KEGG ENZYME: 4.2.1.153

ENZYME: 4.2.1.153

Entry

EC 4.2.1.153                Enzyme

Name

3-methylfumaryl-CoA hydratase;
Meh;
mesaconyl-C4-CoA hydratase;
mesaconyl-coenzyme A hydratase (ambiguous)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

(S)-citramalyl-CoA hydro-lyase (3-methylfumaryl-CoA-forming)

Reaction(IUBMB)

(S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O [RN:R09282]

Reaction(KEGG)

R09282

Substrate

(S)-citramalyl-CoA [CPD:C01011]

Product

3-methylfumaryl-CoA [CPD:C18323];
H2O [CPD:C00001]

Comment

The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.

History

EC 4.2.1.153 created 2014

Pathway

ec00720

Carbon fixation pathways in prokaryotes

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K09709

3-methylfumaryl-CoA hydratase

Genes

SEM:	STMDT12_C09120

SEJ:	STMUK_0862

SETU:

STU288_10120

SETC:

CFSAN001921_12720

SENI:

CY43_04590

SEEN:

SE451236_10320

SPQ:	SPAB_02637

SEI:

SPC_0855

SEC:

SCH_0850

SENH:

CFSAN002069_04565

SEEH:

SEEH1578_13675

SENN:

SN31241_19100

SEW:	SeSA_A1008

SEL:

SPUL_2112

SEGA:

SPUCDC_2098

SENA:

AU38_04165

SENO:

AU37_04150

SENV:

AU39_04155

SENQ:

AU40_04625

SENL:

IY59_04225

SENJ:

CFSAN001992_07155

SEEB:

SEEB0189_015070

SEEP:

I137_09615

SENB:

BN855_8360

SENE:

IA1_04360

SES:	SARI_02574

PGE:	LG71_13515

PSET:

THL1_4235

PLAL:

FXN65_13735

AEI:	AOY20_13435

AUG:

URS_0098

ALKM:

NKI27_11375

ASEM:

NNL22_07730

STAW:

NCG89_13770

THIP:

N838_00845

GAI:	IMCC3135_16895(meh)

HAK:	KO116_00799

ADI:

B5T_00173

AXE:

P40_00850

APAC:

S7S_00615

OME:	OLMES_2171

SDF:	ACG33_03905

RPJ:	N234_09420 N234_24295 N234_29230

REH:	H16_A2424(h16_A2424) H16_B0679(h16_B0679)

CNC:	CNE_2c06310 CNE_2c17680 CNE_BB1p09760

CUH:	BJN34_24690

REU:	Reut_B3538

RME:

Rmet_3897

CTI:	RALTA_B0530

CBW:	RR42_s3314

CGD:	CR3_4507(meh)

CCUP:

BKK81_18890 BKK81_30850 BKK81_32480

CUP:	BKK80_23050 BKK80_23835 BKK80_25505

CUU:	BKK79_28325 BKK79_29120 BKK79_31380

CPAU:

EHF44_20345

COX:	E0W60_08355 E0W60_17875 E0W60_33285

CCAM:

M5D45_27155

CCAX:

KZ686_19445

BTD:

BTI_2432

BOK:

DM82_902

BOC:

BG90_33

BUU:	WS70_10445

BHG:	I6G56_08985

BVI:	Bcep1808_5396

BVE:

AK36_3488

BUR:	Bcep18194_C7300 Bcep18194_C7720

BCM:	Bcenmc03_6655 Bcenmc03_6893

BCH:	Bcen2424_6175

BCJ:

BCAS0019

BCEN:

DM39_6413 DM39_6676

BCEW:

DM40_5520

BCEO:

I35_7018

BAM:

Bamb_6271

BAC:	BamMC406_5975

BCED:

DM42_6390

BCEP:

APZ15_33395

BPYR:

ABD05_34465

BCON:

NL30_33755 NL30_35120

BUB:

BW23_6273

BSEM:

WJ12_18985

BPSL:

WS57_16945 WS57_18520

BMEC:

WJ16_18905 WJ16_19805

BSTG:

WT74_17805

BSTL:

BBJ41_34375 BBJ41_37990

BARI:

NLX30_34670 NLX30_37340

BGD:	bgla_1g16820

BGO:

BM43_2917

BYI:	BYI23_C007610 BYI23_D006010

BUE:	BRPE67_CCDS03790 BRPE67_DCDS07810

BUL:

BW21_2399

BUQ:	AC233_24745

BGP:	BGL_1c14840

BPLA:

bpln_1g14540

BUD:	AQ610_11350

BURK:

DM992_35065

BXE:	Bxe_B2585 Bxe_C0575 Bxe_C0656

BXB:	DR64_4918 DR64_7789 DR64_7871

BGE:	BC1002_5321 BC1002_5361

BPY:	Bphyt_6604

BUZ:	AYM40_06755 AYM40_33270

BFN:	OI25_3905 OI25_5158 OI25_7324 OI25_7336 OI25_7419

BCAI:

K788_0001674

PSPW:

BJG93_20460 BJG93_29320

PARA:

BTO02_26490

PARB:

CJU94_30260

PHS:	C2L64_38455 C2L64_40685

PTER:

C2L65_34450

PGP:	CUJ91_18845

PCJ:	CUJ87_29645

PCAF:

DSC91_002606

PMEG:

FNZ07_05305

PTRO:

G5S35_09240 G5S35_27045

PGIS:

I6I06_17970

PACP:

FAZ97_08815

PACS:

FAZ98_08650 FAZ98_25495 FAZ98_25520

PEW:	KZJ38_29045

PDIO:

PDMSB3_0487.1(meh)

PBRY:

NDK50_34495

PNU:

Pnuc_1241

PDQ:	CL55_00006440

PTRP:

DCO17_04260

PANI:

DCO16_02300

PCOS:

C2747_03250

PYT:	PKF023_11790

PTX:	ABW99_01565 ABW99_18550

CABA:

SBC2_19170(meh)

BPAR:

BN117_0582

BPA:

BPP0616

BBH:	BN112_2817

BBR:

BB0622

BBM:	BN115_0595

BBX:	BBS798_0596

BBRO:

BAU06_00055

BFZ:	BAU07_00030

BOH:	AKI39_00025

BOJ:	CBF45_05140

ADY:	HLG70_00400

PIG:	EGT29_19990

PACR:

FXN63_11585

KGY:	EHF36_05545

PARK:

LSG25_15045

RFR:

Rfer_3484

RHY:	RD110_23575

RHF:	EUB48_08780

POL:	Bpro_0584 Bpro_4554

PNA:	Pnap_2143 Pnap_3808

PVAC:

HC248_01526(meh)

AJS:

Ajs_0119

ACID:

CBP33_00605

ACIP:

CBP36_00655

ACIN:

CBP34_00615

ACIS:

CBP35_18300

AMON:

H9L24_14975

ARAD:

KI609_00900

ATEM:

PQV96_09105

VEI:

Veis_4807

DAC:

Daci_0197

DEL:	DelCs14_0200

DTS:	BI380_22740

DHK:	BO996_02000

DLA:	I6G47_22705

VAP:	Vapar_2026

VPE:	Varpa_3862

VPD:	VAPA_1c06610 VAPA_1c21470 VAPA_2c05870

VBO:	CKY39_21090

VAM:	C4F17_02325

CTT:	CtCNB1_0220

CTES:

O987_01120

CKE:	B5M06_05515

CSER:

CCO03_14440

CAQT:

KAQ61_17040

CODO:

LAD35_00905

ADN:	Alide_0163 Alide_2927

ADK:	Alide2_0152 Alide2_1520

RTA:	Rta_14200 Rta_16620

OTK:	C6570_10715

OTD:	J1M35_12325

LIH:	L63ED372_02961

HYB:

Q5W_20095

HYL:	LPB072_14645

HYN:	F9K07_24625 F9K07_27755

HTN:	KI616_13915

DPY:	BA022_14250

DIH:	G7047_08595 G7047_22695 G7047_24165 G7047_26170

DAER:

H9K75_13280

DRG:	H9K76_23180

DIA:	Dtpsy_0137

MELA:

C6568_08405

MJE:	LVC68_00530

STHM:

IS481_02890

ATER:

MW290_10325 MW290_30855

LCH:	Lcho_0819 Lcho_2415

HSE:	Hsero_2799

HSZ:	ACP92_14045

HHT:	F506_16010

HRB:	Hrubri_2850

HEE:	hmeg3_12915

HHF:	E2K99_14680

HFR:	G5S34_14670

MASW:

AM586_25995

MFLA:

GO485_26100

NOK:	FAY22_02470

GLC:	JQN73_04420

XYK:	GT347_01945

URU:	DSM104443_00819(meh)

ARES:

IWH25_16380

RBU:	PG1C_11190

OTR:	OTERR_27840(meh)

APET:

ToN1_04120 ToN1_05500

AZA:

AZKH_1921

AZR:	CJ010_16450 CJ010_17080

AZQ:	G3580_09945

ACOM:

CEW83_02955

APP:	CAP2UW1_2504

BPRC:

D521_0597

BEBA:

BWI17_00520

MCI:	Mesci_6211

MOP:	Mesop_2795

MESW:

A9K65_031200

MESP:

C1M53_21180

MESO:

BSQ44_23715

NIY:	FQ775_07240

SFH:	SFHH103_02514

SIX:	BSY16_6076

EMX:	FKV68_30915

ALF:	CFBP5473_24785

REP:	IE4803_PC00151

REI:	IE4771_PD00151

RIR:	BN877_p0638

RHT:

NT26_0720

RFV:	RFYW14_04040

SHZ:

shn_33390

ABAW:

D5400_02105

BME:

BMEII1075

BMEL:

DK63_2183

BMI:	BMEA_B0168

BMZ:	BM28_B0161

BMG:	BM590_B0161

BMW:	BMNI_II0159

BMEE:

DK62_2093

BMF:

BAB2_0163

BMB:	BruAb2_0162

BMC:	BAbS19_II01550

BAA:	BAA13334_II00475

BABO:

DK55_2161

BABR:

DO74_2286

BABT:

DK49_2269

BABB:

DK48_2531

BABU:

DK53_2974

BABS:

DK51_2462

BABC:

DO78_3183

BMS:

BRA0167

BSI:	BS1330_II0164

BSF:	BSS2_II0158

BSUI:

BSSP1_II0127

BSUP:

BSPT1_II0128

BSUV:

BSPT2_II0128

BSUC:

BSSP2_II0129

BMT:	BSUIS_B0170

BSZ:

DK67_2188

BSV:	BSVBI22_B0163

BSW:	IY71_09925 IY71_11905

BSG:	IY72_09665 IY72_11445

BOV:

BOV_A0148

BCS:	BCAN_B0167

BSK:	BCA52141_II0977

BOL:	BCOUA_II0167

BCAR:

DK60_3043

BMR:

BMI_II164

BPP:

BPI_II164

BPV:

DK65_2305

BCET:

V910_201037

BCEE:

V568_201209

BVL:	BF3285c2_0641

BRU:	BFS01_11180

BRJ:	BKD03_01610

BIO:	BR141012304_20027

OPS:	A8A54_19015

BJA:	blr7247(blr7247)

BJU:	BJ6T_21450

BJP:	RN69_10505

BRA:

BRADO1440

BBT:

BBta_6665

BRS:

S23_58710

AOL:

S58_15660

BRC:	BCCGELA001_07440

BRAD:

BF49_2777

BIC:	LMTR13_05605

BRO:	BRAD285_0942

BRK:	CWS35_35360

BOT:	CIT37_18880

BRQ:	CIT40_05115

BGQ:	X265_30470 X265_39745

BGZ:	XH91_28930 XH91_34300

BBET:

F8237_09020

BARH:

WN72_40055 WN72_41405

BVZ:	BRAD3257_1394

BEL:	BE61_32670

BDG:	LPJ38_11605

BSEP:

HAP48_0025610

BQB:	J4P68_0010440

BSEI:

KMZ68_05895

BBAN:

J4G43_011225

BCAN:

BcanWSM471_31805

RPA:

RPA1610

RPB:

RPB_3937

RPC:

RPC_4267

RPD:

RPD_3697

RPE:

RPE_4306

RPT:

Rpal_1800

RPX:	Rpdx1_3913

RBK:	E0H22_07405 E0H22_24955

TRB:	HB776_15075

BOS:	BSY19_3911

BVV:	BHK69_16395

BOI:	BLM15_13655

BOF:	FQV39_06310 FQV39_10050 FQV39_32460

XAU:

Xaut_1345

XDI:	EZH22_00440 EZH22_12120 EZH22_23005 EZH22_28780

AZC:

AZC_2508

SNO:

Snov_0364

ANC:	GBB76_18375

APOL:

K9D25_21915

MRD:	Mrad2831_2851

MET:

M446_5229

MNO:

Mnod_6786

MOR:

MOC_3216

MAQU:

Maq22A_c24950

MPHY:

MCBMB27_02291

MEE:	DA075_23495

METX:

A3862_17540

METI:

DK427_09375

MTEA:

DK419_27665

MIND:

mvi_24510

MTAD:

M6G65_16775

MOC:	BB934_09990

MLG:	CWB41_06950

CHEL:

AL346_22455

RHZ:	RHPLAN_59150

NTD:	EGO55_04515

MMED:

Mame_00532

AALA:

IGS74_02985 IGS74_16275

AALM:

LUX29_18370

JIE:	OH818_14605

LAP:	ACP90_10505

LABR:

CHH27_09900

LABT:

FIU93_16065

LAGG:

B0E33_22425

SIW:	GH266_08400

PSTG:

E8M01_03170

ACUT:

MRB58_12355 MRB58_13700

CCR:

CC_1109

CCS:	CCNA_01166

CHQ:	AQ619_04930

CAUF:

CSW63_08165

CAUL:

KCG34_02820

PZU:

PHZ_c2566

TSV:	DSM104635_00476

SIL:

SPO1598

SIT:	TM1040_3340

RUA:	D1823_17060

RUT:	FIU92_14400

RLI:	RLO149_c031950

DSH:	Dshi_1047 Dshi_2493

OAT:	OAN307_c05440

OAR:	OA238_c01680

OTM:

OSB_01640

OCT:	FTO60_00820

LEJ:	ETW24_16585

LEV:	ETW23_02345

LCAE:

K3721_01965

RED:	roselon_02263

MALG:

MALG_03764

CON:	TQ29_18895

YAN:	AYJ57_15860

TPRO:

Ga0080559_TMP1645

PABY:

Ga0080574_TMP5123

SUAM:

BOO69_01195 BOO69_21610

SULZ:

C1J03_21135

SULI:

C1J05_19140

SMED:

JNX03_11990

SPSE:

SULPSESMR1_03470(meh) SULPSESMR1_04144(meh)

TOM:	BWR18_13440 BWR18_14695

RMM:	ROSMUCSMR3_02201(meh)

ROK:	RAK1035_0985

RID:	RIdsm_00211 RIdsm_01155 RIdsm_04625

ROM:	EI983_15855

ROH:	FIU89_16610 FIU89_18565

AHT:	ANTHELSMS3_00805 ANTHELSMS3_05144

SAGU:

CDO87_11210 CDO87_15520 CDO87_24220

THAA:

CFI11_02310 CFI11_18065

MARU:

FIU81_05555

ROT:	FIV09_02230 FIV09_12810

MALU:

KU6B_14490 KU6B_52380(meh)

TGL:	HFZ77_10300 HFZ77_15560

LSAL:

KBK07_02520

PDE:	Pden_0194 Pden_0221 Pden_4111

PYE:	A6J80_20575

PCON:

B0A89_09820

PZH:	CX676_16845

PARU:

CYR75_12710

PARS:

DRW48_03075

PSAN:

HGN31_06345

PMEH:

JWJ88_18455

PSEW:

JHW44_13855

PSAP:

JHX88_01625

PFIS:

JHX87_16660

RSU:	NHU_02252 NHU_03858

RHM:	B5V46_01310 B5V46_07925

RHC:

RGUI_2865

DAA:	AKL17_1608 AKL17_4341

RBG:	BG454_05630

SEDI:

EBB79_09205

HML:	HmaOT1_14850

PSEB:

EOK75_18775

LIT:	FPZ52_16960

PPRU:

FDP22_07400

MON:	G8E03_07240

PAMO:

BAR1_15750

PSHQ:

F3W81_18710

POZ:	I0K15_19130

PGV:	SL003B_0531

CACT:

HZ995_04835

THAS:

C6Y53_15095

HDH:	G5B40_17340

ACRO:

K3J57_00710

AMAQ:

GO499_02500

HBC:	AEM38_02605

ZMO:

ZMO0486

ZMN:

Za10_0768

ZMM:

Zmob_1013

ZMB:

ZZ6_0779

ZMI:

ZCP4_0797

ZMC:	A265_00787

ZMR:	A254_00787

ZMP:	Zymop_0731

NAR:

Saro_3796

NPP:	PP1Y_AT31363 PP1Y_AT32009

NPN:	JI59_17590

NOR:	FA702_12975

NGF:	FRF71_05155

NOG:	GKE62_08300

SAL:

Sala_1693

SPHK:

SKP52_16110

SPHP:

LH20_14910 LH20_19540

SMAG:

AN936_15845

SMAZ:

LH19_02445

STER:

AOA14_14400

SGI:	SGRAN_3004

SPHQ:

BWQ93_19320

SPHO:

C3E99_10390

SPHX:

E5675_04465

SPHU:

SPPYR_0404

SPHD:

HY78_18250 HY78_30010

RDI:	CMV14_04070

SPHA:

D3Y57_02040 D3Y57_02185 D3Y57_03950

SLAN:

GV829_02850

SPAP:

H3Z74_06290

SCHY:

GVO57_11750

SRAD:

LLW23_04525

SNAP:

PQ455_08165

SCH:	Sphch_0993

SYB:	TZ53_19650

SPHB:

EP837_03071

SPHT:

K426_13805 K426_15975 K426_18725 K426_23319

SYA:	A6768_05910

SCLO:

SCLO_1006490

SUFL:

FIL70_08825 FIL70_14445

SBAR:

H5V43_03380 H5V43_06495

SPPH:

KFK14_04860

CIJ:	WG74_00625

SPHG:

AZE99_04460

SFLA:

SPHFLASMR4Y_01388(meh)

SPHY:

CHN51_00940

BLAS:

BSY18_3599 BSY18_3945

SPHJ:

BSL82_08405

AEP:	AMC99_02361

ALH:	G6N82_07875

AMX:	AM2010_2445

PMAS:

NCF86_13705

ADO:	A6F68_00853

TFV:	IDJ81_01935

ERY:	CP97_12710

EFV:	CHH26_00245

QCI:	NCF85_15350

ELI:

ELI_12040

ELQ:	Ga0102493_11762

ERK:	CD351_03080

ERR:	DVR09_01645

ERF:	FIU90_03310

EMV:	HQR01_04845

PNS:	A9D12_05430

PORL:

BG023_11588

PHZ:	CHX26_03240

POT:	E2E27_01895

ACR:

Acry_2579

AMV:	ACMV_29040

RGI:	RGI145_21785

RMT:	IAI58_03500 IAI58_04060

RCV:	PFY06_14740

SRF:	LHU95_13055 LHU95_17440

RAP:	RHOA_0689(meh)

ABS:	AZOBR_p150096 AZOBR_p330131

ABQ:	ABAZ39_15020 ABAZ39_20985

ABF:	AMK58_14525

ATI:	AL072_22055

AZT:	TSH58p_23070 TSH58p_25135

AZM:	DM194_21440

AARE:

D3093_19945 D3093_21530

SKT:	IGS68_05135

SMUC:

JL100_022620

SROE:

JL101_021270

MAG:

amb0879

MAGX:

XM1_1789

MAGN:

WV31_16735

FER:	FNB15_13590

HTQ:	FRZ44_08670

HADH:

FRZ61_08610

DEX:	HWD60_12840

TMO:	TMO_0524(htd2)

ELIO:

KO353_15230

APB:	SAR116_0876

SNEA:

NBZ79_16605

MID:

MIP_00232

MMM:

W7S_08350

MDX:	BTO20_25345

MSAK:

MSAS_56260

MSM:	MSMEG_1993

MSG:	MSMEI_1949

MSB:	LJ00_09945

MSN:	LI99_09945

MSH:	LI98_09945

MVA:

Mvan_0531

MGI:	Mflv_0552 Mflv_0634

MSP:	Mspyr1_01900

MVQ:

MYVA_0215

MDU:	MDUV_29920

MMAG:

MMAD_55310

MDF:	K0O62_00545

NNO:	NONO_c28430 NONO_c33480

RHS:	A3Q41_04797(meh)

RKO:	JWS14_41695

GOC:	CXX93_03630

GIT:	C6V83_01035

GAM:	GII34_22330

GOI:	LK459_05350

SPIN:

KV203_05300

TOY:	FO059_14035

SCIN:

CP977_30965

STUI:

GCM10017668_62540

SGJ:	IAG43_24595

SINE:

KI385_04075

SLF:	JEQ17_46545

SAKB:

K1J60_08825

YIA:	LO772_34930

MIO:	AOA12_04740

MIH:	BJP65_11495

SALC:

C2138_12295

SALD:

FVA74_01335

LYD:	D7I47_06160

PLAP:

EAO79_06730

LINS:

G7067_12365

LARI:

KI794_06455

SUBA:

LQ955_15075

PEI:	H9L10_11005

BLY:	A2T55_01925

BLIN:

BLSMQ_0280

BRI:	FDF13_01700

BLUT:

EW640_12870

DCO:	SAMEA4475696_1392

GYU:	FE374_03290

PAC:

PPA2185

PAK:	HMPREF0675_5250

PAV:	TIA2EST22_10670

PAX:	TIA2EST36_10650

PAZ:	TIA2EST2_10600

PAW:	PAZ_c22680

PAD:	TIIST44_03745

PCN:	TIB1ST10_11120

PACC:

PAC1_11120

PACH:

PAGK_2083

PACN:

TIA1EST1_10735

CACN:

RN83_11230

PRA:	PALO_11370

PRL:	BCB70_07470

AACI:

ASQ49_06830

AEF:	GEV26_00900

ACTW:

F7P10_39315

NOW:	GBF35_13600

SEN:

SACE_4582

SACG:

FDZ84_33570

AOI:	AORI_4918(meh)

AJA:	AJAP_14945

AMQ:	AMETH_3801

AMYC:

CU254_14600 CU254_18705

AACD:

LWP59_10295

AROO:

NQK81_42325

ATHM:

L1857_20980

PSEA:

WY02_06585

PSEH:

XF36_08215

PSEQ:

AD006_28125

PECQ:

AD017_07720

PAUT:

Pdca_37050

PPEL:

H6H00_19830 H6H00_21370

KPHY:

AOZ06_25460

LED:	BBK82_38645

SACE:

GIY23_13725

PLAB:

C6361_21485

PLAT:

C6W10_16410

PFLA:

Pflav_031930

PSUU:

Psuf_090480

RRS:	RoseRS_4177

RCA:

Rcas_0908

CAU:

Caur_0180

CHL:	Chy400_0192

CAG:

Cagg_1332

AMUC:

Pan181_06510

GGR:	HKW67_06670

DIN:	Selin_1611

» show all

Reference

1 [PMID:19955419]

Authors

Zarzycki J, Brecht V, Muller M, Fuchs G

Title

Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus.

Journal

Proc Natl Acad Sci U S A 106:21317-22 (2009)
DOI:10.1073/pnas.0908356106

Sequence

[cau:Caur_0180]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.153

IUBMB Enzyme Nomenclature:

4.2.1.153

ExPASy - ENZYME nomenclature database:

4.2.1.153

BRENDA, the Enzyme Database:

4.2.1.153

DBGET integrated database retrieval system