Entry |
|
Name |
uroporphyrinogen-III synthase;
porphobilinogenase;
uroporphyrinogen isomerase;
uroporphyrinogen III cosynthase;
URO-synthase;
hydroxymethylbilane hydro-lyase (cyclizing)
|
Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
|
Sysname |
hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)
|
Reaction(IUBMB) |
hydroxymethylbilane = uroporphyrinogen III + H2O [RN: R03165]
|
Reaction(KEGG) |
|
Substrate |
hydroxymethylbilane [CPD: C01024]
|
Product |
|
Comment |
In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen III from porphobilinogen.
|
History |
EC 4.2.1.75 created 1982
|
Pathway |
ec01110 | Biosynthesis of secondary metabolites |
ec01120 | Microbial metabolism in diverse environments |
|
Orthology |
K01719 | uroporphyrinogen-III synthase |
K13542 | uroporphyrinogen III methyltransferase / synthase |
K13543 | uroporphyrinogen III methyltransferase / synthase |
|
Genes |
BMUS: | 118882294(UROS) 118902080 |
LVE: | 103070979(UROS) 103086247 |
OOR: | 101271671 101284054(UROS) |
PCAD: | 102976236 102991893(UROS) |
PSIU: | 116741749(UROS) 116761203 |
XLA: | 447178(uros.L) 496102(uros.S) |
PTET: | 122333566(uros) 122333585 |
PFOR: | 103150340 103150380(uros) 103150430 |
PLAI: | 106937667 106942890 |
PMEI: | 106912157 106912315 106912389 |
SLAL: | 111655233(uros) 111667826 |
SASA: | 100196505(hem4) 106593753(uros) |
STRU: | 115184969 115185035 |
OMY: | 110515215(uros) 110515885 |
OGO: | 124022414 124029682 124029981 |
OKI: | 109883397 116360849 116364083 |
SNH: | 120041332 120041334(uros) |
LPIC: | 129273179 129273334 |
DME: | Dmel_CG1885(Uros1) Dmel_CG9589(Uros2) |
DSI: | Dsimw501_GD19046(Dsim_GD19046) Dsimw501_GD27476(Dsim_GD27476) |
DYA: | Dyak_GE17428 Dyak_GE24337 |
ASTE: | 118513791 118517115 |
AALB: | 109421499 109622955 |
ACER: | 107994429 107994465 |
MAEA: | 128211026 128211818 |
CSAT: | 104703185 104709839 104714119 104752280 104766594 |
HSYR: | 120168267 120198883 |
AHF: | 112705821 112763736 112765328 |
QSA: | O6P43_016093 O6P43_018899 |
MSYL: | 126603540 126631609 |
CMAX: | 111492039 111496019 |
CMOS: | 111454223 111462623 |
CPEP: | 111798445 111806046 |
MESC: | 110605855 110614517 |
SSPL: | 121792131 121792709 |
ECAD: | 122589860 122608906 |
MING: | 122074560 122078731 |
PSOM: | 113289472 113297294 113297302 |
TAES: | 100037610 123084682 123093428 |
MFLO: | 136505527 136540518 |
SITA: | 101763667 101783745 |
PVIR: | 120642509 120647061 120691032 |
ACAK: | 137935904 137940967 |
SMO: | SELMODRAFT_403066 SELMODRAFT_422651 |
CVR: | CHLNCDRAFT_144105 CHLNCDRAFT_34953 |
MPP: | MICPUCDRAFT_50233(HEMD) |
CGR: | 2891021(GVI51_L10945) |
NCS: | NCAS_0B00550(NCAS0B00550) |
NDI: | NDAI_0E00840(NDAI0E00840) |
TPF: | TPHA_0G00600(TPHA0G00600) |
TBL: | TBLA_0B03480(TBLA0B03480) |
TDL: | TDEL_0B03750(TDEL0B03750) |
KAF: | KAFR_0A04180(KAFR0A04180) |
KNG: | KNAG_0G02900(KNAG0G02900) |
LBG: | 92208920(LODBEIA_P37240) |
CAL: | CAALFM_C210340WA(HEM4) |
YLI: | 2908703(YALI2_F00791g) |
NTE: | NEUTE1DRAFT131286(NEUTE1DRAFT_131286) |
SMP: | 10808772(SMAC4_03490) |
TATV: | 25774944(TrAtP1_008076) |
TASP: | 36607719(TrAFT101_003287) |
MAW: | 19244411(HEM4_1) 90963606(HEM4_2) |
PLJ: | 28884408(PLICBS_005667) |
CDET: | 87939892(CDEST_03389) |
BFU: | BCIN_02g05180(Bchem4) |
CPW: | 9691014(D8B26_001502) |
PTRR: | 6349945(PtrM4_030130) |
CDEP: | 91086742(L203_102530) |
KMG: | 30161396(I203_105771) |
KNE: | 92183363(IAR55_006105) |
CCAC: | CcaHIS019_0112350(HEM4) |
ABP: | AGABI1DRAFT122520(AGABI1DRAFT_122520) |
ABV: | AGABI2DRAFT227053(AGABI2DRAFT_227053) |
SCM: | SCHCO_02564554(SCHCODRAFT_02564554) |
PTI: | PHATRDRAFT_44610(HemD) |
FCY: | FRACYDRAFT_244684(UROS) |
TPS: | THAPSDRAFT_2950(UroS) |
EHX: | EMIHUDRAFT_54852 EMIHUDRAFT_54867 |
GTT: | GUITHDRAFT_70083(HemD/UroS) |
ECOO: | ECRM13514_4867(hemD) |
ECOH: | ECRM13516_4651(hemD) |
ELR: | ECO55CA74_22050(hemD) |
ECW: | EcE24377A_4319(hemD) |
ECOA: | APECO78_22850(hemD) |
EDJ: | ECDH1ME8569_3683(hemD) |
SEM: | STMDT12_C40870(hemD) |
SETC: | CFSAN001921_20745(hemD) |
SEEN: | SE451236_01215(hemD) |
SENH: | CFSAN002069_12355(hemD) |
SEEH: | SEEH1578_05780(hemD) |
SENJ: | CFSAN001992_13995(hemD) |
SEEC: | CFSAN002050_02570(hemD) |
SEEB: | SEEB0189_022650(hemD) |
SENC: | SEET0819_03540(hemD) |
REE: | electrica_04885(hemD) |
BEC: | GN160_02500(hemD) GN160_02575(hemD) |
AHN: | NCTC12129_04748(hemD) |
PTF: | PROFFT_A_06950(hemD) |
YPG: | YpAngola_A0535(hemD) |
YPI: | YpsIP31758_0197(hemD) |
SMW: | SMWW4_v1c01860(hemD) |
SERS: | SERRSCBI_00780(hemD) |
SSAR: | SSARUM_000141(hemD) |
PAQU: | DMB82_0019130(hemD) |
PARL: | PEC302110_01830(hemD) |
DIC: | Dpoa569_000281(hemD) |
EHD: | ERCIPSTX3056_311(hemD) |
BAPF: | BUMPF009_CDS00013(hemd) |
BAPG: | BUMPG002_CDS00013(hemd) |
BAPU: | BUMPUSDA_CDS00013(hemd) |
BAPW: | BUMPW106_CDS00013(hemd) |
PDAG: | 4362423_01976(hemD) |
ALIG: | NCTC10568_00292(hemD) |
RPNE: | NCTC8284_00481(hemD_1) |
PAET: | NCTC13378_00299(hemD) |
XFH: | XFHB_06330 XFHB_07045 |
XFU: | XFF4834R_chr01870(hemD) |
XPH: | XppCFBP6546_10850(XppCFBP6546P_10850) |
XHD: | LMG31886_02340(hemD) |
RGL: | CS053_10220 CS053_17010 |
DJI: | CH75_04035 CH75_22190 |
DJA: | HY57_00470 HY57_17750 |
DTL: | H8F01_04050 H8F01_07750 |
VAU: | VANGNB10_cI0070c(hemD) |
VPL: | SA104470976_02617(hemD) |
VIB: | VspSTUT11_00580(hemD) |
VIS: | VspSTUT16_00570(hemD) |
PAEB: | NCGM1900_6058(hemD) |
PPRC: | PFLCHA0_c59600(hemD) |
PMUD: | NCTC8068_05211(hemD) |
PFW: | PF1751_v1c53410(hemD) |
PPUU: | PputUW4_05274(hemD) |
PGY: | AWU82_07435 AWU82_12800 |
PTW: | TUM18999_03490(hemD) |
PTAE: | NCTC10697_04373(hemD) |
HPEG: | EAO82_17860 EAO82_20765 |
HAES: | LO767_02810 LO767_18340 |
HARR: | HV822_04490 HV822_10380 |
PNN: | KEM63_00960 KEM63_03515 |
PPHA: | BVH74_00705 BVH74_06345 |
MSHE: | MAALD49_05470(hemD) |
ALJ: | G8D99_07490 G8D99_14275 |
SCAA: | TUM17387_35330(hemD) |
SALH: | HMF8227_02893(hemD) |
FES: | HER31_05060(cobA) HER31_15060 |
MARQ: | MARGE09_P0866 MARGE09_P3623 |
CBS: | COXBURSA331_A0008(hemD) |
LCJ: | NCTC11976_00287(hemD) |
MEEF: | JWZ97_14270 JWZ97_14275 |
MMOT: | QZJ86_18690 QZJ86_18695 |
MEEP: | JWZ98_01790 JWZ98_01795 |
MEEC: | PL263_12205 PL263_12210 |
MEUP: | QC632_21820 QC632_21825 |
MSZE: | MSZNOR_4027 MSZNOR_4028 |
MECH: | Q9L42_007230 Q9L42_007235 |
MEIY: | MIN45_P1080 MIN45_P1081 |
TLR: | Thiosp_01692(hemD_1) Thiosp_02857(hemD_2) |
TFRI: | Thiofri_01578(hemD_1) Thiofri_02091(hemD_2) Thiofri_03316(hemD_3) |
TWG: | Thiowin_02567(hemD_1) Thiowin_02835(hemD_2) |
TNI: | TVNIR_3828(hemD_[H]) |
SPIU: | SPICUR_00165 SPICUR_05355 |
SROS: | BBH56_04685 BBH56_08825 |
SHAI: | LMH63_00080 LMH63_11520 |
APRS: | BI364_00065 BI364_05285 |
AAEO: | BJI67_00070 BJI67_10275 |
AFY: | BW247_00075 BW247_07110 |
HNA: | Hneap_1109 Hneap_2162 |
HAZ: | A9404_00160 A9404_09300 |
GAI: | IMCC3135_00045(hemD) |
GHL: | GM160_00255 GM160_08225 |
THIC: | TspCOW1_24140(hemD) |
HAXI: | HAALTHF_11280n(hemD) |
ALCA: | ASALC70_02784(hemD) |
SOK: | D0B54_06805 D0B54_22255 |
FCE: | JN531_004725 JN531_008265 |
SALN: | SALB1_0614 SALB1_1793 |
CDIZ: | CEDIAZO_03685(hemD) |
NMQ: | NMBM04240196_1387(hemD) |
NMZ: | NMBNZ0533_0828(hemD) |
NMX: | NMA510612_1108(hemD) |
NWE: | SAMEA3174300_1067(hemD) |
NZO: | SAMEA4504057_1448(hemD) |
NCI: | NCTC10296_02140(hemD) |
BPM: | BURPS1710b_1231(hemX) |
PLG: | NCTC10937_00115(hemD) |
MYCO: | MPB2EB_0839 MPB2EB_0840 |
BTRM: | SAMEA390648703980(hemD) |
LIM: | L103DPR2_02446(hemD) |
LIH: | L63ED372_00801(hemD) |
HYY: | JNX00_05615 JNX00_05620 |
PAQA: | K9V56_008880 K9V56_008885 |
PAIS: | PFX98_23035 PFX98_23040 |
SMIO: | CATMQ487_44570 CATMQ487_44580 |
MENY: | LSQ66_05485 LSQ66_05490 |
MLIR: | LPB04_21005 LPB04_21010 |
PLUE: | EWM63_04035 EWM63_04040 |
DZO: | SR858_06935 SR858_06940 |
EHB: | E7V67_008405 E7V67_008410 |
UCY: | RF679_12815 RF679_12820 |
ETB: | N7L95_09255 N7L95_09260 |
MPAU: | ZMTM_00390 ZMTM_00400(hemD) |
THAG: | CKCBHOJB_01057(hemD) |
FPHO: | SHINM1_015300(hemD) |
ERU: | Erum5380(probable_hemD) |
NIY: | FQ775_07440 FQ775_16000 |
SMEL: | SM2011_c03232(hemD) |
SAME: | SAMCFNEI73_Ch3515(hemD) |
AGR: | AGROH133_08878(hemD) |
AVV: | RvVAT039_14660(hem4) |
REC: | RHECIAT_CH0004189(hemD) |
REL: | REMIM1_CH03998(hemD) |
REP: | IE4803_CH04290(hemD) |
REI: | IE4771_CH04232(hemD) |
RTR: | RTCIAT899_CH16920(hemD) |
RGA: | RGR602_CH03825(hemD) |
RPHA: | AMC79_CH04123(hemD) |
NEO: | CYG48_13705 CYG48_20030 |
NEN: | NCHU2750_34370(hemD) |
LAS: | CLIBASIA_04685(hemD) |
SHIN: | LHJ69_19445 LHJ69_19450 |
BIO: | BR141012304_10832(hemD) |
BJA: | bll0566(bll0566) blr5956(blr5956) |
BJU: | BJ6T_05370 BJ6T_37470 |
BJP: | RN69_02625 RN69_18165 |
BRC: | BCCGELA001_01270 BCCGELA001_25360 |
BRAD: | BF49_0274 BF49_5690 |
BIC: | LMTR13_10955 LMTR13_38295 |
BRO: | BRAD285_1977 BRAD285_7585 |
BRK: | CWS35_06580 CWS35_31685 |
BOT: | CIT37_11585 CIT37_24510 |
BRQ: | CIT40_21760 CIT40_32625 |
BGQ: | X265_01425 X265_13895 |
BGZ: | XH91_01615 XH91_11715 |
BSYM: | CIT39_21035 CIT39_31620 |
BBET: | F8237_15770 F8237_26510 |
BARH: | WN72_01440 WN72_33075 |
BVZ: | BRAD3257_0277 BRAD3257_3159 |
BEL: | BE61_06980(hemD) BE61_40630 |
BDG: | LPJ38_04710 LPJ38_31790 |
BSEP: | HAP48_0014900 HAP48_0047450 |
BQB: | J4P68_0006630 J4P68_0018915 |
BSEI: | KMZ68_01290 KMZ68_18830 |
BBAN: | J4G43_001520 J4G43_035650 |
BCAN: | BcanWSM471_01510 BcanWSM471_26425 |
BAUT: | QA635_01475 QA635_15705 |
BBRA: | QA636_01455 QA636_16225 |
BGK: | IC762_01310 IC762_24725 |
BCOU: | IC761_01330 IC761_11855 |
BPAH: | QA639_01415 QA639_29355 |
BXN: | I3J27_01350 I3J27_25770 |
BROS: | QUH67_01310 QUH67_25725 |
BRAZ: | LRP30_00345 LRP30_27440 |
BOY: | LQG66_22220 LQG66_35020 |
BRAY: | ML401_00350 ML401_22975 |
RPA: | TX73_001330 TX73_020895 |
RPX: | Rpdx1_0378 Rpdx1_4291 |
RBK: | E0H22_01050 E0H22_09375 |
PCAX: | AFIC_000249 AFIC_001054 |
TRB: | HB776_03290 HB776_23795 |
TALZ: | RPMA_00420 RPMA_10105 |
METI: | DK427_04615 DK427_08540 |
MOC: | BB934_13625 BB934_25260 |
MIV: | C4E04_00810 C4E04_01785 |
MTEZ: | HPT29_001960 HPT29_011775 |
MLD: | U0023_09350 U0023_30105 U0023_30470 U0023_32760 |
MTUN: | MTUNDRAET4_0007(HEM4) |
MLG: | CWB41_03855 CWB41_08290 |
MEDK: | QEV83_08975 QEV83_09700 |
MMYR: | MXMO3_00408 MXMO3_03599 |
MHAR: | L1P08_11635 L1P08_13480 |
RSQ: | Rsph17025_2913 Rsph17025_4324 |
CAZT: | LV780_13325 LV780_21450 |
SPHU: | SPPYR_1581 SPPYR_3601 |
SARI: | H5J25_04355 H5J25_17925 |
SCLO: | SCLO_1002220 SCLO_1021050 |
SPHJ: | BSL82_05040 BSL82_12155 |
QCI: | NCF85_06040 NCF85_09765 |
AZL: | AZL_004030 AZL_e02930(hemD) |
ALI: | AZOLI_0254(hemD) AZOLI_p50183 |
ABF: | AMK58_02020 AMK58_28540 |
ATI: | AL072_06010 AL072_29670 |
AHU: | A6A40_01000 A6A40_13380 |
AZM: | DM194_09920 DM194_25480 |
AZZ: | DEW08_05845 DEW08_26400 |
AOZ: | HUE56_21785 HUE56_22850 |
AZS: | E6C72_02610 E6C72_29245 |
AZP: | E6C67_09550 E6C67_29645 |
RGI: | RGI145_03055 RGI145_05990 |
ROS: | CTJ15_11395 CTJ15_20895 |
RMUC: | FOB66_07815 FOB66_17090 |
HPO: | HMPREF4655_21415(hemD) |
HPX: | HMPREF0462_1238(hemD) |
HPYA: | HPAKL117_05790(hemD) |
HPYK: | HPAKL86_01255(hemD) |
HHM: | BN341_9580 BN341_9610 |
HCL: | NCTC13205_00377(hemD) |
TDN: | Suden_0423 Suden_1228 |
SULN: | FJR47_01750 FJR47_04385 |
SULG: | FJR48_09095 FJR48_09780 |
SULC: | CVO_05195 CVO_07650 |
CJV: | MTVDSCj20_1084(hemD) |
CFV: | CFVI03293_1313(hemD) |
CAMP: | CFT03427_1239(hemD) |
CCOC: | CCON33237_1413(hemD) |
CLR: | UPTC16701_1093(hemD) |
CLM: | UPTC16712_1124(hemD) |
CAMR: | CAQ16704_1114(hemD) |
CHV: | CHELV3228_1368(hemD) |
CPIN: | CPIN18020_1236(hemD) |
CAMZ: | CVIC12175_0528(hemD) |
SMUL: | SMUL_0775(hemD) SMUL_1563(cobA_hemD) |
SHAL: | SHALO_0767 SHALO_1527 |
SULS: | Sdiek1_0717 Sdiek1_1620 |
SULJ: | SJPD1_0713 SJPD1_1540 |
SULT: | FA592_00240(cobA) FA592_10615 |
ANT: | Arnit_1684 Arnit_1777 |
ALP: | LPB137_05895 LPB137_07500 |
HEBR: | AEBR_1589(hemD) AEBR_2944 |
SMAB: | LN246_09035 LN246_10600 |
GEC: | GEO60473_26920(cobA) |
GBN: | GEOBRER4_04030(hemD) |
PACE: | A6070_00005 A6070_00055 |
DVE: | DESUT3_05650(hemD) DESUT3_19590 |
DTR: | RSDT_0530(hemD_cobA) |
CFUS: | CYFUS_002995 CYFUS_007467 |
SCL: | sce0014(hemD) sce6449 |
SCU: | SCE1572_00065 SCE1572_38165 |
CCRO: | CMC5_000180(cobA) CMC5_072470(hemD) |
PAUU: | E8A73_014995 E8A73_017405(cobA) |
MRM: | A7982_07742 A7982_07805 |
CTJT: | CTJTET1_02275(hemD) |
CTFS: | CTRC342_02295(hemD) |
CTHF: | CTRC852_02310(hemD) |
CTCJ: | CTRC943_02255(hemD) |
CTHJ: | CTRC953_02255(hemD) |
CTMJ: | CTRC966_02270(hemD) |
CTTJ: | CTRC971_02260(hemD) |
CTJS: | CTRC122_02290(hemD) |
OBG: | Verru16b_03095(hemD) |
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