Entry
Name
D-lactate dehydratase;
glyoxylase III;
GLO3
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(R)-lactate hydro-lyase
Reaction(IUBMB)
(R)-lactate = 2-oxopropanal + H2O [RN:
R09796 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC
4.4.1.5 (lactoylglutathione lyase) and EC
3.1.2.6 (hydroxyacylglutathione hydrolase).
History
EC 4.2.1.130 created 2011
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K05523 D-lactate dehydratase / protein deglycase
Genes
ATH : AT2G38860(YLS5) AT3G02720(DJ1D) AT3G54600(DJ1F)
ALY : 9312329 9317686 9318316
CRB : 17887335 17890045 17893619
CSAT : 104712063 104744352 104763889 104778106 104781326 104782338 104785565 104791729 104792699
EUS : EUTSA_v10010428mg EUTSA_v10016752mg EUTSA_v10021062mg
BRP : 103829987 103864103 103870900
BNA : 106352871 106410448 106446299 106453221
BOE : 106300197 106336900 106343236
RSZ : 108814118 108829307 108834072 108861274
THJ : 104802426 104824175 104824176
CPAP : 110806854 110806863 110813866 110813874 110814769
GHI : 107899375 107924031 107924119 107953939
EGR : 104423472 104430779 104440084 104443815 104449772 104457091
APRC : 113848036 113849147
LJA : Lj2g3v2475540.1(Lj2g3v2475540.1) Lj6g3v0353790.1(Lj6g3v0353790.1)
AIP : 107608055 107631399 110265349
AHF : 112721297 112733795 112767026 112791698
LANG : 109345164 109356078
PPER : 109947823 109947861 109947908 109947909 109947911 109948158 109948159 109948160 109948161
PMUM : 103327328 103327330 103327332 103327333 103327424 103327481
PAVI : 110745932 110765119 110765120 110765184
PDUL : 117621064 117621301 117621302 117621303 117621305 117621306 117621307
ZJU : 107434701 107434704 107434708
MESC : 110600167 110611415 110621125
POP : 18106498 18106499 7494513 7494515
PEU : 105112048 105112049 105115962 105135277
PALZ : 118030280 118030281 118037144 118037145 118037207 118055032 118055033
CILL : 122302983 122302984
SSPL : 121783305 121787483
LSV : 111898934 111898937 111898949
DCR : 108206713 108218153 108219409
CSIN : 114278313 114322617
MING : 122092034 122094220
PSOM : 113275281 113298293 113319157 113337787 113350019
DOSA : Os04t0671700-01(Os04g0671700) Os11t0591550-00(Os11g0591550)
TDC : 119332470 119337233 119366304
TAES : 123047323 123055126 123148912 123157367 123168374 123190979
SITA : 101752662 101773459
PHAI : 112900435 112903033
EGU : 105035496 105035502 105055359 105058906
NCOL : 116246095 116260524
SMO : SELMODRAFT_271043 SELMODRAFT_271634
SCE : YDR533C(HSP31) YMR322C(SNO4) YOR391C(HSP33) YPL280W(HSP32)
SEUB : DI49_2822 DI49_4808
SPAO : SPAR_D07060 SPAR_O04900
KLA : KLLA0_D00682g KLLA0_D00704g
VPO : Kpol_1058p1 Kpol_196p3
TBL : TBLA_0H02460(TBLA0H02460) TBLA_0H02470(TBLA0H02470)
TDL : TDEL_0F00110(TDEL0F00110)
KAF : KAFR_0C00500(KAFR0C00500) KAFR_0I02470(KAFR0I02470) KAFR_0K01480(KAFR0K01480)
DHA : DEHA2D00880g DEHA2E03762g DEHA2E17270g DEHA2G01474g
LEL : LELG_02042 LELG_02043 LELG_02044
CAL : CAALFM_C302610CA(GLX3)
CTP : CTRG_02436 CTRG_02543
COT : CORT_0B04350 CORT_0E00590
YLI : YALI0C22000g YALI0F00682g
TMN : UCRPA7_2911 UCRPA7_307
NHE : NECHADRAFT_45064 NECHADRAFT_49514
CHIG : CH63R_03318 CH63R_06740
ANG : ANI_1_1122094(An11g08940)
SPO : SPAC11D3.13 SPAC1F7.06 SPAC5H10.02c SPBC947.09 SPCC757.03c
ACAN : ACA1_080640 ACA1_357050
ECOO : ECRM13514_2522(yedU)
ECOH : ECRM13516_2449(yedU)
ECW : EcE24377A_2198(hchA)
EDJ : ECDH1ME8569_1907(hchA)
ECOI : ECOPMV1_02055(hchA)
PSHI : SAMEA2665130_1829(hchA)
SMW : SMWW4_v1c32350(hchA)
ASEG : NCTC10977_00014(hchA)
AVT : NCTC3438_00989(hchA)
RPNE : NCTC8284_03882(hchA)
SINC : DAIF1_16630(hchA_1)
PAEB : NCGM1900_1460(yedU)
AVZ : HWI77_08360(hchA) HWI77_17645(hchA)
NANI : NCTC12227_01155(hchA)
REH : H16_B1347(h16_B1347)
SAUT : SAI1T1_2004220(hchA)
SAUJ : SAI2T2_1004220(hchA)
SAUK : SAI3T3_1004220(hchA)
SAUQ : SAI4T8_1004220(hchA)
SAUV : SAI7S6_1004210(hchA)
SAUW : SAI5S5_1004190(hchA)
SAUX : SAI6T6_1004200(hchA)
SAUY : SAI8T7_1004210(hchA)
SSH : NCTC13712_00504(hchA)
SSIM : SAMEA4384339_0498(hchA_1)
GHA : NCTC10459_00603(hchA)
MPHU : MPHO_27630 MPHO_43310(hchA)
MMUC : C1S78_004555(hchA) C1S78_025650(hchA)
KVR : CIB50_0000892(hchA_2)
AVC : NCTC10951_01353(hchA)
ABAS : ACPOL_6563 ACPOL_6579
STHA : NCTC11429_04249(hchA)
» show all
Taxonomy
Reference
Authors
Hasim S, Hussin NA, Alomar F, Bidasee KR, Nickerson KW, Wilson MA
Title
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.
Journal
Sequence
Reference
Authors
Zhao Q, Su Y, Wang Z, Chen C, Wu T, Huang Y
Title
Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.130