KEGG   ENZYME: 4.2.1.143
Entry
EC 4.2.1.143                Enzyme                                 

Name
versicolorin B synthase;
versiconal cyclase;
VBS
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
versiconal hydro-lyase (versicolorin-B forming)
Reaction(IUBMB)
versiconal = versicolorin B + H2O [RN:R10402]
Reaction(KEGG)
R10402
Substrate
versiconal [CPD:C20507]
Product
versicolorin B [CPD:C20575];
H2O [CPD:C00001]
Comment
Isolated from the aflatoxin-producing mold Aspergillus parasiticus. Involved in aflatoxin biosynthesis.
History
EC 4.2.1.143 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17646  5'-oxoaverantin cyclase / versicolorin B synthase
Genes
PAN: PODANSg8556
ANI: AN7812.2
AOR: AO090026000028
AFV: AFLA_139190
Reference
1  [PMID:1731640]
  Authors
Lin BK, Anderson JA
  Title
Purification and properties of versiconal cyclase from Aspergillus parasiticus.
  Journal
Arch Biochem Biophys 293:67-70 (1992)
DOI:10.1016/0003-9861(92)90366-5
  Sequence
Reference
2  [PMID:8784203]
  Authors
McGuire SM, Silva JC, Casillas EG, Townsend CA
  Title
Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis of the stereodifferentiating cyclization in aflatoxin biosynthesis essential to DNA interaction.
  Journal
Biochemistry 35:11470-86 (1996)
DOI:10.1021/bi960924s
  Sequence
Reference
3  [PMID:8662689]
  Authors
Silva JC, Minto RE, Barry CE 3rd, Holland KA, Townsend CA
  Title
Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Expansion of the aflatoxin b1 biosynthetic gene cluster.
  Journal
J Biol Chem 271:13600-8 (1996)
DOI:10.1074/jbc.271.23.13600
  Sequence
Reference
4  [PMID:8995367]
  Authors
Silva JC, Townsend CA
  Title
Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus parasiticus. A key enzyme in the aflatoxin B1 biosynthetic pathway.
  Journal
J Biol Chem 272:804-13 (1997)
DOI:10.1074/jbc.272.2.804
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.143
IUBMB Enzyme Nomenclature: 4.2.1.143
ExPASy - ENZYME nomenclature database: 4.2.1.143
BRENDA, the Enzyme Database: 4.2.1.143

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