KEGG   ENZYME: 4.2.1.155
Entry
EC 4.2.1.155                Enzyme                                 
Name
(methylthio)acryloyl-CoA hydratase;
DmdD
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
3-(methylsulfanyl)prop-2-enoyl-CoA hydro-lyase (acetaldehyde-forming)
Reaction(IUBMB)
3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + methanethiol + CoA + CO2 (overall reaction) [RN:R10936];
(1a) 3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA [RN:R10945];
(1b) 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol [RN:R10946];
(1c) 3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA [RN:R10947];
(1d) 3-oxopropanoate = acetaldehyde + CO2 [RN:R06973]
Reaction(KEGG)
R06973 R10936 R10945 R10946 R10947
Substrate
3-(methylsulfanyl)acryloyl-CoA [CPD:C20955];
H2O [CPD:C00001];
3-hydroxy-3-(methylsulfanyl)propanoyl-CoA [CPD:C20968];
3-oxopropanoyl-CoA [CPD:C05989];
3-oxopropanoate [CPD:C00222]
Product
acetaldehyde [CPD:C00084];
methanethiol [CPD:C00409];
CoA [CPD:C00010];
CO2 [CPD:C00011];
3-hydroxy-3-(methylsulfanyl)propanoyl-CoA [CPD:C20968];
3-oxopropanoyl-CoA [CPD:C05989];
3-oxopropanoate [CPD:C00222]
Comment
The enzyme is involved in the degradation of 3-(dimethylsulfonio)propanoate, an osmolyte produced by marine phytoplankton. Isolated from the bacterium Ruegeria pomeroyi.
History
EC 4.2.1.155 created 2015
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K20036  (methylthio)acryloyl-CoA hydratase
Genes
PFS: PFLU_2454
PTV: AA957_02575
PAZO: AYR47_18985
PFW: PF1751_v1c21520
PFF: PFLUOLIPICF725950
PFX: A7318_10225
PPEG: KUA23_11310
APRS: BI364_09690
HEL: HELO_3943
HAK: KO116_00192
HHH: CLM76_03085
HCAM: I4484_18915
HSX: HNO51_18970
HSV: HNO53_19245
HTX: EKK97_21245
MMW: Mmwyl1_3020
MME: Marme_2603
MPC: Mar181_1042
MPRI: MP3633_1206
MARD: IBG28_06875
MFOI: JSY38_15840
MPRF: J8N69_12515
MRHI: KDW99_13955
MARL: HH196_06500
VFF: VITFI_CDS3132
REU: Reut_B4798 Reut_B5283
RME: Rmet_2366
CBW: RR42_s1574
CCUP: BKK81_29835
CUP: BKK80_26520
CUU: BKK79_32405
COX: E0W60_20475
BGF: BC1003_5123
BGD: bgla_2g28180
BXE: Bxe_C0923
BXB: DR64_7526
PCAF: DSC91_002454
PACS: FAZ98_16225
PPK: U875_11015
PPNO: DA70_03425
PPNM: LV28_02900
PRB: X636_23685
PPUL: RO07_21765
PSPU: NA29_15325
PAPI: SG18_20730
PVE: UC34_13105
POX: MB84_17630
PFG: AB870_00175
PNR: AT302_19050
PFIB: PI93_014860
PCOM: NTU39_14705
BOJ: CBF45_03330 CBF45_06585
PUT: PT7_0125
PUD: G9Q38_03570 G9Q38_10260
AFA: UZ73_01330 UZ73_07535
AFQ: AFA_11055
AAQU: D3M96_11865
AAMM: FE795_10295
PIG: EGT29_13920
KGY: EHF36_03780 EHF36_07020
RFR: Rfer_0274
RSB: RS694_00925
RHY: RD110_11725
RHF: EUB48_13060
RHOA: HZ993_17690
POL: Bpro_3111
PNA: Pnap_0605
ACK: C380_01285
ACRA: BSY15_1662
ACIO: EAG14_20805
AANT: HUK68_18610
ARAD: KI609_01255
VAP: Vapar_4402
VPE: Varpa_5065
VPD: VAPA_1c45750
VAA: AX767_13925
VBO: CKY39_14475 CKY39_27680
VAM: C4F17_23700
CTT: CtCNB1_2298 CtCNB1_4139
CTES: O987_24730
CAQT: KAQ61_13310
RTA: Rta_25000
OTK: C6570_11155
LIM: L103DPR2_01477(paaF_3)
LIH: L63ED372_00989(paaF_3)
HYR: BSY239_2238
HYB: Q5W_08965
HYL: LPB072_16170
HYC: E5678_08855
HPSE: HPF_07975(paaF3)
HYN: F9K07_12120
HTN: KI616_18245
HCZ: G9Q37_03380
CBAA: SRAA_0578
CBAB: SMCB_0808
STHM: IS481_04375 IS481_07635
PBH: AAW51_0441
SNN: EWH46_03165
ATER: MW290_20370
LCH: Lcho_0994
HSE: Hsero_4006
HSZ: ACP92_20000
HRB: Hrubri_3960
HEE: hmeg3_01130
HHF: E2K99_20860
HFR: G5S34_21750
SHD: SUTH_01232
DOE: DENOEST_0611(dmdD)
EBA: ebA5318 ebA5619
ABRE: pbN1_04090
APET: ToN1_09320
AZO: azo2498(paaG3)
AOA: dqs_2651
AZA: AZKH_2163
AZI: AzCIB_2731
AZD: CDA09_14720
TMZ: Tmz1t_2492
TCL: Tchl_1082
THK: CCZ27_15680 CCZ27_17835
TAK: Tharo_1120
DDZ: DSYM_02080
BEBA: BWI17_21020
MLO: mlr6976
MESO: BSQ44_21420
HOE: IMCC20628_02027
NIY: FQ775_21445
ORM: HTY61_05125
ESJ: SJ05684_b59780
EAK: EKH55_4145
ATU: Atu1417(fad)
ALF: CFBP5473_16040
AVQ: HRR99_21620
NGL: RG1141_CH41200
NGG: RG540_CH41720
NEO: CYG48_15380
RHT: NT26_3192(fad)
RFV: RFYW14_03205
PDES: FE840_020140
BJA: blr7844(fad)
BJU: BJ6T_84670
BJP: RN69_40915
BRA: BRADO0962
BBT: BBta_5093 BBta_7093
BRS: S23_09440(fad)
AOL: S58_66670
BRC: BCCGELA001_33005
BRAD: BF49_4145
BIC: LMTR13_35510
BRO: BRAD285_0457
BRK: CWS35_02980
BOT: CIT37_06570
BRQ: CIT40_28175
BGQ: X265_33275
BGZ: XH91_31675
BSYM: CIT39_27190
BBET: F8237_19635
BARH: WN72_05965
BVZ: BRAD3257_8266(fad)
BEL: BE61_14310(fad)
BDG: LPJ38_00680
BSEP: HAP48_0019025
BQB: J4P68_0022520
BSEI: KMZ68_23760
BBAN: J4G43_047470
BCAN: BcanWSM471_05700
RPA: RPA1786
RPB: RPB_3578
RPD: RPD_1886
RPE: RPE_3803
RPT: Rpal_1988
RPX: Rpdx1_3746
RBK: E0H22_20670
TRB: HB776_16035
MNO: Mnod_6456
MAQU: Maq22A_c00770(caiD)
MEE: DA075_12475
MTEA: DK419_20350
MIND: mvi_14950(paaG)
RHZ: RHPLAN_62540 RHPLAN_69940
PHL: KKY_2321
PEM: OF122_05250
DEQ: XM25_21120
DEI: C4375_05470
DEA: FPZ08_20665
DSAL: K1X15_01035
DEVO: H4N61_07420
YTI: FNA67_02440
BVR: BVIR_1682
BLAG: BLTE_16420(fad)
MAAD: AZF01_17850 AZF01_20095
MLUT: JET14_00305 JET14_17550
BRN: D1F64_22285
PSIN: CAK95_06170 CAK95_14960
PPHR: APZ00_03860 APZ00_05265
LAP: ACP90_06325
LABR: CHH27_14215
LABT: FIU93_11965(paaF2)
LAGG: B0E33_17875
PHR: C6569_04915
PSTG: E8M01_13635
ACUT: MRB58_01555 MRB58_08790(dmdD)
SIL: SPO3805(dmdD)
JAN: Jann_0665
PGA: PGA1_262p01540 PGA1_262p01850
PGL: PGA2_239p1720
PGD: Gal_03918
PHP: PhaeoP97_03685
PPIC: PhaeoP14_03588
PHQ: D1820_17695
LMD: METH_04510
LEJ: ETW24_05600
LEV: ETW23_14095
CID: P73_1463
CEH: CEW89_18655
YPAC: CEW88_03015
YAN: AYJ57_10060
SUAM: BOO69_11775
SULZ: C1J03_19935
SPOT: G6548_08570
SMED: JNX03_19590(dmdD)
SPSE: SULPSESMR1_00293(dmdD) SULPSESMR1_03318(dmdD)
AHT: ANTHELSMS3_04102(dmdD)
SAGU: CDO87_15325
OCD: FHY55_02030
MARU: FIU81_05950(echA1)
MALU: KU6B_17010(fad)
TGL: HFZ77_03705 HFZ77_13875
PALX: GQA70_14310
PDE: Pden_2560
PCON: B0A89_04960
PZH: CX676_15280
PARO: CUV01_03995 CUV01_04030 CUV01_08275
PARU: CYR75_11380
PARS: DRW48_04255
PARR: EOJ32_01265
PKD: F8A10_09685
PPAN: ESD82_11390
PSAN: HGN31_07185
PMAU: CP157_00210(dmdD)
PMEH: JWJ88_01160
PSEW: JHW44_00370
PSAP: JHX88_11465
PFIS: JHX87_11675
PTP: RCA23_c26210(crt)
DON: BSK21_06015
RBZ: B9057_07500
RBG: BG454_07465
SALO: EF888_01205 EF888_16370
SEDI: EBB79_18915
PPRU: FDP22_13980
PSHQ: F3W81_00380 F3W81_12695
PALW: PSAL_022640(dmdD)
PGV: SL003B_2869(fad)
GCE: KYE46_16960
NSM: JO391_18160
SINR: O5O51_14205(dmdD)
AMAQ: GO499_03935
SSY: SLG_07670 SLG_35020
ERY: CP97_08825
RAP: RHOA_5185(dmdD)
FER: FNB15_11965
TMO: TMO_c0641
TII: DY252_19175
THAI: IT893_02215
NACI: NUH88_16325
PAUU: E8A73_040205
SLAU: SLA_7088
SPHV: F9278_04880
SGX: H4W23_04770
KIT: CFP65_0448
ALX: LVQ62_14330
ARS: ADJ73_05985
BLIN: BLSMQ_1405
BCAU: I6G59_01295
AGRA: AGRA3207_007192
FRI: FraEuI1c_2567
AMD: AMED_3269(paaG)
AMN: RAM_16630
AMM: AMES_3233(paaG)
AMZ: B737_3233(paaG)
APRT: MUY14_19030
PSEH: XF36_04825
PAUT: Pdca_17660(paaG_4)
PBRO: HOP40_01125
PPEL: H6H00_01695
DVC: Dvina_24630
DAUR: Daura_31230
DMAT: Dmats_20240
JTL: M6D93_11190
HHY: Halhy_0462
SLI: Slin_1561
SPIR: CWM47_14210
SPIK: EXU85_00745
SRHO: HH216_17380
RHOZ: GXP67_01720
RSI: Runsl_0511
RUP: DTQ70_10440
EOL: Emtol_1593
MARB: CJ263_16340
 » show all
Reference
1  [PMID:23704947]
  Authors
Tan D, Crabb WM, Whitman WB, Tong L
  Title
Crystal structure of DmdD, a crotonase superfamily enzyme that catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA.
  Journal
PLoS One 8:e63870 (2013)
DOI:10.1371/journal.pone.0063870
  Sequence
[sil:SPO3805]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.155
IUBMB Enzyme Nomenclature: 4.2.1.155
ExPASy - ENZYME nomenclature database: 4.2.1.155
BRENDA, the Enzyme Database: 4.2.1.155

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (13)   
   KEGG REACTION (5)   
   KEGG RCLASS (8)   
Gene (907)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (324)   
   KEGG MGENES (449)   
   RefGene (133)   
Protein sequence (151)   
   UniProt (41)   
   SWISS-PROT (1)   
   RefSeq(pep) (109)   
DNA sequence (450)   
   RefSeq(nuc) (305)   
   GenBank (95)   
   EMBL (50)   
Protein domain (4)   
   InterPro (4)   
All databases (1538)   

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