KEGG ENZYME: 4.2.1.93

ENZYME: 4.2.1.93

Entry

EC 4.2.1.93                 Enzyme

Name

ATP-dependent NAD(P)H-hydrate dehydratase;
reduced nicotinamide adenine dinucleotide hydrate dehydratase;
ATP-dependent H4NAD(P)+OH dehydratase;
(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing);
(6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing;
NADH-forming)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing; NADH-forming)

Reaction(IUBMB)

(1) ATP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH [RN:R00129];
(2) ATP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH [RN:R10288]

Reaction(KEGG)

R00129 R10288

Substrate

ATP [CPD:C00002];
(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide [CPD:C04856];
(6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate [CPD:C04899]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
NADH [CPD:C00004];
NADPH [CPD:C00005]

Comment

Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers, and these are interconverted by EC 5.1.99.6, NAD(P)H-hydrate epimerase, to a 60:40 ratio [4]. Hence EC 4.2.1.93 together with EC 5.1.99.6 can restore the mixture of hydrates into NAD(P)H [3,4]. The enzyme from eukaryotes has no activity with ADP, contrary to the enzyme from bacteria (cf. EC 4.2.1.136, ADP-dependent NAD(P)H-hydrate dehydratase) [4].

History

EC 4.2.1.93 created 1992, modified 2012

Orthology

K17757

ATP-dependent NAD(P)H-hydrate dehydratase

Genes

HSA:	55739(NAXD)

PTR:	452663(NAXD)

PPS:	100977905(NAXD)

GGO:	101150913(NAXD)

PON:	100173186(NAXD)

PPYG:

129011180(NAXD)

NLE:	100604464(NAXD)

HMH:	116467565(NAXD)

SSYN:

129463945(NAXD)

MCC:	694722(NAXD)

MCF:	102128889(NAXD)

MTHB:

126940600

MNI:	105485297(NAXD)

CSAB:

103214799(NAXD)

CATY:

105584911(CARKD)

PANU:

101013916(NAXD)

TGE:	112611019(NAXD)

MLEU:

105546554(CARKD)

RRO:	104679240(NAXD)

RBB:	108527064(NAXD)

TFN:	117063505(NAXD)

PTEH:

111546322(NAXD)

CANG:

105505902(CARKD)

CJC:	100405542(NAXD)

SBQ:	101045356(CARKD)

CIMI:

108284939(NAXD)

ANAN:

105725623(NAXD)

CSYR:

103252288(NAXD)

MMUR:

105864236(NAXD)

LCAT:

123649309(NAXD)

PCOQ:

105805128(CARKD)

OGA:	100950662(NAXD)

MMU:	69225(Naxd)

MCAL:

110299905(Naxd)

MPAH:

110336623(Naxd)

RNO:	361185(Naxd)

MCOC:

116068908(Naxd)

ANU:	117721932(Naxd)

ASYL:

127668375(Naxd)

MUN:	110548879(Naxd)

CGE:	100767494(Naxd)

MAUA:

101838334(Naxd)

PROB:

127220252(Naxd)

PLEU:

114695102(Naxd)

MORG:

121455782 121462427(Naxd)

MFOT:

126498355

AAMP:

119813741(Naxd)

NGI:	103739906 103751678(Naxd)

HGL:	101717804(Naxd)

CPOC:

100729574(Naxd)

CCAN:

109687738(Naxd)

DORD:

105990458(Carkd)

DSP:	122122757(Naxd)

DMER:

138813972(Naxd)

PLOP:

125348105(Naxd)

NCAR:

124984474

MMMA:

107140894(Naxd)

ITI:	101964428(Naxd)

OCU:	100358583 127486357

OPI:	101526369(NAXD)

TUP:	102481205(NAXD)

GVR:	103583058(CARKD)

CFA:	607381(NAXD)

CLUD:

112655955(NAXD)

VVP:	112927463(NAXD)

VLG:	121476991(NAXD)

NPO:	129516575(NAXD)

AML:	100479259(NAXD)

UMR:	103657622(NAXD)

UAH:	113251542(NAXD)

UAR:	123776762(NAXD)

ELK:

111146893

LLV:

125094837

MPUF:

101679129(CARKD)

MNP:	132003001(NAXD)

MLK:	131813529(NAXD)

NVS:	122907245(NAXD)

ORO:	101380814(CARKD)

EJU:	114196624(NAXD)

ZCA:	113919821(NAXD)

MLX:	118009233(NAXD)

NSU:	110585800(NAXD)

LWW:	102740171(NAXD)

FCA:	101096534(NAXD)

PYU:	121037707(NAXD)

PCOO:

112860698(NAXD)

PBG:	122483519(NAXD)

PVIV:

125167862(NAXD)

LRUF:

124513711

LGF:	123599791(NAXD)

AJU:

106986360

PTG:	102954132(NAXD)

PPAD:

109264066(NAXD)

PUC:

125933957

PLEZ:

122215042(NAXD)

HHV:	120228354(NAXD)

BTA:	613996(NAXD)

BOM:	102284176(NAXD)

BIU:	109566961(NAXD)

BBUB:

102390706(NAXD)

CHX:	102171618(NAXD)

OAS:	101116066(NAXD)

BTAX:

128057536(NAXD)

CSUM:

138088988(NAXD)

ODA:	120883369(NAXD)

CCAD:

122447112(NAXD)

MREE:

136144508(NAXD)

OVR:	110150447(NAXD)

MBEZ:

129556515(NAXD)

SSC:	100153456(NAXD)

CFR:	102507835(NAXD)

CBAI:

105066895(CARKD)

CDK:	105094105(NAXD)

VPC:	102540455(NAXD)

BACU:

103009018(NAXD)

BMUS:

118883994(NAXD)

LVE:	103089164(CARKD)

OOR:	101275937(NAXD)

LALB:

132508814(NAXD)

GMF:	115853356(NAXD)

DLE:	111176381(NAXD)

PCAD:

102977529(NAXD)

PSIU:

116743137(NAXD)

PPHC:

136137572(NAXD)

NASI:

112405562(NAXD)

ECB:	100066349(NAXD)

EPZ:	103565641(NAXD)

EAI:	106838205(NAXD)

MYB:	102242541(NAXD)

MYD:	102771854(NAXD)

MMYO:

118651352(NAXD)

MLF:	102427413(NAXD)

MDT:	132228545(NAXD)

MYUM:

139006075(NAXD)

PKL:	118728888(NAXD)

EFUS:

103288229(NAXD)

MNA:	107530386(NAXD)

DRO:	112321417(NAXD)

SHON:

118981572(NAXD)

AJM:	119043631(NAXD)

PDIC:

114508731(NAXD)

PHAS:

123807654(NAXD)

MMF:	118622801(NAXD)

PPAM:

129071217(NAXD)

HAI:	109383911(NAXD)

RFQ:	117021520(NAXD)

PALE:

102886483(NAXD)

PGIG:

120605332(NAXD)

PVP:	105301341(NAXD)

RAY:	107511119(NAXD)

TOD:	119259722(NAXD)

SARA:

101551445(CARKD)

SFUM:

130019111(NAXD)

SETR:

126015577(NAXD)

LAV:	100653762(NAXD)

TMU:

101345818

ETF:	101641105(NAXD)

DNM:	101435484(NAXD)

MDO:	100023457(NAXD)

GAS:	123242627(NAXD)

SHR:	100924303(NAXD)

AFZ:

127553470

PCW:	110193392(NAXD)

TVP:	118848248(NAXD)

PBRV:

138165776(NAXD)

OAA:	100084483(NAXD)

TACU:

119941638(NAXD)

GGA:	418755(NAXD)

PCOC:

116242800(NAXD)

MGP:	100549983(NAXD)

CJO:	107307941(NAXD)

TPAI:

128092233(NAXD)

LMUT:

125691826(NAXD)

NMEL:

110407500(NAXD)

APLA:

101804240(NAXD)

ACYG:

106044453(NAXD)

CATA:

118257507(NAXD)

AFUL:

116491712(NAXD)

TGU:	100219904(NAXD)

LSR:	110478761(NAXD)

SCAN:

103812661(NAXD)

PMOA:

120504580(NAXD)

OTC:	121343182(NAXD)

PRUF:

121356160(NAXD)

ATRC:

139591696(NAXD)

GFR:	102034719(NAXD)

FAB:	101817373(NAXD)

OMA:	130260018(NAXD)

PHI:	102099739(CARKD)

PMAJ:

107201575(NAXD)

CCAE:

111944791(NAXD)

CCW:	104686126(NAXD)

CBRC:

103617566(NAXD)

ACOE:

138104819(NAXD)

ETL:	114059816(NAXD)

ZAB:	102064630(NAXD)

ZLE:	135445885(NAXD)

SVG:	106857262(CARKD)

MMEA:

130589025(NAXD)

HRT:	120749693(NAXD)

SATI:

136358020(NAXD)

CCIC:

134058027(NAXD)

FPG:	101910319(CARKD) 101923883(NAXD)

FCH:	102046376(NAXD)

CCRI:

104162866(CARKD)

SHAB:

115604571(NAXD)

ACUN:

113480275(NAXD)

TALA:

104367255(NAXD)

ACHC:

115334522(NAXD)

HALD:

104325826

HLE:	104836955(CARKD)

AGEN:

126053061

HHAR:

128135135(NAXD)

GCL:

127025432

CSTI:

104556049(CARKD)

LDI:	104345480(CARKD)

MNB:	103775883(CARKD)

DPUB:

104298645(CARKD)

PPUS:

135175519(NAXD)

AVIT:

104279143(CARKD)

BRHI:

104498742

EGZ:	104132456(NAXD)

NNI:	104012566(CARKD)

PCAO:

104042467(CARKD)

PADL:

103915651(CARKD)

AFOR:

103896251(NAXD)

FGA:

104080302

GSTE:

104255708(CARKD)

CBOY:

140646248(NAXD)

CLV:	102088516(NAXD)

CNIC:

136003082(NAXD)

PGUU:

104471256(CARKD)

PLET:

104619475(CARKD)

EHS:	104509525(CARKD)

CMAC:

104480082(CARKD)

CUCA:

104068397(NAXD)

OHA:	104328453(CARKD)

CPEA:

104388980(CARKD)

CVF:	104292723(CARKD)

RTD:	128904267(NAXD)

CRID:

134516849(NAXD)

AAM:	106493918(NAXD)

AROW:

112967175(NAXD)

NPD:	112945127(NAXD)

TGT:	104579795(CARKD)

DNE:	112984530(NAXD)

SCAM:

104138691(CARKD)

ASN:	102367921(NAXD)

AMJ:	102559151(NAXD)

CPOO:

109306316(NAXD)

GGN:	109302679(NAXD)

PSS:	102453397(NAXD)

CMY:	102941875(NAXD)

CCAY:

125638873(NAXD)

DCC:	119849709(NAXD)

CPIC:

101943239(NAXD)

TST:	117870800(NAXD)

CABI:

116816039

MRV:	120403517(NAXD)

ACS:	100554347(naxd)

ASAO:

132771505(NAXD)

PVT:	110079338(NAXD)

SUND:

121925391(NAXD)

PBI:	103060468(NAXD)

PMUR:

107283854(NAXD)

CTIG:

120300544(NAXD)

TSR:	106554966(CARKD)

PGUT:

117666147(NAXD)

PCAE:

139316421(NAXD)

APRI:

131200253(NAXD)

PTEX:

113441339(NAXD)

NSS:	113412947(NAXD)

VKO:	123022529(NAXD)

PMUA:

114596467(NAXD)

PRAF:

128411880(NAXD)

ZVI:	118084701(NAXD)

HCG:	128352224(NAXD)

GJA:	107110343(NAXD)

STOW:

125431495(NAXD)

EMC:	129326775(NAXD)

XLA:	108708461(naxd.L) 108709737(naxd.S)

XTR:	549064(naxd)

NPR:	108787452(NAXD)

RTEM:

120926371(NAXD)

ACAT:

141127748(NAXD)

BBUF:

120995790(NAXD)

BGAR:

122931208(NAXD)

DTC:	141060549(NAXD)

PWL:	138250340(NAXD)

MUO:	115469173(NAXD)

GSH:	117362372(NAXD)

DRE:	797867(naxd)

SRX:	107715914 107721606

SANH:

107688713 107702869

SGH:	107557926 107559509

CCAR:

109069423 109069430

CAUA:

113053636 113108926

CGIB:

127965234 128019451

PTET:

122332482(naxd)

LROH:

127170613(naxd)

GRF:	141340721(naxd)

OMC:	131528490 131546664(naxd)

PPRM:

120487313(naxd)

RKG:	130085843(naxd)

MAMB:

125269976(naxd)

CIDE:

127519337

CERY:

137036280(naxd)

MASI:

127447520 127448189

TROS:

130556026(naxd)

TDW:	130427227(naxd)

MANU:

129451752(naxd)

PDAB:

135782575(naxd)

IPU:

108261034

IFU:	128608665(naxd)

PHYP:

113525967(naxd)

SMEO:

124382681(naxd)

TFD:	113654377(naxd)

TVC:	132850100(naxd)

CGAR:

128524127(naxd)

NGRA:

132891768(naxd)

TRN:	134324311(naxd)

AMEX:

103035327(naxd)

CMAO:

118824292(naxd)

EEE:	113586364(naxd)

CHAR:

105893227(naxd)

SPIL:

134078434(naxd)

TRU:	101070180(naxd)

TFS:	130530326(naxd)

TNG:	GSTEN00025998G001

LCO:	104932339(naxd)

NCC:	104955102(carkd)

TBEN:

117481444(naxd)

CGOB:

115026244(naxd)

PGEO:

117466945(naxd)

GACU:

117556788(naxd)

EMAC:

134867798(naxd)

ELY:	117250465(naxd)

EFO:	125900007(naxd)

PLEP:

121938324 121949518

SLUC:

116046747(naxd)

ECRA:

117953351(naxd)

ESP:	116697741(naxd)

PFLV:

114564632(naxd)

GAT:	120833669(naxd)

PPUG:

119228551(naxd)

AFB:	129104466(naxd)

CLUM:

117750099(naxd)

PSWI:

130202901(naxd)

CANA:

137803381(naxd)

CVE:	137868262(naxd)

MSAM:

119904233(naxd)

SCHU:

122885464(naxd)

CUD:	121522139(naxd)

SPUL:

138592928(naxd)

LMIX:

132986796(naxd)

ALAT:

119025827(naxd)

ASTR:

137604861(naxd)

MZE:	106676152 112430068

ONL:	100711325(naxd)

OAU:	116316096(naxd)

OLA:	101163124(naxd)

OML:	112155381(naxd)

CSAI:

133445853(naxd)

XMA:	102234599(naxd)

XCO:	114148128(naxd)

XHE:	116722812(naxd)

PRET:

103459757(naxd)

PFOR:

103140292(naxd)

PLAI:

106934725(carkd)

PMEI:

106927505(carkd)

GAF:	122839406(naxd)

PPRL:

129361432(naxd)

CVG:	107096499(carkd)

CTUL:

119786379(naxd)

GMU:	124871572(naxd)

NFU:	107389845(naxd)

KMR:	108232361(naxd)

ALIM:

106523937(carkd)

NWH:	119419202(naxd)

AOCE:

111566599(naxd)

EJA:	138200989(naxd)

BFRE:

138629722(naxd)

MCEP:

125017349(naxD)

CSEM:

103392143(naxd)

POV:	109631177(naxd)

SSEN:

122763066(naxd)

SSOE:

131455496(naxd)

HHIP:

117754632(naxd)

HSP:	118120392(naxd)

PPLT:

128455812(naxd)

SMAU:

118282702(naxd)

LCF:

108899727

SDU:	111218097(naxd)

SLAL:

111662159(naxd)

XGL:	120801491(naxd)

HCQ:	109524678(naxd)

SSCV:

125974021(naxd)

SBIA:

133511842(naxd)

PEE:	133411093(naxd)

PTAO:

133486624(naxd)

BPEC:

110173162(naxd)

ENY:	140359622(naxd)

MALB:

109965384(naxd)

BSPL:

114847098(naxd)

SJO:	128368252(naxd)

SSCO:

133993214(naxd)

GMH:	115532857(naxd)

SASA:

106582132 106586673

STRU:

115156314 115161197

OTW:	112225413(naxd) 112241578

OMY:	110502008(naxd) 110520478

OGO:	124045327(naxd)

ONE:	115112641 115126226

OKI:	109869872 109871014

OKE:	118386169(naxd)

OMM:	135519085 135547383

OCLA:

139380669 139403951

SALP:

111959596(naxd) 111979264

SNH:	120058461 120064179(naxd)

CCLU:

121536494 121571617

ELS:	105016496(naxd)

OEP:	134017485(naxd)

SFM:	108933210(naxd)

PKI:	111851659(naxd)

AANG:

118224202(naxd)

AROT:

135250352(naxd)

CCOG:

133124899(naxd)

LOC:	102683617(carkd)

PSPA:

121320811 121328157

ARUT:

117405696 117407508

PSEX:

120524064(naxd)

LCM:	102349649(NAXD)

CMK:	103177553(naxd)

RTP:	109923229(naxd)

CPLA:

122550470(naxd)

HOC:	132816366(naxd)

LERI:

129697896(naxd)

HAKA:

140716365(naxd)

PMRN:

116942882(NAXD)

LRJ:	133342910(NAXD)

BFO:

118418927

BBEL:

109468036

CIN:

100183233

SCLV:

120328057

SPU:

586141

LPIC:

129260873 129260909

AJJ:

139979920

APLC:

110975932

ARUN:

117293407

AAMU:

139936062

AFIL:

140160845

AJC:

117100235

SKO:

100371541

PFLL:

139131978

DME:	Dmel_CG10424(Naxd)

DER:

6545338

DSE:

6618386

DSI:	Dsimw501_GD12303(Dsim_GD12303)

DYA:	Dyak_GE22522 Dyak_GE22782

DSR:

110188794

DPO:

6903406

DPE:

6593555

DMN:

108162850

DWI:	6643716 6652659

DGR:

6566429

DMO:	Dmoj_GI19565

DAZ:

108612072

DNV:

108650037

DHE:

111594708

DVI:	6629174(Naxd)

CCAT:

101459700

BOD:

106617635

BDR:

105231028

RZE:

108355684

AOQ:

129239375

ALUD:

128855727

TDA:	119678191 119686033

MDE:	101891655 131801000

SCAC:

106080864

LCQ:

111684508

LSQ:

119608349

CVJ:	135957347(Naxd)

GFS:

119641945

ECOE:

129953897

CLON:

129605945

HIS:

119649308

AGA:

1280688

ACOZ:

120958443

AARA:

120903529

AMER:

121600312

ASTE:

118503854

AMAP:

126568358

AFUN:

125770112

AMOU:

128296759

AMRS:

128708248

AALI:

118465330

ACOS:

131272216

AAG:

5565418

AALB:

109426011 115268032

ASUA:

134202225 134224281

CQU:	CpipJ_CPIJ005232 CpipJ_CPIJ013574

CPII:

120416381

CBRI:

134838047

CNS:

116344387

BCOO:

119066427

LLL:

129796849

PPAP:

129802171

AME:

550956

ACER:

108003976

ALAB:

122712135

ADR:

102681983

AFLR:

100870788

BIM:

100747542

BBIF:

117216312

BVK:

117233515

BVAN:

117154868

BHUN:

126872351

BTER:

100648143

BAFF:

126922385

BPYO:

122574417

BPAS:

132911096

FVI:

122529352

CCAL:

108627518

OBB:

114881528

OLG:

117610877

MGEN:

117220523

NMEA:

116428529

CGIG:

122404487

SOC:

105199404

MPHA:

105829014

AEC:

105149171

ACEP:

105626756

ACOC:

108693361

MZT:	108725615(Naxd)

PBAR:

105427939

VEM:

105558925

COBS:

139110872(Naxd)

TLN:	139812675(Naxd)

HST:

105187053

DQU:

106744267

CFO:

105249629

FEX:

115233311

PMEC:

138942012(Naxd)

LHU:	105675374(Naxd)

PGC:

109854690

OBO:

105280739

PCF:

106786341

PFUC:

122521151

VPS:

122627115

VCRB:

124425239

VVE:

124957916

NVI:

100120400

CSOL:

105365338

TPRE:

106652155 106652167

LHT:

122510411

LBD:

127288344

MDL:

103569008

CGLO:

123260313

CTYP:

141534593(Naxd)

FAS:

105263499

DAM:

107043541

AGIF:

122855641

CINS:

118069437

VCAN:

122415819

CCIN:

107268312

DSM:

124413701

NPT:	124221670(Naxd)

NFB:

124184667

NLO:

107223045

NVG:

124307618

AROA:

105693372

TCA:

663809

TMOL:

138132869(Naxd)

SOY:

115879964

AGRG:

126740740

ATD:

109597775

CSET:

123316228

HAXR:

123683451

AGB:

108912581

LDC:

111504003

DVV:

114340353

NVL:

108563047

APLN:

108736379

PPYR:

116168687

OTU:

111428732

BMOR:

101737541 101741762

BMAN:

114239341 114247582

MSEX:

115445830 115447342

DPL:	KGM_210464

BANY:

112042869 112047181

MJU:	123867872 123870290 123875709

NIQ:	126768993 126775004

VCD:	124532205 124537593

MCIX:

123655318 123661487

PMAC:

106716489 106717445

PPOT:

106102306 106103691

PXU:	106114051 106120739

BPHI:

137921568 137931549(Naxd)

PRAP:

110996938

PBX:

123710753

PNAP:

125053058

ZCE:	119832315 119838348

CCRC:

123692959 123695268

LSIN:

126967213

AAGE:

121727272 121736926

HAW:	110374516 110378340

HZE:	124631605 124638526

TNL:	113500667 113503337

SLIU:

111355454 111365132

OFU:	114354887 114363823

ONU:	135073925 135079657

ATRA:

106132603 106134717

GMW:	113515364 113521864

PXY:	105382801 105394440 105394447

PGW:	126369879 126374198

LGLY:

125234400 125242696

CSTB:

134743771 134749545

CFUM:

141427465(Naxd) 141434680 141435220 141443490

CFEL:

113372685

CCRN:

123293142

API:

100159510

DNX:

107163478

AGS:

114130332

RMD:

113557248

ACOO:

126838357

DVT:

126896457

BTAB:

109036431

DCI:

103518627

CLEC:

106670247

HHAL:

106682712(Naxd)

NLU:

111055879

HVI:	124366021 124369112 124371523

MQU:	128997818 129002692 129002805

PHU:	Phum_PHUM417680

FOC:

113215393

TPAL:

117639080

ZNE:

110838069

CSEC:

111862715

PAME:

138698077(Naxd)

SGRE:

126355211

BROR:

134527162

IEL:

124167074

HAMR:

139695108(Naxd)

FCD:

110855848

DMK:

116917734

DPZ:

124314766

PVM:	113807843(Naxd)

PJA:

122251185

PCHN:

125025154

PMOO:

119572593

HAME:

121862070

PCLA:

123746862 138359865

CQD:	128699178(Naxd)

PTRU:

123511548

ESN:

127008279

MNZ:

135214389

MRJ:	136854974(Naxd)

PORN:

139757236(Naxd)

HAZT:

108681880

EAF:

111707462

LSM:	121120533(Naxd)

TCF:

131877973

PPOI:

119102188

DSV:

119464337

RSAN:

119401355

RMP:

119164020

VDE:

111249604

VJA:

111261103

GOE:

100905070

TUT:

107363089

DPTE:

113798684

DFR:

124500353

CSCU:

111630796

CVS:	136978839(Naxd)

PTEP:

107449951

ABRU:

129976502

UDV:

129228308

SDM:

118183791

LPOL:

106469608 106475778

PMEO:

129593512

CEL:	CELE_R107.2(R107.2)

CBR:

CBG_06820

NAI:	NECAME_17250

BMY:	BM_BM14087(Bm14087)

LOA:	LOAG_04267

HRO:	HELRODRAFT_185644

LGI:	LOTGIDRAFT_114759

PCAN:

112559901 112559902

LSAX:

138969123

BGT:

106063460

GAE:	121375568 121392570

HRJ:	124257821 124278356 124288526

HCRA:

139450845

CRG:

105336406

CANU:

128156279

CVN:

111124377

OED:

125682444

MYI:

110454118

PMAX:

117329417

AIRR:

138327079

MMER:

123557693

RPHI:

132732035

DPOL:

127879535

MAEA:

128225714

OBI:

106884448

OSN:

115225949

LJP:

135473112

LAK:	106167578 106175570

SMM:	Smp_000470

SHX:	MS3_00005756

OVI:	T265_01156

EGL:

EGR_02260

LLON:

135493671

NVE:

5517715

EPA:

110233995

ATEN:

116304332

ADF:

107337387

AMIL:

114963938

MCAZ:

138015756

MFOO:

138000314

PDAM:

113686949

SPIS:

111336422

DGT:

114525199

XEN:

124445694

HMG:

105844798

HSY:

130645627

RES:

135686928

TAD:	TRIADDRAFT_25123

AQU:

100636397

ATH:

AT5G19150

ALY:

9307934

CRB:

17883242

CSAT:

104706234 104770265 109124747

EUS:	EUTSA_v10013830mg

BRP:	103851208 103856369

BNA:	106383494 106383498 106431463 106434215 111212886 125575654

BOE:	106322153 106322173 106327075 106334448

RSZ:	108842756 108844017 130507494

THJ:

104818802

CPAP:

110808283

CIT:

102608672

CIC:	CICLE_v10005119mg

PVY:

116135072

MINC:

123219921

TCC:

18602914

GRA:

105796627

GHI:	107927761 107942832

GAB:

108476080

HSYR:

120204788

DZI:

111307930

EGR:

104424730

RARG:

115744835

GMX:	100807779 100808704

GSJ:	114394233 114420143

PVU:

137806855

VRA:

106765509

VAR:	108342505 128193622

VUN:	114176612 114177462

VUM:

124824723

CCAJ:

109809615

APRC:

113846301 113846498

MTR:

25486107

TPRA:

123896333 123897924

CAM:

101494709

PSAT:

127078455

VVO:	131595463 131631005

LJA:

130722991

ADU:	107468897 107468904 107482641

AIP:

107638601

AHF:	112715030 112717258 112741181 112795874 112795879

LANG:

109329796

PCIN:

129309227

QSA:	O6P43_003421

FVE:

101310981

AANS:

126791555

RCN:	112181374 112181376 112193180 112199850

PPER:

18788705

PMUM:

103322821

PAVI:

110745186 110750485

PDUL:

117615122

MDM:

103403850

MSYL:

126606850

PXB:

103930821

PCOX:

137731467

ZJU:

107423291

MNT:

21390754

CSAV:

115722630

CSV:

101209583

CMO:

103483736

BHJ:

120070474

MCHA:

111009202

CMAX:

111479195

CMOS:

111457620

CPEP:

111791306

RCU:

8271588

MEAN:

126667237

JCU:

105631929

HBR:

110655219

MESC:

110611326

POP:

7454254

PEU:

105115532

PALZ:

118061047

PNZ:

133705304

JRE:

109005882

CILL:

122300519

CAVE:

132167410

AGLU:

133882111

QSU:

112026383

QLO:

115993549

TWL:

120011999

VVI:

100244161

VRI:

117914373

SLY:

101252921

SPEN:

107008335

SOT:

102584947

SSTN:

125869960

SDUL:

129887155

CANN:

107841242

LBB:

132644979

NTA:	107801700 107832081

NSY:

104238446

NTO:

104087355

NAU:

109241513

INI:	109175761 109192142

ITR:	116002884 116017205

SIND:

105171385

OEU:	111382138 111396618

EGT:

105953356

SSPL:

121795883

SMIL:

130991535

SHIS:

125196285 125219541

APAN:

127249364

HPUM:

140882596

PHUA:

140980534

PEBU:

140830703

HAN:

110894085

ECAD:

122596002

LSV:

111900451

CCAV:

112516233

DCR:

108226051

CSIN:

114307010 114316175

AEW:	130772217 130772261

DLT:

127800638

BVG:

104888818

SOE:

110775306

CQI:

110697984

ATRI:

130811321

MOF:

131150226

NNU:

104596442

MING:

122090506 122094819

TSS:	122668674 122671300

PSOM:

113273035 113282510

OSA:

4350275

DOSA:

Os11g0276300

OBR:

102702978

OGL:

127755425

BDI:

100837614

ATS:

109743558

TDC:	119286618 119295138

TAES:

123086816 123091154 123096159

TUA:

125550689

LPER:

127293939

LRD:	124703464 124703668

SBI:

8071812

ZMA:

100216749

MFLO:

136482124 136486707

SITA:

101782503

SVS:

117833558

PVIR:

120644253 120675801 120685479

PHAI:

112903423

PAUA:

133886893 133930566

TANG:

140779257

PDA:

103708561

EGU:

105038634

MUS:

135615192

ZOF:	122042331 122046846

DCT:

110095628

PEQ:

110027509

AOF:

109831733

MSIN:

131252563

ACAK:

137963893

NCOL:

116245224 116250054

ATR:

18448538

CJF:

131069533

SMO:	SELMODRAFT_112587 SELMODRAFT_165748

PPP:

112285318

CRE:	CHLRE_05g234664v5 CHLRE_06g250500v5

VCN:	VOLCADRAFT_116306 VOLCADRAFT_82819

MNG:

MNEG_3436

CSL:	COCSUDRAFT_55490

CVR:	CHLNCDRAFT_57702

APRO:

F751_5687

OLU:	OSTLU_18471

OTA:	OT_ostta17g00540

BPG:	Bathy06g01420

MIS:	MICPUN_82051

MPP:	MICPUCDRAFT_23275

CME:	CYME_CMA033C

GSL:	Gasu_56680

CCP:	CHC_T00002442001

SCE:	YKL151C(NNR2)

SEUB:

DI49_3229

SPAO:

SPAR_K00670

AGO:	AGOS_ACR055W

ERC:

Ecym_8245

KLA:	KLLA0_D04510g

KMX:	KLMA_20469

LTH:	KLTH0G07414g

VPO:	Kpol_543p68

ZRO:	ZYRO0C10802g

CGR:	2887385(GVI51_E06083)

NCS:	NCAS_0F02350(NCAS0F02350)

NDI:	NDAI_0C03850(NDAI0C03850)

TPF:	TPHA_0E02390(TPHA0E02390)

TBL:	TBLA_0A10100(TBLA0A10100)

TGB:	HG536_0E03810

TDL:	TDEL_0E03700(TDEL0E03700)

KAF:	KAFR_0E01710(KAFR0E01710)

KNG:	KNAG_0F02790(KNAG0F02790)

ZMK:	HG535_0A04850

SLUD:

SCDLUD_004770

DHA:	DEHA2E08206g

PIC:	PICST_68225

PGU:	PGUG_05496

SPAA:

SPAPADRAFT_143283

LEL:	PVL30_005545

LBG:	92209302(LODBEIA_P41060)

CAL:	CAALFM_C602030CA(CaO19.3508)

CTP:	CTRG_02900

COT:	CORT_0F02780

CDU:	CD36_62160

CTEN:

18247164(PSN45_004062)

CLU:	CLUG_03344

CLUS:

A9F13_01g08481

CAUR:

CJI96_0002216

ASAU:

88173833(PUMCH_002769)

PPA:	PAS_chr4_0738

PKZ:	C5L36_0B01900

BNN:	FOA43_003692

BBRX:

BRETT_000737

OPA:	HPODL_01232

YLI:	2910735(YALI2_D00888g)

SLB:	AWJ20_4706

NCR:

NCU02513

NTE:	NEUTE1DRAFT126541(NEUTE1DRAFT_126541)

SMP:	10808657(SMAC4_05960)

PAN:	PODANSg10114

PBEL:

QC761_108380

PPSD:

QC762_108380

PPSP:

QC763_108380

PPSA:

QC764_108380

TTT:	THITE_2114110

MTM:	MYCTH_2295666

CTHR:

CTHT_0073020

RTHE:

98123356(VTJ83DRAFT_2441)

MGR:

MGG_13834

PGRI:

PgNI_09315

TMN:	UCRPA7_2738

SSCK:

SPSK_04353

FGR:	FGSG_01069

FPU:	FPSE_10734

FPOA:

FPOAC1_001157

FVN:	FVRRES_01340

FVR:	FVEG_01208

FOX:	FOXG_00311

NHE:	NECHADRAFT_98759

FFC:	NCS54_00076900

FKR:	NCS57_00074900

FMU:	J7337_000810

TRE:	TRIREDRAFT_45675

TRR:	M419DRAFT_107783

TATV:

25776394(TrAtP1_007948)

TASP:

36618344(TrAFT101_007528)

MAW:	19249563(J3458_003384)

MAJ:

MAA_03978

MBRN:

26240957(NNRD)

PCHM:

VFPPC_12841

CMT:

CCM_06173

AMUS:

LMH87_005058

PLJ:	28885691(PLICBS_007223)

PTKZ:

JDV02_007037

VAL:	VDBG_05019

VDA:	VDAG_10346

CFJ:	CFIO01_07431

CLUP:

CLUP02_11877

CHIG:

CH63R_11361

CDET:

87946113(CDEST_09610)

SAPO:

SAPIO_CDS3583

ELA:	UCREL1_2319

PFY:	PFICI_00848

SSL:	SS1G_01686

BFU:	BCIN_02g03660

MBE:

MBM_02219

PSCO:

LY89DRAFT_690887

GLZ:	GLAREA_12272

ANI:	ANIA_05994

AFM:	AFUA_2G10120

ACT:	ACLA_069150

NFI:	NFIA_085530

AOR:	AO090011000624

ANG:	An16g04910

AFV:	AFLA_008026

ALUC:

AKAW2_70419A

ACHE:

ACHE_40983S

APUU:

APUU_11039A

PCS:	N7525_004342

PDP:	PDIP_64510

POU:	POX_f07907

TMF:	EYB26_007685

TRG:	TRUGW13939_01104

CIM:	CIMG_02220

CPW:	9696263(D8B26_001105)

URE:	UREG_01498

ABE:

ARB_06465

TVE:

TRV_07085

PBL:	PAAG_04693

PBN:	PADG_02448

AJE:	HCAG_02705

BGH:	BDBG_04435

PNO:	SNOG_04206

PTE:

PTT_19720

PTRR:

6345833(PtrM4_141320)

BZE:	COCCADRAFT_33338

BSC:	COCSADRAFT_161745

BOR:	COCMIDRAFT_89571

AALT:

CC77DRAFT_1024428

ADAC:

96087272(ACET3X_006950)

ARAB:

EKO05_0002363

ZTR:	MYCGRDRAFT_98664

PFJ:	MYCFIDRAFT_27723

FFU:	CLAFUR5_00433

CBET:

CB0940_01713

BCOM:

BAUCODRAFT_244891

NPA:	UCRNP2_6071

TML:	GSTUM_00010535001

SPO:	2539500(nnr2)

SOM:	SOMG_04456(nnr2)

CNE:

CNL05250

CNB:

CNBI1570

CNG:	CNAG_05097

CGI:	CGB_D1770W

CDEU:

CNBG_4593

CDEC:

89987450(IAS62_000674)

CTEG:

91987031(I308_100173)

CBAS:

91980729(I312_100681)

CDEP:

91087977(L203_103767)

KMG:	30163981(I203_103737)

KNE:	92179076(IAR55_001817)

KDJ:	28967971(I303_104748)

KBI:	30209660(I302_106138)

KPIN:

30172677(I206_104116)

KSH:	87955629(IL334_003498)

KER:	91100205(V865_001401)

TMS:	TREMEDRAFT_29037

TASA:

A1Q1_06429

CCAC:

CcaHIS019_0509270(CcaverHIS019_0509270)

PPL:	POSPLDRAFT_104462 POSPLDRAFT_96500

TVS:	TRAVEDRAFT_168170

DSQ:	DICSQDRAFT_163516

PCO:	PHACADRAFT_263991

SHS:	STEHIDRAFT_121607

HIR:	HETIRDRAFT_477924

PSQ:	PUNSTDRAFT_93565

ADL:	AURDEDRAFT_108391 AURDEDRAFT_129786 AURDEDRAFT_129796

FME:	FOMMEDRAFT_22449

GTR:	GLOTRDRAFT_120849

RSX:	RhiXN_04742

LBC:	LACBIDRAFT_187613

CCI:	CC1G_00865

ABP:	AGABI1DRAFT126077(AGABI1DRAFT_126077)

ABV:	AGABI2DRAFT143608(AGABI2DRAFT_143608)

PCUB:

JR316_0008000

MPR:	MPER_02631

MRR:	Moror_6968

E1B28_007467

SCM:	SCHCO_02619546(SCHCODRAFT_02619546)

CPUT:

CONPUDRAFT_127559

SLA:	SERLADRAFT_473270

WSE:	WALSEDRAFT_68473

WIC:	J056_001528

UMA:	UMAG_05844

PFP:	PFL1_02697

SGRA:

EX895_003238

MGL:

MGL_0838

MRT:

MRET_2073

MSYM:

MSY001_0874

PGR:	PGTG_19074 PGTG_19583

PTRC:

PtA15_2A469

PSTR:

Pst134EA_005355 Pst134EA_032919

MLR:	MELLADRAFT_50177

ECU:	ECU03_1390

EIN:	Eint_031290

EHE:	EHEL_031310

ERO:	EROM_031260

NCE:	NCER_100449

VNX:	VNE69_01388

RIE:	OCT59_025123

DDI:	DDB_G0290799

DPP:	DICPUDRAFT_151213

DFA:

DFA_08558

EHI:	EHI_194450(46.t00021)

EDI:	EDI_289560

EIV:	EIN_496870

ACAN:

ACA1_261480

PYO:	PY17X_0906500

PCB:	PCHAS_0706300

PBE:	PBANKA_0905100

PKN:	PKNH_0941800

PVX:	PVX_092800 PVX_230290

PCY:	PCYB_094950

BMIC:

BMR1_01G03000

CPV:

cgd7_3640

CHO:	Chro.70406

TGO:	TGME49_258160

TET:	TTHERM_00133729

PTM:	GSPATT00013458001

PTI:	PHATRDRAFT_19831

FCY:	FRACYDRAFT_218033

AAF:	AURANDRAFT_27953

PIF:	PITG_02281

PSOJ:

PHYSODRAFT_353744

SPAR:

SPRG_00224

NGR:	NAEGRDRAFT_32974

TVA:	4766774(TVAGG3_0981950)

GLA:	GL50803_004255

EHX:	EMIHUDRAFT_441654 EMIHUDRAFT_442290

GTT:	GUITHDRAFT_68606

» show all

Reference

1 [PMID:13331940]

Authors

MEINHART JO, CHAYKIN S, KREBS EG

Title

Enzymatic conversion of a reduced diphosphopyridine nucleotide derivative to reduced diphosphopyridine nucleotide.

Journal

J Biol Chem 220:821-9 (1956)

Sequence

[sce:YKL151C]

Reference

Authors

Regueiro Varela B, Amelunxen R, Grisolia S.

Title

Synthesis and degradation of monohydroxytetrahydronicotinamide adenine dinucleotide phosphate.

Journal

Physiol Chem Phys 2:445-454 (1970)

Reference

3 [PMID:3061454]

Authors

Acheson SA, Kirkman HN, Wolfenden R.

Title

Equilibrium of 5,6-hydration of NADH and mechanism of ATP-dependent dehydration.

Journal

Biochemistry 27:7371-5 (1988)
DOI:10.1021/bi00419a030

Sequence

[sce:YKL151C]

Reference

4 [PMID:21994945]

Authors

Marbaix AY, Noel G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL

Title

Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair.

Journal

J Biol Chem 286:41246-52 (2011)
DOI:10.1074/jbc.C111.310847

Sequence

[mmu:69225] [sce:YKL151C]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.93

IUBMB Enzyme Nomenclature:

4.2.1.93

ExPASy - ENZYME nomenclature database:

4.2.1.93

BRENDA, the Enzyme Database:

4.2.1.93

CAS:	116669-08-0

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Gene (2040)   
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   RefGene (1771)   
Protein sequence (4842)   
   UniProt (4665)   
   SWISS-PROT (42)   
   RefSeq(pep) (92)   
   PDBSTR (43)   
DNA sequence (245)   
   RefSeq(nuc) (164)   
   GenBank (48)   
   EMBL (33)   
3D Structure (27)   
   PDB (27)   
Protein domain (3)   
   InterPro (3)   
All databases (7157)   

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