KEGG   ENZYME: 4.2.1.176
Entry
EC 4.2.1.176                Enzyme                                 
Name
L-lyxonate dehydratase;
lyxD (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
L-lyxonate hydro-lyase
Reaction(IUBMB)
L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O [RN:R12761]
Reaction(KEGG)
R12761
Substrate
L-lyxonate [CPD:C05412]
Product
2-dehydro-3-deoxy-L-arabinonate [CPD:C00684];
H2O [CPD:C00001]
Comment
The enzyme, characterized from several bacterial species, is involved in an L-lyxonate degradation pathway.
History
EC 4.2.1.176 created 2021
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Orthology
K25260  L-lyxonate dehydratase
Genes
VNIVIBNI_A2748
PAEPA2215
PAEVN297_2288
PAEIN296_2288
PAUPA14_36070
PAPPSPA7_3074
PAGPLES_31101
PAFPAM18_2820
PNCNCGM2_3197
PDKPADK2_14580
PSGG655_14075
PRPM062_11485
PAEPPA1S_14655
PAERPA1R_gp5686
PAEMU769_14255
PAELT223_15885
PAESSCV20265_3159
PAEUBN889_02428
PAEGAI22_19130
PAECM802_2285
PAEOM801_2287
PFUWKF707C_35940
PFVPsefu_3500
PORAPT59_10125
PFLPFL_1526
PPRCPFLCHA0_c15650(rhmD)
PPROPPC_1579
PMANOU5_1926
PPUUPputUW4_03993
PCZPCL1606_45950
PSESPSCI_3331
PSEMTO66_07560
PPSLBJP27_01105
PSETTHL1_1954
PSILPMA3_22190
PUMHGP31_07660
PAZEKSS91_21525
PWYHU734_016075
CSACsal_3195
HELHELO_1039
HHUAR456_00250
HAFC8233_17710
CMAIBFX80_06500
CAMHLCW13_10980
NIKF5I99_14090
ZDFAN401_02135
RPJN234_21945
REHH16_B0217(h16_B0217)
CNCCNE_2c02020(rhmD)
CUHBJN34_21110
CTIRALTA_B0224
CBWRR42_s0469
CPAUEHF44_25900
COXE0W60_07040
BURBcep18194_B3056
BCNBcen_5055
BCHBcen2424_5805
BCMBcenmc03_4374
BCJBCAM0105
BAMBamb_5071
BACBamMC406_3211
BCTGEM_5480
BPYRABD05_20730
BCONNL30_24960
BUBBW23_4350
BDFWI26_15740
BMECWJ16_20385
BSTGWT74_22170
BANNJFN94_18895
BURKDM992_26930
PSPWBJG93_18985
PHSC2L64_52295
PGPCUJ91_33860
PTSCUJ90_25765
PCAFDSC91_001465
PGISI6I06_18815
PLGNCTC10937_00902(rhmD)
CABASBC2_46440(rhmD_1)
BUOBRPE64_CCDS05550
BHOD560_1638
BHMD558_1625
BPDZBBN53_13500
AXYAXYL_04352
AXONH44784_063341
AXNAX27061_4575
AXXERS451415_04606(rhmD)
ADTAPT56_21020
AISBUW96_10935
ASWCVS48_23110
ACHRC2U31_16370
ACHBDVB37_17500
ADYHLG70_02410
ODIODI_R4259
PIGEGT29_26810
PARKLSG25_14225
POLBpro_2836
AAAAcav_4647
AMONH9L24_15660
AANTHUK68_00050
VEIVeis_2709
DACDaci_4982
DELDelCs14_1863
DTSBI380_30720
DHKBO996_22905
DLAI6G47_31130
CTTCtCNB1_3909
CTESO987_23540
XYKGT347_21920
LAPACP90_11025
LABTFIU93_16600(rhmD)
LAGGB0E33_22960
SILSPOA0245
DSHDshi_2447
OAROA238_c12500
MALGMALG_04380
SULZC1J03_13125
SULDB5M07_05335
SINLDSM14862_02692(rhmD)
THAACFI11_20010
RMBK529_014370
LITFPZ52_15855
FAPGR316_08205
NOVTQ38_021080
SPLKAV944_09450
SECHB18_22990
SPYGYGS_C2P0893
PELSAR11G3_00242
PEGE5R92_02240
CPRFK7H06_02625
LASAL9O85_02320
GRWFTO74_13075
TRSTerro_1099
TALBFTW19_09760
ABASACPOL_3229
EDAGWR55_02175
SUSAcid_5323
GBAJ421_4870
SPIBG8759_22500
FIBA6C57_05160
 » show all
Reference
1  [PMID:24831290]
  Authors
Ghasempur S, Eswaramoorthy S, Hillerich BS, Seidel RD, Swaminathan S, Almo SC, Gerlt JA.
  Title
Discovery of a novel L-lyxonate degradation pathway in Pseudomonas aeruginosa PAO1.
  Journal
Biochemistry 53:3357-66 (2014)
DOI:10.1021/bi5004298
  Sequence
[pae:PA2215]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.176
IUBMB Enzyme Nomenclature: 4.2.1.176
ExPASy - ENZYME nomenclature database: 4.2.1.176
BRENDA, the Enzyme Database: 4.2.1.176

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