KEGG   ENZYME: 4.2.1.154Help
Entry
EC 4.2.1.154                Enzyme                                 

Name
tetracenomycin F2 cyclase;
tcmI (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
tetracenomycin F2 hydro-lyase (tetracenomycin-F1-forming)
Reaction(IUBMB)
tetracenomycin F2 = tetracenomycin F1 + H2O [RN:R06699]
Reaction(KEGG)
Substrate
tetracenomycin F2 [CPD:C12366]
Product
tetracenomycin F1 [CPD:C12367];
H2O [CPD:C00001]
Comment
The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.
History
EC 4.2.1.154 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01130  Biosynthesis of antibiotics
Orthology
K15968  tetracenomycin F2 cyclase
Genes
SGU: SGLAU_26345(tcmI)
STRC: AA958_32660
Taxonomy
Reference
1  [PMID:8218177]
  Authors
Shen B, Hutchinson CR.
  Title
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis  of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:11149-54 (1993)
  Sequence
Reference
2  [PMID:15231835]
  Authors
Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I
  Title
Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.
  Journal
J Biol Chem 279:37956-63 (2004)
DOI:10.1074/jbc.M406144200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.154
IUBMB Enzyme Nomenclature: 4.2.1.154
ExPASy - ENZYME nomenclature database: 4.2.1.154
BRENDA, the Enzyme Database: 4.2.1.154

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