KEGG ENZYME: 4.2.1.137

ENZYME: 4.2.1.137

Entry

EC 4.2.1.137                Enzyme

Name

sporulenol synthase;
sqhC (gene name)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

tetraprenyl-beta-curcumene---sporulenol cyclase

Reaction(IUBMB)

sporulenol = tetraprenyl-beta-curcumene + H2O [RN:R10269]

Reaction(KEGG)

R10269

Substrate

sporulenol [CPD:C20475]

Product

tetraprenyl-beta-curcumene [CPD:C20276];
H2O [CPD:C00001]

Comment

The reaction occurs in the reverse direction. Isolated from Bacillus subtilis. Similar sesquarterpenoids are present in a number of Bacillus species.

History

EC 4.2.1.137 created 2012

Orthology

K18115

sporulenol synthase

Genes

MFB:	MFUL124B02_24605

BSU:	BSU19320(sqhC)

BSR:

I33_2170

BSL:

A7A1_2802

BSH:	BSU6051_19320(sqhC)

BSY:	I653_10000

BSUT:

BSUB_02079(sqhC)

BSUL:

BSUA_02079(sqhC)

BSUS:

Q433_11505

BSO:	BSNT_08495(sqhC)

BSN:	BSn5_01005

BSQ:	B657_19320(sqhC)

BSX:	C663_1984(sqhC)

BSP:	U712_10185

BSS:	BSUW23_10325(sqhC)

BST:

GYO_2334

BIT:	BIS30_00190

BLI:	BL00583(sqhC)

BLD:	BLi02253(sqhC)

BLH:	BaLi_c23390(sqhC)

BAY:	RBAM_019070

BAQ:	BACAU_1907(sqhC)

BYA:	BANAU_2030(sqhC)

BAMP:

B938_09870

BQY:	MUS_2281(sqhC)

BAML:

BAM5036_1838(sqhC)

BAMA:

RBAU_1876(sqhC)

BAMN:

BASU_1857(sqhC)

BAMB:

BAPNAU_1839(sqhC)

BAMT:

AJ82_10830

BAMY:

V529_19370(sqhC)

BMP:	NG74_01985(sqhC)

BAO:	BAMF_2003(sqhC)

BAZ:	BAMTA208_07505(sqhC)

BQL:	LL3_02103(sqhC)

BXH:	BAXH7_01526(sqhC)

BAMI:

KSO_009830

BAMC:

U471_19660

BAMF:

U722_10400

BSIA:

CWD84_11460

BAE:	BATR1942_08330

BVM:	B9C48_09720

BSON:

S101395_02353

BHT:	DIC78_20945

BMOJ:

HC660_19950(sqhC)

BTEQ:

G4P54_11105

BIQ:	AN935_10240

BSTR:

QI003_10455(sqhC) QI003_13885(sqhC)

BAN:

BA_3612

BAR:

GBAA_3612

BAT:

BAS3351

BAH:	BAMEG_1018

BAI:

BAA_3641

BAX:	H9401_3435

BANT:

A16_36190

BANR:

A16R_36650

BANS:

BAPAT_3460

BANH:

HYU01_17675

BANV:

DJ46_2332

BCE:

BC3557

BCA:

BCE_3572

BCZ:	BCE33L3265(sqhC)

BCR:	BCAH187_A3582

BCB:	BCB4264_A3665

BCU:	BCAH820_3565

BCG:	BCG9842_B1652

BCQ:	BCQ_3351(sqhC)

BCX:

BCA_3651

BAL:	BACI_c35010(sqhC)

BNC:

BCN_3367

BCF:

bcf_17630

BCER:

BCK_17475

BCY:	Bcer98_2232

BTK:	BT9727_3315(sqhC)

BTL:

BALH_3198

BTB:	BMB171_C3232

BTT:

HD73_3829

BTHI:

BTK_18835

BTC:	CT43_CH3501

BTF:	YBT020_17420

BTM:

MC28_2706

BTG:	BTB_c36330(sqhC)

BTI:

BTG_01595

BTN:	BTF1_15540

BTHT:

H175_ch3559

BTHU:

YBT1518_19510

BTW:

BF38_4731

BTHY:

AQ980_12175

BWE:	BcerKBAB4_3260

BWW:	bwei_1382(sqhC)

BMYO:

BG05_2454

BTY:	Btoyo_0769

BMYC:

DJ92_540

BBY:	CY96_16780

BWD:	CT694_18920

BTRO:

FJR70_10680

BMOB:

MLA2C4_18465

BNT:	GSN03_16820

BPAC:

LMD38_09315

BPAN:

NLJ82_16800

BALU:

QRY64_20400

BPU:

BPUM_1858

BPUM:

BW16_10200

BPUS:

UP12_09510

BIF:	N288_03275

BMET:

BMMGA3_09020(sqhC)

BGY:

BGLY_2506

BXI:	BK049_17630

BALT:

CFN77_10030

BAER:

BAE_17185

BSAF:

BSL056_10480

BFD:	NCTC4823_02717(shc)

BSHI:

LGQ02_01785(shc)

BBAD:

K7T73_02185(shc)

BCAB:

EFK13_10690

BRY:	M0696_10390

BJS:

MY9_2114

BACI:

B1NLA3E_12450

GST:	HW35_02125

BACW:

QR42_09455

BACP:

SB24_19160

BACB:

OY17_12665

BACY:

QF06_08785

BACL:

BS34A_21430(sqhC)

BALM:

BsLM_2054

BACS:

AUL54_00845

BACQ:

DOE78_14295(shc)

BACA:

FAY30_14445(shc) FAY30_23255(shc)

BZH:	NF868_08345

BHAI:

KJK41_05785(shc)

BCAO:

LC087_15740

BARD:

QRY57_17510

BAEI:

RE735_10425

BCO:	Bcell_4159

BHK:	B4U37_04765

BCOH:

BC6307_06410

BCIR:

C2I06_20385(shc)

NTX:	NQZ71_01195

NIL:	L8T27_001135

BMQ:

BMQ_2177

BMD:

BMD_2134

BMH:	BMWSH_3068(sqhC)

BMEG:

BG04_4486

BEO:

BEH_07115

BFX:	BC359_12515

PKS:	IE339_08645(shc)

BLE:	BleG1_3670 BleG1_3918

SHUA:

PQ477_05995(shc) PQ477_07255

BGI:	BGM20_04245

BON:	A361_05265 A361_16480

BKO:	CKF48_03415(shc)

CGOT:

J1899_04750

CFIR:

NAF01_14800(shc)

CSOA:

LIS82_13990

CPSS:

M5V91_04610(shc) M5V91_16485(shc)

BDA:	FSZ17_11405(shc)

OCN:	CUC15_03395

OJD:	NP439_01715(shc)

OON:	NP440_01605(shc)

GTK:	GT3570_09355

GTM:	GT3921_09615

GTN:

GTNG_1884

GYC:	GYMC61_2820

GYA:	GYMC52_1950

GCT:	GC56T3_1526

GGH:	GHH_c20510(sqhC)

GJF:	M493_10215

GSR:	GS3922_06695

GZA:	IC807_06050(shc)

PCAL:

BV455_03497(sqhC)

PARG:

PspKH34_23190(sqhC)

ANM:	GFC28_391(shc)

ANL:	GFC29_1233(shc)

AND:	GRQ40_10780(shc)

ACAI:

ISX45_04965(shc)

LAGR:

FJQ98_10990

HLI:	HLI_08450(shc)

HSAN:

MUN89_14200

TAP:	GZ22_07850

TAID:

KS242_08955

FPN:	ABE65_010130

FAR:	ABE41_011440

FEC:	QNH15_12590 QNH15_16420

ACOP:

RI196_12255(shc)

BSJ:	UP17_23310

BMUR:

ABE28_021965

PBUT:

DTO10_09775(shc)

PASA:

BAOM_4536(sqhC)

PPSR:

I6J18_16685

PFRI:

L8956_24805(shc)

PERI:

RE409_25670(shc)

PSYO:

PB01_08655 PB01_10655(shc)

PRD:	F7984_09750(shc)

NMK:	CHR53_04600(shc) CHR53_17450(shc)

NDT:	L1999_14425(shc) L1999_18820

NCM:	QNK12_14820(shc) QNK12_20015(shc)

NNV:	QNH39_15970(shc) QNH39_18415(shc)

MEKU:

HUW50_25460(shc)

MSEM:

GMB29_13635(shc)

MDG:	K8L98_13865

MLIT:

KDJ21_015580

MENL:

MVE64_03255

MEBZ:

LPC09_15155

BLEN:

NCTC4824_02884(shc)

BVQ:	FHE72_06360(shc)

RMF:	D5E69_07135

RAZ:	U9J35_06345(shc)

ROD:	P8596_06525(shc)

ROSS:

V2W31_06285(shc)

BVJ:	I5776_05865 I5776_12795

BOU:	I5818_15890

HSPO:

JGZ69_21255

MCUI:

G8O30_14925

GAJ:	MY490_01840 MY490_12110

SFOR:

QNH23_09135(shc)

ECTO:

MUG87_03425(shc)

ALKG:

MOJ78_11590

PUK:	PU629_08725(shc)

BBE:	BBR47_38010

BLR:	BRLA_c023400

BFM:	BP422_14320

BRW:	GOP56_04470(shc)

BCHS:

JNE38_19295(shc)

BPAB:

PSE45_17515(shc)

BREH:

HP435_18030(shc)

PJD:	Pjdr2_1272

PTA:	HPL003_17185

PDU:	PDUR_09960

POD:	PODO_14705

PAEF:

R50345_14930

PAEJ:

H70737_14335

PBJ:	VN24_17045

PNP:	IJ22_50250

POW:	IJ21_14410

PYG:	AWM70_12730

PSWU:

SY83_08975

PKB:	B4V02_09195 B4V02_23645

PAIH:

ASL14_02240

PVO:	PVOR_14164 PVOR_18979

PPSC:

EHS13_17320

PLUT:

EI981_01490(shc)

PALB:

EJC50_21855

PCHI:

PC41400_15280

PBK:	Back11_10430(sqhC)

PPRT:

ET464_05620(shc)

PRZ:	GZH47_29060

PLYC:

GXP70_18545

PCEL:

HUB94_22235

PALR:

HGI30_17265

PTHI:

NDS46_07810(shc)

PMAH:

PTQ21_19880(shc)

PMAE:

LMZ02_15515(shc)

PWN:	QNH46_01260(shc)

PSPN:

L1F29_20245

PPAB:

KET34_15850(shc)

PKP:	SK3146_05957(sqhC)

PGLU:

A3958_20175 A3958_23185

PHEX:

L0M14_06985(shc)

ASOC:

CB4_01918(sqhC_1) CB4_02694(sqhC_2)

AUD:	PO771_10325(shc)

ANEU:

PP175_14315(shc)

COH:	EAV92_12540

CHEB:

HH215_24340

COHL:

J4772_05810

PLIG:

NAG76_16320(shc)

AFX:	JZ786_07805 JZ786_16330

AACO:

K1I37_12905 K1I37_18515

AFAS:

NZD89_18100

ALIC:

GI364_11930

EFF:	skT53_00210(sqhC)

FFE:	LSG31_15230

SPSY:

AZE41_09705

PANC:

E2636_17165(shc)

LFB:	C1X05_04645

TVU:	AB849_001480

KPUL:

GXN76_06125

KEB:	GXN75_07200 GXN75_07205

PABS:

JIR001_24940(sqhC)

DGI:	Desgi_2958

ACIT:

HPK19_06615(shc) HPK19_20000

LPAV:

PLANPX_1690 PLANPX_6175

PND:	Pla175_51910

DRC:	G0Q07_17955

MCOS:

GM418_05460

MBY:	MSBRM_1470

MBAR:

MSBR2_0931

MAC:

MA_3182

MSJ:	MSSAC_1277

MSZ:	MSSIH_1095

MSW:	MSSIT_1144

MTHE:

MSTHC_1971

» show all

Reference

1 [PMID:21627333]

Authors

Sato T, Yoshida S, Hoshino H, Tanno M, Nakajima M, Hoshino T

Title

Sesquarterpenes (C35 terpenes) biosynthesized via the cyclization of a linear C35 isoprenoid by a tetraprenyl-beta-curcumene synthase and a tetraprenyl-beta-curcumene cyclase: identification of a new terpene cyclase.

Journal

J Am Chem Soc 133:9734-7 (2011)
DOI:10.1021/ja203779h

Sequence

[bsu:BSU19320]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.137

IUBMB Enzyme Nomenclature:

4.2.1.137

ExPASy - ENZYME nomenclature database:

4.2.1.137

BRENDA, the Enzyme Database:

4.2.1.137

DBGET integrated database retrieval system