KEGG   ENZYME: 4.2.1.163
Entry
EC 4.2.1.163                Enzyme                                 

Name
2-oxo-hept-4-ene-1,7-dioate hydratase;
HpcG
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(4S)-4-hydroxy-2-oxoheptanedioate hydro-lyase [(4Z)-2-oxohept-4-enedioate-forming]
Reaction(IUBMB)
(4Z)-2-oxohept-4-enedioate + H2O = (4S)-4-hydroxy-2-oxoheptanedioate
Substrate
(4Z)-2-oxohept-4-enedioate;
H2O [CPD:C00001]
Product
(4S)-4-hydroxy-2-oxoheptanedioate
Comment
Requires Mg2+ [2]. Part of a 4-hydroxyphenylacetate degradation pathway in Escherichia coli C.
History
EC 4.2.1.163 created 2016
Reference
1
  Authors
Burks, E.A., Johnson, W.H., Jr. and Whitman, C.P.
  Title
Stereochemical and isotopic labeling studies of 2-oxo-hept-4-ene-1,7-dioate hydratase: evidence for an enzyme-catalyzed ketonization step in the hydration reaction.
  Journal
J Am Chem Soc 120:7665-7675 (1998)
Reference
2  [PMID:17559873]
  Authors
Izumi A, Rea D, Adachi T, Unzai S, Park SY, Roper DI, Tame JR
  Title
Structure and mechanism of HpcG, a hydratase in the homoprotocatechuate degradation pathway of Escherichia coli.
  Journal
J Mol Biol 370:899-911 (2007)
DOI:10.1016/j.jmb.2007.05.006
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.163
IUBMB Enzyme Nomenclature: 4.2.1.163
ExPASy - ENZYME nomenclature database: 4.2.1.163
BRENDA, the Enzyme Database: 4.2.1.163

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