KEGG   ENZYME: 4.2.1.74
Entry
EC 4.2.1.74                 Enzyme                                 
Name
medium-chain-enoyl-CoA hydratase;
long-chain enoyl coenzyme A hydratase (incorrect);
long-chain-enoyl-CoA hydratase (incorrect);
long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase (incorrect)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
medium-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase
Reaction(IUBMB)
a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain trans-2-enoyl-CoA + H2O [RN:R02685]
Reaction(KEGG)
R02685 > R04170 R04738 R04740 R04744 R04746 R04749 R07889 R07893 R07897
Substrate
medium-chain (3S)-3-hydroxyacyl-CoA
Product
medium-chain trans-2-enoyl-CoA;
H2O [CPD:C00001]
Comment
Acts in the reverse direction. The best substrate for the porcine enzyme is oct-2-enoyl-CoA. Unlike EC 4.2.1.17 enoyl-CoA hydratase, it does not act on crotonoyl-CoA.
History
EC 4.2.1.74 created 1981, modified 2022
Pathway
ec00062  Fatty acid elongation
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Reference
1  [PMID:833142]
  Authors
Fong JC, Schulz H.
  Title
Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues.
  Journal
J Biol Chem 252:542-7 (1977)
Reference
2  [PMID:4828315]
  Authors
Schulz H.
  Title
Long chain enoyl coenzyme A hydratase from pig heart.
  Journal
J Biol Chem 249:2704-9 (1974)
Reference
3  [PMID:20463021]
  Authors
Arent S, Christensen CE, Pye VE, Norgaard A, Henriksen A
  Title
The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2.
  Journal
J Biol Chem 285:24066-77 (2010)
DOI:10.1074/jbc.M110.106005
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.74
IUBMB Enzyme Nomenclature: 4.2.1.74
ExPASy - ENZYME nomenclature database: 4.2.1.74
BRENDA, the Enzyme Database: 4.2.1.74
CAS: 62009-81-8

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Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (21)   
   KEGG COMPOUND (21)   
Chemical reaction (12)   
   KEGG REACTION (10)   
   KEGG RCLASS (2)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (12)   
   RefSeq(nuc) (6)   
   GenBank (3)   
   EMBL (3)   
All databases (55)   

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