KEGG   ENZYME: 4.2.1.154
Entry
EC 4.2.1.154                Enzyme                                 

Name
tetracenomycin F2 cyclase;
tcmI (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
tetracenomycin F2 hydro-lyase (tetracenomycin-F1-forming)
Reaction(IUBMB)
tetracenomycin F2 = tetracenomycin F1 + H2O [RN:R06699]
Reaction(KEGG)
R06699
Substrate
tetracenomycin F2 [CPD:C12366]
Product
tetracenomycin F1 [CPD:C12367];
H2O [CPD:C00001]
Comment
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
History
EC 4.2.1.154 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15968  tetracenomycin F2 cyclase
Genes
SGU: SGLAU_26345(tcmI)
STRC: AA958_32660
Reference
1  [PMID:8218177]
  Authors
Shen B, Hutchinson CR.
  Title
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis  of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:11149-54 (1993)
DOI:10.1021/bi00092a026
  Sequence
Reference
2  [PMID:15231835]
  Authors
Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I
  Title
Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.
  Journal
J Biol Chem 279:37956-63 (2004)
DOI:10.1074/jbc.M406144200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.154
IUBMB Enzyme Nomenclature: 4.2.1.154
ExPASy - ENZYME nomenclature database: 4.2.1.154
BRENDA, the Enzyme Database: 4.2.1.154

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