KEGG   ENZYME: 4.2.1.130
Entry
EC 4.2.1.130                Enzyme                                 
Name
D-lactate dehydratase;
glyoxylase III;
GLO3
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(R)-lactate hydro-lyase
Reaction(IUBMB)
(R)-lactate = 2-oxopropanal + H2O [RN:R09796]
Reaction(KEGG)
R09796
Substrate
(R)-lactate [CPD:C00256]
Product
2-oxopropanal [CPD:C00546];
H2O [CPD:C00001]
Comment
The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).
History
EC 4.2.1.130 created 2011
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05523  D-lactate dehydratase / protein deglycase
K18881  D-lactate dehydratase
K22211  D-lactate dehydratase
Genes
AJM119039118
ATHAT2G38860(YLS5) AT3G02720(DJ1D) AT3G54600(DJ1F)
ALY9312329 9317686 9318316
CRB17887335 17890045 17893619
CSAT104712063 104744352 104763889 104778106 104781326 104782338 104785565 104791729 104792699
EUSEUTSA_v10010428mg EUTSA_v10016752mg EUTSA_v10021062mg
BRP103829987 103864103 103870900
BNA106352871 106410448 106446299 106453221
BOE106300197 106336900 106343236
RSZ108814118 108829307 108834072 108861274
THJ104802426 104824175 104824176
CPAP110806854 110806863 110813866 110813874 110814769
CIT102624325
CICCICLE_v10011868mg
PVY116124576 116124585
MINC123226441
TCC18601214 18613247
GRA105788832 105803151
GHI107899375 107924031 107924119 107953939
GAB108457545 108473525
DZI111305823 111306104
EGR104423472 104430779 104440084 104443815 104449772 104457091
GMX100791599 100795300
GSJ114395469 114396507
PVUPHAVU_006G085000g
VRA106776237
VAR108340996
VUN114187101
CCAJ109799212
APRC113848036 113849147
MTRMTR_3g064140
CAM101494485
LJALj2g3v2475540.1(Lj2g3v2475540.1) Lj6g3v0353790.1(Lj6g3v0353790.1)
ADU107458019 107480995
AIP107608055 107631399 110265349
AHF112721297 112733795 112767026 112791698
LANG109345164 109356078
FVE101301721 101313350
RCN112192111 112192308
PPER109947823 109947861 109947908 109947909 109947911 109948158 109948159 109948160 109948161
PMUM103327328 103327330 103327332 103327333 103327424 103327481
PAVI110745932 110765119 110765120 110765184
PDUL117621064 117621301 117621302 117621303 117621305 117621306 117621307
MDM103444254 103444255
PXB103933884 103933886
ZJU107434701 107434704 107434708
MNT21389895 21389896
CSV101208672
CMO103494789
BHJ120091841
MCHA111013252
CMAX111492880
CMOS111452219
CPEP111788975
RCU8277864 8277865
JCU105636128 105649913
HBR110631730 110638958
MESC110600167 110611415 110621125
POP18106498 18106499 7494513 7494515
PEU105112048 105112049 105115962 105135277
PALZ118030280 118030281 118037144 118037145 118037207 118055032 118055033
JRE108988092 108988093
QSU112040100
QLO115994881
TWL119991384 120011282
VVI100247956
VRI117908173 117912925
SLY101263864
SPEN107011681
SOT102591897
CANN107859656
NTA107783336 107790977
NSY104230336
NTO104106699
NAU109226966
INI109167578
ITR116014192
SIND105175971
OEU111378094 111401220
EGT105961840
SSPL121783305 121787483
HAN110912749
ECAD122586804
LSV111898934 111898937 111898949
CCAV112515269
DCR108206713 108218153 108219409
CSIN114278313 114322617
BVG104891255 104891256
SOE110798222
CQI110708249 110711117
NNU104607008 104609573
MING122092034 122094220
TSS122645945 122662274
PSOM113275281 113298293 113319157 113337787 113350019
NCOL116246095 116260524
OSA4337361 4350819
DOSAOs04t0671700-01(Os04g0671700) Os11t0591550-00(Os11g0591550)
OBR102700620
BDI100841497
ATS109758946 109776890
TDC119332470 119337233 119366304
TAES123047323 123055126 123148912 123157367 123168374 123190979
TUA125522436 125540251
SBI8071985 8082591
ZMA100280536
SITA101752662 101773459
SVS117847941 117866484
PVIR120642830
PHAI112900435 112903033
PDA103717548
EGU105035496 105035502 105055359 105058906
MUS103978686
DCT110107083
PEQ110033908
AOF109836333 109836334
ATR18437741
SMOSELMODRAFT_271043 SELMODRAFT_271634
PPP112287601
APROF751_5969
CMECYME_CMB034C
SCEYDR533C(HSP31) YMR322C(SNO4) YOR391C(HSP33) YPL280W(HSP32)
SEUBDI49_2822 DI49_4808
SPAOSPAR_D07060 SPAR_O04900
KLAKLLA0_D00682g KLLA0_D00704g
KMXKLMA_80019(HSP31)
VPOKpol_1058p1 Kpol_196p3
CGRCAGL0C00275g
TBLTBLA_0H02460(TBLA0H02460) TBLA_0H02470(TBLA0H02470)
TDLTDEL_0F00110(TDEL0F00110)
TGBHG536_0H04940
KAFKAFR_0C00500(KAFR0C00500) KAFR_0I02470(KAFR0I02470) KAFR_0K01480(KAFR0K01480)
DHADEHA2D00880g DEHA2E03762g DEHA2E17270g DEHA2G01474g
PICPICST_59509
PGUPGUG_04657
SPAASPAPADRAFT_51238
LELLELG_02042 LELG_02043 LELG_02044
CALCAALFM_C302610CA(GLX3)
CTPCTRG_02436 CTRG_02543
COTCORT_0B04350 CORT_0E00590
CDUCD36_82570
CTENCANTEDRAFT_115959
YLIYALI0C22000g YALI0F00682g
CLUCLUG_02395
CLUSA9F13_24g00165
SLBAWJ20_5029(HSP31)
TMNUCRPA7_2911 UCRPA7_307
SSCKSPSK_04538
FGRFGSG_03354
FPUFPSE_04686
FVRFVEG_08620
FOXFOXG_09865
NHENECHADRAFT_45064 NECHADRAFT_49514
PLJVFPFJ_01550
CFJCFIO01_09832
CHIGCH63R_03318 CH63R_06740
PFYPFICI_12001
PSCOLY89DRAFT_609778
ACTACLA_067030
AORAO090012000129
ANGANI_1_1122094(An11g08940)
AFVAFLA_001842
ACHEACHE_70273A
APUUAPUU_20078S
TMFPMAA_010240
TRGTRUGW13939_00171
CIMCIMG_03805
CPWCPC735_005110
UREUREG_07480
PBLPAAG_07213
PBNPADG_11179(PADG_00973)
ABEARB_05407
TVETRV_03863
BGHBDBG_02868
BORCOCMIDRAFT_9161
NPAUCRNP2_9349
SPOSPAC11D3.13 SPAC1F7.06 SPAC5H10.02c SPBC947.09 SPCC757.03c
TASAA1Q1_00757
MGLMGL_4192
ACANACA1_080640 ACA1_357050
GTTGUITHDRAFT_85381
ECOb1967(hchA)
ECJJW1950(hchA)
ECDECDH10B_2110(hchA)
EBWBWG_1768(hchA)
ECOKECMDS42_1594(hchA)
ECEZ3059(yedU)
ECSECs_2705(hchA)
ECFECH74115_2746(hchA)
ETWECSP_2573(hchA)
ELXCDCO157_2499
EOIECO111_2546(hchA)
EOHECO103_2215(hchA)
ECOOECRM13514_2522(yedU)
ECOHECRM13516_2449(yedU)
ESLO3K_09775
ESOO3O_15850
ESMO3M_09740
ECKEC55989_2193(hchA)
ECGE2348C_2078(hchA)
EOKG2583_2417(hchA)
ELRECO55CA74_11625
ELHETEC_2067
ECWEcE24377A_2198(hchA)
EUNUMNK88_2444
ECPECP_1900
ENAECNA114_1913(yedU)
ECOSEC958_2231(hchA)
ECVAPECO1_1002(hchA)
ECOAAPECO78_13615
ECXEcHS_A2068(hchA)
ECMEcSMS35_1218(hchA)
ECYECSE_2196
ECRECIAI1_2047(hchA)
ECQECED1_2232(hchA)
EUMECUMN_2258(hchA)
ECTECIAI39_1090(hchA)
EOCCE10_2245(hchA)
EBRECB_01882(yedU)
EBLECD_01882(hchA)
EBDECBD_1680
ECIUTI89_C2166(hchA)
EIHECOK1_2080(hchA)
ECZECS88_2019(hchA)
ECCc2385(yedU)
ELOEC042_2123(hchA)
ELNNRG857_09820
ESEECSF_1816
ECLEcolC_1678
EKOEKO11_1809
EKFKO11_12890(hchA)
EABECABU_c22250(hchA)
EDHEcDH1_1684
EDJECDH1ME8569_1907(hchA)
ELUUM146_07365
ELWECW_m2139(hchA)
ELLWFL_10490(hchA)
ELCi14_2198(yedU)
ELDi02_2198(yedU)
ELPP12B_c1056(hchA)
ELFLF82_0965(hchA)
ECOLLY180_10185
ECOIECOPMV1_02055(hchA)
ECOJP423_10675
EFEEFER_1951(hchA)
EALEAKF1_ch4074c(hchA)
EMAC1192_02055
ESZFEM44_24790(hchA)
SFLSF2014(yedU)
SFXS2111(yedU)
SFVSFV_2012(yedU)
SFESFxv_2246(hchA)
SFNSFy_2882
SFSSFyv_2948
SFTNCTC1_02190(yedU)
SSNSSON_2023(yedU)
SBCSbBS512_E0916(hchA)
KPKA593_25505
KVDKR75_23415
EAEEAE_21665
EARCCG29602
KGRJJJ10_09865(hchA)
CBRAA6J81_03355
PGELG71_03170
YREHEC60_06150(hchA)
PSHISAMEA2665130_1829(hchA)
SMARSM39_2702
SMACSMDB11_2472
SMWSMWW4_v1c32350(hchA)
SMAFD781_2748
SLQM495_12165
SERFL085_12445
SERSSERRSCBI_15625
SRZAXX16_2303
SSURATE40_012695
SURIJ0X03_07825(hchA)
SENPKHA73_15790(hchA)
EAMEAMY_3249(yedU)
EAYEAM_0353(hchA)
ETAETA_30440(hchA)
EPYEpC_32470(hchA)
EPREPYR_03495(yedU)
ERJEJP617_07320(yedU)
PAMPANA_1765(hchA)
PLFPANA5342_2437(hchA)
PAJPAJ_1107(hchA)
PAQPAGR_g2345
PANTPSNIH1_p01785
PERLAC65_18005(hchA)
PCOLF1325_07900(hchA)
EICNT01EI_2286
ETRETAE_2048(hchA)
ETDETAF_1847(hchA)
ETEETEE_0036(hchA)
ETCETAC_09485
EDWQY76_09980
EDLAAZ33_10890(hchA)
EHOA9798_05955
PATLKGI96_03515(hchA)
ASEGNCTC10977_00014(hchA)
GANUMN179_01029
APAGEIA51_03490(hchA)
AVTNCTC3438_00989(hchA)
RPNENCTC8284_03882(hchA)
RHEYFEE42_06700(hchA)
SMLSmlt1840
SMTSmal_1576
BUJBurJV3_1624
SMZSMD_1773(hchA)
STENCCR98_08610
STEMCLM74_08875
STESMG068_08065
SINCDAIF1_16630(hchA_1)
SPAQSTNY_R16960(hchA)
DJAHY57_13100
VCFIR04_03875
VCEVch1786_II0573
VCQEN18_02730
VCOVC0395_0351
VCRVC395_A0912
VCLVCLMA_B0650
VTAB1336(hchA)
PAEPA1135
PAEVN297_1175(hchA)
PAEIN296_1175(hchA)
PAUPA14_49710(yedU)
PAGPLES_41841
PAFPAM18_3897
PNCNCGM2_2007(yedU)
PAEBNCGM1900_1460(yedU)
PDKPADK2_19995
PSGG655_19565
PRPM062_06185
PAEPPA1S_20210
PAERPA1R_gp4748
PAEMU769_20085
PAELT223_21385
PAESSCV20265_4289
PAEUBN889_01209
PAEGAI22_13740
PAECM802_1171(hchA)
PAEOM801_1175(hchA)
PMKMDS_2717
PMOSO165_007180
PMOLCLJ08_01895
PFNHZ99_05485
PFOPfl01_2246(yedU)
PENPSEEN2870
PCZPCL1606_34340
PSWLK03_13980
PPVNJ69_06010
PSEMTO66_13415
PSECCCOS191_3061(hchA)
PGYAWU82_15905
PTYJWV26_23650(hchA)
PSEPC4K39_5532
PXNHU772_013190(hchA)
PMUYKSS95_14970(hchA)
PMAMKSS90_10645(hchA)
PORYEJA05_13005(hchA)
PSYAAOT82_1858
ACBA1S_2765
ABYABAYE0719(hchA)
ABCACICU_03015
ABNAB57_3265
ABBABBFA_00703(hchA_1)
ABXABK1_3067
ABZABZJ_03197(hchA)
ABRABTJ_00698
ABDABTW07_3236(hchA)
ABHM3Q_3245
ABADABD1_27110(hchA)
ABJBJAB07104_03099
ABABBJAB0715_03166
ABAJBJAB0868_03057
ABAZP795_3320
ABKLX00_15120
ABAAIX88_16995
ABWBL01_05395
ABALABLAC_07170
ACCBDGL_002217(hchA)
ANORR32_03570
ALCOTEC02_03630
ACALBUM88_15940
ASEII8T81_03705(hchA)
ACDAOLE_03385
ACIACIAD1164(hchA)
ACWA0J50_03450
AHLAHTJS_08160
AJNBVL33_10040
AGUAS4_33930(hchA)
ADSFPL17_04795(hchA)
ABERBSR55_16685
AGYLFPL18_16850(hchA)
SWDSwoo_2968
COLWA3Q33_20280
AHAAHA_3120(hchA)
AHYAHML_16790
AHRV428_17395
AHPV429_17430
AHJV469_05865
AHHRY45_16090
AHIVU14_06065
AAJBOQ57_15980
AVOAMS64_17855
ADHCK627_10160
NEKCGZ77_07010
NANINCTC12227_01155(hchA)
NMUSH7A79_1958
NDNH3L92_07325(hchA)
NAWLVJ86_08340(hchA)
KOAH3L93_10625(hchA)
PTESJQU52_10935(hchA)
USULVJ78_03720(hchA)
REHH16_B1347(h16_B1347)
CBWRR42_s3366
CCUPBKK81_33095
BURBcep18194_B3049
BCNBcen_5029
BCHBcen2424_5831
BCMBcenmc03_4348
BCJBCAM0131(hchA)
BCEWDM40_3483(hchA)
BCEOI35_4112(hchA)
BCTGEM_5453
BCEDDM42_5050(hchA)
BLATWK25_19845
BSTGWT74_24065
BSTLBBJ41_22555
DACDaci_2046
DHKBO996_09500
CTTCtCNB1_2595
OTKC6570_12645
AGRAGROH133_14589
SHZshn_04630
BRKCWS35_21920
BELBE61_62090
BOIBLM15_17500
LNEFZC33_14180(hchA)
BIDBind_2506
RHJHZY79_03845(hchA)
AALAIGS74_02950(hchA)
SDOSD1155_04915
RMMROSMUCSMR3_03433
PZHCX676_03515
PAROCUV01_06400
PAMNJCM7685_0332(hchA)
SPAUDRN02_015890(hchA)
SECHB18_17365
POQKZX46_22355(hchA)
GXYGLX_23440
KEUS101446_03111(hchA)
AACEA0U92_02185
AOYEOV40_007355(hchA)
RGIRGI145_16655
NEHE3E11_03240
SWFE3E12_02545
HJOAY555_09080
SAUSA0509
SAVSAV0551
SAWSAHV_0549
SAHSaurJH1_0588
SAJSaurJH9_0574
SAMMW0506
SASSAS0509
SARSAR0556
SACSACOL0597
SAXUSA300HOU_0544
SAASAUSA300_0536
SAOSAOUHSC_00533
SAENWMN_0513
SADSAAV_0514
SUUM013TW_0538(hchA)
SUVSAVC_02345
SUESAOV_0586
SUJSAA6159_00505
SUKSAA6008_00557
SUCECTR2_505
SUTSAT0131_00604
SUQHMPREF0772_12638
SUZMS7_0541
SUDST398NM01_0626
SUXSAEMRSA15_04780
SUWSATW20_06210
SUGSAPIG0626
SUFSARLGA251_04870
SAUASAAG_00969
SAUERSAU_000503(hchA)
SAUNSAKOR_00537
SAUSSA40_0491
SAUUSA957_0506
SAUGSA268_0504
SAUZSAZ172_0553
SAUTSAI1T1_2004220(hchA)
SAUJSAI2T2_1004220(hchA)
SAUKSAI3T3_1004220(hchA)
SAUQSAI4T8_1004220(hchA)
SAUVSAI7S6_1004210(hchA)
SAUWSAI5S5_1004190(hchA)
SAUXSAI6T6_1004200(hchA)
SAUYSAI8T7_1004210(hchA)
SAUFX998_0592
SABSAB0502
SUYSA2981_0528
SAUBC248_0626
SAUMBN843_5440
SAUCCA347_567
SAURSABB_00602(hchA)
SAUIAZ30_02790
SAUDCH52_03000
SAMSNI36_02740
SUHSAMSHR1132_04950
SWAA284_11100
SPASSTP1_1532(hchA)
SMUSC7J88_05210
SSHNCTC13712_00504(hchA)
SSIMSAMEA4384339_0498(hchA_1)
GHANCTC10459_00603(hchA)
STRGSRT_12400
DPMFNV33_01550(hchA)
AINAcin_1683
MYVG155_06540
MDXBTO20_05165
MFJMFLOJ_00940(hchA)
MPAGC0J29_17025
MBRDMBRA_12600(hchA)
MSENK3U95_23455(hchA)
MFTXA26_13060
MPHUMPHO_27630 MPHO_43310(hchA)
MMUCC1S78_004555(hchA) C1S78_025650(hchA)
MMATMMAGJ_38750(hchA)
MBOKMBOE_23670(hchA)
MFGK6L26_07365(hchA)
MABMAB_1932c
MMVMYCMA_1003
MABBMASS_1920
MABLMMASJCM_1942
MCHEBB28_10055
MIZBAB75_15755
MSTEMSTE_01869
MSAOMYCSP_08415
CKPckrop_0392
CFNCFAL_02575
DTMBJL86_0430
SALSSLNWT_1739
SCADDN051_04905
SFYGFH48_36620(hchA)
SSEOD0Z67_04815(hchA)
SCOECP976_19120
KPLKPaMU14_03050
KVRCIB50_0000892(hchA_2)
RAMAIDM48_09825(hchA)
RKRI6G21_04740(hchA)
DAYFV141_02565(hchA)
YIMJ5M86_11355(hchA)
SERJSGUI_2126
BCAUI6G59_10525(hchA)
NROK8W59_06575(hchA)
AMYCCU254_23335
PSEEFRP1_13125
PSEHXF36_09380
PSEQAD006_20805
PECQAD017_00385
PAUTPdca_36460(hchA)
AVCNCTC10951_01353(hchA)
EKEEK0264_05750(hchA)
ABASACPOL_6563 ACPOL_6579
STHANCTC11429_04249(hchA)
SSPII6J01_00745(hchA)
SMUII6J00_01400
SSIYJVX97_20385
FLLEI427_16705(hchA)
FKAKM029_25905(hchA)
WINWPG_2158
FBUUJ101_01147(hchA)
RANRiean_0767
RAIRA0C_1004
RARRIA_1482
RAGB739_1117
RAEG148_0856
RATM949_1586
EBVF0358_13370(hchA)
 » show all
Reference
1  [PMID:24302734]
  Authors
Hasim S, Hussin NA, Alomar F, Bidasee KR, Nickerson KW, Wilson MA
  Title
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.
  Journal
J Biol Chem 289:1662-74 (2014)
DOI:10.1074/jbc.M113.505784
  Sequence
Reference
2  [PMID:24758716]
  Authors
Zhao Q, Su Y, Wang Z, Chen C, Wu T, Huang Y
  Title
Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.
  Journal
BMC Evol Biol 14:86 (2014)
DOI:10.1186/1471-2148-14-86
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.130
IUBMB Enzyme Nomenclature: 4.2.1.130
ExPASy - ENZYME nomenclature database: 4.2.1.130
BRENDA, the Enzyme Database: 4.2.1.130

DBGET integrated database retrieval system