KEGG   ENZYME: 4.2.2.1Help
Entry
EC 4.2.2.1                  Enzyme                                 

Name
hyaluronate lyase;
hyaluronidase (ambiguous);
glucuronoglycosaminoglycan lyase (ambiguous);
spreading factor;
mucinase (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
BRITE hierarchy
Sysname
hyaluronate lyase
Reaction(IUBMB)
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. [RN:R02465 R06242]
Reaction(KEGG)
Comment
The enzyme catalyses the degradation of hyaluronan by a beta-elimination reaction. Also acts on chondroitin. The product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose
History
EC 4.2.2.1 created 1961 as EC 4.2.99.1, transferred 1972 to EC 4.2.2.1, modified 2001
Orthology
K01727  hyaluronate lyase
Genes
CTU: CTU_30970
YEF: FORC2_p069
YRU: BD65_2430
VVY: VV0533
VFI: VF_A0994
VFM: VFMJ11_A1113
BUT: X994_6505(xly)
HFE: HFELIS_14140
HBI: HBZC1_15820
HHM: BN341_6200
BSE: Bsel_0843
SAU: SA2003(hysA)
SAV: SAV2202(hysA)
SAW: SAHV_2186(hysA)
SAM: MW2129(hysA)
SAS: SAS2103
SAR: SAR1892(hysA1) SAR2292(hysA2)
SAC: SACOL2194(hysA)
SAX: USA300HOU_2197(hysA)
SAA: SAUSA300_2161(hysA)
SAE: NWMN_2106(hysA)
SAD: SAAV_2263
SUE: SAOV_2247
SUK: SAA6008_02243(hysA)
SUZ: MS7_2224
SUX: SAEMRSA15_21070(hysA2)
SUW: SATW20_23400(hysA)
SAUE: RSAU_001662(hysA) RSAU_002045(hysA2)
SAUS: SA40_1662(hysA) SA40_1956(hysA)
SAUU: SA957_1745(hysA) SA957_2040(hysA)
SAUG: SA268_1750(hysA) SA268_2111(hysA)
SAUZ: SAZ172_2305(hysA)
SAUT: SAI1T1_2016390(hysA)
SAUJ: SAI2T2_1016400(hysA)
SAUK: SAI3T3_1016390(hysA)
SAUQ: SAI4T8_1016400(hysA)
SAUF: X998_2189
SAB: SAB1663(hysA1) SAB2082(hysA2)
SUY: SA2981_2139(hysA)
SAUB: C248_1856(hysA1) C248_2244(hysA2)
SAUC: CA347_2289
SAUR: SABB_04270(hysA)
SAUI: AZ30_11650
SAUD: CH52_07940
SAMS: NI36_10880
SHU: SHYC_11715(hysA)
SAGQ: EP23_10455
PSWU: SY83_13390
SPY: SPy_1032(hylA)
SPZ: M5005_Spy0757(hylA)
SPYM: M1GAS476_0819(hylA)
SPYA: A20_0798c
SPH: MGAS10270_Spy0874(hylA)
SPI: MGAS10750_Spy0909(hylA)
SPK: MGAS9429_Spy0871(hylA)
SPB: M28_Spy0736(hylA)
STG: MGAS15252_0784(hylA)
STX: MGAS1882_0780(hylA)
SOZ: Spy49_0811c(hylA)
SPYH: L897_03945
SPN: SP_0314
SPD: SPD_0287
SPR: spr0286(hysA)
SPW: SPCG_0322
SJJ: SPJ_0310
SPX: SPG_0285(hyl)
SNT: SPT_0364
SND: MYY_0397
SPNN: T308_01575
SPV: SPH_0426
SPP: SPP_0350
SPNG: HMPREF1038_00364(hysA)
SNP: SPAP_0347
SAG: SAG1197
SAN: gbs1270
SAK: SAK_1284(hylB)
SGC: A964_1170
SAGS: SaSA20_1016(hylB)
SAGL: GBS222_1026(hylB)
SAGM: BSA_12760
SAGI: MSA_13200
SAGR: SAIL_13150
SAGP: V193_05585
SAGC: DN94_05585
SAGE: EN72_06630
SAGG: EN73_06165
SUP: YYK_05005
SSUY: YB51_6050
SSUI: T15_0747
SEZ: Sez_1299(hylB)
SEQ: SZO_06680
SEQU: Q426_02630
SDS: SDEG_0654
SDA: GGS_0628(hylB)
SDC: SDSE_0694(hylB)
STK: STP_1167
SIE: SCIM_1362
SIB: SIR_1547
SIU: SII_1533
SANC: SANR_1718
SCG: SCI_1642
SCON: SCRE_1598
SCOS: SCR2_1598
SIK: K710_0217
LPAP: LBPC_2660
LCS: LCBD_2903
LCE: LC2W_2877
LRL: LC705_02696(xalA)
LRA: LRHK_2805
EFL: EF62_0109
EFS: EFS1_2467
EFQ: DR75_1758
ENE: ENT_22740
EHR: EHR_14305
EMU: EMQU_2462
CBN: CbC4_2106
CBV: U729_2500
ERH: ERH_0150(hylA) ERH_0765(hylB) ERH_1210(hylC)
MCD: MCRO_0392
MFR: MFE_04780
MFP: MBIO_0039
SCO: SCO5534(SC1C2.15)
SGR: SGR_291
SGB: WQO_33115
SCT: SCAT_4363
SFA: Sfla_2926
SBH: SBI_01112
SHY: SHJG_6645
SVE: SVEN_5221
SALS: SLNWT_4661
STRP: F750_3862
SFI: SFUL_16
SALU: DC74_5664
SALL: SAZ_29920
STRE: GZL_03204
SLD: T261_2519
SRW: TUE45_06045(xly)
SLE: sle_21210(sle_21210)
STRD: NI25_11545
SMAL: SMALA_0375
SLAU: SLA_5431
SALJ: SMD11_2031
SLX: SLAV_04325(xly)
MTS: MTES_2849
ART: Arth_1698
ARM: ART_3702
AAU: AAur_3068
LMOI: VV02_06880
PAC: PPA0380
PAW: PAZ_c03930(hylB)
PACC: PAC1_01925
PACH: PAGK_0394
CACN: RN83_02370
SRO: Sros_4208
AMD: AMED_5970
AMN: RAM_30620
AMM: AMES_5886
AMZ: B737_5886
AOI: AORI_4997
KAL: KALB_2559
SNA: Snas_0850
SMF: Smon_0125
 » show all
Taxonomy
Reference
1  [PMID:13762462]
  Authors
LINKER A, HOFFMAN P, MEYER K, SAMPSON P, KORN ED.
  Title
The formation of unsaturated disacharides from mucopoly-saccharides and their cleavage to alpha-keto acid by bacterial enzymes.
  Journal
J Biol Chem 235:3061-5 (1960)
Reference
2  [PMID:14943668]
  Authors
MEYER K, RAPPORT MM.
  Title
Hyaluronidases.
  Journal
Adv Enzymol Relat Subj Biochem 13:199-236 (1952)
Reference
3  [PMID:5642600]
  Authors
Moran F, Nasuno S, Starr MP.
  Title
Extracellular and intracellular polygllacturonic acid trans-eliminases of Erwinia carotovora.
  Journal
Arch Biochem Biophys 123:298-306 (1968)
DOI:10.1016/0003-9861(68)90138-0
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.1
IUBMB Enzyme Nomenclature: 4.2.2.1
ExPASy - ENZYME nomenclature database: 4.2.2.1
BRENDA, the Enzyme Database: 4.2.2.1
CAS: 37259-53-3

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