KEGG   ENZYME: 4.2.1.94
Entry
EC 4.2.1.94                 Enzyme                                 
Name
scytalone dehydratase;
scytalone 7,8-hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)
Reaction(IUBMB)
scytalone = 1,3,8-trihydroxynaphthalene + H2O [RN:R02907]
Reaction(KEGG)
R02907
Substrate
scytalone [CPD:C00779]
Product
1,3,8-trihydroxynaphthalene [CPD:C01173];
H2O [CPD:C00001]
Comment
Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi.
History
EC 4.2.1.94 created 1992
Orthology
K17740  scytalone dehydratase
Genes
NCR: NCU07823
NTE: NEUTE1DRAFT116788(NEUTE1DRAFT_116788)
SMP: 10807942(SMAC4_02101)
PAN: PODANSg5567
PBEL: QC761_711610(SCD1)
PPSD: QC762_711610(SCD1)
PPSP: QC763_711610(SCD1)
PPSA: QC764_711610(SCD1)
TTT: THITE_2120303
MTM: MYCTH_102118 MYCTH_2294550 MYCTH_2305635
CTHR: CTHT_0071160
RTHE: 98122112(VTJ83DRAFT_1321)
MGR: MGG_05059
PPEI: PpBr36_03433
PGRI: PgNI_01243
TMN: UCRPA7_1777 UCRPA7_5366
SSCK: SPSK_06530
FGR: FGSG_06477
FPU: FPSE_10132
FPOA: FPOAC1_010187
FVN: FVRRES_11171
FVR: FVEG_12220 FVEG_13808
FOX: FOXG_13320 FOXG_17008 FOXG_20830
FKR: NCS57_01084600
FMU: J7337_007550 J7337_012176
TATV: 25775244(TrAtP1_013301)
TASP: 36618148(TrAFT101_009496)
MAW: 19252540(J3458_013095)
MAJ: MAA_03241 MAA_07697
MBRN: 90967997(Arp1_5)
PCHM: VFPPC_05304
CMT: CCM_03517 CCM_03661
AMUS: LMH87_010603
VAL: VDBG_06239
VDA: VDAG_03393
CFJ: CFIO01_04902 CFIO01_12532
CLUP: CLUP02_04896 CLUP02_06380
CHIG: CH63R_00358
CDET: 87939057(CDEST_02554)
SAPO: SAPIO_CDS5047
ELA: UCREL1_5769 UCREL1_8372
PFY: PFICI_00097 PFICI_02498 PFICI_03271
SSL: SS1G_13314
BFU: BCIN_03g08110(Bcscd1) BCIN_15g01680(Bcscd2)
MBE: MBM_07652 MBM_08143
PSCO: LY89DRAFT_639476 LY89DRAFT_742875
GLZ: GLAREA_06715 GLAREA_07438
AFM: AFUA_2G17580
ACT: ACLA_076480
NFI: NFIA_092990 NFIA_101590
ANG: An08g09920
AFV: AFLA_002062
ALUC: AKAW2_51771S
ACHE: ACHE_20820A(ARP1)
APUU: APUU_12004S APUU_22041S APUU_51443A(ARP1_2) APUU_60817A
PCS: N7525_008171 N7525_010676
PDP: PDIP_49310
POU: POX_a00754 POX_b03428
TMF: EYB26_001620 EYB26_004248 EYB26_006506 EYB26_006988
TRG: TRUGW13939_00029 TRUGW13939_07450
PNO: SNOG_11546
PTE: PTT_09808 PTT_17822
PTRR: 6340946(PtrM4_062960) 6342999(PtrM4_117080)
BZE: COCCADRAFT_28430 COCCADRAFT_39775
BSC: COCSADRAFT_101310 COCSADRAFT_144875 COCSADRAFT_178687
BOR: COCMIDRAFT_106780 COCMIDRAFT_37042 COCMIDRAFT_94596
AALT: CC77DRAFT_1025632 CC77DRAFT_945423
ADAC: 96087300(ACET3X_006978)
ARAB: EKO05_0003730
ZTR: MYCGRDRAFT_18775(MgSCY1) MYCGRDRAFT_90337
PFJ: MYCFIDRAFT_58137
FFU: CLAFUR5_04641 CLAFUR5_12909
CBET: CB0940_02505 CB0940_11965
BCOM: BAUCODRAFT_119992
NPA: UCRNP2_5381
 » show all
Reference
1
  Authors
Butler MJ, Lazarovits G, Higgins VJ, Lachance M-A.
  Title
Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi.
  Journal
Exp Mycol 12:367-376 (1988)
Reference
2
  Authors
Tajima S, Kubo Y, Furusawa I, Shishiyama J.
  Title
Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus.
  Journal
Exp Mycol 13:69 (1989)
Reference
3
  Authors
Wheeler MH, Greenblatt GA.
  Title
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.
  Journal
Exp Mycol 12:151-160 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.94
IUBMB Enzyme Nomenclature: 4.2.1.94
ExPASy - ENZYME nomenclature database: 4.2.1.94
BRENDA, the Enzyme Database: 4.2.1.94
CAS: 118901-79-4

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Gene (44)   
   RefGene (44)   
Protein sequence (82)   
   UniProt (37)   
   SWISS-PROT (4)   
   RefSeq(pep) (16)   
   PDBSTR (20)   
   PMD (5)   
DNA sequence (39)   
   RefSeq(nuc) (32)   
   GenBank (4)   
   EMBL (3)   
3D Structure (8)   
   PDB (8)   
Protein domain (3)   
   InterPro (3)   
All databases (176)   

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