KEGG ENZYME: 4.2.1.94

ENZYME: 4.2.1.94

Entry

EC 4.2.1.94                 Enzyme

Name

scytalone dehydratase;
scytalone 7,8-hydro-lyase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)

Reaction(IUBMB)

scytalone = 1,3,8-trihydroxynaphthalene + H2O [RN:R02907]

Reaction(KEGG)

R02907

Substrate

scytalone [CPD:C00779]

Product

1,3,8-trihydroxynaphthalene [CPD:C01173];
H2O [CPD:C00001]

Comment

Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi.

History

EC 4.2.1.94 created 1992

Orthology

K17740

scytalone dehydratase

Genes

QSU:	111989963 112000554

NCR:

NCU07823

NTE:	NEUTE1DRAFT116788(NEUTE1DRAFT_116788)

SMP:	SMAC_02101(sdh)

PAN:	PODANSg5567

TTT:	THITE_2120303

MTM:	MYCTH_102118 MYCTH_2294550 MYCTH_2305635

CTHR:

CTHT_0071160

MGR:

MGG_05059

TMN:	UCRPA7_1777 UCRPA7_5366

SSCK:

SPSK_06530

FGR:	FGSG_06477

FPU:	FPSE_10132

FVR:	FVEG_12220 FVEG_13808

FOX:	FOXG_13320 FOXG_17008 FOXG_20830

MAW:

MAC_08229

MAJ:	MAA_03241 MAA_07697

CMT:	CCM_03517 CCM_03661

VAL:	VDBG_06239

VDA:	VDAG_03393

CFJ:	CFIO01_04902 CFIO01_12532

SAPO:

SAPIO_CDS5047

ELA:	UCREL1_5769 UCREL1_8372

PFY:	PFICI_00097 PFICI_02498 PFICI_03271

SSL:	SS1G_13314

BFU:	BCIN_03g08110(Bcscd1) BCIN_15g01680(Bcscd2)

MBE:	MBM_07652 MBM_08143

PSCO:

LY89DRAFT_639476 LY89DRAFT_742875

GLZ:	GLAREA_06715 GLAREA_07438

AFM:	AFUA_2G17580

ACT:	ACLA_076480

NFI:	NFIA_092990 NFIA_101590

ANG:	ANI_1_2396074(An08g09920)

AFV:	AFLA_002062

ALUC:

AKAW2_51771S

ACHE:

ACHE_20820A(ARP1)

APUU:

APUU_12004S APUU_22041S APUU_51443A(ARP1_2) APUU_60817A

PCS:	Pc16g10760 Pc21g16420

PDP:	PDIP_49310

TMF:	PMAA_031650 PMAA_082040 PMAA_095520 PMAA_100560

TRG:	TRUGW13939_00029 TRUGW13939_07450

PNO:	SNOG_11546

PTE:	PTT_09808 PTT_17822

BZE:	COCCADRAFT_28430 COCCADRAFT_39775

BSC:	COCSADRAFT_101310 COCSADRAFT_144875 COCSADRAFT_178687

BOR:	COCMIDRAFT_106780 COCMIDRAFT_37042 COCMIDRAFT_94596

AALT:

CC77DRAFT_1025632 CC77DRAFT_945423

ZTR:	MYCGRDRAFT_18775(MgSCY1) MYCGRDRAFT_90337

PFJ:	MYCFIDRAFT_58137

BCOM:

BAUCODRAFT_119992

NPA:	UCRNP2_5381

» show all

Reference

Authors

Butler, M.J., Lazarovits, G., Higgins, V.J. and Lachance, M.-A.

Title

Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi.

Journal

Exp Mycol 12:367-376 (1988)

Reference

Authors

Tajima, S., Kubo, Y., Furusawa, I. and Shishiyama, J.

Title

Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus.

Journal

Exp Mycol 13:69 (1989)

Reference

Authors

Wheeler, M.H. and Greenblatt, G.A.

Title

The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.

Journal

Exp Mycol 12:151-160 (1988)

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.94

IUBMB Enzyme Nomenclature:

4.2.1.94

ExPASy - ENZYME nomenclature database:

4.2.1.94

BRENDA, the Enzyme Database:

4.2.1.94

CAS:	118901-79-4

DBGET integrated database retrieval system