KEGG   ENZYME: 4.2.1.160
Entry
EC 4.2.1.160                Enzyme                                 

Name
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one cyclohydrolase
Reaction(IUBMB)
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one = 7,8-dihydroneopterin 3'-phosphate + H2O [RN:R11072]
Reaction(KEGG)
R11072
Substrate
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304]
Product
7,8-dihydroneopterin 3'-phosphate [CPD:C05925];
H2O [CPD:C00001]
Comment
The enzyme participates in a folate biosynthesis pathway in Chlamydia.
History
EC 4.2.1.160 created 2015
Pathway
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K22100  2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
Genes
CTR: CT_327(trpC)
CTD: CTDEC_0327(trpC)
CTF: CTDLC_0327(trpC)
CTRD: SOTOND1_00344
CTRO: SOTOND5_00341
CTRT: SOTOND6_00341
CTA: CTA_0354(trpC)
CTY: CTR_3231(trpC)
CRA: CTO_0354
CTRQ: A363_00348
CTB: CTL0581(trpC)
CTL: CTLon_0577(trpC)
CTO: CTL2C_17
CTJ: JALI_3231(trpC)
CTZ: CTB_3231(trpC)
CSW: SW2_3301(trpC)
CES: ESW3_3301(trpC)
CTRB: BOUR_00345
CTEC: EC599_3351(trpC)
CFS: FSW4_3301(trpC)
CFW: FSW5_3301(trpC)
CTFW: SWFP_3511(trpC)
CTCH: O173_01780
CTRI: BN197_3281(trpC)
CTRA: BN442_3281(trpC)
CTCT: CTW3_01780
CMU: TC_0603(trpF)
CMUR: Y015_03180
CMX: DNC_03060
CMZ: TAC_03180
CPM: G5S_1085(trpF)
CPEC: CPE3_0675(trpF)
CPEO: CPE1_0674(trpF)
CPER: CPE2_0675(trpF)
CFE: CF0437(trpF)
SNG: SNE_A10200(tRPF)
 » show all
Reference
1  [PMID:25006229]
  Authors
Adams NE, Thiaville JJ, Proestos J, Juarez-Vazquez AL, McCoy AJ, Barona-Gomez F, Iwata-Reuyl D, de Crecy-Lagard V, Maurelli AT
  Title
Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species.
  Journal
MBio 5:e01378-14 (2014)
DOI:10.1128/mBio.01378-14
  Sequence
[ctb:CTL0581]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.160
IUBMB Enzyme Nomenclature: 4.2.1.160
ExPASy - ENZYME nomenclature database: 4.2.1.160
BRENDA, the Enzyme Database: 4.2.1.160

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