KEGG   ENZYME: 4.2.1.94
Entry
EC 4.2.1.94                 Enzyme                                 
Name
scytalone dehydratase;
scytalone 7,8-hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)
Reaction(IUBMB)
scytalone = 1,3,8-trihydroxynaphthalene + H2O [RN:R02907]
Reaction(KEGG)
R02907
Substrate
scytalone [CPD:C00779]
Product
1,3,8-trihydroxynaphthalene [CPD:C01173];
H2O [CPD:C00001]
Comment
Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi.
History
EC 4.2.1.94 created 1992
Orthology
K17740  scytalone dehydratase
Genes
QSU111989963 112000554
NCRNCU07823
NTENEUTE1DRAFT116788(NEUTE1DRAFT_116788)
SMPSMAC_02101(sdh)
PANPODANSg5567
TTTTHITE_2120303
MTMMYCTH_102118 MYCTH_2294550 MYCTH_2305635
CTHRCTHT_0071160
MGRMGG_05059
TMNUCRPA7_1777 UCRPA7_5366
SSCKSPSK_06530
FGRFGSG_06477
FPUFPSE_10132
FVRFVEG_12220 FVEG_13808
FOXFOXG_13320 FOXG_17008 FOXG_20830
MAWMAC_08229
MAJMAA_03241 MAA_07697
CMTCCM_03517 CCM_03661
VALVDBG_06239
VDAVDAG_03393
CFJCFIO01_04902 CFIO01_12532
SAPOSAPIO_CDS5047
ELAUCREL1_5769 UCREL1_8372
PFYPFICI_00097 PFICI_02498 PFICI_03271
SSLSS1G_13314
BFUBCIN_03g08110(Bcscd1) BCIN_15g01680(Bcscd2)
MBEMBM_07652 MBM_08143
PSCOLY89DRAFT_639476 LY89DRAFT_742875
GLZGLAREA_06715 GLAREA_07438
AFMAFUA_2G17580
ACTACLA_076480
NFINFIA_092990 NFIA_101590
ANGANI_1_2396074(An08g09920)
AFVAFLA_002062
ALUCAKAW2_51771S
ACHEACHE_20820A(ARP1)
APUUAPUU_12004S APUU_22041S APUU_51443A(ARP1_2) APUU_60817A
PCSPc16g10760 Pc21g16420
PDPPDIP_49310
TMFPMAA_031650 PMAA_082040 PMAA_095520 PMAA_100560
TRGTRUGW13939_00029 TRUGW13939_07450
PNOSNOG_11546
PTEPTT_09808 PTT_17822
BZECOCCADRAFT_28430 COCCADRAFT_39775
BSCCOCSADRAFT_101310 COCSADRAFT_144875 COCSADRAFT_178687
BORCOCMIDRAFT_106780 COCMIDRAFT_37042 COCMIDRAFT_94596
AALTCC77DRAFT_1025632 CC77DRAFT_945423
ZTRMYCGRDRAFT_18775(MgSCY1) MYCGRDRAFT_90337
PFJMYCFIDRAFT_58137
BCOMBAUCODRAFT_119992
NPAUCRNP2_5381
 » show all
Reference
1
  Authors
Butler, M.J., Lazarovits, G., Higgins, V.J. and Lachance, M.-A.
  Title
Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi.
  Journal
Exp Mycol 12:367-376 (1988)
Reference
2
  Authors
Tajima, S., Kubo, Y., Furusawa, I. and Shishiyama, J.
  Title
Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus.
  Journal
Exp Mycol 13:69 (1989)
Reference
3
  Authors
Wheeler, M.H. and Greenblatt, G.A.
  Title
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.
  Journal
Exp Mycol 12:151-160 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.94
IUBMB Enzyme Nomenclature: 4.2.1.94
ExPASy - ENZYME nomenclature database: 4.2.1.94
BRENDA, the Enzyme Database: 4.2.1.94
CAS: 118901-79-4

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