KEGG   ENZYME: 4.2.1.149
Entry
EC 4.2.1.149                Enzyme                                 

Name
crotonobetainyl-CoA hydratase;
CaiD;
L-carnityl-CoA dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming]
Reaction(IUBMB)
L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O [RN:R10675]
Reaction(KEGG)
R10675
Substrate
L-carnitinyl-CoA [CPD:C20750]
Product
(E)-4-(trimethylammonio)but-2-enoyl-CoA [CPD:C20748];
H2O [CPD:C00001]
Comment
The enzyme is also able to use crotonyl-CoA as substrate, with low efficiency [2].
History
EC 4.2.1.149 created 2014
Orthology
K08299  crotonobetainyl-CoA hydratase
Genes
ECO: b0036(caiD)
ECJ: JW0035(caiD)
ECD: ECDH10B_0037(caiD)
EBW: BWG_0034(caiD)
ECOK: ECMDS42_0029(caiD)
ECE: Z0042(caiD)
ECS: ECs0039
ECF: ECH74115_0040(caiD)
ETW: ECSP_0039(caiD)
ELX: CDCO157_0038
EOI: ECO111_0037(caiD)
EOJ: ECO26_0037(caiD)
EOH: ECO103_0038(caiD)
ECOO: ECRM13514_0037(caiD)
ECOH: ECRM13516_0039(caiD)
ESL: O3K_21365
ESO: O3O_04020
ESM: O3M_21265
ECK: EC55989_0036(caiD)
ECG: E2348C_0037(caiD)
EOK: G2583_0038(caiD)
ELH: ETEC_0036
ECW: EcE24377A_0038(caiD)
EUN: UMNK88_36
ECP: ECP_0036
ENA: ECNA114_0023(caiD)
ECOS: EC958_0170(caiD)
ECV: APECO1_1945(caiD)
ECX: EcHS_A0040(caiD)
ECM: EcSMS35_0037(caiD)
ECY: ECSE_0037
ECR: ECIAI1_0038(caiD)
ECQ: ECED1_0035(caiD)
EUM: ECUMN_0038(caiD)
ECT: ECIAI39_0037(caiD)
EOC: CE10_0037(caiD)
EBR: ECB_00040(caiD)
EBL: ECD_00040(caiD)
EBE: B21_00039(caiD)
EBD: ECBD_3579
ECI: UTI89_C0042(caiD)
EIH: ECOK1_0035(caiD)
ECZ: ECS88_0039(caiD)
ECC: c0045(caiD)
ELO: EC042_0038(caiD)
ESE: ECSF_0041
EKF: KO11_00180(caiD)
EAB: ECABU_c00410(caiD)
EDJ: ECDH1ME8569_0035(caiD)
ELW: ECW_m0036(caiD)
ELL: WFL_00180(caiD)
ELC: i14_0038(caiD)
ELD: i02_0038(caiD)
ELP: P12B_c0031(caiD)
ELF: LF82_0260(caiD)
ECOI: ECOPMV1_00037(caiD_1)
ECOJ: P423_00180
EFE: EFER_0044(caiD)
EAL: EAKF1_ch1386(caiD)
ESZ: FEM44_14675(caiD)
STY: STY0080(caiD)
STT: t0071(caiD)
STM: STM0070(caiD)
SEO: STM14_0083(caiD)
SEY: SL1344_0071(caiD)
SEJ: STMUK_0071(caiD)
SEB: STM474_0073(caiD)
SEF: UMN798_0078(caiD)
SENR: STMDT2_00711(caiD)
SEND: DT104_00711(caiD)
SENI: CY43_00345
SPT: SPA0071(caiD)
SEK: SSPA0067
SEI: SPC_0075(caiD)
SEC: SCH_0064(caiD)
SHB: SU5_0705
SENS: Q786_00345
SED: SeD_A0076
SEG: SG0073(caiD)
SEL: SPUL_0075(caiD)
SEGA: SPUCDC_0075(caiD)
SET: SEN0071(caiD)
SENA: AU38_00345
SENO: AU37_00345
SENV: AU39_00345
SENQ: AU40_00380
SENL: IY59_00360
SEEP: I137_00325
SENB: BN855_730(caiD)
SENE: IA1_00355
SBG: SBG_0055(caiD)
SBZ: A464_58
SFL: SF0033(caiD)
SFX: S0035(caiD)
SFV: SFV_0030(caiD)
SFE: SFxv_0034(caiD)
SFN: SFy_0042
SFS: SFyv_0046
SFT: NCTC1_00033(caiD)
SSN: SSON_0042(caiD)
SDY: SDY_0058(caiD)
CRO: ROD_00381(caiD)
CKO: CKO_03347
CPOT: FOB25_07465(caiD)
CAMA: F384_00195
EBT: EBL_c33170(caiD)
METY: MRY16398_47870(caiD)
YRE: HEC60_04850(caiD)
PDZ: HHA33_24115(caiD)
EBF: D782_3833
PMR: PMI2658(caiD)
PMIB: BB2000_2649(caiD)
PHAU: PH4a_04765
PCIB: F9282_17065(caiD)
PCOL: F1325_16720(caiD)
PRG: RB151_007330(caiD)
PHEI: NCTC12003_00741(caiD)
PRQ: CYG50_11980(caiD)
ETR: ETAE_2660(caiD)
ETD: ETAF_2398
ETE: ETEE_0761
PRAG: EKN56_12475(caiD)
LRI: NCTC12151_02501(caiD)
SLO: Shew_2672
SSE: Ssed_3225
SPL: Spea_4034
SHL: Shal_0224
SWP: swp_4934
GAI: IMCC3135_12755(caiD)
BXE: Bxe_C0322
VEI: Veis_3503
CRX: CRECT_1855(caiD)
MLO: mlr5044
MHUA: MCHK_6109(caiD)
AMIH: CO731_02018(caiD)
NIY: FQ775_14120(caiD)
SME: SMc01641
SMX: SM11_chr1006(caiD)
SMI: BN406_02077(caiD)
SMEL: SM2011_c01641(caiD)
SMER: DU99_12620
SMD: Smed_2177
SFH: SFHH103_02057(caiD)
SFD: USDA257_c45520(caiD)
SIX: BSY16_546
SAME: SAMCFNEI73_Ch2523(caiD)
EAD: OV14_3675
EMX: FKV68_14635(caiD)
ARA: Arad_9264
REL: REMIM1_PB00143(caiD)
REP: IE4803_PD00564(caiD)
REI: IE4771_PE00579(caiD)
RLE: pRL100378 pRL110025(caiD)
RLG: Rleg_6427
RGA: RGR602_PC01930(caiD)
RHN: AMJ98_PB00186(caiD)
RPHA: AMC79_PA00228(caiD)
RHX: AMK02_PB00200(caiD)
RHK: Kim5_PD00537(caiD)
REZ: AMJ99_PA00186(caiD)
NEN: NCHU2750_44880(caiD)
SHZ: shn_12110
NOH: G5V57_30520(caiD)
SIL: SPO2706(caiD-1) SPOA0285(caiD-2)
RUT: FIU92_19795(caiD3)
RDE: RD1_0613(caiD)
RLI: RLO149_c000760(caiD)
RPON: G3256_17965(caiD)
PKD: F8A10_13515(caiD)
PGA: PGA1_c34200(caiD)
PGL: PGA2_c32410(caiD)
PGD: Gal_03487
PHP: PhaeoP97_03321(caiD)
PPIC: PhaeoP14_03227(caiD)
OAT: OAN307_c01290(caiD)
OAR: OA238_c47080(caiD)
OTM: OSB_31140(caiD)
OCT: FTO60_02315(caiD)
LEJ: ETW24_19425(caiD)
LAQU: R2C4_18445(caiD)
PTP: RCA23_c04470(caiD)
MALG: MALG_01859
LABP: FJ695_03415(caiD)
LABT: FIU93_14330(caiD1)
SPSE: SULPSESMR1_03035(caiD)
RID: RIdsm_00642(caiD_1) RIdsm_04076(caiD_5)
ROH: FIU89_03985(caiD)
LVS: LOKVESSMR4R_02271(caiD)
AHT: ANTHELSMS3_00030(caiD)
PSEB: EOK75_06680(caiD) EOK75_14575(caiD)
PAED: G5B38_05425(caiD) G5B38_10250(caiD)
MALU: KU6B_41080(caiD)
THAS: C6Y53_14720(caiD)
HDH: G5B40_03925(caiD)
SAL: Sala_1808
SMAZ: LH19_02315
SPHU: SPPYR_2860(caiD)
BFD: NCTC4823_03672(caiD)
MPA: MAP_2645c(echA1)
MAO: MAP4_1173
MAVI: RC58_05820
MAVU: RE97_05815
MID: MIP_01900
MYO: OEM_12000
MUL: MUL_0972(echA1_1)
MMC: Mmcs_4079
MKM: Mkms_4155
MMI: MMAR_4317(echA1_1)
MMAE: MMARE11_41310(echA1_1)
MMM: W7S_05790
MLI: MULP_04515(echA1_1)
MSHG: MSG_03869
MVA: Mvan_4588
MGI: Mflv_2117
MVQ: MYVA_4366
MTHN: 4412656_03465(caiD_7)
MHAS: MHAS_02938(caiD_1)
MJD: JDM601_1118(echA1_1)
MTER: 4434518_01077(echA1_1)
MMIN: MMIN_27540
NFA: NFA_29420(echA13)
NFR: ERS450000_01146(caiD_2)
NAD: NCTC11293_03570(caiD_6)
ROP: ROP_71000
RCR: NCTC10994_01638(caiD_5)
ART: Arth_1079
AAU: AAur_1078
PDX: Psed_2574
NAX: HC341_11765(caiD)
 » show all
Reference
1  [PMID:11409545]
  Authors
Engemann C, Elssner T, Kleber HP.
  Title
Biotransformation of crotonobetaine to L(-)-carnitine in Proteus sp.
  Journal
Arch Microbiol 175:353-9 (2001)
DOI:10.1007/s002030100272
  Sequence
Reference
2  [PMID:11551212]
  Authors
Elssner T, Engemann C, Baumgart K, Kleber HP
  Title
Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and  a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli.
  Journal
Biochemistry 40:11140-8 (2001)
DOI:10.1021/bi0108812
  Sequence
[eco:b0036]
Reference
3  [PMID:15731894]
  Authors
Engemann C, Elssner T, Pfeifer S, Krumbholz C, Maier T, Kleber HP
  Title
Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp.
  Journal
Arch Microbiol 183:176-89 (2005)
DOI:10.1007/s00203-005-0760-2
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.149
IUBMB Enzyme Nomenclature: 4.2.1.149
ExPASy - ENZYME nomenclature database: 4.2.1.149
BRENDA, the Enzyme Database: 4.2.1.149

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