| Entry |
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| Name |
CDP-glucose 4,6-dehydratase;
cytidine diphosphoglucose oxidoreductase;
CDP-glucose 4,6-hydro-lyase
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)
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| Reaction(IUBMB) |
CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O [RN: R02426]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
CDP-4-dehydro-6-deoxy-D-glucose [CPD: C01219];
H2O [CPD: C00001]
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| Comment |
Requires bound NAD+.
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| History |
EC 4.2.1.45 created 1972
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
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| Orthology |
| K01709 | CDP-glucose 4,6-dehydratase |
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| Genes |
| KIE: | NCTC12125_00626(rfbG_2) |
| YPI: | YpsIP31758_3050(ddhB) |
| SERA: | Ser39006_021620(rfbG) |
| VAU: | VANGNB10_cI2516c(rfbG) |
| PFW: | PF1751_v1c16350(rfbG) |
| PPUU: | PputUW4_03902(rfbG) |
| LADL: | NCTC12735_01356(rfbG) |
| MMOB: | F6R98_00940(rfbG) F6R98_18990(rfbG) |
| MISZ: | MishRS11D_15740(rfbG) |
| TFRI: | Thiofri_00241(rfbG) |
| GAI: | IMCC3135_26280(rfbG) |
| AEL: | NCTC12917_02824(rfbG) |
| CHRO: | CXB49_01900(rfbG) CXB49_18015(rfbG) |
| REH: | H16_A2896(h16_A2896) |
| BPM: | BURPS1710b_A1962(rfbG) |
| BPL: | BURPS1106A_A0569(rfbG) |
| BPD: | BURPS668_A0663(rfbG) |
| BPZ: | BP1026B_II0471(rfbG) |
| ACIO: | EAG14_02800 EAG14_17740(rfbG) |
| JAL: | BZG29_24195 BZG29_26725 |
| JRI: | P9875_25255(rfbG) P9875_27780(rfbG) |
| HRB: | Hrubri_4298(rfbG) Hrubri_4345(rfbG) |
| HEE: | hmeg3_01990(rfbG) hmeg3_21265(rfbG) |
| HHF: | E2K99_22560(rfbG) E2K99_22970(rfbG) |
| HEW: | HBDW_04800(rfbG) HBDW_45590(rfbG) |
| SHD: | SUTH_02775 SUTH_03353 |
| URU: | DSM104443_03774(rfbG) |
| UPL: | DSM104440_03342(rfbG) |
| RBS: | RHODOSMS8_00396(rfbG) |
| SMEL: | SM2011_b21417(ddhB) |
| SFD: | USDA257_c48650(rfbG) |
| SAME: | SAMCFNEI73_Ch2771(rfbG) |
| EMX: | FKV68_15800(rfbG) FKV68_32445(rfbG) |
| ENU: | PYH37_001046(rfbG) PYH37_004950(rfbG) |
| EGI: | PZN02_002220(rfbG) PZN02_005107(rfbG) |
| STEG: | QA637_12385(rfbG) QA637_20775(rfbG) |
| ENP: | JVX98_07310(rfbG) JVX98_26985(rfbG) |
| AVV: | RvVAT039_21390(rfbG) |
| AVF: | RvVAR031_08690(rfbG) |
| REP: | IE4803_CH00258(rfbG) |
| REI: | IE4771_CH00259(rfbG) |
| RLW: | RlegWSM1455_22895(rfbG) |
| NGG: | RG540_CH01820 RG540_PA05490 |
| PDES: | FE840_019230(rfbG) FE840_019245(rfbG) |
| VGO: | GJW-30_1_04051(rfbG) |
| MMES: | MMSR116_01450(rfbG) |
| PHP: | PhaeoP97_00697(rfbG) |
| NHUM: | PQ457_09205(rfbG) PQ457_20535(rfbG) |
| SPHI: | TS85_04855 TS85_23705 |
| SKR: | BRX40_11815 BRX40_15875 |
| SRF: | LHU95_01725(rfbG) LHU95_05590(rfbG) |
| HCL: | NCTC13205_00576(rfbG) |
| DEF: | CNY67_09330(rfbG) CNY67_09800(rfbG) |
| DOV: | DSCO28_33550(rfbG_2) |
| BDC: | DOE51_07840(rfbG) DOE51_07855(rfbG) |
| BAZ: | BAMTA208_03300(yfnG) |
| BCB: | BCB4264_A3374(rfbG1) BCB4264_A3529(rfbG2) |
| BCG: | BCG9842_B1702(rfbG_1) BCG9842_B3401(rfbG_2) |
| BTB: | BMB171_C3048(rfbG_2) BMB171_C3190(rfbG_1) |
| BTHR: | YBT1520_17835 YBT1520_18635 |
| BTHI: | BTK_17825 BTK_18590 |
| BTHU: | YBT1518_18230 YBT1518_19235 YBT1518_31760 YBT1518_33142 |
| BTHY: | AQ980_12430 AQ980_13190 |
| BBY: | CY96_15840 CY96_16555 |
| BWD: | CT694_17855(rfbG) CT694_29525(rfbG) |
| BTRO: | FJR70_02475(rfbG) FJR70_06625(rfbG) |
| PSOP: | KP014_14055(rfbG) KP014_25625(rfbG) |
| PDY: | QJQ58_25340(rfbG) QJQ58_30030(rfbG) |
| COHN: | KCTCHS21_21040(rfbG_1) KCTCHS21_55310(rfbG_2) |
| COHL: | J4772_33115(rfbG) J4772_33415(rfbG) |
| FFE: | LSG31_03815(rfbG) LSG31_12765(rfbG) |
| DFG: | B0537_06805 B0537_09385 |
| AMIC: | Ami3637_05725(rfbG) |
| MANA: | MAMMFC1_01060(rfbG) |
| MMAE: | MMARE11_22580(galE6) |
| MBAI: | MB901379_02169(rfbG) |
| BALA: | DSM104299_05323(rfbG) |
| SYNW: | SynWH8103_00506(rfbG) |
| CMP: | Cha6605_3683 Cha6605_5432 |
| TSIN: | OXH18_11545(rfbG) OXH18_17350(rfbG) |
| MVZ: | myaer102_45070(rfbG) |
| PRUN: | PCC7821_04167(yfnG) |
| OAC: | Oscil6304_0538 Oscil6304_3532 |
| NSPH: | BDGGKGIB_01798(rfbG) |
| PBF: | CFX0092_A2655(rfbG) CFX0092_A3612(yfnG) |
| VBC: | C5Q97_10055(rfbG) C5Q97_10265(rfbG) |
| TALB: | FTW19_08030(rfbG) FTW19_15130(rfbG) |
| BFG: | BF638R_0780 BF638R_2596 BF638R_3484 |
| BFB: | VU15_06455 VU15_11520 VU15_16420 |
| BCAC: | CGC64_13040(rfbG) CGC64_18590(rfbG) |
| BEG: | INE88_03487(rfbG_1) INE88_04048(rfbG_2) |
| CFAS: | Cfast33896_17340(rfbG) |
| AALG: | AREALGSMS7_03238(rfbG) |
| OCY: | OSSY52_03570 OSSY52_07670 |
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| Reference |
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| Authors |
Hey AE, Elbein AD. |
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| Title |
Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase. |
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| Journal |
J Biol Chem 241:5473-8 (1966) |
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| Reference |
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| Authors |
Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL. |
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| Title |
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3. Cytidine diphosphate D-glucose oxidoreductase. |
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| Journal |
J Biol Chem 241:4283-7 (1966) |
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| Reference |
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| Authors |
Melo A, Elliott WH, Glaser L. |
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| Title |
The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase. |
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| Journal |
J Biol Chem 243:1467-74 (1968) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.1.45 |
| ExPASy - ENZYME nomenclature database: | 4.2.1.45 |
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