KEGG ENZYME: 4.2.1.152

ENZYME: 4.2.1.152

Entry

EC 4.2.1.152                Enzyme

Name

hydroperoxy icosatetraenoate dehydratase;
epidermal lipoxygenase-3 (ambiguous);
eLOX3 (ambiguous)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)

Reaction(IUBMB)

a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O [RN:R10761]

Reaction(KEGG)

R10761

Substrate

hydroperoxyicosatetraenoate [CPD:C20832]

Product

oxoicosatetraenoate [CPD:C20833];
H2O [CPD:C00001]

Comment

Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase.

History

EC 4.2.1.152 created 2014

Orthology

K18684

hydroperoxy icosatetraenoate dehydratase/isomerase

Genes

HSA:	59344(ALOXE3)

PTR:	455102(ALOXE3)

PPS:	100972484(ALOXE3)

GGO:	101143347(ALOXE3)

PON:	100451294(ALOXE3)

NLE:

100586195

MCC:	716840(ALOXE3)

MCF:	102115677(ALOXE3)

CSAB:

103242340(ALOXE3)

CATY:

105581968(ALOXE3)

PANU:

101015325(ALOXE3)

TGE:	112609608(ALOXE3)

RRO:	104661680(ALOXE3)

RBB:	108514454(ALOXE3)

TFN:	117067738(ALOXE3)

PTEH:

111527078(ALOXE3)

CJC:	100410917(ALOXE3)

SBQ:	101049071(ALOXE3)

CSYR:

103263442(ALOXE3)

MMUR:

105877288(ALOXE3)

OGA:	100958391(ALOXE3)

MMU:	23801(Aloxe3)

MCAL:

110305086(Aloxe3)

MPAH:

110332034(Aloxe3)

RNO:	287424(Aloxe3)

MCOC:

116078132(Aloxe3)

MUN:	110551722(Aloxe3)

CGE:	100754187(Aloxe3)

PLEU:

114693158(Aloxe3)

NGI:	103752100(Aloxe3)

HGL:	101709560(Aloxe3)

CPOC:

100731721(Aloxe3)

CCAN:

109693886(Aloxe3)

DORD:

105983368(Aloxe3)

DSP:	122100410(Aloxe3)

OCU:	100342323(ALOXE3)

OPI:	101524657(ALOXE3)

TUP:	102493953(ALOXE3)

CFA:	489487(ALOXE3)

VVP:	112924867(ALOXE3)

VLG:	121500136(ALOXE3)

AML:	100479842(ALOXE3)

UMR:	103660488(ALOXE3)

UAH:	113271146(ALOXE3)

UAR:	123792055(ALOXE3)

ELK:

111161151

LLV:

125088017

MPUF:

101671256(ALOXE3)

ORO:	101371570(ALOXE3)

EJU:	114225375(ALOXE3)

ZCA:	113939629(ALOXE3)

MLX:	118000045(ALOXE3)

FCA:	101101515(ALOXE3)

PYU:	121015957(ALOXE3)

PBG:	122484921(ALOXE3)

PPAD:

109245905(ALOXE3)

AJU:	106972447(ALOXE3)

HHV:	120231419(ALOXE3)

BTA:	517001(ALOXE3)

BOM:	102276466(ALOXE3)

BIU:	109573427(ALOXE3)

BBUB:

102408112(ALOXE3)

CHX:	102173227(ALOXE3)

OAS:	101121693(ALOXE3)

ODA:	120866020(ALOXE3)

CCAD:

122445980(ALOXE3)

SSC:	100511043(ALOXE3)

CFR:	102517831(ALOXE3)

CBAI:

105077530(ALOXE3)

CDK:

105103062

VPC:	102528339(ALOXE3)

BACU:

102998369(ALOXE3)

OOR:

101281475

DLE:	111185793(ALOXE3)

PCAD:

102992018

ECB:	100062351(ALOXE3)

EPZ:	103564279(ALOXE3)

EAI:	106844234(ALOXE3)

MYB:	102250064(ALOXE3)

MYD:	102763007(ALOXE3)

MMYO:

118672110(ALOXE3)

MLF:	102435376(ALOXE3)

MNA:	107544535(ALOXE3)

PKL:

118726788

HAI:	109395102(ALOXE3)

DRO:	112308514(ALOXE3)

SHON:

118974644

AJM:	119049055(ALOXE3)

PDIC:

114515164

PHAS:

123809290(ALOXE3)

MMF:	118634238(ALOXE3)

RFQ:	117013451(ALOXE3)

PALE:

102893198(ALOXE3)

PGIG:

120589697(ALOXE3)

PVP:	105291240(ALOXE3)

RAY:	107515646(ALOXE3)

MJV:	108409698(ALOXE3)

TOD:	119232234(ALOXE3)

SARA:

101554994(ALOXE3)

LAV:	100671875(ALOXE3)

TMU:

101348431

DNM:	101433166(ALOXE3)

MDO:	100014706(ALOXE3)

GAS:	123243987(ALOXE3)

SHR:	100934620(ALOXE3)

PCW:

110194412

OAA:	100078389(ALOXE3)

GGA:	425997(ALOX15B)

CJO:

107314128

NMEL:

110401191

ACYG:

106049819

TGU:

115493074

LSR:	110480955 110482566

SCAN:

103824640

PMOA:

120503612

OTC:

121337727

PRUF:

121357289

GFR:	102043765(ALOXE3)

FAB:	101818404(ALOXE3) 101820391

PHI:	102104136 102111055(ALOXE3)

PMAJ:

107198965

CCAE:

111942155

CCW:

120412173

ETL:

114071482

ZAB:

102064963

NNI:

104022923

TALA:

116963178

ACHC:

115337612 115337613

AAM:	106484843 106500300(ALOXE3)

AROW:

112962918 112972483

ASN:	102375634 102379888

AMJ:	102558959(ALOXE3) 102564354

PSS:

102450844

CMY:	102946032 102946254 114018354 119564589 119564653

CPIC:

101934678 101943453 101947851 101948565 101952038(ALOX12B)

TST:	117869933 117869934 117869955 117870000 117870107

CABI:

116839650 116839651

MRV:	120381499 120381501 120381799 120381807 120381808 120381913

ACS:	100557249 100557446 100557643 100557840 100558037 100558230 100558427 100558626

PVT:	110071007 110071137 110071138 110087753 110088257 110088279 110088292

SUND:

121933934 121934888 121934889 121935423 121935497

PBI:	103062621 103064438 107326021 112540458(ALOXE3)

PMUR:

107297127 107297128 107297129 107297130 107297132

PGUT:

117657096 117660229 117671250 117671251 117671255

VKO:	123016598 123016642 123016652

PMUA:

114581886 114581887 114582384 114582617 114583620

ZVI:	118094283 118094804 118094805 118094999

GJA:	107115224 107120726 107120728

XLA:	108707611 108707612(alox15b.L) 108707613 108708795 108708797 108708798 734312(alox12b.S)

XTR:	100494252(alox15b) 100494678 116408939 548458(alox12b)

NPR:	108796083 108796085 108796093 108799096

RTEM:

120928225 120929270 120929271 120929272

BGAR:

122924120

DRE:	794132(si:dkey-17e16.9)

SRX:

107756080

SANH:

107673846 107699996

SGH:

107548144

CCAR:

109063989 109113592

CAUA:

113038569

EEE:

113590746

TRU:	101063080 101064929 101065403

TNG:	GSTEN00023059G001 GSTEN00033460G001

LCO:	104926147 104928887 104939860 109137379

NCC:	104945566 104965473(b3gntl1)

CGOB:

115003520 115003907 115003908

ELY:	117250386 117270324 117270482 117270947 117270948 117270949 117271028 117271031 117271148

PLEP:

121955229 121955231 121955232

SLUC:

116066135 116066173

ECRA:

117961557(si:dkey-17e16.9)

CUD:	121521149 121521554

MZE:	101465465 101468181 101476255 101480284 112429854 112434905

ONL:	100689972 100691581 100694795 100701198 100702747 100706043 100706304 100712588 109194246 109194292

OAU:	116309996(zgc:152891) 116310798(si:dkey-17e16.9) 116327369 116327377 116327379 116329960 116330064 116330065 116330066 116330067

OLA:	101165367 101168429

OML:

112158170

XMA:	102225361 102225623

XCO:	114144052 114158302

XHE:	116733716 116733717

PRET:

103457519 103457522 103457523

PFOR:

103134921 103134944

PLAI:

106958151 106959115

PMEI:

106928763 106928764

GAF:

122825686

CVG:

107086029

CTUL:

119795946

NFU:

107374447

KMR:	108228955(zgc:152891)

ALIM:

106517057

NWH:

119418224

AOCE:

111570537 111570984 111575944

CSEM:

103381087 103393539 103393540

POV:

109636209

SSEN:

122783964 122783965 122783967

HHIP:

117758044 117758046 117758047 117758048 117758050

LCF:	108880880 108891324

SDU:	111236613 111236740 111236750 111236756

SLAL:

111653009 111655584 111655591 111655606

XGL:	120788899(si:dkey-17e16.9) 120802480(zgc:152891)

HCQ:

109527797

BPEC:

110155993 110156036

MALB:

109955487

SASA:

100194745(loxe3) 106593018 106602265 106602285 106607993 106607999 106610314 106610332

OTW:	112217364 112217711 112226389

OMY:	110491145 110497317 110514910 110517354 110521065 110522385 110534564 118941428 118941429

OGO:	123995239 123995544

ONE:

115139270

SALP:

111972916 111973191

SNH:	120019324 120019325

ELS:	105008072 105010254 105014517 105020997 105029908 114830628

SFM:

108925302

AANG:

118224951 118225212

LOC:	102692216 102697403

PSPA:

121305636(zgc:152891) 121319168 121319184

ARUT:

117396925

LCM:

102352103

PJA:

122248285

HAZT:

108675024

VDE:

111245717

VJA:

111262905

BGT:	106071023 106071096

CRG:

105319482

MYI:

110442376

PMAX:

117321221

MMER:

123534520 123541244 123550058 123551042 123551206 123551207 123553547

ATEN:

116292301

XEN:

124451873

CIC:	CICLE_v10027295mg

SLY:

101244897

EHX:	EMIHUDRAFT_102763 EMIHUDRAFT_247361

» show all

Reference

1 [PMID:12881489]

Authors

Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR

Title

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.

Journal

Proc Natl Acad Sci U S A 100:9162-7 (2003)
DOI:10.1073/pnas.1633612100

Sequence

[hsa:59344]

Reference

2 [PMID:17045234]

Authors

Yu Z, Schneider C, Boeglin WE, Brash AR

Title

Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.

Journal

Arch Biochem Biophys 455:188-96 (2006)
DOI:10.1016/j.abb.2006.09.002

Sequence

[hsa:59344] [mmu:23801]

Reference

3 [PMID:20921226]

Authors

Zheng Y, Brash AR

Title

Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.

Journal

J Biol Chem 285:39866-75 (2010)
DOI:10.1074/jbc.M110.155374

Sequence

[hsa:59344]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.152

IUBMB Enzyme Nomenclature:

4.2.1.152

ExPASy - ENZYME nomenclature database:

4.2.1.152

BRENDA, the Enzyme Database:

4.2.1.152

All links

Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (584)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (420)   
   KEGG MGENES (25)   
   RefGene (138)   
Protein sequence (561)   
   UniProt (467)   
   SWISS-PROT (44)   
   RefSeq(pep) (50)   
DNA sequence (59)   
   RefSeq(nuc) (59)   
Protein domain (19)   
   InterPro (19)   
All databases (1227)   

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