KEGG   ENZYME: 4.2.1.130
Entry
EC 4.2.1.130                Enzyme                                 

Name
D-lactate dehydratase;
glyoxylase III;
GLO3
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(R)-lactate hydro-lyase
Reaction(IUBMB)
(R)-lactate = 2-oxopropanal + H2O [RN:R09796]
Reaction(KEGG)
R09796
Substrate
(R)-lactate [CPD:C00256]
Product
2-oxopropanal [CPD:C00546];
H2O [CPD:C00001]
Comment
The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).
History
EC 4.2.1.130 created 2011
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05523  D-lactate dehydratase / protein deglycase
K18881  D-lactate dehydratase
K22211  D-lactate dehydratase
Genes
ATH: AT2G38860(YLS5) AT3G02720(DJ1D) AT3G54600(DJ1F)
ALY: 9312329 9317686 9318316
CRB: 17887335 17890045 17893619
CSAT: 104712063 104744352 104763889 104778106 104781326 104782338 104785565 104791729 104792699
EUS: EUTSA_v10010428mg EUTSA_v10016752mg EUTSA_v10021062mg
BRP: 103829987 103864103 103870900
BNA: 106352871 106410448 106446299 106453221
BOE: 106300197 106336900 106343236
RSZ: 108814118 108829307 108834072 108861274
THJ: 104802426 104824175 104824176
CPAP: 110806854 110806863 110813866 110813874 110814769
CIT: 102624325
CIC: CICLE_v10011868mg
TCC: 18601214 18613247
GRA: 105788832 105803151
GHI: 107899375 107924031 107924119 107953939
GAB: 108457545 108473525
DZI: 111305823 111306104
EGR: 104423472 104430779 104440084 104443815 104449772 104457091
GMX: 100791599 100795300
GSJ: 114395469 114396507
PVU: PHAVU_006G085000g
VRA: 106776237
VAR: 108340996
VUN: 114187101
CCAJ: 109799212
MTR: MTR_3g064140
CAM: 101494485
LJA: Lj2g3v2475540.1(Lj2g3v2475540.1) Lj6g3v0353790.1(Lj6g3v0353790.1)
ADU: 107458019 107480995
AIP: 107608055 107631399 110265349
LANG: 109345164 109356078
FVE: 101301721 101313350
RCN: 112192111 112192308
PPER: 109947823 109947861 109947908 109947909 109947911 109948158 109948159 109948160 109948161
PMUM: 103327328 103327330 103327332 103327333 103327424 103327481
PAVI: 110745932 110765119 110765120 110765184
MDM: 103444254 103444255
PXB: 103933884 103933886
ZJU: 107434701 107434704 107434708
CSV: 101208672
CMO: 103494789
MCHA: 111013252
CMAX: 111492880
CMOS: 111452219
CPEP: 111788975
RCU: 8277864 8277865
JCU: 105636128 105649913
HBR: 110631730 110638958
MESC: 110600167 110611415 110621125
POP: 18106498 18106499 7494513 7494515
PEU: 105112048 105112049 105115962 105135277
JRE: 108988092 108988093
QSU: 112040100
VVI: 100247956
SLY: 101263864
SPEN: 107011681
SOT: 102591897
CANN: 107859656
NTA: 107783336 107790977
NSY: 104230336
NTO: 104106699
NAU: 109226966
INI: 109167578
SIND: 105175971
OEU: 111378094 111401220
HAN: 110912749
LSV: 111898934 111898937 111898949
CCAV: 112515269
DCR: 108206713 108218153 108219409
BVG: 104891255 104891256
SOE: 110798222
CQI: 110708249 110711117
NNU: 104607008 104609573
PSOM: 113275281 113298293 113319157 113337787 113350019
OSA: 4337361 4350819
DOSA: Os04t0671700-01(Os04g0671700) Os11t0591550-00(Os11g0591550)
OBR: 102700620
BDI: 100841497
ATS: 109758946(LOC109758946) 109776890(LOC109776890)
SBI: 8071985 8082591
ZMA: 100280536
SITA: 101752662 101773459
PDA: 103717548
EGU: 105035496 105035502 105055359 105058906
MUS: 103978686
DCT: 110107083
PEQ: 110033908
AOF: 109836333 109836334
ATR: 18437741
SMO: SELMODRAFT_271043 SELMODRAFT_271634
PPP: 112287601
APRO: F751_5969
CME: CYME_CMB034C
SCE: YDR533C(HSP31) YMR322C(SNO4) YOR391C(HSP33) YPL280W(HSP32)
KLA: KLLA0_D00682g KLLA0_D00704g
KMX: KLMA_80019(HSP31)
VPO: Kpol_1058p1 Kpol_196p3
CGR: CAGL0C00275g
TBL: TBLA_0H02460(TBLA0H02460) TBLA_0H02470(TBLA0H02470)
TDL: TDEL_0F00110(TDEL0F00110)
KAF: KAFR_0C00500(KAFR0C00500) KAFR_0I02470(KAFR0I02470) KAFR_0K01480(KAFR0K01480)
DHA: DEHA2D00880g DEHA2E03762g DEHA2E17270g DEHA2G01474g
PIC: PICST_59509
PGU: PGUG_04657
SPAA: SPAPADRAFT_51238
LEL: LELG_02042 LELG_02043 LELG_02044
CAL: CAALFM_C302610CA(GLX3)
CTP: CTRG_02436 CTRG_02543
COT: CORT_0B04350 CORT_0E00590
CDU: CD36_82570
CTEN: CANTEDRAFT_115959
YLI: YALI0C22000g YALI0F00682g
CLU: CLUG_02395
CLUS: A9F13_24g00165
SLB: AWJ20_5029(HSP31)
TMN: UCRPA7_2911 UCRPA7_307
SSCK: SPSK_04538
FGR: FGSG_03354
FPU: FPSE_04686
FVR: FVEG_08620
FOX: FOXG_09865
NHE: NECHADRAFT_45064 NECHADRAFT_49514
PLJ: VFPFJ_01550
CFJ: CFIO01_09832
PFY: PFICI_12001
PSCO: LY89DRAFT_609778
ACT: ACLA_067030
AOR: AO090012000129
ANG: ANI_1_1122094(An11g08940)
TMF: PMAA_010240
TRG: TRUGW13939_00171
CIM: CIMG_03805
CPW: CPC735_005110
PBL: PAAG_07213
PBN: PADG_11179(PADG_00973)
URE: UREG_07480
ABE: ARB_05407
TVE: TRV_03863
BGH: BDBG_02868
BOR: COCMIDRAFT_9161
NPA: UCRNP2_9349
SPO: SPAC11D3.13 SPAC1F7.06 SPAC5H10.02c SPBC947.09 SPCC757.03c
TASA: A1Q1_00757
MGL: MGL_4192
ACAN: ACA1_080640 ACA1_357050
GTT: GUITHDRAFT_85381
ECO: b1967(hchA)
ECJ: JW1950(hchA)
ECD: ECDH10B_2110(hchA)
EBW: BWG_1768(hchA)
ECOK: ECMDS42_1594(hchA)
ECE: Z3059(yedU)
ECS: ECs2705
ECF: ECH74115_2746(hchA)
ETW: ECSP_2573(hchA)
ELX: CDCO157_2499
EOI: ECO111_2546(hchA)
EOH: ECO103_2215(hchA)
ECOO: ECRM13514_2522(yedU)
ECOH: ECRM13516_2449(yedU)
ESL: O3K_09775
ESO: O3O_15850
ESM: O3M_09740
ECK: EC55989_2193(hchA)
ECG: E2348C_2078(hchA)
EOK: G2583_2417(hchA)
ELR: ECO55CA74_11625
ELH: ETEC_2067
ECW: EcE24377A_2198(hchA)
EUN: UMNK88_2444
ECP: ECP_1900
ENA: ECNA114_1913(yedU)
ECOS: EC958_2231(hchA)
ECV: APECO1_1002(hchA)
ECOA: APECO78_13615
ECX: EcHS_A2068(hchA)
ECM: EcSMS35_1218(hchA)
ECY: ECSE_2196
ECR: ECIAI1_2047(hchA)
ECQ: ECED1_2232(hchA)
EUM: ECUMN_2258(hchA)
ECT: ECIAI39_1090(hchA)
EOC: CE10_2245(hchA)
EBR: ECB_01882(yedU)
EBL: ECD_01882(hchA)
EBD: ECBD_1680
ECI: UTI89_C2166(hchA)
EIH: ECOK1_2080(hchA)
ECZ: ECS88_2019(hchA)
ECC: c2385(yedU)
ELO: EC042_2123(hchA)
ELN: NRG857_09820
ESE: ECSF_1816
ECL: EcolC_1678
EKO: EKO11_1809
EKF: KO11_12890(hchA)
EAB: ECABU_c22250(hchA)
EDH: EcDH1_1684
EDJ: ECDH1ME8569_1907(hchA)
ELU: UM146_07365
ELW: ECW_m2139(hchA)
ELL: WFL_10490(hchA)
ELC: i14_2198(yedU)
ELD: i02_2198(yedU)
ELP: P12B_c1056(hchA)
ELF: LF82_0965(hchA)
ECOL: LY180_10185
ECOI: ECOPMV1_02055(hchA)
ECOJ: P423_10675
EFE: EFER_1951(hchA)
EAL: EAKF1_ch4074c(hchA)
EMA: C1192_02055
ESZ: FEM44_24790(hchA)
SFL: SF2014(yedU)
SFX: S2111(yedU)
SFV: SFV_2012(yedU)
SFE: SFxv_2246(hchA)
SFN: SFy_2882
SFS: SFyv_2948
SFT: NCTC1_02190(yedU)
SSN: SSON_2023(yedU)
SBC: SbBS512_E0916(hchA)
KPK: A593_25505
KVD: KR75_23415
EAE: EAE_21665
EAR: CCG29602
CBRA: A6J81_03355
PGE: LG71_03170
YRE: HEC60_06150(hchA)
SMAR: SM39_2702
SMAC: SMDB11_2472
SMW: SMWW4_v1c32350(hchA)
SMAF: D781_2748
SLQ: M495_12165
SERF: L085_12445
SERS: SERRSCBI_15625
SRZ: AXX16_2303
SSUR: ATE40_012695
EAM: EAMY_3249(yedU)
EAY: EAM_0353(hchA)
ETA: ETA_30440(hchA)
EPY: EpC_32470(hchA)
EPR: EPYR_03495(yedU)
ERJ: EJP617_07320(yedU)
PAM: PANA_1765(hchA)
PLF: PANA5342_2437(hchA)
PAJ: PAJ_1107(hchA)
PAQ: PAGR_g2345
PANT: PSNIH1_p01785
PCOL: F1325_07900(hchA)
EIC: NT01EI_2286
ETR: ETAE_2048(hchA)
ETD: ETAF_1847(hchA)
ETE: ETEE_0036(hchA)
ETC: ETAC_09485
EDW: QY76_09980
EDL: AAZ33_10890
EHO: A9798_05955
PSHI: SAMEA2665130_1829(hchA)
ASEG: NCTC10977_00014(hchA)
GAN: UMN179_01029
APAG: EIA51_03490(hchA)
AVT: NCTC3438_00989(hchA)
RPNE: NCTC8284_03882(hchA)
RHEY: FEE42_06700(hchA)
SML: Smlt1840
SMT: Smal_1576
BUJ: BurJV3_1624
SMZ: SMD_1773(hchA)
STEN: CCR98_08610
STEM: CLM74_08875
STES: MG068_08065
DJA: HY57_13100
VCF: IR04_03875
VCE: Vch1786_II0573
VCQ: EN18_02730
VCO: VC0395_0351
VCR: VC395_A0912
VCL: VCLMA_B0650
VTA: B1336(hchA)
PAE: PA1135
PAEV: N297_1175(hchA)
PAEI: N296_1175(hchA)
PAU: PA14_49710(yedU)
PAG: PLES_41841
PAF: PAM18_3897
PNC: NCGM2_2007(yedU)
PAEB: NCGM1900_1460(yedU)
PDK: PADK2_19995
PSG: G655_19565
PRP: M062_06185
PAEP: PA1S_20210
PAER: PA1R_gp4748
PAEM: U769_20085
PAEL: T223_21385
PAES: SCV20265_4289
PAEU: BN889_01209
PAEG: AI22_13740
PAEC: M802_1171(hchA)
PAEO: M801_1175(hchA)
PMK: MDS_2717
PMOS: O165_007180
PFO: Pfl01_2246(yedU)
PFN: HZ99_05485
PEN: PSEEN2870
PCZ: PCL1606_34340
PSW: LK03_13980
PPV: NJ69_06010
PSEM: TO66_13415
PSEC: CCOS191_3061(hchA)
PSYA: AOT82_1858
ACB: A1S_2765
ABY: ABAYE0719(hchA)
ABC: ACICU_03015
ABN: AB57_3265
ABB: ABBFA_00703(hchA_1)
ABX: ABK1_3067
ABZ: ABZJ_03197(hchA)
ABR: ABTJ_00698
ABD: ABTW07_3236(hchA)
ABH: M3Q_3245
ABAD: ABD1_27110(hchA)
ABJ: BJAB07104_03099
ABAB: BJAB0715_03166
ABAJ: BJAB0868_03057
ABAZ: P795_3320
ABK: LX00_15120
ABAA: IX88_16995
ABW: BL01_05395
ABAL: ABLAC_07170
ACC: BDGL_002217(hchA)
ANO: RR32_03570
ALC: OTEC02_03630
ACAL: BUM88_15940
ACD: AOLE_03385
ACI: ACIAD1164(hchA)
ACW: A0J50_03450
AHL: AHTJS_08160
AJN: BVL33_10040
AGU: AS4_33930(hchA)
ADS: FPL17_04795(hchA)
ABER: BSR55_16685
SWD: Swoo_2968
COLW: A3Q33_20280
AHA: AHA_3120(hchA)
AHY: AHML_16790
AHR: V428_17395
AHP: V429_17430
AHJ: V469_05865
AHH: RY45_16090
AHI: VU14_06065
AAJ: BOQ57_15980
AVO: AMS64_17855
ADH: CK627_10160
NEK: CGZ77_07010
NANI: NCTC12227_01155(hchA)
KOA: H3L93_10625(hchA)
REH: H16_B1347(h16_B1347)
CBW: RR42_s3366
CCUP: BKK81_33095
BUR: Bcep18194_B3049
BCN: Bcen_5029
BCH: Bcen2424_5831
BCM: Bcenmc03_4348
BCJ: BCAM0131(hchA)
BCEW: DM40_3483(hchA)
BCEO: I35_4112(hchA)
BCT: GEM_5453
BCED: DM42_5050(hchA)
BLAT: WK25_19845
BSTG: WT74_24065
BSTL: BBJ41_22555
DAC: Daci_2046
DHK: BO996_09500
CTT: CtCNB1_2595
OTK: C6570_12645
AGR: AGROH133_14589
SHZ: shn_04630
BRK: CWS35_21920
BOI: BLM15_17500
LNE: FZC33_14180(hchA)
BID: Bind_2506
RHJ: HZY79_03845(hchA)
AALA: IGS74_02950(hchA)
PZH: CX676_03515
PARO: CUV01_06400
PAMN: JCM7685_0332(hchA)
SDO: SD1155_04915
RMM: ROSMUCSMR3_03433
SPAU: DRN02_015890(hchA)
SECH: B18_17365
GXY: GLX_23440
KEU: S101446_03111(hchA)
AACE: A0U92_02185
AOY: EOV40_007355(hchA)
RGI: RGI145_16655
NEH: E3E11_03240
SWF: E3E12_02545
HJO: AY555_09080
SAU: SA0509
SAV: SAV0551
SAW: SAHV_0549
SAH: SaurJH1_0588
SAJ: SaurJH9_0574
SAM: MW0506
SAS: SAS0509
SAR: SAR0556
SAC: SACOL0597
SAX: USA300HOU_0544
SAA: SAUSA300_0536
SAO: SAOUHSC_00533
SAE: NWMN_0513
SAD: SAAV_0514
SUU: M013TW_0538(hchA)
SUV: SAVC_02345
SUE: SAOV_0586
SUJ: SAA6159_00505
SUK: SAA6008_00557
SUC: ECTR2_505
SUT: SAT0131_00604
SUQ: HMPREF0772_12638
SUZ: MS7_0541
SUD: ST398NM01_0626
SUX: SAEMRSA15_04780
SUW: SATW20_06210
SUG: SAPIG0626
SUF: SARLGA251_04870
SAUA: SAAG_00969
SAUE: RSAU_000503(hchA)
SAUN: SAKOR_00537
SAUS: SA40_0491
SAUU: SA957_0506
SAUG: SA268_0504
SAUZ: SAZ172_0553
SAUT: SAI1T1_2004220(hchA)
SAUJ: SAI2T2_1004220(hchA)
SAUK: SAI3T3_1004220(hchA)
SAUQ: SAI4T8_1004220(hchA)
SAUV: SAI7S6_1004210(hchA)
SAUW: SAI5S5_1004190(hchA)
SAUX: SAI6T6_1004200(hchA)
SAUY: SAI8T7_1004210(hchA)
SAUF: X998_0592
SAB: SAB0502
SUY: SA2981_0528
SAUB: C248_0626
SAUM: BN843_5440
SAUC: CA347_567
SAUR: SABB_00602(hchA)
SAUI: AZ30_02790
SAUD: CH52_03000
SAMS: NI36_02740
SUH: SAMSHR1132_04950
SWA: A284_11100
SPAS: STP1_1532(hchA)
SMUS: C7J88_05210
SSH: NCTC13712_00504(hchA)
SSIM: SAMEA4384339_0498(hchA_1)
GHA: NCTC10459_00603(hchA)
STRG: SRT_12400
DPM: FNV33_01550(hchA)
AIN: Acin_1683
MYV: G155_06540
MDX: BTO20_05165
MFJ: MFLOJ_00940(hchA)
MPAG: C0J29_17025
MFT: XA26_13060
MAB: MAB_1932c
MMV: MYCMA_1003
MABB: MASS_1920
MABL: MMASJCM_1942
MCHE: BB28_10055
MIZ: BAB75_15755
MSTE: MSTE_01869
MSAO: MYCSP_08415
CKP: ckrop_0392
CFN: CFAL_02575
DTM: BJL86_0430
SALS: SLNWT_1739
KPL: KPaMU14_03050
KVR: CIB50_0000892(hchA_2)
RAMA: IDM48_09825(hchA)
DAY: FV141_02565(hchA)
SERJ: SGUI_2126
AMYC: CU254_23335
PSEE: FRP1_13125
PSEH: XF36_09380
PSEQ: AD006_20805
PECQ: AD017_00385
PAUT: Pdca_36460(hchA)
AVC: NCTC10951_01353(hchA)
EKE: EK0264_05750(hchA)
ABAS: ACPOL_6563 ACPOL_6579
STHA: NCTC11429_04249(hchA)
FLL: EI427_16705(hchA)
WIN: WPG_2158
FBU: UJ101_01147(hchA)
RAN: Riean_0767
RAI: RA0C_1004
RAR: RIA_1482
RAG: B739_1117
RAE: G148_0856
RAT: M949_1586
EBV: F0358_13370(hchA)
 » show all
Reference
1  [PMID:24302734]
  Authors
Hasim S, Hussin NA, Alomar F, Bidasee KR, Nickerson KW, Wilson MA
  Title
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.
  Journal
J Biol Chem 289:1662-74 (2014)
DOI:10.1074/jbc.M113.505784
  Sequence
Reference
2  [PMID:24758716]
  Authors
Zhao Q, Su Y, Wang Z, Chen C, Wu T, Huang Y
  Title
Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.
  Journal
BMC Evol Biol 14:86 (2014)
DOI:10.1186/1471-2148-14-86
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.130
IUBMB Enzyme Nomenclature: 4.2.1.130
ExPASy - ENZYME nomenclature database: 4.2.1.130
BRENDA, the Enzyme Database: 4.2.1.130

  All links  
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3116)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (635)   
   KEGG MGENES (1268)   
   RefGene (1210)   
Protein sequence (640)   
   UniProt (591)   
   SWISS-PROT (14)   
   RefSeq(pep) (6)   
   PDBSTR (29)   
DNA sequence (827)   
   RefSeq(nuc) (9)   
   GenBank (410)   
   EMBL (408)   
3D Structure (7)   
   PDB (7)   
Protein domain (4)   
   InterPro (4)   
All databases (4605)   

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