KEGG   ENZYME: 4.2.1.155
Entry
EC 4.2.1.155                Enzyme                                 
Name
(methylthio)acryloyl-CoA hydratase;
DmdD
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
3-(methylsulfanyl)prop-2-enoyl-CoA hydro-lyase (acetaldehyde-forming)
Reaction(IUBMB)
3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + methanethiol + CoA + CO2 (overall reaction) [RN:R10936];
(1a) 3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA [RN:R10945];
(1b) 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol [RN:R10946];
(1c) 3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA [RN:R10947];
(1d) 3-oxopropanoate = acetaldehyde + CO2 [RN:R06973]
Reaction(KEGG)
Substrate
3-(methylsulfanyl)acryloyl-CoA [CPD:C20955];
H2O [CPD:C00001];
3-hydroxy-3-(methylsulfanyl)propanoyl-CoA [CPD:C20968];
3-oxopropanoyl-CoA [CPD:C05989];
3-oxopropanoate [CPD:C00222]
Product
acetaldehyde [CPD:C00084];
methanethiol [CPD:C00409];
CoA [CPD:C00010];
CO2 [CPD:C00011];
3-hydroxy-3-(methylsulfanyl)propanoyl-CoA [CPD:C20968];
3-oxopropanoyl-CoA [CPD:C05989];
3-oxopropanoate [CPD:C00222]
Comment
The enzyme is involved in the degradation of 3-(dimethylsulfonio)propanoate, an osmolyte produced by marine phytoplankton. Isolated from the bacterium Ruegeria pomeroyi.
History
EC 4.2.1.155 created 2015
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K20036  (methylthio)acryloyl-CoA hydratase
Genes
PFSPFLU_2454
PTVAA957_02575
PAZOAYR47_18985
PFWPF1751_v1c21520
PFFPFLUOLIPICF725950
PFXA7318_10225
PPEGKUA23_11310
APRSBI364_09690
HELHELO_3943
HAKKO116_00192
HHHCLM76_03085
HSVHNO53_19245
HASOB2G49_18265
HCAMI4484_18915
HSXHNO51_18970
HTXEKK97_21245
MMWMmwyl1_3020
MMEMarme_2603
MPCMar181_1042
MPRIMP3633_1206
MARDIBG28_06875
MFOIJSY38_15840
MPRFJ8N69_12515
MRHIKDW99_13955
MPONMACH16_21730(fad)
MARLHH196_06500
VFFVITFI_CDS3132
REUReut_B4798 Reut_B5283
RMERmet_2366
CBWRR42_s1574
CCUPBKK81_29835
CUPBKK80_26520
CUUBKK79_32405
COXE0W60_20475
BGFBC1003_5123
BGDbgla_2g28180
BXEBxe_C0923
BXBDR64_7526
PCAFDSC91_002454
PACSFAZ98_16225
PPKU875_11015
PPNODA70_03425
PPNMLV28_02900
PRBX636_23685
PPULRO07_21765
PSPUNA29_15325
PAPISG18_20730
PVEUC34_13105
POXMB84_17630
PFGAB870_00175
PNRAT302_19050
PFIBPI93_014860
PCOMNTU39_14705
TVLFAZ95_34500
BOJCBF45_03330 CBF45_06585
PUTPT7_0125
PUDG9Q38_03570 G9Q38_10260
AFAUZ73_01330 UZ73_07535
AFQAFA_11055
AAQUD3M96_11865
AAMMFE795_10295
PIGEGT29_13920
KGYEHF36_03780 EHF36_07020
RFRRfer_0274
RSBRS694_00925
RHYRD110_11725
RHFEUB48_13060
RHOAHZ993_17690
RHOBHTY51_10060
POLBpro_3111
PNAPnap_0605
ACKC380_01285
ACRABSY15_1662
ACIOEAG14_20805
ARADKI609_01255
VAPVapar_4402
VPEVarpa_5065
VPDVAPA_1c45750
VAAAX767_13925
VBOCKY39_14475 CKY39_27680
VAMC4F17_23700
CTTCtCNB1_2298 CtCNB1_4139
CTESO987_24730
CAQTKAQ61_13310
AANTHUK68_18610
CRJQMY55_20410
RTARta_25000
OTKC6570_11155
LIML103DPR2_01477(paaF_3)
LIHL63ED372_00989(paaF_3)
HYRBSY239_2238
HYBQ5W_08965
HYLLPB072_16170
HYCE5678_08855
HPSEHPF_07975(paaF3)
HYNF9K07_12120
HTNKI616_18245
HCZG9Q37_03380
CBAASRAA_0578
CBABSMCB_0808
HGRDW355_09600
STHMIS481_04375 IS481_07635
PBHAAW51_0441
SNNEWH46_03165
SMIOCATMQ487_34530(fad_1) CATMQ487_47190(fad_2)
ATERMW290_20370
LCHLcho_0994
HSEHsero_4006
HSZACP92_20000
HRBHrubri_3960
HEEhmeg3_01130
HHFE2K99_20860
HFRG5S34_21750
SHDSUTH_01232
DOEDENOEST_0611(dmdD)
EBAebA5318 ebA5619
ABREpbN1_04090
APETToN1_09320
AZOazo2498(paaG3)
AOAdqs_2651
AZAAZKH_2163
AZIAzCIB_2731
AZDCDA09_14720
TMZTmz1t_2492
TCLTchl_1082
THKCCZ27_15680 CCZ27_17835
TAKTharo_1120
DDZDSYM_02080
BEBABWI17_21020
MLOmlr6976
NIYFQ775_21445
NTUNTH_01134(dmdD)
MESOBSQ44_21420
CHEAPVE73_06185
AMISAmn_19980
ORMHTY61_05125
ESJSJ05684_b59780
EAKEKH55_4145
ATUAtu1417(fad)
ALFCFBP5473_16040
AVQHRR99_21620
ASALCFBP5507_05425
ALEGCFBP4996_22065
NGLRG1141_CH41200
NGGRG540_CH41720
NEOCYG48_15380
NPMQEO92_25050
RHTNT26_3192(fad)
RFVRFYW14_03205
PDESFE840_020140
HOEIMCC20628_02027
BJAblr7844(fad)
BJUBJ6T_84670
BJPRN69_40915
BRABRADO0962
BBTBBta_5093 BBta_7093
BRSS23_09440(fad)
AOLS58_66670
BRCBCCGELA001_33005
BRADBF49_4145
BICLMTR13_35510
BROBRAD285_0457
BRKCWS35_02980
BOTCIT37_06570
BRQCIT40_28175
BGQX265_33275
BGZXH91_31675
BSYMCIT39_27190
BBETF8237_19635
BARHWN72_05965
BVZBRAD3257_8266(fad)
BELBE61_14310(fad)
BDGLPJ38_00680
BSEPHAP48_0019025
BQBJ4P68_0022520
BSEIKMZ68_23760
BBANJ4G43_047470
BCANBcanWSM471_05700
BAUTQA635_39400
BBRAQA636_40455
BGKIC762_33975
BCOUIC761_33305
BPAHQA639_39410
BXNI3J27_36065
BROSQUH67_04225
BRAZLRP30_39450
BOYLQG66_19995
RPATX73_009185
RPBRPB_3578
RPDRPD_1886
RPERPE_3803
RPTRpal_1988
RPXRpdx1_3746
RBKE0H22_20670
TRBHB776_16035
TALZRPMA_23635
BVESQO058_30965
MNOMnod_6456
MAQUMaq22A_c00770(caiD)
MEEDA075_12475
MTEADK419_20350
MINDmvi_14950(paaG)
RHZRHPLAN_62540 RHPLAN_69940
PHLKKY_2321
PEMOF122_05250
DEQXM25_21120
DEIC4375_05470
DEAFPZ08_20665
DSALK1X15_01035
DEVOH4N61_07420
DOYJI749_05660
YTIFNA67_02440
MHARL1P08_13135
BVRBVIR_1682
BLAGBLTE_16420(fad)
MAADAZF01_17850 AZF01_20095
MLUTJET14_00305 JET14_17550
PSINCAK95_06170 CAK95_14960
BRND1F64_22285
PPHRAPZ00_03860 APZ00_05265
LAPACP90_06325
LABRCHH27_14215
LABTFIU93_11965(paaF2)
LAGGB0E33_17875
RPOPK1718_06715
PHRC6569_04915
PSTGE8M01_13635
PAQTE8L99_07120
ACUTMRB58_01555 MRB58_08790(dmdD)
SILSPO3805(dmdD)
JANJann_0665
PGAPGA1_262p01540 PGA1_262p01850
PGLPGA2_239p1720
PGDGal_03918
PHPPhaeoP97_03685
PPICPhaeoP14_03588
PHQD1820_17695
LMDMETH_04510
LEJETW24_05600
LEVETW23_14095
CIDP73_1463
CEHCEW89_18655
CBAKDA792_03695
YPACCEW88_03015
YANAYJ57_10060
SUAMBOO69_11775
SULZC1J03_19935
SPOTG6548_08570
SMEDJNX03_19590(dmdD)
SUALKDD17_12510
SPSESULPSESMR1_00293(dmdD) SULPSESMR1_03318(dmdD)
AHTANTHELSMS3_04102(dmdD)
SAGUCDO87_15325
OCDFHY55_02030
MALUKU6B_17010(fad)
TGLHFZ77_03705 HFZ77_13875
PALXGQA70_14310
LALGLentiSH36_00182
TRYQF118_09170
PLCGRVY76_09350
MARUFIU81_05950(echA1)
PDEPden_2560
PCONB0A89_04960
PZHCX676_15280
PAROCUV01_03995 CUV01_04030 CUV01_08275
PARUCYR75_11380
PARSDRW48_04255
PARREOJ32_01265
PKDF8A10_09685
PPANESD82_11390
PSANHGN31_07185
PMAUCP157_00210(dmdD)
PMEHJWJ88_01160
PSEWJHW44_00370
PSAPJHX88_11465
PFISJHX87_11675
PAEXJHW48_01000 JHW48_17445
PSTLJHW45_02485
PVERE3U25_21305
PALSPAF20_15865
PDIMPAF18_14755
PFEOE3U26_09575
PTPRCA23_c26210(crt)
DONBSK21_06015
RBZB9057_07500
SALOEF888_01205 EF888_16370
SEDIEBB79_18915
PPSOQPJ95_17065
PPRUFDP22_13980
PALWPSAL_022640(dmdD)
PSHQF3W81_00380 F3W81_12695
PGVSL003B_2869(fad)
GCEKYE46_16960
NSMJO391_18160
SINRO5O51_14205(dmdD)
AMYLQBD29_08785
AMAQGO499_03935
PBAEP8S53_04770
RBGBG454_07465
SSYSLG_07670 SLG_35020
ERYCP97_08825
RAPRHOA_5185(dmdD)
FERFNB15_11965
TIIDY252_19175
THAIIT893_02215
TTBMACH01_04440(fad)
NACINUH88_16325
TMOTMO_c0641
PAUUE8A73_040205
SGRFSGFS_022310
SLAUSLA_7088
SPHVF9278_04880
SGXH4W23_04770
KITCFP65_0448
ALXLVQ62_14330
ARSADJ73_05985
BLINBLSMQ_1405
BCAUI6G59_01295
AGRAAGRA3207_007192
FRIFraEuI1c_2567
AMDAMED_3269(paaG)
AMNRAM_16630
AMMAMES_3233(paaG)
AMZB737_3233(paaG)
APRTMUY14_19030
AMOGQRX60_32475
PSEHXF36_04825
PAUTPdca_17660(paaG_4)
PBROHOP40_01125
PPELH6H00_01695
ACTYOG774_06220
DVCDvina_24630
DAURDaura_31230
DMATDmats_20240
JTLM6D93_11190
HHYHalhy_0462
SLISlin_1561
SPIRCWM47_14210
SPIKEXU85_00745
SRHOHH216_17380
SENFGJR95_37955
RHOZGXP67_01720
EOLEmtol_1593
RSIRunsl_0511
RUPDTQ70_10440
MARBCJ263_16340
MLIONYZ99_12385
 » show all
Reference
1  [PMID:23704947]
  Authors
Tan D, Crabb WM, Whitman WB, Tong L
  Title
Crystal structure of DmdD, a crotonase superfamily enzyme that catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA.
  Journal
PLoS One 8:e63870 (2013)
DOI:10.1371/journal.pone.0063870
  Sequence
[sil:SPO3805]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.155
IUBMB Enzyme Nomenclature: 4.2.1.155
ExPASy - ENZYME nomenclature database: 4.2.1.155
BRENDA, the Enzyme Database: 4.2.1.155

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