KEGG   ENZYME: 4.2.1.153
Entry
EC 4.2.1.153                Enzyme                                 

Name
3-methylfumaryl-CoA hydratase;
Meh;
mesaconyl-C4-CoA hydratase;
mesaconyl-coenzyme A hydratase (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(S)-citramalyl-CoA hydro-lyase (3-methylfumaryl-CoA-forming)
Reaction(IUBMB)
(S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O [RN:R09282]
Reaction(KEGG)
R09282
Substrate
(S)-citramalyl-CoA [CPD:C01011]
Product
3-methylfumaryl-CoA [CPD:C18323];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.
History
EC 4.2.1.153 created 2014
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K09709  3-methylfumaryl-CoA hydratase
Genes
SEM: STMDT12_C09120
SEJ: STMUK_0862
SETU: STU288_10120
SETC: CFSAN001921_12720
SENI: CY43_04590
SEEN: SE451236_10320
SPQ: SPAB_02637
SEI: SPC_0855
SEC: SCH_0850
SENH: CFSAN002069_04565
SEL: SPUL_2112
SENA: AU38_04165
SENO: AU37_04150
SENV: AU39_04155
SENQ: AU40_04625
SENL: IY59_04225
SEEP: I137_09615
SENB: BN855_8360
SENE: IA1_04360
PSET: THL1_4235
AUG: URS_0098
GAI: IMCC3135_16895(meh)
ADI: B5T_00173
APAC: S7S_00615
AXE: P40_00850
REH: H16_A2424(h16_A2424) H16_B0679(h16_B0679)
RME: Rmet_3897
CGD: CR3_4507(meh)
BTD: BTI_2432
BOK: DM82_902
BOC: BG90_33
BVE: AK36_3488
BCN: Bcen_5811
BCJ: BCAS0019
BCEW: DM40_5520
BCEO: I35_7018
BAM: Bamb_6271
BCED: DM42_6390
BUB: BW23_6273
BSEM: WJ12_18985
BSTG: WT74_17805
BGO: BM43_2917
BUL: BW21_2399
PNU: Pnuc_1241
CABA: SBC2_19170(meh)
BPAR: BN117_0582
BPA: BPP0616
BBR: BB0622
RFR: Rfer_3484
AJS: Ajs_0119
VEI: Veis_4807
DAC: Daci_0197
CTES: O987_01120
HYB: Q5W_20095
OTR: OTERR_27840(meh)
AZA: AZKH_1921
BPRC: D521_0597
RHT: NT26_0720
SHZ: shn_33390
BME: BMEII1075
BMEL: DK63_2183
BMEE: DK62_2093
BMF: BAB2_0163
BABO: DK55_2161
BABR: DO74_2286
BABT: DK49_2269
BABB: DK48_2531
BABU: DK53_2974
BABS: DK51_2462
BABC: DO78_3183
BMS: BRA0167
BSZ: DK67_2188
BOV: BOV_A0148
BCAR: DK60_3043
BMR: BMI_II164
BPP: BPI_II164
BPV: DK65_2305
BJA: blr7247
BRA: BRADO1440
BBT: BBta_6665
BRS: S23_58710
AOL: S58_15660
BRAD: BF49_2777
RPA: RPA1610
RPB: RPB_3937
RPC: RPC_4267
RPD: RPD_3697
RPE: RPE_4306
RPT: Rpal_1800
XAU: Xaut_1345
AZC: AZC_2508
SNO: Snov_0364
MET: M446_5229
MNO: Mnod_6786
MOR: MOC_3216
MMED: Mame_00532
CCR: CC_1109
PZU: PHZ_c2566
SIL: SPO1598
OTM: OSB_01640
MALG: MALG_03764
RHC: RGUI_2865
RMM: ROSMUCSMR3_02201(meh)
ZMO: ZMO0486
ZMN: Za10_0768
ZMM: Zmob_1013
ZMB: ZZ6_0779
ZMI: ZCP4_0797
NAR: Saro_3796
SAL: Sala_1693
SMAZ: LH19_02445
SPHU: SPPYR_0404
SFLA: SPHFLASMR4Y_01388(meh)
ELI: ELI_12040
ACR: Acry_2579
MAG: amb0879
MAGX: XM1_1789
MAGN: WV31_16735
TMO: TMO_0524(htd2)
MID: MIP_00232
MMM: W7S_08350
MVA: Mvan_0531
MVQ: MYVA_0215
RHS: A3Q41_04797(meh)
BLIN: BLSMQ_0280
PAC: PPA2185
PACC: PAC1_11120
PACH: PAGK_2083
CACN: RN83_11230
SEN: SACE_4582
AOI: AORI_4918(meh)
PSEA: WY02_06585
PSEH: XF36_08215
PAUT: Pdca_37050
RCA: Rcas_0908
CAU: Caur_0180
CAG: Cagg_1332
 » show all
Reference
1  [PMID:19955419]
  Authors
Zarzycki J, Brecht V, Muller M, Fuchs G.
  Title
Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus.
  Journal
Proc Natl Acad Sci U S A 106:21317-22 (2009)
DOI:10.1073/pnas.0908356106
  Sequence
[cau:Caur_0180]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.153
IUBMB Enzyme Nomenclature: 4.2.1.153
ExPASy - ENZYME nomenclature database: 4.2.1.153
BRENDA, the Enzyme Database: 4.2.1.153

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