KEGG ENZYME: 4.2.1.131

ENZYME: 4.2.1.131

Entry

EC 4.2.1.131                Enzyme

Name

carotenoid 1,2-hydratase;
CrtC

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

lycopene hydro-lyase (1-hydroxy-1,2-dihydrolycopene-forming)

Reaction(IUBMB)

(1) 1-hydroxy-1,2-dihydrolycopene = lycopene + H2O [RN:R07519];
(2) 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene = 1-hydroxy-1,2-dihydrolycopene + H2O [RN:R09790]

Reaction(KEGG)

R07519 R09790;
(other) R07516 R07522 R07528 R07532 R07536 R07539 R07543

Substrate

1-hydroxy-1,2-dihydrolycopene [CPD:C19795];
1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene [CPD:C19894]

Product

lycopene [CPD:C05432];
H2O [CPD:C00001];
1-hydroxy-1,2-dihydrolycopene [CPD:C19795]

Comment

In Rubrivivax gelatinosus [1] and Thiocapsa roseopersicina [2] both products are formed, whereas Rhodobacter capsulatus [1] only gives 1-hydroxy-1,2-dihydrolycopene. Also acts on neurosporene giving 1-hydroxy-1,2-dihydroneurosporene with both organism but 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene only with Rubrivivax gelatinosus.

History

EC 4.2.1.131 created 2011

Pathway

ec00906

Carotenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K09844

carotenoid 1,2-hydratase

Genes

PAQM:

E0F26_06860

ALV:	Alvin_2567

ATEP:

Atep_25200

TVI:	Thivi_2016

TMB:	Thimo_3010

MPUR:

MARPU_13285

TSY:	THSYN_31075

TTP:	E6P07_01715

THIP:

N838_12470 N838_26735

CJAP:

GWK36_12665

THIM:

KFB96_13185

TBOG:

LT988_08930

TLR:	Thiosp_04249(crtC)

TFRI:

Thiofri_00871(crtC)

TWG:	Thiowin_04459(crtC)

HHA:

Hhal_1615

HHK:	HH1059_06240

HHC:	M911_10375

EBS:	ECTOBSL9_3051

PDQ:	CL55_00013480

PANI:

DCO16_03410

PCOS:

C2747_06900

PWU:	A8O14_08370

POLY:

PSHI2_19260

POLN:

PSHI8_19270

RAC:	RA876_06055

LIM:	L103DPR2_00984(crtC)

LIH:	L63ED372_00639(crtC)

HYR:	BSY239_1369

HCZ:	G9Q37_00105

METP:

C1M51_03600

RGE:	RGE_33580(crtC)

RBN:	RBXJA2T_09497

RDP:	RD2015_1032

ROI:	N4261_01180

ATER:

MW290_02545

METR:

BSY238_2444

BEB:	AEM42_07450

RPOD:

E0E05_11765

AGC:	BSY240_3674

RROS:

D4A92_02610

ABAW:

D5400_04855

PDES:

FE840_002300

BRA:	BRADO1613(crtC)

BBT:	BBta_6442(crtC)

BRS:	S23_19130(crtC)

AOL:

S58_59230

BRO:	BRAD285_5787(crtC)

BRQ:	CIT40_23965

BBET:

F8237_24650

BROS:

QUH67_09810

BOY:	LQG66_15995

RPA:	TX73_007800

RPB:

RPB_4006

RPC:

RPC_1288

RPD:

RPD_3761

RPE:

RPE_1320

RPT:

Rpal_1705

RPX:	Rpdx1_4003

RHOL:

RBJ75_13170

BOS:	BSY19_4061

MEA:	Mex_1p2922

MDI:	METDI3491(crtC)

MEX:

Mext_2725

MCH:

Mchl_2952

MPO:

Mpop_2847

MZA:	B2G69_21165

MRD:	Mrad2831_2823

MET:

M446_3692

MOR:

MOC_3188

META:

Y590_13115

MAQU:

Maq22A_1p32520

MPHY:

MCBMB27_02264

MEE:	DA075_03935

METD:

C0214_15280

METX:

A3862_17675

METS:

DK389_31460

METI:

DK427_17920

MMES:

MMSR116_13590

MTEA:

DK419_04890

MIND:

mvi_08930

MOG:	MMB17_23910

MTAD:

M6G65_16650

MSL:

Msil_2047

BBAR:

RHAL1_03019

RVA:

Rvan_0206

RLAC:

QMO75_01190

MROS:

EHO51_17010

MESZ:

LNB28_08155

CMET:

K6K41_01650

AUZ:	Sa4125_27800

AUB:	LXB15_06400

JIE:	OH818_18180

BSB:	Bresu_3049

BRL:	BZG35_15475

BREA:

HZ989_10905

RUT:	FIU92_10180(crtC)

JAN:	Jann_0184(crtC)

RDE:	RD1_0116(crtC)

RLI:	RLO149_p940110(crtC)

RPON:

G3256_18635

RFU:	ROLI_040990(crtC)

DSH:	Dshi_3512(crtC)

RED:	roselon_01073

SUAM:

BOO69_19435

SUAL:

KDD17_18645

TOM:	BWR18_20215

RMM:	ROSMUCSMR3_00910(crtC)

ROK:	RAK1035_3779

RID:	RIdsm_01750

ROM:	EI983_05415

ROH:	FIU89_14260(crtC)

THAA:

CFI11_23525

ROT:	FIV09_18045(crtC)

RMH:	LVO79_17395

MALU:

KU6B_16380(crtC)

PLCG:

RVY76_13915

MARU:

FIU81_13885(crtC)

RMAI:

MACH21_32740(crtC)

RSP:	RSP_0267(crtC)

RSH:	Rsph17029_1911

RSQ:	Rsph17025_2041

RSK:	RSKD131_1594

CAZT:

LV780_09100

RCP:	RCAP_rcc00682(crtC)

RBL:	B6K69_00165

FYT:	QF092_06625

PTP:	RCA23_c29570(crtC)

RSU:

NHU_04282

RHM:	B5V46_17510

RHC:

RGUI_1966

LVS:	LOKVESSMR4R_03674(crtC)

GEH:	HYN69_05500

TAW:	EI545_18920

POZ:	I0K15_00035

NSM:	JO391_16440

PBAE:

P8S53_17200

RBG:	BG454_03010

FAQ:	G5B39_11905

RBX:	I3V23_09365

HBC:	AEM38_14605

NOT:	C7W88_00460

NGF:	FRF71_09125

NOG:	GKE62_08415

NCP:	U0041_19220

SPHI:

TS85_22885

SSAN:

NX02_18470

SGLC:

M1K48_13825

SQO:	NMP03_02100

SRAD:

LLW23_12125

CIJ:	WG74_05025

SLAA:

EUU25_10250

BLAS:

BSY18_2719

BFW:	B5J99_04545

PALG:

HFP57_06970

PARJ:

J4G78_07555

SAND:

H3309_05730

POQ:	KZX46_18725

PMEA:

KTC28_17035

ALH:	G6N82_11410

ARUE:

QQX03_04190

ELQ:	Ga0102493_111842

ERK:	CD351_13850

ERF:	FIU90_13810(crtC)

PNS:	A9D12_01270

ERYT:

KDC96_01035

PORL:

BG023_112666

PHZ:	CHX26_14480

POT:	E2E27_07355

PORC:

CBR61_14905

AMV:	ACMV_18840(crtC)

RFL:

Rmf_22360

SRF:	LHU95_13835

RAP:

RHOA_2423

NCB:	C0V82_18190

SKT:	IGS68_17140

SMUC:

JL100_008895

SROE:

JL101_015320

RRU:

Rru_A2985

RRF:

F11_15290

RPM:	RSPPHO_02322(crtC)

ELIO:

KO353_03100

THAR:

T8K17_11740

MXA:

MXAN_0898

MSD:	MYSTI_00908

MYM:	A176_006083

MFB:	MFUL124B02_05140

MYX:	QEG98_05190

MLAN:

JY572_22020

CCX:	COCOR_00783(crtC)

MFU:	LILAB_04220

MMAS:

MYMAC_000922

PPAK:

JY651_34680

SUR:	STAUR_7077

AGE:	AA314_01870

AVM:	JQX13_22185

MBD:	MEBOL_004337

CFUS:

CYFUS_001184

SCL:	sce0584(crtC)

SCU:	SCE1572_04050

CCRO:

CMC5_014480

PAUU:

E8A73_015955

MRM:	A7982_08936

NANN:

O0S08_04900

BSED:

DN745_03195

PCAY:

FRD00_10885

BBAE:

FRD01_09570

LEPV:

J4558_14785 J4558_24605

IPA:

Isop_1565

TPLA:

ElP_59610(crtC)

HBS:	IPV69_02315

CTM:	Cabther_A0575

CVL:	J8C06_08655

CTE:	CT0301(crtC)

CPC:

Cpar_1736

CLZ:	BIU88_01405

CCH:

Cag_0393

CPH:	Cpha266_0428

CPB:	Cphamn1_1988

CLI:

Clim_0360

PVI:

Cvib_1502

PLT:

Plut_1720

PPH:

Ppha_0465

PAA:

Paes_1781

PROC:

Ptc2401_01879

PRS:	B9H02_08945

PROS:

CHL67_02450

PROW:

OO006_02715

PROI:

OO005_02675

CTS:

Ctha_1182

CPRV:

CYPRO_1942

» show all

Reference

1 [PMID:12745254]

Authors

Steiger S, Mazet A, Sandmann G

Title

Heterologous expression, purification, and enzymatic characterization of the acyclic carotenoid 1,2-hydratase from Rubrivivax gelatinosus.

Journal

Arch Biochem Biophys 414:51-8 (2003)
DOI:10.1016/S0003-9861(03)00099-7

Sequence

[rcp:RCAP_rcc00682] [rge:RGE_33580]

Reference

2 [PMID:21590288]

Authors

Hiseni A, Arends IW, Otten LG

Title

Biochemical characterization of the carotenoid 1,2-hydratases (CrtC) from Rubrivivax gelatinosus and Thiocapsa roseopersicina.

Journal

Appl Microbiol Biotechnol 91:1029-36 (2011)
DOI:10.1007/s00253-011-3324-1

Sequence

[rge:RGE_33580] [ag:AAP59035]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.131

IUBMB Enzyme Nomenclature:

4.2.1.131

ExPASy - ENZYME nomenclature database:

4.2.1.131

BRENDA, the Enzyme Database:

4.2.1.131

DBGET integrated database retrieval system