KEGG ENZYME: 4.2.1.152

ENZYME: 4.2.1.152

Entry

EC 4.2.1.152                Enzyme

Name

hydroperoxy icosatetraenoate dehydratase;
epidermal lipoxygenase-3 (ambiguous);
eLOX3 (ambiguous)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)

Reaction(IUBMB)

a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O [RN:R10761]

Reaction(KEGG)

R10761 > R13044 R13045

Substrate

hydroperoxyicosatetraenoate [CPD:C20832]

Product

oxoicosatetraenoate [CPD:C20833];
H2O [CPD:C00001]

Comment

Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase.

History

EC 4.2.1.152 created 2014

Pathway

ec00590

Arachidonic acid metabolism

Orthology

K18684

hydroperoxy icosatetraenoate dehydratase/isomerase

Genes

HSA:	59344(ALOXE3)

PTR:	455102(ALOXE3)

PPS:	100972484(ALOXE3)

GGO:	101143347(ALOXE3)

PON:	100451294(ALOXE3)

NLE:

100586195

HMH:	116458633(ALOXE3)

MCC:	716840(ALOXE3)

MCF:	102115677(ALOXE3)

MTHB:

126939828

MNI:	105473880(ALOXE3)

CSAB:

103242340(ALOXE3)

CATY:

105581968(ALOXE3)

PANU:

101015325(ALOXE3)

TGE:	112609608(ALOXE3)

MLEU:

105549852(ALOXE3)

RRO:	104661680(ALOXE3)

RBB:	108514454(ALOXE3)

TFN:	117067738(ALOXE3)

PTEH:

111527078(ALOXE3)

CANG:

105523640(ALOXE3)

CJC:	100410917(ALOXE3)

SBQ:	101049071(ALOXE3)

CIMI:

108306542(ALOXE3)

CSYR:

103263442(ALOXE3)

MMUR:

105877288(ALOXE3)

LCAT:

123650919(ALOXE3)

PCOQ:

105819408(ALOXE3)

OGA:	100958391(ALOXE3)

MMU:	23801(Aloxe3)

MCAL:

110305086(Aloxe3)

MPAH:

110332034(Aloxe3)

RNO:	287424(Aloxe3)

MCOC:

116078132(Aloxe3)

ANU:	117710950(Aloxe3)

MUN:	110551722(Aloxe3)

CGE:	100754187(Aloxe3)

MAUA:

101838996(Aloxe3)

PROB:

127219082(Aloxe3)

PLEU:

114693158(Aloxe3)

MORG:

121457114(Aloxe3)

MFOT:

126514115

AAMP:

119812707(Aloxe3)

NGI:	103752100(Aloxe3)

HGL:	101709560(Aloxe3)

CPOC:

100731721(Aloxe3)

CCAN:

109693886(Aloxe3)

DORD:

105983368(Aloxe3)

DSP:	122100410(Aloxe3)

NCAR:

124980809

OCU:

100342323

OPI:	101524657(ALOXE3)

TUP:	102493953(ALOXE3)

GVR:	103597843(ALOXE3)

CFA:	489487(ALOXE3)

CLUD:

112647409(ALOXE3)

VVP:	112924867(ALOXE3)

VLG:	121500136(ALOXE3)

AML:	100479842(ALOXE3)

UMR:	103660488(ALOXE3)

UAH:	113271146(ALOXE3)

UAR:	123792055(ALOXE3)

ELK:

111161151

LLV:

125088017

MPUF:

101671256(ALOXE3)

NVS:	122906730(ALOXE3)

ORO:	101371570(ALOXE3)

EJU:	114225375(ALOXE3)

ZCA:	113939629(ALOXE3)

MLX:	118000045(ALOXE3)

NSU:	110584484(ALOXE3)

LWW:	102728543(ALOXE3)

FCA:	101101515(ALOXE3)

PYU:	121015957(ALOXE3)

PCOO:

112857009

PBG:	122484921(ALOXE3)

LRUF:

124519582

PPAD:

109245905(ALOXE3)

PUC:	125917697 125917698

AJU:	106972447(ALOXE3)

HHV:	120231419(ALOXE3)

BTA:	517001(ALOXE3)

BOM:	102276466(ALOXE3)

BIU:	109573427(ALOXE3)

BBUB:

102408112(ALOXE3)

BBIS:

104990749(ALOXE3)

CHX:	102173227(ALOXE3)

OAS:	101121693(ALOXE3)

ODA:	120866020(ALOXE3)

CCAD:

122445980(ALOXE3)

SSC:	100511043(ALOXE3)

CFR:	102517831(ALOXE3)

CBAI:

105077530(ALOXE3)

CDK:

105103062

VPC:	102528339(ALOXE3)

BACU:

102998369(ALOXE3)

OOR:

101281475

DLE:	111185793(ALOXE3)

PCAD:

102992018

NASI:

112401885(ALOXE3)

ECB:	100062351(ALOXE3)

EPZ:	103564279(ALOXE3)

EAI:	106844234(ALOXE3)

MYB:	102250064(ALOXE3)

MYD:	102763007(ALOXE3)

MMYO:

118672110(ALOXE3)

MLF:	102435376(ALOXE3)

MNA:	107544535(ALOXE3)

PKL:

118726788

HAI:	109395102(ALOXE3)

DRO:	112308514(ALOXE3)

SHON:

118974644

AJM:	119049055(ALOXE3)

PDIC:

114515164

PHAS:

123809290(ALOXE3)

MMF:	118634238(ALOXE3)

RFQ:	117013451(ALOXE3)

PALE:

102893198(ALOXE3)

PGIG:

120589697(ALOXE3)

PVP:	105291240(ALOXE3)

RAY:	107515646(ALOXE3)

MJV:	108409698(ALOXE3)

TOD:	119232234(ALOXE3)

SARA:

101554994(ALOXE3)

LAV:	100671875(ALOXE3)

TMU:

101348431

ETF:

101660496

DNM:	101433166(ALOXE3)

MDO:	100014706(ALOXE3)

GAS:	123243987(ALOXE3)

SHR:	100934620(ALOXE3)

AFZ:

127560852

PCW:

110194412

OAA:	100078389(ALOXE3)

GGA:	425997(ALOX15B)

CJO:

107314128

NMEL:

110401191

ACYG:

106049819

TGU:

115493074

LSR:	110480955 110482566

SCAN:

103824640

PMOA:

120503612

OTC:

121337727

PRUF:

121357289

GFR:	102043765(ALOXE3)

FAB:	101818404(ALOXE3) 101820391

PHI:	102104136 102111055

PMAJ:

107198965

CCAE:

111942155

CCW:

120412173

CBRC:

103625181

ETL:

114071482

ZAB:

102064963

SVG:

106863902

NNI:

104022923

PLET:

104621328

PCRI:

104030873

TALA:

116963178

ACHC:

115337612 115337613

HLE:	104834235 104836076

AGEN:

126037044

GCL:

127028893

CCRI:

104154924

LDI:

104350827

ACAR:

114818373

AVIT:

104280152

AAM:	106484843 106500300(ALOXE3)

AROW:

112962918 112972483

SCAM:

104142868

ASN:	102375634 102379888

AMJ:	102558959(ALOXE3) 102564354

PSS:

102450844

CMY:	102946032 102946254 114018354 119564589 119564653

CPIC:

101934678 101943453 101947851 101948565 101952038(ALOX12B)

TST:	117869933 117869934 117869955 117870000 117870107

CABI:

116839650 116839651

MRV:	120381499 120381501 120381799 120381807 120381808 120381913

ACS:	100557249 100557446 100557643 100557840 100558037 100558230 100558427 100558626

PVT:	110071007 110071137 110071138 110087753 110088257 110088279 110088292

SUND:

121933934 121934888 121934889 121935423 121935497

PBI:	103062621 103064438 107326021 112540458(ALOXE3)

PMUR:

107297127 107297128 107297129 107297130 107297132

CTIG:

120305736 120305737 120305739 120305742

PGUT:

117657096 117660229 117671250 117671251 117671255

VKO:	123016598 123016642 123016652

PMUA:

114581886 114581887 114582384 114582617 114583620

ZVI:	118094283 118094804 118094805 118094999

HCG:	128329520 128331538 128331593 128331594

GJA:	107115224 107120726 107120728

STOW:

125444427 125444768 125444782 125445316

XLA:	108707611 108707612(alox15b.L) 108707613 108708795 108708797 108708798 734312(alox12b.S)

XTR:	100494252(alox15b) 100494678 100496875 116408939 548458(alox12b)

NPR:	108796083 108796085 108796093 108799096

RTEM:

120928225 120929270 120929271 120929272

BGAR:

122924120

DRE:	794132(si:dkey-17e16.9)

SRX:

107756080

SANH:

107673846 107699996

SGH:

107548144

CCAR:

109063989

CAUA:

113038569

CGIB:

127985407(si:dkey-17e16.9)

MAMB:

125253227(si:dkey-17e16.9)

CIDE:

127504177(si:dkey-17e16.9)

MASI:

127428480(si:dkey-17e16.9)

EEE:

113590746

TRU:	101063080 101064929 101065403

TNG:	GSTEN00023059G001 GSTEN00033460G001

LCO:	104926147 104928887 104939860 109137379

NCC:	104945566 104965473(b3gntl1)

CGOB:

115003520 115003907 115003908

ELY:	117250386 117270324 117270482 117270947 117270948 117270949 117271028 117271031 117271148

EFO:	125896652 125896654 125896655 125896673 125897371 125897569 125897570 125897571

PLEP:

121955229 121955231 121955232

SLUC:

116066135 116066173

ECRA:

117961557(si:dkey-17e16.9)

ESP:

116705832

CUD:	121521149 121521554

ALAT:

119012490 119012492 119012534 119012535

MZE:	101465465 101468181 101476255 101480284 112429854 112434905

ONL:	100689972 100691581 100694795 100701198 100702747 100706043 100706304 109194246 109194292

OAU:	116309996(zgc:152891) 116310798(si:dkey-17e16.9) 116327369 116327377 116327379 116329960 116330064 116330065 116330066 116330067

OLA:	101165367 101168429

OML:

112158170

XMA:	102225361 102225623

XCO:	114144052 114158302

XHE:	116733716 116733717

PRET:

103457519 103457522 103457523

PFOR:

103134921 103134944

PLAI:

106958151 106959115

PMEI:

106928763 106928764

GAF:

122825686

CVG:

107086029

CTUL:

119795946

NFU:

107374447

KMR:	108228955(zgc:152891) 108240061

ALIM:

106517057 106519785

NWH:

119418224

AOCE:

111570537 111570984 111575944

MCEP:

124999076 124999077 124999078 124999079 124999091

CSEM:

103381087 103393539 103393540

POV:

109636209

SSEN:

122783964 122783965 122783967

HHIP:

117758044 117758046 117758047 117758048 117758050

HSP:	118099179 118099180 124851192 124851193 124851194

LCF:	108880880(si:dkey-17e16.9) 108891324(zgc:152891)

SDU:	111236613 111236740 111236750 111236756

SLAL:

111653009 111655584 111655591 111655606

XGL:	120788899(si:dkey-17e16.9) 120802480(zgc:152891)

HCQ:

109527797

SSCV:

125990038 125990039

BPEC:

110155993 110156036

MALB:

109955487

SASA:

100194745(loxe3) 106593018 106602265 106602285 106607993 106607999 106610314 106610332

STRU:

115179646 115179723 115206553

OTW:	112217364 112217711 112226389

OMY:	110491145 110497317 110514910 110517354 110521065 110522385 110534564 118941428 118941429

OGO:	123995239 123995544

ONE:

115139270

SALP:

111972916 111973191

SNH:	120019324 120019325

CCLU:

121549254

ELS:	105008072 105010254 105014517 105020997 105029908 114830628

SFM:

108925302

AANG:

118224951 118225212

LOC:	102692216 102697403

PSPA:

121319168 121319184

ARUT:

117396925

PSEX:

120525109 120526473

LCM:

102352103

PJA:

122248285

PCHN:

125029265

HAZT:

108675024

VDE:

111245717

VJA:

111262905

BGT:	106071023 106071096

CRG:

105319482

MYI:

110442376

PMAX:

117321221

MMER:

123541244 123551042 123551206 123551207

DPOL:

127849020 127849037 127850057 127857276 127859244

ATEN:

116292301

XEN:

124451873

CIC:	CICLE_v10027295mg

SLY:

101244897

EHX:	EMIHUDRAFT_102763 EMIHUDRAFT_247361

» show all

Reference

1 [PMID:12881489]

Authors

Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR

Title

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.

Journal

Proc Natl Acad Sci U S A 100:9162-7 (2003)
DOI:10.1073/pnas.1633612100

Sequence

[hsa:59344]

Reference

2 [PMID:17045234]

Authors

Yu Z, Schneider C, Boeglin WE, Brash AR

Title

Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.

Journal

Arch Biochem Biophys 455:188-96 (2006)
DOI:10.1016/j.abb.2006.09.002

Sequence

[hsa:59344] [mmu:23801]

Reference

3 [PMID:20921226]

Authors

Zheng Y, Brash AR

Title

Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.

Journal

J Biol Chem 285:39866-75 (2010)
DOI:10.1074/jbc.M110.155374

Sequence

[hsa:59344]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.152

IUBMB Enzyme Nomenclature:

4.2.1.152

ExPASy - ENZYME nomenclature database:

4.2.1.152

BRENDA, the Enzyme Database:

4.2.1.152

DBGET integrated database retrieval system