| Entry |
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| Name |
L-galactonate dehydratase;
LGD1
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
L-galactonate hydro-lyase (2-dehydro-3-deoxy-L-galactonate-forming)
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| Reaction(IUBMB) |
L-galactonate = 2-dehydro-3-deoxy-L-galactonate + H2O [RN: R10532]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
2-dehydro-3-deoxy-L-galactonate [CPD: C20680];
H2O [CPD: C00001]
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| Comment |
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Trichoderma reesei (Hypocrea jecorina) and Aspergillus niger.
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| History |
EC 4.2.1.146 created 2013
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| Pathway |
| ec00040 | Pentose and glucuronate interconversions |
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| Orthology |
| K18102 | L-galactonate dehydratase |
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| Genes |
| SLB: | AWJ20_3253 AWJ20_3295 |
| NTE: | NEUTE1DRAFT131658(NEUTE1DRAFT_131658) |
| MTM: | MYCTH_2064932 MYCTH_82505 |
| TMN: | UCRPA7_2751 UCRPA7_4700 |
| SSCK: | SPSK_00800 SPSK_03340 SPSK_06299 |
| FVR: | FVEG_03852 FVEG_12512 FVEG_12549 |
| FOX: | FOXG_05984 FOXG_15221 FOXG_17432 |
| NHE: | NECHADRAFT_56323 NECHADRAFT_66837 |
| TRE: | TRIREDRAFT_104599 TRIREDRAFT_66662 |
| TRR: | M419DRAFT_11053 M419DRAFT_73300 |
| PLJ: | VFPFJ_04113 VFPFJ_07689 |
| SAPO: | SAPIO_CDS5438 SAPIO_CDS6402 |
| BFU: | BCIN_01g09450(Bclgd1) |
| ANG: | ANI_1_1784144(An16g05390) |
| PCS: | Pc16g00120 Pc22g19710 |
| TRG: | TRUGW13939_01876 TRUGW13939_04485 |
| TMS: | TREMEDRAFT_30567 TREMEDRAFT_58672 |
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| Reference |
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| Authors |
Kuorelahti S, Jouhten P, Maaheimo H, Penttila M, Richard P |
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| Title |
L-galactonate dehydratase is part of the fungal path for D-galacturonic acid catabolism. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Martens-Uzunova ES, Schaap PJ |
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| Title |
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.1.146 |
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