KEGG ENZYME: 4.2.1.180

ENZYME: 4.2.1.180

Entry

EC 4.2.1.180                Enzyme

Name

(E)-benzylidenesuccinyl-CoA hydratase;
bbsH (gene name)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

(R,S)-2-(alpha-hydroxybenzyl)succinyl-CoA hydro-lyase

Reaction(IUBMB)

(R,S)-2-(alpha-hydroxybenzyl)succinyl-CoA = (E)-benzylidenesuccinyl-CoA + H2O [RN:R05599]

Reaction(KEGG)

R05599

Substrate

(R,S)-2-(alpha-hydroxybenzyl)succinyl-CoA [CPD:C09819]

Product

(E)-benzylidenesuccinyl-CoA [CPD:C09818];
H2O [CPD:C00001]

Comment

The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway in which it catalyses the hydration of (E)-benzylidenesuccinyl-CoA.

History

EC 4.2.1.180 created 2022

Pathway

ec00623

Toluene degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K07546

(E)-benzylidenesuccinyl-CoA hydratase

Genes

PRE:	PCA10_26500

PLAL:

FXN65_14895

PMUI:

G4G71_17125

PNT:	G5B91_15070

PMAN:

OU5_6050

PPUU:

PputUW4_02070

PAZE:

KSS91_11305

PIZ:	LAB08_R35060

PMOR:

PMm318_A48080

PDEN:

F1C79_11835

SMAV:

CFF01_02735

HARO:

R50071_22550

RPJ:	N234_31185

REH:	H16_B1905(h16_B1905)

CNC:	CNE_2c18660(caiD2) CNE_BB2p01290

COX:	E0W60_03075 E0W60_35025

CCAM:

M5D45_25520

CCAX:

KZ686_22995

CUK:	KB879_14580

CNAN:

A2G96_24510

CUPP:

CTP10_R54210

BYI:	BYI23_D000190 BYI23_D015950

BURT:

BTHE68_61670

BXB:

DR64_8166

BCAI:

K788_0001079

PHS:	C2L64_18845

PTER:

C2L65_16730

PSAA:

QEN71_15965

PPAI:

E1956_34645

PLAD:

PPGU16_47700(yngF)

PAZZ:

PBP221_56420

PPK:	U875_00905

PPNM:

LV28_12090

PRB:	X636_08490

PVE:	UC34_12395

POX:	MB84_16750

PFG:	AB870_22545

PFIB:

PI93_015345

PCOM:

NTU39_13845

CABK:

NK8_52780

BUE:	BRPE67_DCDS02180 BRPE67_ECDS03050

BFZ:	BAU07_03780

BGM:	CAL15_20540

AXY:	AXYL_00935

AIS:	BUW96_15820

ADY:	HLG70_07290

APES:

FOC84_07700 FOC84_19010

AVH:	WHX56_07060

ACHJ:

LN047_19405

BOZ:	DBV39_02115 DBV39_02665

PIG:	EGT29_02605

VEI:

Veis_4267

VAP:	Vapar_4306

VAM:	C4F17_28090

VAE:	RZE79_31645

HYN:	F9K07_04540 F9K07_12795 F9K07_30315

EBA:	c2A309(bbsH)

ABRE:

pbN1_02910 pbN1_41240

APET:

ToN1_01530(bbsH) ToN1_01950

AZI:	AzCIB_4518

AZD:	CDA09_07460 CDA09_21955

TCL:

Tchl_1392

TAK:	Tharo_3083

MESP:

C1M53_21095

MESR:

FGU64_03160 FGU64_18225

STEG:

QA637_27470

BGEP:

ACP2YO_07910

BOI:	BLM15_17800

XDI:	EZH22_10235

MNO:

Mnod_3481

DEA:	FPZ08_05385

SIW:	GH266_20290

TPRO:

Ga0080559_TMP200

AHT:	ANTHELSMS3_05105(dpgD)

SALO:

EF888_14740

CMAG:

CBW24_16040

NPN:	JI59_22085

SWI:

Swit_1831

SPHD:

HY78_16425

SMIC:

SmB9_10450

GOY:	GLS_c14570

AZL:	AZL_a11240

ABF:	AMK58_28010

AOZ:	HUE56_26015

GME:	Gmet_1524(bbsH)

GEO:	Geob_2423(bbsH)

DTO:	TOL2_C01540(bbsH) TOL2_C04970(bhsH)

DOV:	DSCO28_00450 DSCO28_15530(crt_1) DSCO28_65690

DWD:	DSCW_52990

DVR:	Dvar_31660 Dvar_48670

DMM:	dnm_089830(bhsH)

DGI:	Desgi_0648 Desgi_0671

MPA:

MAP_1681c

MAO:

MAP4_2154

MAVI:

RC58_10730

MAVU:

RE97_10740

MAV:	MAV_1898 MAV_2609 MAV_2740

MAVM:

MAA44156_01671(echA8_5)

MIT:

OCO_13910

MIA:

OCU_14380

MIR:

OCQ_28520

MMAN:

MMAN_42740(paaG_2)

MSER:

MTY59_17300(paaG)

MMC:

Mmcs_2664

MKM:

Mkms_2709

MJL:	Mjls_2694 Mjls_4074

MXE:	MYXE_08760(paaG_1)

MGOR:

H0P51_13730

MBAI:

MB901379_02694(echA8_7)

MHEK:

JMUB5695_00854(paaG_1)

MSPG:

F6B93_12730

MVQ:	MYVA_1802(paaG)

MHAS:

MHAS_01402(dpgD_4) MHAS_02973(crt_5) MHAS_03145(crt_8)

MDU:	MDUV_18880(paaG_2) MDUV_30820(paaG_5)

MCHT:

MCHIJ_11390(paaG_1)

MMOR:

MMOR_28350(paaG_7)

MALV:

MALV_21510(paaG_2)

MHEV:

MHEL_51450

MPOF:

MPOR_04110

MBOK:

MBOE_58920(paaG)

MMON:

EWR22_20920

MGO:	AFA91_20450

MJD:	JDM601_3786(echA16_1)

MTER:

4434518_02926(caiD_2)

MHIB:

MHIB_00880(paaG_1)

MVM:	MJO54_11515

SCAD:

DN051_35625

SALU:

DC74_1107

SALL:

SAZ_06030

STSD:

HEP87_54950

CHRE:

IE160_04085

LDN:	H9L06_08065

ARR:	ARUE_c19020

PSUL:

AU252_00885

FAL:

FRAAL3397

AMQ:	AMETH_4631(paaG)

AMYY:

YIM_21815(caiD3)

BSOL:

FSW04_12815

TBH:	Tbon_00390 Tbon_03710

TFLA:

O0235_09860

» show all

Reference

1 [PMID:34601806]

Authors

von Horsten S, Lippert ML, Geisselbrecht Y, Schuhle K, Schall I, Essen LO, Heider J.

Title

Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation.

Journal

FEBS J 289:1023-1042 (2022)
DOI:10.1111/febs.16216

Sequence

[ag:AAF89843]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.180

IUBMB Enzyme Nomenclature:

4.2.1.180

ExPASy - ENZYME nomenclature database:

4.2.1.180

BRENDA, the Enzyme Database:

4.2.1.180

All links

Gene (245)   
   MGENES (245)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
All databases (251)   

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