KEGG   ENZYME: 4.2.1.141
Entry
EC 4.2.1.141                Enzyme                                 
Name
2-dehydro-3-deoxy-D-arabinonate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
2-dehydro-3-deoxy-D-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O [RN:R09186]
Reaction(KEGG)
R09186
Substrate
2-dehydro-3-deoxy-D-arabinonate [CPD:C03826]
Product
2,5-dioxopentanoate [CPD:C00433];
H2O [CPD:C00001]
Comment
The enzyme participates in pentose oxidation pathways that convert pentose sugars to the tricarboxylic acid cycle intermediate 2-oxoglutarate.
History
EC 4.2.1.141 created 2013
Pathway
ec00040  Pentose and glucuronate interconversions
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Orthology
K14259  2-dehydro-3-deoxy-D-arabinonate dehydratase
Genes
PSUPsesu_2921
PSUWWQ53_05940
PDDMNQ95_04575
SCLsce8243(faa)
SCUSCE1572_47080
BMEGBG04_4038
BEOBEH_11885
BCLABC1112
GKAGK1967
GTMGT3921_09715
GTNGTNG_1866
GCTGC56T3_1547
GJFM493_09690 M493_10125
GEJA0V43_07475
PCALBV455_03525
ASEDIRT44_16585
HLIHLI_15940
BMURABE28_011530
PBUTDTO10_00810
PFRIL8956_13705
GRCGI584_03860
SCIBHUG20_02255
NMKCHR53_12340
MEKUHUW50_20550 HUW50_22775
MSEMGMB29_13525
BCHSJNE38_24875
GYMGYMC10_3270
PMSKNP414_02097
PMQPM3016_2383
PMWB2K_12085
PNPIJ22_43730
PXLBS614_19565
PIBBBD41_22200
PLWD5F53_14060
PBACHUB98_02105
TCOTheco_0429
CCHLFPL14_24935
AACOK1I37_06120
ACURJZ785_21475
EFFskT53_25860(hpaG)
PHCBBI08_12035
SURESporoP32a_11185
PANCE2636_15560
NTRB0W44_08260
PABSJIR001_13580(hpaG)
GEKkuro4_03490(hpaG)
SVLStrvi_5334
SRCM271_45795
SMALSMALA_0412
SSOII1A49_05580
SBHSBI_09206
SAUOBV401_05820
SBATG4Z16_12510
LEIFHF024_03020 HF024_15480
HUWFPZ11_10065
GRYD7I44_08845 D7I44_11540
BCVBcav_0314
NOYEXE57_11600
KFLKfla_6633
KQIF1D05_17895
STRREKD16_17080
SAIUJ4H86_18420
NOABKM31_31745
NOWGBF35_12545
NCXNocox_11695
NGNLCN96_13520
NAKEH165_00860 EH165_12535
GOBGobs_0128
BSDBLASA_1409
AMDAMED_6194
AMNRAM_31775
AMMAMES_6104
AMZB737_6104
AMYCCU254_21935
AACDLWP59_13195
KPHYAOZ06_50695
AMSAMIS_27870
AFSAFR_12580
PFLAPflav_039260
PSUUPsuf_084850
ATLAthai_61710
ASERAsera_13690
NHYJQS43_03110
PLAKA1s21155_05865
PSUFA1sIA56_05795
ABAMB1s21122_01870
NHIB1s21160_01625
JTLM6D93_07035
RXYRxyl_0545
RUBGBA63_01670
ERZER308_02575 ER308_18835
TROtrd_1918
CAPCLDAP_15110
KBSEPA93_38865
TTRTter_0269
PMETG4Y79_10140
DPDDeipe_4109
FGIOP10G_0813
OTEOter_2671
OBGVerru16b_01749
ROOG5S37_23855
RBARB8851(hpaG)
PSLPsta_0399
PIRVN12_22430
RULUC8_07870
RMLFF011L_11260
MFFMFFC18_01760
ROLCA51_16340
AHELQ31a_23800
LCREPla8534_61440
AAGGETAA8_20750
BVOPan97_46530
RLCK227x_12920
PNDPla175_38680
PLMPlim_2320
PEHSpb1_30970
PBSPlabr_0388
PLSVT03_23690
PLHVT85_19355
FMRFuma_03150
GMRGmarT_07590
GIMF1728_10480
GPNPan110_08240
MRIMal4_55190
SDYNMal52_14970
PLONPla110_09160
GESVT84_23245
GOGC1280_16035
GMSSOIL9_38880
TIMGMBLW1_25960
LRSPX52LOC_06028
FTJFTUN_6503
ULIETAA1_49580
TSPHKIH39_25615
IPAIsop_2260
SACISinac_2247
PBORBSF38_01248
AGVOJF2_22150
HBSIPV69_26210
ACAACP_0198
GRWFTO74_13960
TRSTerro_2790
TALBFTW19_14930
EDAGWR55_11400
ADINH7849_17970
SUSAcid_0967
PFERIRI77_26560
ABACLuPra_06005
NKONiako_0093
FLNFLA_2805
PSEGD3H65_15910
PGINFRZ67_04845
PGOFSB84_27240
FLSGLV81_12740
LACSH4075_19550
FLCKJS93_12195
HHYHalhy_0224
PGSCPT03_06695
PEKFFJ24_008600
SHGSph21_2642
MUCMuYL_3112
MGOTMgSA37_02342
MUHHYN43_007300 HYN43_020440
MGINFRZ54_15315
MGKFSB76_02295 FSB76_16455
MRUBDEO27_020555
MGOSDIU38_021550
AGDFRZ59_07585
OLIFKG96_10570
CMRCycma_4404
CAMUCA2015_4342
ALMAO498_02430
SLISlin_1198
SRDSD10_07360
SMONAWR27_03240
SPIRCWM47_25220
SPIKEXU85_10265
SPIBG8759_29120
STAEHNV11_17560
SRHOHH216_23715
PSEZHME7025_01774(kdxD)
RHOZGXP67_22365
DFEDfer_3859
DSNHWI92_18795
LBYLbys_1449
RSIRunsl_5756
RUNDR864_10925
RUPDTQ70_27775
EOLEmtol_1794
FAEFAES_1942
FIBA6C57_24550
ALSDJ013_18160
ADDHUW48_19460
ASWUHUW51_13565
CHKD4L85_05715
RBIRB2501_03955
FBCFB2170_10656
MARTBTR34_07835
LULLPB138_14640
AALGAREALGSMS7_04663
EMARD1013_11485
SABUMBM09_06890
HHBHhub_4019 Hhub_4032
HNOLT974_08040
HALREFA46_010930 EFA46_011065
HAADMW046_12225
HMArrnAC1339
HHIHAH_1926
HHNHISP_09825
HABSG26_02140
HTABVU17_09300
HALJG9465_01195 G9465_10995
HSINKDQ40_03840
HRRHZS55_16705 HZS55_21925
HPELHZS54_19520 HZS54_25415
HLTI7X12_14460 I7X12_18970
HDOMUK72_12460
HVOHVO_B0027(xacE)
HGIABY42_15580 ABY42_16735
HALEG3A49_07050
HRAEI982_03010
HLMDV707_16940
HLAHlac_2243
SRUBC2R22_00805 C2R22_01260
HALNB4589_002500
HALGHUG10_09705
HALUHUG12_05225 HUG12_08670
HTUHtur_4483 Htur_4503
HSALJMJ58_23245 JMJ58_23350
HXAHalxa_3765 Halxa_3794
NVRFEJ81_08225
NAYHYG81_01540
NOUNatoc_3152
HLRHALLA_01780 HALLA_04540
SSOSSO3118
SOLSsol_0860
SSOASULA_0896
SSOLSULB_0898
SSOFSULC_0897
SSHIJ5U23_00366
SCASSACC_27700
SAISaci_1939
SACNSacN8_09570
SACRSacRon12I_09590
SACSSUSAZ_09015
SISLS215_2412
SIAM1425_2245
SIMM1627_2324
SIDM164_2246
SIYYG5714_2378
SINYN1551_0530
SIILD85_2519
SIHSiH_2188
SIRSiRe_2129
SICSiL_2093
SULABFU36_07540
SULEGFS03_12115
SULOGFS33_03940
SULLEWF20_06415
AMANB6F84_00720
SACDHS1genome_1631
CMACmaq_0259
VMOVMUT_1239
CSUCSUB_C0654
 » show all
Reference
1  [PMID:16849334]
  Authors
Brouns SJ, Walther J, Snijders AP, van de Werken HJ, Willemen HL, Worm P, de Vos MG, Andersson A, Lundgren M, Mazon HF, van den Heuvel RH, Nilsson P, Salmon L, de Vos WM, Wright PC, Bernander R, van der Oost J
  Title
Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment.
  Journal
J Biol Chem 281:27378-88 (2006)
DOI:10.1074/jbc.M605549200
  Sequence
[sso:SSO3118]
Reference
2  [PMID:18448118]
  Authors
Brouns SJ, Barends TR, Worm P, Akerboom J, Turnbull AP, Salmon L, van der Oost J
  Title
Structural insight into substrate binding and catalysis of a novel 2-keto-3-deoxy-D-arabinonate dehydratase illustrates common mechanistic features  of the FAH superfamily.
  Journal
J Mol Biol 379:357-71 (2008)
DOI:10.1016/j.jmb.2008.03.064
  Sequence
[sso:SSO3118]
Reference
3  [PMID:19584053]
  Authors
Johnsen U, Dambeck M, Zaiss H, Fuhrer T, Soppa J, Sauer U, Schonheit P
  Title
D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii.
  Journal
J Biol Chem 284:27290-303 (2009)
DOI:10.1074/jbc.M109.003814
  Sequence
[hvo:HVO_B0027]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.141
IUBMB Enzyme Nomenclature: 4.2.1.141
ExPASy - ENZYME nomenclature database: 4.2.1.141
BRENDA, the Enzyme Database: 4.2.1.141

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