KEGG ENZYME: 4.2.1.152

ENZYME: 4.2.1.152

Entry

EC 4.2.1.152 Enzyme

Name

hydroperoxy icosatetraenoate dehydratase;
epidermal lipoxygenase-3 (ambiguous);
eLOX3 (ambiguous)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)

Reaction(IUBMB)

a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O [RN:R10761]

Reaction(KEGG)

R10761

Substrate

hydroperoxyicosatetraenoate [CPD:C20832]

Product

oxoicosatetraenoate [CPD:C20833];
H2O [CPD:C00001]

Comment

Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase.

History

EC 4.2.1.152 created 2014

Orthology

K18684

hydroperoxy icosatetraenoate dehydratase/isomerase

Genes

HSA:	59344(ALOXE3)

PTR:	455102(ALOXE3)

PPS:	100972484(ALOXE3)

GGO:	101143347(ALOXE3)

PON:	100451294(ALOXE3)

NLE:

100586195

MCC:	716840(ALOXE3)

MCF:	102115677(ALOXE3)

CSAB:

103242340(ALOXE3)

RRO:	104661680(ALOXE3)

RBB:	108514454(ALOXE3)

CJC:	100410917(ALOXE3)

SBQ:	101049071(ALOXE3)

MMU:	23801(Aloxe3)

MCAL:

110305086(Aloxe3)

MPAH:

110332034(Aloxe3)

RNO:	287424(Aloxe3)

MUN:	110551722(Aloxe3)

CGE:	100754187(Aloxe3)

NGI:	103752100(Aloxe3)

HGL:	101709560(Aloxe3)

CCAN:

109693886(Aloxe3)

OCU:	100342323(ALOXE3)

TUP:	102493953(ALOXE3)

CFA:	489487(ALOXE3)

VVP:	112924867(ALOXE3)

AML:	100479842(ALOXE3)

UMR:	103660488(ALOXE3)

UAH:	113271146(ALOXE3)

ORO:	101371570(ALOXE3)

ELK:

111161151

FCA:	101101515(ALOXE3)

PPAD:

109245905(ALOXE3)

AJU:	106972447(ALOXE3)

BTA:	517001(ALOXE3)

BOM:	102276466(ALOXE3)

BIU:	109573427(ALOXE3)

BBUB:

102408112(ALOXE3)

CHX:	102173227(ALOXE3)

OAS:	101121693(ALOXE3)

SSC:	100511043(ALOXE3)

CFR:	102517831(ALOXE3)

CDK:

105103062

BACU:

102998369(ALOXE3)

OOR:

101281475

DLE:	111185793(ALOXE3)

PCAD:

102992018

ECB:	100062351(ALOXE3)

EPZ:	103564279(ALOXE3)

EAI:	106844234(ALOXE3)

MYB:	102250064(ALOXE3)

MYD:	102763007(ALOXE3)

MNA:	107544535(ALOXE3)

HAI:	109395102(ALOXE3)

DRO:	112308514(ALOXE3)

PALE:

102893198(ALOXE3)

RAY:	107515646(ALOXE3)

MJV:	108409698(ALOXE3)

LAV:	100671875(ALOXE3)

TMU:

101348431

MDO:	100014706(ALOXE3)

SHR:	100934620(ALOXE3)

PCW:

110194412

OAA:	100078389(ALOXE3)

GGA:	425997(ALOX15B)

CJO:

NMEL:

ACYG:

TGU:

LSR:	110480955 110482566

SCAN:

103824640

GFR:	102043765(ALOXE3)

FAB:	101818404(ALOXE3) 101820391

PHI:	102104136 102111055(ALOXE3)

PMAJ:

CCAE:

ETL:

NNI:

AAM:	106500300(ALOXE3)

ASN:	102375634 102379888

AMJ:	102558959(ALOXE3) 102564354

PSS:

102450844

CMY:

102945124

CPIC:

101934678 101947851 101948565 101952038(ALOXE3) 103307163

ACS:	100557249 100557446 100557643 100557840 100558037 100558230 100558427 100558626

PVT:	110071007 110071137 110071138 110087753 110088257 110088279 110088292

PBI:	103062621 103064438 112540458(ALOXE3)

PMUR:

107297127 107297128 107297129 107297130 107297132

PMUA:

114581886 114581887 114582384 114582617 114583620

GJA:	107115224 107120726 107120728

XLA:	108707611 108707612 108707613 108708795 108708797 108708798 734312(alox12b.S)

XTR:	100494252(alox15b) 100494678 116408939 548458(alox12b)

NPR:	108796083 108796085 108796093 108799096

DRE:	794132(si:dkey-17e16.9)

SRX:

SANH:

SGH:

CCAR:

EEE:

TRU:	101063080 101064929 101065403

TNG:	GSTEN00023059G001 GSTEN00033460G001

LCO:	104926147 104928887 104939860 109137379

NCC:	104945566 104965473(b3gntl1)

MZE:	101465465 101468181 101476255 101480284 112429854 112434905

ONL:	100689972 100691581 100694795 100701198 100702747 100706043 100706304 100712588 109194246 109194292

OLA:	101165367 101168429

XMA:	102225361 102225623

XCO:	114144052 114158302

PRET:

103457519

CVG:

107086029

NFU:

107374447

KMR:	108228955(zgc:152891)

ALIM:

106517057

AOCE:

111570537 111570984 111575944

CSEM:

103381087 103393539 103393540

POV:

109636209

LCF:	108880880 108891324

SDU:	111236613 111236740 111236750 111236756

SLAL:

111653009 111655584 111655591 111655606

HCQ:

109527797

BPEC:

110155993 110156036

MALB:

109955487

SASA:

100194745(loxe3) 106593018 106602265 106602285 106607993 106607999 106610314 106610332

OTW:	112217364 112217372 112217711 112217758 112226389

SALP:

111972916 111973191

ELS:	105008072 105010254 105014517 105020997 105029908 114830628

SFM:

108925302

LCM:

102352103

MYI:

110442376

CIC:	CICLE_v10027295mg

SLY:

101244897

EHX:	EMIHUDRAFT_102763 EMIHUDRAFT_247361

» show all

Reference

1 [PMID:12881489]

Authors

Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR

Title

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.

Journal

Proc Natl Acad Sci U S A 100:9162-7 (2003)
DOI:10.1073/pnas.1633612100

Sequence

[hsa:59344]

Reference

2 [PMID:17045234]

Authors

Yu Z, Schneider C, Boeglin WE, Brash AR

Title

Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.

Journal

Arch Biochem Biophys 455:188-96 (2006)
DOI:10.1016/j.abb.2006.09.002

Sequence

[hsa:59344] [mmu:23801]

Reference

3 [PMID:20921226]

Authors

Zheng Y, Brash AR

Title

Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.

Journal

J Biol Chem 285:39866-75 (2010)
DOI:10.1074/jbc.M110.155374

Sequence

[hsa:59344]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.152

IUBMB Enzyme Nomenclature:

4.2.1.152

ExPASy - ENZYME nomenclature database:

4.2.1.152

BRENDA, the Enzyme Database:

4.2.1.152

All links

Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (397)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (234)   
   KEGG MGENES (24)   
   RefGene (138)   
Protein sequence (872)   
   UniProt (788)   
   SWISS-PROT (44)   
   RefSeq(pep) (40)   
DNA sequence (48)   
   RefSeq(nuc) (48)   
Protein domain (19)   
   InterPro (19)   
All databases (1340)   

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