| Entry |
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| Name |
cystathionine beta-synthase;
serine sulfhydrase;
beta-thionase;
methylcysteine synthase;
cysteine synthase (incorrect);
serine sulfhydrylase;
L-serine hydro-lyase (adding homocysteine)
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
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| Reaction(IUBMB) |
L-serine + L-homocysteine = L-cystathionine + H2O [RN: R01290]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal-phosphate protein. A multifunctional enzyme: catalyses beta-replacement reactions between L-serine, L-cysteine, cysteine thioethers, or some other beta-substituted alpha-L-amino acids, and a variety of mercaptans.
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| History |
EC 4.2.1.22 created 1961 (EC 4.2.1.21 created 1961, incorporated 1964, EC 4.2.1.23 created 1961, incorporated 1972)
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| Pathway |
| ec00260 | Glycine, serine and threonine metabolism |
| ec00270 | Cysteine and methionine metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K01697 | cystathionine beta-synthase |
| K10150 | cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Braunstein AE, Goryachenkova EV, Tolosa EA, Willhardt IH, Yefremova LL. |
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| Title |
Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine -synthase. |
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| Journal |
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| Reference |
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| Authors |
Nakagawa H, Kimura H. |
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| Title |
Purification and properties of cystathionine synthetase synthetase from rat liver: separation of cystathionine synthetase from serine dehydratase. |
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| Journal |
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| Reference |
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| Authors |
SCHLOSSMANN K, BRUEGGEMANN J, LYNEN F. |
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| Title |
[Biosynthesis of cysteine. I. Detection and isolation of serine sulfhydrase from baker's yeast.] |
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| Journal |
Biochem Z 336:258-73 (1962) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.1.22 |
| ExPASy - ENZYME nomenclature database: | 4.2.1.22 |
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