Entry
Name
hydroperoxy icosatetraenoate dehydratase;
epidermal lipoxygenase-3 (ambiguous);
eLOX3 (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)
Reaction(IUBMB)
a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O [RN:
R10761 ]
Reaction(KEGG)
Substrate
hydroperoxyicosatetraenoate [CPD:
C20832 ]
Product
Comment
Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC
5.4.4.7 , hydroperoxy icosatetraenoate isomerase.
History
EC 4.2.1.152 created 2014
Pathway
ec00590 Arachidonic acid metabolism
Orthology
K18684 hydroperoxy icosatetraenoate dehydratase/isomerase
Genes
FAB : 101818404(ALOXE3) 101820391
ACHC : 115337612 115337613
AAM : 106484843 106500300(ALOXE3)
AROW : 112962918 112972483
AMJ : 102558959(ALOXE3) 102564354
CMY : 102946032 102946254 114018354 119564589 119564653
CPIC : 101934678 101943453 101947851 101948565 101952038(ALOX12B)
TST : 117869933 117869934 117869955 117870000 117870107
CABI : 116839650 116839651
MRV : 120381499 120381501 120381799 120381807 120381808 120381913
ACS : 100557249 100557446 100557643 100557840 100558037 100558230 100558427 100558626
PVT : 110071007 110071137 110071138 110087753 110088257 110088279 110088292
SUND : 121933934 121934888 121934889 121935423 121935497
PBI : 103062621 103064438 107326021 112540458(ALOXE3)
PMUR : 107297127 107297128 107297129 107297130 107297132
CTIG : 120305736 120305737 120305739 120305742
PGUT : 117657096 117660229 117671250 117671251 117671255
VKO : 123016598 123016642 123016652
PMUA : 114581886 114581887 114582384 114582617 114583620
ZVI : 118094283 118094804 118094805 118094999
HCG : 128329520 128331538 128331593 128331594
GJA : 107115224 107120726 107120728
STOW : 125444427 125444768 125444782 125445316
XLA : 108707611 108707612(alox15b.L) 108707613 108708795 108708797 108708798 734312(alox12b.S)
XTR : 100494252(alox15b) 100494678 100496875 116408939 548458(alox12b)
NPR : 108796083 108796085 108796093 108799096
RTEM : 120928225 120929270 120929271 120929272
DRE : 794132(si:dkey-17e16.9)
SANH : 107673846 107699996
CGIB : 127985407(si:dkey-17e16.9)
MAMB : 125253227(si:dkey-17e16.9)
CIDE : 127504177(si:dkey-17e16.9)
MASI : 127428480(si:dkey-17e16.9)
TRU : 101063080 101064929 101065403
TNG : GSTEN00023059G001 GSTEN00033460G001
LCO : 104926147 104928887 104939860 109137379
NCC : 104945566 104965473(b3gntl1)
CGOB : 115003520 115003907 115003908
ELY : 117250386 117270324 117270482 117270947 117270948 117270949 117271028 117271031 117271148
EFO : 125896652 125896654 125896655 125896673 125897371 125897569 125897570 125897571
PLEP : 121955229 121955231 121955232
SLUC : 116066135 116066173
ECRA : 117961557(si:dkey-17e16.9)
ALAT : 119012490 119012492 119012534 119012535
MZE : 101465465 101468181 101476255 101480284 112429854 112434905
ONL : 100689972 100691581 100694795 100701198 100702747 100706043 100706304 109194246 109194292
OAU : 116309996(zgc:152891) 116310798(si:dkey-17e16.9) 116327369 116327377 116327379 116329960 116330064 116330065 116330066 116330067
PRET : 103457519 103457522 103457523
PFOR : 103134921 103134944
PLAI : 106958151 106959115
PMEI : 106928763 106928764
KMR : 108228955(zgc:152891) 108240061
ALIM : 106517057 106519785
AOCE : 111570537 111570984 111575944
MCEP : 124999076 124999077 124999078 124999079 124999091
CSEM : 103381087 103393539 103393540
SSEN : 122783964 122783965 122783967
HHIP : 117758044 117758046 117758047 117758048 117758050
HSP : 118099179 118099180 124851192 124851193 124851194
LCF : 108880880(si:dkey-17e16.9) 108891324(zgc:152891)
SDU : 111236613 111236740 111236750 111236756
SLAL : 111653009 111655584 111655591 111655606
XGL : 120788899(si:dkey-17e16.9) 120802480(zgc:152891)
SSCV : 125990038 125990039
BPEC : 110155993 110156036
SASA : 100194745(loxe3) 106593018 106602265 106602285 106607993 106607999 106610314 106610332
STRU : 115179646 115179723 115206553
OTW : 112217364 112217711 112226389
OMY : 110491145 110497317 110514910 110517354 110521065 110522385 110534564 118941428 118941429
SALP : 111972916 111973191
ELS : 105008072 105010254 105014517 105020997 105029908 114830628
AANG : 118224951 118225212
PSPA : 121319168 121319184
PSEX : 120525109 120526473
MMER : 123541244 123551042 123551206 123551207
DPOL : 127849020 127849037 127850057 127857276 127859244
EHX : EMIHUDRAFT_102763 EMIHUDRAFT_247361
» show all
Taxonomy
Reference
Authors
Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR
Title
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.
Journal
Sequence
Reference
Authors
Yu Z, Schneider C, Boeglin WE, Brash AR
Title
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.
Journal
Sequence
Reference
Authors
Zheng Y, Brash AR
Title
Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.152