KEGG   ENZYME: 4.2.1.22Help
Entry
EC 4.2.1.22                 Enzyme                                 

Name
cystathionine beta-synthase;
serine sulfhydrase;
beta-thionase;
methylcysteine synthase;
cysteine synthase (incorrect);
serine sulfhydrylase;
L-serine hydro-lyase (adding homocysteine)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
Reaction(IUBMB)
L-serine + L-homocysteine = L-cystathionine + H2O [RN:R01290]
Reaction(KEGG)
Substrate
L-serine [CPD:C00065];
L-homocysteine [CPD:C00155]
Product
L-cystathionine [CPD:C02291];
H2O [CPD:C00001]
Comment
A pyridoxal-phosphate protein. A multifunctional enzyme: catalyses beta-replacement reactions between L-serine, L-cysteine, cysteine thioethers, or some other beta-substituted alpha-L-amino acids, and a variety of mercaptans.
History
EC 4.2.1.22 created 1961 (EC 4.2.1.21 created 1961, incorporated 1964, EC 4.2.1.23 created 1961, incorporated 1972)
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K01697  cystathionine beta-synthase
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
Genes
HSA: 102724560(CBSL) 875(CBS)
PTR: 736626(CBS)
PPS: 100974696(CBS)
GGO: 101149756(CBS)
PON: 100459501(CBS)
NLE: 100597744(CBS)
MCC: 100423684(CBS)
MCF: 102115084(CBS)
CSAB: 103221104(CBS)
RRO: 104677999(CBS)
RBB: 108529529(CBS)
CJC: 100414619(CBS)
SBQ: 101033999(CBS)
MMU: 12411(Cbs)
RNO: 24250(Cbs)
CGE: 100762141(Cbs)
NGI: 103729336(Cbs)
HGL: 101703797(Cbs)
CCAN: 109675930(Cbs)
OCU: 100008766(CBS)
TUP: 102470867(CBS)
CFA: 611071(CBS)
AML: 100471372(CBS)
UMR: 103680763(CBS)
ORO: 101364319(CBS)
FCA: 101093038(CBS)
PTG: 102966178(CBS)
AJU: 106985645(CBS)
BTA: 514525(CBS)
BOM: 102285677(CBS)
BIU: 109560704(CBS)
PHD: 102331951(CBS)
CHX: 102184667(CBS)
OAS: 101106301(CBS)
SSC: 110256498(CBS)
CFR: 102520717(CBS)
CDK: 105105848(CBS)
BACU: 103018542(CBS)
LVE: 103083927(CBS)
OOR: 101281381(CBS)
MYB: 102252595(CBS)
MYD: 102771679(CBS)
HAI: 109395181(CBS)
RSS: 109454747(CBS)
PALE: 102882734(CBS)
LAV: 100658430(CBS)
TMU: 101347618
MDO: 100024374(CBS)
SHR: 100919929(CBS)
OAA: 100080879(CBS)
GGA: 418544 418545(CBS)
MGP: 100550886 100551038(CBS)
APLA: 101797717(CBS) 101798015
TGU: 100222166(CBS) 100225076
GFR: 102034131(CBS) 102037167
FAB: 101819123 101819452(CBS)
PHI: 102106314 102108034(CBS)
FPG: 101917543
FCH: 102048888 102052943(CBS)
ASN: 102379548(CBS) 102382178
AMJ: 102560906(CBS) 102563571
CMY: 102931998
ACS: 100566358(cbs) 100566739
XLA: 380308(cbs.L) 446655(cbs.S)
XTR: 493533(cbs)
DRE: 266987(cbsb) 550524(cbsa)
IPU: 100304674(cbs) 108266313
HCQ: 109528297
ELS: 105027337 105031003(cbs)
SFM: 108920076 108933121(cbs)
LCM: 102364567(CBS)
CMK: 103188727(cbs)
CIN: 100180445
SPU: 591266
DME: Dmel_CG1753(Cbs)
DSI: Dsimw501_GD17507(Dsim_GD17507)
MDE: 101897352
AAG: 5570648
AME: 551341(Cbs)
BIM: 100741040
BTER: 100644376
SOC: 105200196
AEC: 105153347
ACEP: 105621555
HST: 105181778
CFO: 105255802
LHU: 105672985
PGC: 109853767
NVI: 100115316
TCA: 656954
NVL: 108557274
PMAC: 106721687
PRAP: 110997439
PXY: 105382358
DNX: 107167969
ZNE: 110839840
TUT: 107361305
CEL: CELE_F54A3.4(cbs-2) CELE_ZC373.1(cbs-1)
CBR: CBG01937
BMY: Bm1_32965
CRG: 105336612
MYI: 110457846
OBI: 106872868
LAK: 106161612
SHX: MS3_01163
EPA: 110242846
SCE: YGR155W(CYS4)
ERC: Ecym_7341
KMX: KLMA_20288(CYS4)
NCS: NCAS_0C05620(NCAS0C05620)
NDI: NDAI_0H00500(NDAI0H00500)
TPF: TPHA_0K01840(TPHA0K01840)
TBL: TBLA_0E01580(TBLA0E01580)
TDL: TDEL_0F02810(TDEL0F02810)
KAF: KAFR_0I01230(KAFR0I01230)
PIC: PICST_77227(CYS4)
SPAA: SPAPADRAFT_131723(CYS4)
CAL: CAALFM_C101870CA(CYS4)
CAUR: QG37_07677
SLB: AWJ20_5157(CYS4)
NCR: NCU08216
NTE: NEUTE1DRAFT64117(NEUTE1DRAFT_64117)
MGR: MGG_07384
MAW: MAC_08907
MAJ: MAA_09697
CMT: CCM_08097
BFU: BCIN_16g03500(Bccys4)
MBE: MBM_09114
ANI: AN5820.2
ANG: ANI_1_354044(An05g00160)
ABE: ARB_07681
TVE: TRV_01035
PTE: PTT_02279
CNE: CNA06170
CNB: CNBA5980
ABP: AGABI1DRAFT70201(AGABI1DRAFT_70201)
ABV: AGABI2DRAFT205908(AGABI2DRAFT_205908)
DDI: DDB_G0267386(cysB)
DFA: DFA_09240(cysB)
SMIN: v1.2.004841.t1(symbB.v1.2.004841.t1)
PTI: PHATRDRAFT_42003(Cbs)
LMA: LMJF_17_0250(CYSB)
LIF: LINJ_17_0300(CYSB)
LBZ: LBRM_17_0230(CYSB)
ENC: ECL_02360
ECLO: ENC_13590
EEC: EcWSU1_01870(cbs)
ECLX: LI66_09405
ECLY: LI62_10175
ESA: ESA_02767
CSK: ES15_2857
CTU: CTU_11050
KPN: KPN_03409
KPU: KP1_4684
KPP: A79E_0713
KPE: KPK_0709
KPJ: N559_0772
KPX: PMK1_00884(cbs)
KPNU: LI86_03740
KPNK: BN49_0695
KVA: Kvar_0682
KOX: KOX_02795
KOE: A225_5008
EAE: EAE_18845
EAR: CCG30114
CKO: CKO_01706
HDE: HDEF_1873(cysK)
YEN: YE1470(uptG)
YEY: Y11_03511
YEW: CH47_888
YET: CH48_177
YEE: YE5303_13201(uptG)
YAL: AT01_1034
YFR: AW19_1752
YIN: CH53_217
YKR: CH54_4034
YRO: CH64_1104
YRU: BD65_3185
SPE: Spro_1627
SRL: SOD_c14980(cbs)
SPLY: Q5A_008100(cbs) Q5A_011975(cysM_1)
SMAF: D781_1541
SMAR: SM39_1070
SERF: L085_20420
ECA: ECA4113
PATR: EV46_20470
PATO: GZ59_41670
PCT: PC1_3903
PLU: plu0524
PAY: PAU_00518(mtcB)
PMR: PMI0235
XBO: XBJ1_3501
XBV: XBW1_3932
XDO: XDD1_3040
XPO: XPG1_0659
PSI: S70_10355
PSX: DR96_1124
ETR: ETAE_1928(uptG)
ETD: ETAF_1740(uptG)
ETE: ETEE_4004
XFA: XF_0603
XFT: PD_1548(cysM)
XCC: XCC0597(cysB)
XCB: XC_3636
XCP: XCR_0750
XCV: XCV3726
XAX: XACM_3503
XAC: XAC3603(cysB)
XCI: XCAW_04305(cysK)
XOO: XOO0777(cysB)
XOM: XOO0707(XOO0707)
XOP: PXO_03155(cysB)
XOR: XOC_3871(cysB)
XAL: XALC_2713
XPH: XppCFBP6546_16305(XppCFBP6546P_16305)
SML: Smlt0616(cbsB)
SMT: Smal_0488
SMZ: SMD_0527(cbsB)
SACZ: AOT14_06060(cbsB)
PSUW: WQ53_11130
PSD: DSC_02405
DKO: I596_69
PAE: PA0399
PAEV: N297_410
PAEI: N296_410
PAEP: PA1S_02025
PAEM: U769_02060
PAEL: T223_02020
PAEG: AI22_01875
PAEC: M802_409
PAEO: M801_410
PCQ: PcP3B5_05400(cbs)
PFS: PFLU_3406
PFB: VO64_0543
PMAN: OU5_5248
PKC: PKB_0418
PSEM: TO66_08620
PANR: A7J50_3129
PSET: THL1_259
PSIL: PMA3_16725
ILO: IL0218(cysM)
PSEN: PNC201_10885(cbs)
CBD: CBUD_2125
CBG: CbuG_2033
CBC: CbuK_2075
LLO: LLO_0076(cysK)
LFA: LFA_3723(cysK)
LHA: LHA_3116(cysK)
LOK: Loa_00120
LCD: clem_00670(cysK)
TMC: LMI_3045
FTU: FTT_1287(cbs)
FTQ: RO31_1496
FTF: FTF1287(cbs)
FTT: FTV_1230(cbs)
FTG: FTU_1314(cbs)
FTL: FTL_1174
FTH: FTH_1148(cysK)
FTA: FTA_1238
FTS: F92_06485
FTI: FTS_1148(cysK)
FTC: DA46_1609
FTV: CH67_1537
FTZ: CH68_1270
FTM: FTM_1079(cysK)
FTN: FTN_1302(cysK)
FTX: AW25_704
FTD: AS84_1211
FTY: CH70_623
FPH: Fphi_1379
FPT: BZ13_610
FPI: BF30_1642
FPM: LA56_782
FPX: KU46_1930
FPZ: LA55_1467
FPJ: LA02_1057
FNA: OOM_0454
HCH: HCH_03693
KKO: Kkor_1767
CVI: CV_3395(cysB2)
PSE: NH8B_0056
BMA: BMA1621
BMAL: DM55_266
BMAE: DM78_1928
BMAQ: DM76_244
BMAI: DM57_441
BMAF: DM51_1317
BMAZ: BM44_1740
BMAB: BM45_1302
BPS: BPSL2215
BPSE: BDL_3329
BPSM: BBQ_1440
BPSU: BBN_1565
BPSD: BBX_1730
BPK: BBK_2744
BPSH: DR55_2365
BPSA: BBU_3349
BPSO: X996_1952
BUT: X994_369
BTQ: BTQ_1940
BTJ: BTJ_414
BTZ: BTL_1655
BTV: BTHA_1809
BTHE: BTN_3113
BTHM: BTRA_1934
BTHA: DR62_3259
BTHL: BG87_1879
BOK: DM82_1802
BOC: BG90_2917
BSTG: WT74_21570
BGP: BGL_2c03850(cysB)
AXX: ERS451415_01161(cbs)
POL: Bpro_2830
JAG: GJA_2053
CFU: CFU_1537(cysM)
CARE: LT85_3220
RGE: RGE_20080(cbs)
RDP: RD2015_67
DSU: Dsui_2043
MXA: MXAN_2041
CCX: COCOR_06049(cbs1)
SCL: sce0438 sce8782(cysB)
HOH: Hoch_5286
BBA: Bd3796
BBAT: Bdt_3675
BBW: BDW_13965
BBAC: EP01_11485
BEX: A11Q_2499
BMX: BMS_3011
MLO: mll4505
AMIH: CO731_00550(cysK_1)
RGA: RGR602_PC00900(cysK-2)
BBT: BBta_0633
RPA: RPA2356
RPT: Rpal_2600
VGO: GJW-30_1_02182(cbs)
RVA: Rvan_1851
BVR: BVIR_363
RBM: TEF_00860
CAK: Caul_4907
PZU: PHZ_c0071
RRU: Rru_A0787
RRF: F11_04035
RCE: RC1_1987(cbs)
MAG: amb1847
TMO: TMO_c0648(cysB)
SAY: TPY_1780
MTU: Rv1077(cbs)
MTV: RVBD_1077
MTC: MT1108
MRA: MRA_1087(cbs)
MTUR: CFBS_1139(cbs)
MTO: MTCTRI2_1105(cbs)
MTD: UDA_1077(cbs)
MTN: ERDMAN_1202(cbs)
MTUE: J114_05815
MTUL: TBHG_01061
MTUT: HKBT1_1138(cbs)
MTUU: HKBT2_1143(cbs)
MTQ: HKBS1_1140(cbs)
MBO: BQ2027_MB1106(cbs)
MBB: BCG_1135(cbs)
MBT: JTY_1108(cbs)
MBM: BCGMEX_1107(cbs)
MBX: BCGT_0896
MAF: MAF_10900(cbs)
MCE: MCAN_10831(cbs)
MCQ: BN44_11193(cbs)
MCV: BN43_30130(cbs)
MCX: BN42_20925(cbs)
MCZ: BN45_30118(cbs)
MLE: ML2396(cysM2)
MLB: MLBr02396(cysM2)
MPA: MAP_1024(cysM2)
MAO: MAP4_2833
MAVI: RC58_14040
MAVU: RE97_14065
MAV: MAV_1201
MAVD: NF84_05290
MAVR: LA63_05410
MAVA: LA64_05425
MIT: OCO_11060
MIA: OCU_11050
MID: MIP_01784
MYO: OEM_11170
MIR: OCQ_11090
MUL: MUL_0203(cbs)
MMC: Mmcs_4149
MKM: Mkms_4224
MJL: Mjls_4380
MMI: MMAR_4390(cbs)
MMAE: MMARE11_42100(cbs)
MMM: W7S_05415
MLI: MULP_04605(cbs)
MHAD: B586_06980
MSG: MSMEI_5131(cbs)
MVA: Mvan_4674
MGI: Mflv_2043
MPHL: MPHLCCUG_04264(cbs)
MVQ: MYVA_4502
MAB: MAB_1195
MABB: MASS_1193
MABO: NF82_06045
MJD: JDM601_1023(cbs)
MTER: 4434518_01009(cbs)
ASD: AS9A_3444
CJK: jk1981(cysY)
CPU: cpfrc_00621(tsb)
CPL: Cp3995_0630(cbs)
CPG: Cp316_0641(cbs)
CPP: CpP54B96_0630(cbs)
CPK: Cp1002_0619(cbs)
CPQ: CpC231_0619(cbs)
CPX: CpI19_0618(cbs)
CPZ: CpPAT10_0620(cbs)
COR: Cp267_0647(cbs)
COP: Cp31_0626(cbs)
COD: Cp106_0603(cbs)
COS: Cp4202_0613(cbs)
COI: CpCIP5297_0630(cbs)
COE: Cp258_0625(cbs)
COU: Cp162_0618(cbs)
CPSE: CPTA_01170
CPSU: CPTB_00362
CPSF: CPTC_01160
CRD: CRES_0026
CUL: CULC22_00669(tsb)
CUN: Cul210932_0697(cbs)
CUS: CulFRC11_0666(cbs)
CUQ: Cul210931_0666(cbs)
CUZ: Cul05146_0715(cbs)
CUJ: CUL131002_0675c(cbs)
NFR: ERS450000_05046(cysM_2) ERS450000_05083(cbs)
RER: RER_42660(cbs)
REY: O5Y_19970
ROP: ROP_59040(cbs)
REQ: REQ_12820(cysB)
RHB: NY08_1978
RFA: A3L23_00312(cbs)
RHS: A3Q41_03095(cbs)
RHU: A3Q40_02404(cbs)
GBR: Gbro_1617
GPO: GPOL_c14990(cysB)
GOR: KTR9_1593
TPR: Tpau_3152
SCO: SCO3077(SCE25.18c)
SMA: SAVERM_3510(cysM1)
SGR: SGR_4452
SGB: WQO_13265
SCT: SCAT_2096(CBS)
SFA: Sfla_3825
SBH: SBI_04548
SHY: SHJG_4550
SDV: BN159_5202(cbs)
SALB: XNR_1985
SALS: SLNWT_2621
STRP: F750_2908
SFI: SFUL_2683
SLV: SLIV_22310(cbs)
SGU: SGLAU_14015(cbs)
STRM: M444_14480
SPRI: SPRI_4467
SRW: TUE45_04581(cbs) TUE45_06288(cysK)
SLE: sle_41970(sle_41970)
SRN: A4G23_02101(cbs)
STRD: NI25_23390
SMAL: SMALA_3191
SLAU: SLA_2809
SLX: SLAV_05465(cysM1) SLAV_22665(cbs)
KSK: KSE_47260(cbs)
LXX: Lxx17700(cysM2)
CMI: CMM_0872(cysB)
CMS: CMS0127
CMC: CMN_00832(cysB)
MTS: MTES_2412
ART: Arth_3062
ARR: ARUE_c31870(cbs1) ARUE_c37930(cbs2)
ARM: ART_2207
ARX: ARZXY2_640 ARZXY2_96(cysK)
AAU: AAur_3038
KRH: KRH_16340
BCV: Bcav_1054
XCE: Xcel_2671
CFL: Cfla_0925
MPH: MLP_44570(cbs)
NCA: Noca_0939
NDK: I601_1991(cbs)
KFL: Kfla_5676
PSIM: KR76_08975
TFU: Tfu_0438
NDA: Ndas_0083
NAL: B005_2873
TCU: Tcur_1048
FAL: FRAAL0784(cysM)
NML: Namu_4422
GOB: Gobs_4209
BSD: BLASA_4025(cbs)
MMAR: MODMU_4605(cbs)
KRA: Krad_1082
SEN: SACE_0899(cysM2)
AMD: AMED_8107
AMQ: AMETH_5891(cysM2)
PSEA: WY02_04595
PSEH: XF36_20675
AMI: Amir_0700
SESP: BN6_07740
KAL: KALB_840
ACTI: UA75_03950
ACAD: UA74_03850
AHG: AHOG_03680(cbs)
ALL: CRK61565
SAQ: Sare_0855
MIL: ML5_1162
AMS: AMIS_7790
ASE: ACPL_4764(cysM) ACPL_952
ACTN: L083_1111(cysM)
AFS: AFR_05430
CAI: Caci_0644
SNA: Snas_0943
BLO: BL1156(cbsSV)
BLJ: BLD_0914(cysK)
BLN: Blon_2004
BLON: BLIJ_2079
BLF: BLIF_0472
BLL: BLJ_0532
BLB: BBMN68_918(cysK)
BLM: BLLJ_0455
BLG: BIL_13890
BAD: BAD_0490(cbsSV)
BADL: BADO_0502
BLA: BLA_1096(cbsSV)
BBB: BIF_00615
BBC: BLC1_0538
BLV: BalV_0541
BLW: W7Y_0566
BLS: W91_0587
BANI: Bl12_0523
BANL: BLAC_02845
BANM: EN10_02870
BDE: BDP_0670(cysK)
BDN: BBDE_0641
BBI: BBIF_1302(cysK)
BBP: BBPR_1344(cysK)
BBF: BBB_1324(cysB)
BBRU: Bbr_0538(cysK)
BBRE: B12L_0456
BBRV: B689b_0516
BBRJ: B7017_0491
BBRC: B7019_0498
BBRN: B2258_0490
BBRS: BS27_0529(cysK)
BBRD: BBBR_0462
BTP: D805_1238
BKS: BBKW_0515
BPSP: AH67_03185
BANG: BBAG_0433
BCAT: BBCT_0473
BPSC: BBPC_0529
BSCA: BBSC_0711
TBI: Tbis_3118
CWO: Cwoe_0908
GLJ: GKIL_3014
AVA: Ava_4156
HAU: Haur_3718
STI: Sthe_2024
PBF: CFX0092_A0187(cbs)
PNL: PNK_0514(cysK)
PUV: PUV_18680(cbs)
WCH: wcw_1144(cysK)
GES: VT84_23005(cysK_2) VT84_30235(cbs)
SACI: Sinac_7195
PBOR: BSF38_05618(cbs)
ABAC: LuPra_04149(cbs)
GAU: GAU_3907(cbs)
GBA: J421_0897
BLQ: L21SP5_03369(cbs)
SRU: SRU_1123
SRM: SRM_01301(cysK) SRM_03001(cysB)
CPI: Cpin_3667
FLN: FLA_4253
SGN: SGRA_2550
PHE: Phep_1434
SMIZ: 4412673_01065(cbs) 4412673_01966(cysK)
MUC: MuYL_1946
MGOT: MgSA37_03351(cbs)
SLI: Slin_5829
FAE: FAES_3839
HSW: Hsw_0648
FLM: MY04_3160
GFO: GFO_2397
FJG: BB050_00103(cbs_1) BB050_00678(cbs_2)
COC: Coch_1829
RAI: RA0C_0694
RAR: RIA_1801
RAG: B739_1544
RAE: G148_1149
RAT: M949_1970
CBAL: M667_14005
CBAT: M666_13875
DDO: I597_1696(cbs_1) I597_1749(cbs_2)
ZGA: ZOBELLIA_2590(cysK2) ZOBELLIA_4054(cysK1)
POM: MED152_00895(cysK) MED152_03850(cbs)
ELB: VO54_00107(cbs_1) VO54_01609(cbs_2)
MYR: MYRA21_2090(cbs)
MPW: MPR_0888
CHZ: CHSO_2070(srpG2) CHSO_2714(srpG2) CHSO_3814(srpG)
TMAR: MARIT_1683 MARIT_1686(cysK)
AALG: AREALGSMS7_04518(cbs)
FBU: UJ101_00487(CBS)
CTE: CT1921
CPC: Cpar_0287
CCH: Cag_1634
CLI: Clim_2126
PLT: Plut_0281
PPH: Ppha_2553
PAA: Paes_1945
PROC: Ptc2401_02021(cbs)
IAL: IALB_2142 IALB_2149(cysM)
MRO: MROS_2424
MARN: LN42_06055
CABY: Cabys_2929
MBN: Mboo_1990
MPL: Mpal_1157
PYN: PNA2_1580
TLT: OCC_05691
THS: TES1_1395
PPAC: PAP_08745
APE: APE_1223.1 APE_1586(cysK)
ACJ: ACAM_0775 ACAM_0997(cysK)
TAG: Tagg_1314
IAG: Igag_1783
HBU: Hbut_1585
PIS: Pisl_1761
TPE: Tpen_1605
ASC: ASAC_0793
 » show all
Taxonomy
Reference
1  [PMID:5121611]
  Authors
Braunstein AE, Goryachenkova EV, Tolosa EA, Willhardt IH, Yefremova LL.
  Title
Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine  -synthase.
  Journal
Biochim Biophys Acta 242:247-60 (1971)
DOI:10.1016/0005-2744(71)90105-7
Reference
2  [PMID:5672136]
  Authors
Nakagawa H, Kimura H.
  Title
Purification and properties of cystathionine synthetase synthetase from rat liver: separation of cystathionine synthetase from serine dehydratase.
  Journal
Biochem Biophys Res Commun 32:209-14 (1968)
Reference
3  [PMID:13991884]
  Authors
SCHLOSSMANN K, BRUEGGEMANN J, LYNEN F.
  Title
[Biosynthesis of cysteine. I. Detection and isolation of serine sulfhydrase from baker's yeast.]
  Journal
Biochem Z 336:258-73 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.22
IUBMB Enzyme Nomenclature: 4.2.1.22
ExPASy - ENZYME nomenclature database: 4.2.1.22
BRENDA, the Enzyme Database: 4.2.1.22
CAS: 9023-99-8

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