KEGG   ENZYME: 4.2.1.177
Entry
EC 4.2.1.177                Enzyme                                 
Name
(2S)-3-sulfopropanediol dehydratase;
hpfG (gene name);
(S)-DHPS dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(2S)-2,3-dihydroxypropane-1-sulfonate hydro-lyase
Reaction(IUBMB)
(2S)-2,3-dihydroxypropane-1-sulfonate = 3-oxopropane-1-sulfonate + H2O [RN:R12762]
Reaction(KEGG)
R12762
Substrate
(2S)-2,3-dihydroxypropane-1-sulfonate [CPD:C22383]
Product
3-oxopropane-1-sulfonate [CPD:C22384];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Klebsiella oxytoca, participates in (2S)-2,3-dihydroxypropane-1-sulfonate degradation. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (AdoMet) and a [4Fe-4S] cluster.
History
EC 4.2.1.177 created 2021
Pathway
ec00566  Sulfoquinovose metabolism
Orthology
K25255  (2S)-3-sulfopropanediol dehydratase
Genes
KLW: DA718_17260
VSI: MTO69_14830
VSH: BSZ05_23405
VID: DBX26_22625
VIC: SNR28_05555
VIV: IUZ65_008655
PACE: A6070_10230
DWD: DSCW_25080(pflF)
DEK: DSLASN_28540(pflD_2)
ECAS: ECBG_00900
ERAF: J9537_17010
HHJ: NQ487_06060
TEM: JW646_00005
TGC: L0P85_08360
TPET: TPHSE_18710(cutC_1)
NCD: ACONDI_00248(cutC_1)
HAS: Halsa_0723
IPO: Ilyop_0053 Ilyop_0060
 » show all
Reference
1  [PMID:32571930]
  Authors
Liu J, Wei Y, Lin L, Teng L, Yin J, Lu Q, Chen J, Zheng Y, Li Y, Xu R, Zhai W, Liu Y, Liu Y, Cao P, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate.
  Journal
Proc Natl Acad Sci U S A 117:15599-15608 (2020)
DOI:10.1073/pnas.2003434117
  Sequence
[ag:PXW36761]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.177
IUBMB Enzyme Nomenclature: 4.2.1.177
ExPASy - ENZYME nomenclature database: 4.2.1.177
BRENDA, the Enzyme Database: 4.2.1.177

  All links  
Protein sequence (249)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (247)   
DNA sequence (385)   
   RefSeq(nuc) (385)   
All databases (634)   

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