KEGG   ENZYME: 4.2.1.77Help
Entry
EC 4.2.1.77                 Enzyme                                 

Name
trans-L-3-hydroxyproline dehydratase;
trans-L-3-hydroxyproline hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
trans-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)
Reaction(IUBMB)
trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O [RN:R04374]
Reaction(KEGG)
Substrate
trans-3-hydroxy-L-proline [CPD:C05147]
Product
1-pyrroline 2-carboxylate [CPD:C03564];
H2O [CPD:C00001]
Comment
Highly specific.
History
EC 4.2.1.77 created 1984
Pathway
ec00330  Arginine and proline metabolism
Orthology
K18384  trans-L-3-hydroxyproline dehydratase
K22548  trans-L-3-hydroxyproline dehydratase
Genes
HSA: 112849(L3HYPDH)
PTR: 112204140(L3HYPDH)
PPS: 100973980(L3HYPDH)
GGO: 101151045(L3HYPDH)
PON: 100172276(L3HYPDH)
NLE: 100585615(L3HYPDH)
MCC: 702076(L3HYPDH)
MCF: 102115940(L3HYPDH)
CSAB: 103229098(L3HYPDH)
RRO: 104662157(L3HYPDH)
RBB: 108524789(L3HYPDH)
CJC: 100402030(L3HYPDH)
SBQ: 101037339(L3HYPDH)
MMU: 67217(L3hypdh)
RNO: 314214(L3hypdh)
CGE: 100764709(L3hypdh)
NGI: 103739192(L3hypdh)
HGL: 101725460(L3hypdh)
CCAN: 109696080(L3hypdh)
OCU: 100354746(L3HYPDH)
TUP: 102490555(L3HYPDH)
CFA: 490715(L3HYPDH)
AML: 100471249(L3HYPDH)
UMR: 103672703(L3HYPDH)
ORO: 101365481(L3HYPDH)
FCA: 101098960(L3HYPDH)
PTG: 102955955(L3HYPDH)
AJU: 106974568(L3HYPDH)
BTA: 510525(L3HYPDH)
BOM: 102267712(L3HYPDH)
BIU: 109565207(L3HYPDH)
PHD: 102331969(L3HYPDH) 102341898
CHX: 102170980(L3HYPDH)
OAS: 101102239(L3HYPDH)
SSC: 110262303(L3HYPDH)
CFR: 102510698(L3HYPDH)
CDK: 105086230(L3HYPDH)
BACU: 103001798(L3HYPDH)
LVE: 103089729(L3HYPDH)
OOR: 101288505(L3HYPDH)
ECB: 100059502(L3HYPDH)
EPZ: 103560585(L3HYPDH)
EAI: 106846079(L3HYPDH)
MYB: 102251331(L3HYPDH)
MYD: 102751344(L3HYPDH)
HAI: 109383857(L3HYPDH)
RSS: 109444418(L3HYPDH)
PALE: 102892379(L3HYPDH)
LAV: 100671364(L3HYPDH)
TMU: 101343227
MDO: 100026616(L3HYPDH)
SHR: 100916958(L3HYPDH)
OAA: 100086994(L3HYPDH)
GGA: 423531(L3HYPDH)
MGP: 104911286(L3HYPDH)
CJO: 107315418(L3HYPDH)
APLA: 101790625(L3HYPDH)
ACYG: 106037183(L3HYPDH)
TGU: 100232596(L3HYPDH)
GFR: 102042007(L3HYPDH)
FAB: 101810740(L3HYPDH)
PHI: 102107944(L3HYPDH)
PMAJ: 107206387(L3HYPDH)
CCW: 104684550(L3HYPDH)
FPG: 101918943(L3HYPDH)
FCH: 102059456(L3HYPDH)
CLV: 102096316(L3HYPDH)
EGZ: 104135281(L3HYPDH)
AAM: 106495231(L3HYPDH)
ASN: 102369998(L3HYPDH)
AMJ: 102565530(L3HYPDH)
PSS: 102462476(L3HYPDH)
CMY: 102947990(L3HYPDH)
CPIC: 101931630(L3HYPDH)
ACS: 100559609(l3hypdh)
PVT: 110083781(L3HYPDH)
PBI: 103049310(L3HYPDH)
GJA: 107120397(L3HYPDH)
XLA: 108698829
XTR: 493490(l3hypdh)
NPR: 108791712(L3HYPDH)
DRE: 565785(l3hypdh)
SRX: 107755210
SANH: 107684001
SGH: 107601901(l3hypdh)
CCAR: 109058095(l3hypdh)
IPU: 108257951(l3hypdh)
AMEX: 103042342(l3hypdh)
TRU: 101066682(l3hypdh)
LCO: 104930547(l3hypdh)
NCC: 104951072(l3hypdh)
MZE: 101483912(l3hypdh)
OLA: 101166521(l3hypdh)
XMA: 102217165(l3hypdh)
PRET: 103457582(l3hypdh)
NFU: 107377581(l3hypdh)
LCF: 108895649(l3hypdh)
HCQ: 109524865(l3hypdh)
BPEC: 110155871(l3hypdh)
SASA: 106571502(l3hypdh)
ELS: 105017645(l3hypdh)
SFM: 108930829(l3hypdh)
LCM: 102352794(L3HYPDH)
CMK: 103178517(l3hypdh)
CIN: 100178125
SPU: 585737
APLC: 110978363
OBI: 106881453
EPA: 110254897
HMG: 100198440
AQU: 100638966
MAW: MAC_07874
MAJ: MAA_06218
ANI: AN2121.2
ANG: ANI_1_1948074(An08g04750)
PAE: PA1255
PAEV: N297_1294
PAEI: N296_1294
PAEP: PA1S_19640
PAEM: U769_19480
PAEL: T223_20730
PAEG: AI22_14325
PAEC: M802_1291
PAEO: M801_1294
PSTT: CH92_01025
MAQ: Maqu_2141
MHC: MARHY1085
MAD: HP15_922(pa45-A)
PIN: Ping_2117
CSA: Csal_2339
HEL: HELO_2887
HAM: HALO1503
MLO: mlr6810
SME: SM_b20270
SMER: DU99_32020
SMD: Smed_3861
ATU: Atu4684
AVI: Avi_7022
RHT: NT26_3279
SHZ: shn_21240
BME: BMEI1586
BMEL: DK63_1903
BMEE: DK62_1049
BMF: BAB1_0366
BABO: DK55_382
BABR: DO74_1505
BABT: DK49_145
BABB: DK48_1745
BABU: DK53_372
BABS: DK51_1092
BABC: DO78_289
BMS: BR0337
BSZ: DK67_1276
BOV: BOV_0353
BCAR: DK60_429
BCAS: DA85_01640
BMR: BMI_I342
BPP: BPI_I371
BPV: DK65_1009
OAN: Oant_0439
OAH: DR92_2500
SNO: Snov_0155
PHL: KKY_1201
SIL: SPO0607
JAN: Jann_1529
PDE: Pden_1184
PGD: Gal_03751
OTM: OSB_16560
MALG: MALG_04515
 » show all
Taxonomy
Reference
1
  Authors
Ramaswamy, S.G.
  Title
Conversion of 3-hydroxyproline to proline in the rat requires reduced pyridine-nucleotides.
  Journal
Fed Proc 42:2232 (1983)
Reference
2  [PMID:22528483]
  Authors
Visser WF, Verhoeven-Duif NM, de Koning TJ
  Title
Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes.
  Journal
J Biol Chem 287:21654-62 (2012)
DOI:10.1074/jbc.M112.363218
  Sequence
[hsa:112849]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.77
IUBMB Enzyme Nomenclature: 4.2.1.77
ExPASy - ENZYME nomenclature database: 4.2.1.77
BRENDA, the Enzyme Database: 4.2.1.77

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