KEGG   ENZYME: 4.2.1.161
Entry
EC 4.2.1.161                Enzyme                                 

Name
bisanhydrobacterioruberin hydratase;
CruF;
C50 carotenoid 2'',3''-hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
bacterioruberin hydro-lyase (bisanhydrobacterioruberin-forming)
Reaction(IUBMB)
bacterioruberin = bisanhydrobacterioruberin + 2 H2O (overall reaction);
(1a) bacterioruberin = monoanhydrobacterioruberin + H2O;
(1b) monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O
Substrate
bacterioruberin;
monoanhydrobacterioruberin
Product
bisanhydrobacterioruberin;
H2O [CPD:C00001];
monoanhydrobacterioruberin
Comment
The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the introduction of hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin to generate bacterioruberin.
History
EC 4.2.1.161 created 2015
Orthology
K08977  bisanhydrobacterioruberin hydratase
Genes
BPF: BpOF4_14580
BWH: A9C19_15115
PLL: I858_009390
PANA: BBH88_05415
PDG: BCM40_01780
PHC: BBI08_10730
PPLA: BBI15_09570
PFAE: AJGP001_15415
PLX: CW734_15670
PANC: E2636_00250
MWO: MWSIV6_0343(cruF)
HAL: VNG_1681C
HSL: OE_3377R
HHB: Hhub_3182
HALH: HTSR_0320
HHSR: HSR6_0306
HMA: rrnAC0318
HHI: HAH_1056
NPH: NP_4768A(cruF)
NMO: Nmlp_3028
HUT: Huta_2375
HTI: HTIA_2108
HMU: Hmuk_1362
HALL: LC1Hm_0583
HWA: HQ_2861A(cruF)
HWC: Hqrw_3255(cruF)
HVO: HVO_2526
HME: HFX_2548
HLA: Hlac_1899
HDF: AArcSl_1203(cruF)
HTU: Htur_2702
NMG: Nmag_1003
NAT: NJ7G_1610
SALI: L593_04755
 » show all
Reference
1  [PMID:25712483]
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.161
IUBMB Enzyme Nomenclature: 4.2.1.161
ExPASy - ENZYME nomenclature database: 4.2.1.161
BRENDA, the Enzyme Database: 4.2.1.161

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