)
(R)-lactate = 2-oxopropanal + H2O [RN:R09796]
Reaction(KEGG)
Substrate
(R)-lactate [CPD:C00256]
Product
2-oxopropanal [CPD:C00546];
H2O [CPD:C00001]
Comment
The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).
History
EC 4.2.1.130 created 2011
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05523  D-lactate dehydratase / protein deglycase
K18881  D-lactate dehydratase
K22211  D-lactate dehydratase
Genes
ATH: AT2G38860(YLS5) AT3G02720(DJ1D) AT3G54600(DJ1F)
ALY: ARALYDRAFT_482901(YLS5) ARALYDRAFT_671244 ARALYDRAFT_896249 ARALYDRAFT_906870
CRB: 17887335 17890045 17893619
CSAT: 104712063 104744352 104763889 104778106 104781326 104782338 104785565 104791729 104792699
EUS: EUTSA_v10010428mg EUTSA_v10016752mg EUTSA_v10021062mg
BRP: 103829987 103864103 103870900
BNA: 106352871 106410448 106446299 106453221
BOE: 106300197 106336900 106343236
RSZ: 108814118 108829307 108834072 108861274
THJ: 104802426 104824175 104824176
CIT: 102624325
VRA: 106776237
VAR: 108340996
VUN: 114187101
CCAJ: 109799212
CAM: 101494485
LJA: Lj2g3v2475540.1(Lj2g3v2475540.1) Lj6g3v0353790.1(Lj6g3v0353790.1)
CSV: 101208672
CMO: 103494789
MCHA: 111013252
CMAX: 111492880
CMOS: 111452219
CPEP: 111788975
VVI: 100247956
SLY: 101263864
SPEN: 107011681
SOT: 102591897
CANN: 107859656
NSY: 104230336
NTO: 104106699
NAU: 109226966
INI: 109167578
SIND: 105175971
HAN: 110912749
CCAV: 112515269
SOE: 110798222
DOSA: Os04t0671700-01(Os04g0671700) Os11t0591550-00(Os11g0591550)
OBR: 102700620
BDI: 100841497
ATS: 109758946(LOC109758946) 109776890(LOC109776890)
ZMA: 100280536
PDA: 103717548
MUS: 103978686
DCT: 110107083
PEQ: 110033908
ATR: 18437741
PPP: 112287601
APRO: F751_5969
SCE: YDR533C(HSP31) YMR322C(SNO4) YOR391C(HSP33) YPL280W(HSP32)
KMX: KLMA_80019(HSP31)
TBL: TBLA_0H02460(TBLA0H02460) TBLA_0H02470(TBLA0H02470)
TDL: TDEL_0F00110(TDEL0F00110)
KAF: KAFR_0C00500(KAFR0C00500) KAFR_0I02470(KAFR0I02470) KAFR_0K01480(KAFR0K01480)
CAL: CAALFM_C302610CA(GLX3)
SLB: AWJ20_5029(HSP31)
SSCK: SPSK_04538
ANG: ANI_1_1122094(An11g08940)
PBN: PADG_11179(PADG_00973)
ABE: ARB_05407
TVE: TRV_03863
MGL: MGL_4192
ECO: b1967(hchA)
ECJ: JW1950(hchA)
ECD: ECDH10B_2110(hchA)
EBW: BWG_1768(hchA)
ECOK: ECMDS42_1594(hchA)
ECE: Z3059(yedU)
ECS: ECs2705
ECF: ECH74115_2746(hchA)
ETW: ECSP_2573(hchA)
EOI: ECO111_2546(hchA)
EOH: ECO103_2215(hchA)
ECOO: ECRM13514_2522(yedU)
ECOH: ECRM13516_2449(yedU)
ECG: E2348C_2078(hchA)
EOK: G2583_2417(hchA)
ESO: O3O_15850
ESM: O3M_09740
ESL: O3K_09775
ECW: EcE24377A_2198(hchA)
ELH: ETEC_2067
ECC: c2385(yedU)
ECP: ECP_1900
ECI: UTI89_C2166(hchA)
ECV: APECO1_1002(hchA)
ECX: EcHS_A2068(hchA)
ECM: EcSMS35_1218(hchA)
ECY: ECSE_2196
ECR: ECIAI1_2047(hchA)
ECQ: ECED1_2232(hchA)
ECK: EC55989_2193(hchA)
ECT: ECIAI39_1090(hchA)
EOC: CE10_2245(hchA)
EUM: ECUMN_2258(hchA)
ECZ: ECS88_2019(hchA)
ELO: EC042_2123(hchA)
ESE: ECSF_1816
EBR: ECB_01882(yedU)
EBD: ECBD_1680
EKF: KO11_12890(hchA)
EAB: ECABU_c22250(hchA)
EDJ: ECDH1ME8569_1907(hchA)
EIH: ECOK1_2080(hchA)
ENA: ECNA114_1913(yedU)
ELW: ECW_m2139(hchA)
ELL: WFL_10490(hchA)
ELC: i14_2198(yedU)
ELD: i02_2198(yedU)
ELP: P12B_c1056(hchA)
EBL: ECD_01882(hchA)
ELF: LF82_0965(hchA)
ECOI: ECOPMV1_02055(hchA)
ECOJ: P423_10675
ECOS: EC958_2231(hchA)
EFE: EFER_1951(hchA)
EAL: EAKF1_ch4074c(hchA)
SFL: SF2014(yedU)
SFX: S2111(yedU)
SFV: SFV_2012(yedU)
SFE: SFxv_2246(hchA)
SFN: SFy_2882
SFS: SFyv_2948
SFT: NCTC1_02190(yedU)
SSN: SSON_2023(yedU)
SBC: SbBS512_E0916(hchA)
EAE: EAE_21665
EAR: CCG29602
SMAF: D781_2748
SMW: SMWW4_v1c32350(hchA)
SMAR: SM39_2702
SERF: L085_12445
ETA: ETA_30440(hchA)
EPY: EpC_32470(hchA)
EPR: EPYR_03495(yedU)
EAM: EAMY_3249(yedU)
EAY: EAM_0353(hchA)
ERJ: EJP617_07320(yedU)
PAM: PANA_1765(hchA)
PLF: PANA5342_2437(hchA)
PAJ: PAJ_1107(hchA)
ETR: ETAE_2048(hchA)
ETD: ETAF_1847(hchA)
ETE: ETEE_0036(hchA)
PSHI: SAMEA2665130_1829(hchA)
ASEG: NCTC10977_00014(hchA)
APAG: EIA51_03490(hchA)
RPNE: NCTC8284_03882(hchA)
SML: Smlt1840
SMT: Smal_1576
SMZ: SMD_1773(hchA)
VTA: B1328 B1336(hchA)
PAE: PA1135
PAEV: N297_1175(hchA)
PAEI: N296_1175(hchA)
PAU: PA14_49710(yedU)
PNC: NCGM2_2007(yedU)
PAEB: NCGM1900_1460(yedU)
PAEP: PA1S_20210
PAEM: U769_20085
PAEL: T223_21385
PAEG: AI22_13740
PAEC: M802_1171(hchA)
PAEO: M801_1175(hchA)
PMK: MDS_2717
PFO: Pfl01_2246(yedU)
PEN: PSEEN2870
PSEM: TO66_13415
PSEC: CCOS191_3061(hchA)
PSYA: AOT82_1858
ACB: A1S_2765
ABY: ABAYE0719(hchA)
ABN: AB57_3265
ABX: ABK1_3067
ABZ: ABZJ_03197(hchA)
ABD: ABTW07_3236(hchA)
ABH: M3Q_3245
ABAD: ABD1_27110(hchA)
ABAZ: P795_3320
ABAA: IX88_16995
ACC: BDGL_002217(hchA)
ACI: ACIAD1164(hchA)
SWD: Swoo_2968
AHA: AHA_3120(hchA)
REH: H16_B1347(h16_B1347)
BCN: Bcen_5029
BCJ: BCAM0131(hchA)
BCEW: DM40_3483(hchA)
BCEO: I35_4112(hchA)
BCT: GEM_5453
BCED: DM42_5050(hchA)
BLAT: WK25_19845
BSTG: WT74_24065
DAC: Daci_2046
SHZ: shn_04630
BID: Bind_2506
PAMN: JCM7685_0332(hchA)
SPAU: DRN02_015890(hchA)
GXY: GLX_23440
KEU: S101446_03111(hchA)
SAU: SA0509
SAV: SAV0551
SAW: SAHV_0549
SAM: MW0506
SAS: SAS0509
SAR: SAR0556
SAC: SACOL0597
SAE: NWMN_0513
SAD: SAAV_0514
SUU: M013TW_0538(hchA)
SUE: SAOV_0586
SUC: ECTR2_505
SUZ: MS7_0541
SUG: SAPIG0626
SAUA: SAAG_00969
SAUE: RSAU_000503(hchA)
SAUS: SA40_0491
SAUU: SA957_0506
SAUG: SA268_0504
SAUT: SAI1T1_2004220(hchA)
SAUJ: SAI2T2_1004220(hchA)
SAUK: SAI3T3_1004220(hchA)
SAUQ: SAI4T8_1004220(hchA)
SAUV: SAI7S6_1004210(hchA)
SAUW: SAI5S5_1004190(hchA)
SAUX: SAI6T6_1004200(hchA)
SAUY: SAI8T7_1004210(hchA)
SAUF: X998_0592
SAB: SAB0502
SAUB: C248_0626
SAUM: BN843_5440
SAUC: CA347_567
SAUR: SABB_00602(hchA)
SAUI: AZ30_02790
SAUD: CH52_03000
SAMS: NI36_02740
SPAS: STP1_1532(hchA)
DPM: FNV33_01550(hchA)
AIN: Acin_1683
MAB: MAB_1932c
MABB: MASS_1920
MCHE: BB28_10055
MSTE: MSTE_01869
SALS: SLNWT_1739
SERJ: SGUI_2126
PSEE: FRP1_13125
PSEH: XF36_09380
PAUT: Pdca_36460(hchA)
FLL: EI427_16705(hchA)
RAI: RA0C_1004
RAR: RIA_1482
RAG: B739_1117
RAE: G148_0856
RAT: M949_1586
WIN: WPG_2158
FBU: UJ101_01147(hchA)
 » show all
Taxonomy
Reference
1  [PMID:24302734]
  Authors
Hasim S, Hussin NA, Alomar F, Bidasee KR, Nickerson KW, Wilson MA
  Title
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.
  Journal
J Biol Chem 289:1662-74 (2014)
DOI:10.1074/jbc.M113.505784
  Sequence
Reference
2  [PMID:24758716]
  Authors
Zhao Q, Su Y, Wang Z, Chen C, Wu T, Huang Y
  Title
Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.
  Journal
BMC Evol Biol 14:86 (2014)
DOI:10.1186/1471-2148-14-86
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.130
IUBMB Enzyme Nomenclature: 4.2.1.130
ExPASy - ENZYME nomenclature database: 4.2.1.130
BRENDA, the Enzyme Database: 4.2.1.130

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