| Entry |
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| Name |
heparin-sulfate lyase;
heparin-sulfate eliminase;
heparitin-sulfate lyase;
heparitinase I;
heparitinase II
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| Class |
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
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| Sysname |
heparin-sulfate lyase
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| Reaction(IUBMB) |
Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
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| Comment |
Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.
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| History |
EC 4.2.2.8 created 1972
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| Orthology |
| K19051 | heparin/heparan-sulfate lyase |
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| Genes |
| LPRO: | PQO03_05670 PQO03_05680 |
| BTHO: | Btheta7330_03330(hepC_1) Btheta7330_03335(hepC_2) |
| BOA: | Bovatus_04863(hepC_2) Bovatus_04868(hepC_3) |
| BCEL: | BcellWH2_01704(hepC) |
| BEG: | INE88_00172(hepB_1) INE88_01080(hepC_1) INE88_01245(hepC_2) INE88_01975(hepB_2) |
| BSTE: | K6V31_02525 K6V31_04695 K6V31_09835 K6V31_14020 K6V31_14045 |
| BFE: | K6V30_11670 K6V30_11705 |
| BFC: | BacF7301_13570 BacF7301_13595 BacF7301_13600 |
| BFIN: | BFINE_16790 BFINE_49980 BFINE_50170 |
| BDS: | ACNOGP_18980(hepC) ACNOGP_18990(hepC) ACNOGP_19015(hepC) |
| BZA: | ACNOHN_01825 ACNOHN_21100(hepC) ACNOHN_21110(hepC) ACNOHN_21135(hepC) ACNOHN_21905(hepC) |
| COPR: | Cop2CBH44_22930 Cop2CBH44_22940 Cop2CBH44_27650 |
| ASEN: | NQ519_12975 NQ519_12980 |
| COY: | HF329_08420 HF329_21215 |
| PSN: | Pedsa_0684 Pedsa_1814 Pedsa_1818 |
| TPEL: | P0M28_18290 P0M28_23265 |
| FPLU: | NLG42_15400 NLG42_15405 |
| PKP: | SK3146_03003(hepB_1) SK3146_03009(hepB_2) |
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| Reference |
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| Authors |
Hovingh P, Linker A. |
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| Title |
The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria. |
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| Journal |
J Biol Chem 245:6170-5 (1970) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.2.8 |
| ExPASy - ENZYME nomenclature database: | 4.2.2.8 |
| BRENDA, the Enzyme Database: | 4.2.2.8 |
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