KEGG ENZYME: 4.2.3.104

ENZYME: 4.2.3.104

Entry

EC 4.2.3.104                Enzyme

Name

alpha-humulene synthase;
ZSS1

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase (alpha-humulene-forming)

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate [RN:R08373]

Reaction(KEGG)

R08373

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

alpha-humulene [CPD:C09684];
diphosphate [CPD:C00013]

Comment

The enzyme from Zingiber zerumbet, shampoo ginger, also gives traces of beta-caryophyllene.

History

EC 4.2.3.104 created 2012

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

Orthology

K14184

alpha-humulene/beta-caryophyllene synthase

Genes

ATH:	AT5G23960(TPS21)

CRB:	17882696 17886620

CSAT:

104706692

EUS:	EUTSA_v10012105mg EUTSA_v10012129mg

BRP:	103849526 103849591 103874257

BNA:	106352011 106380498

BOE:	106301560 106326551

RSZ:	108831150 108831714 108832465 108840558

THJ:	104818160 104818164 104818498

MEAN:

126679799

TWL:	119985452 119988733 120010736

TDC:

119345609

EGU:

105034997

MUS:

103992270

» show all

Reference

1 [PMID:18273640]

Authors

Yu F, Okamto S, Nakasone K, Adachi K, Matsuda S, Harada H, Misawa N, Utsumi R

Title

Molecular cloning and functional characterization of alpha-humulene synthase, a possible key enzyme of zerumbone biosynthesis in shampoo ginger (Zingiber zerumbet Smith).

Journal

Planta 227:1291-9 (2008)
DOI:10.1007/s00425-008-0700-x

Sequence

[ag:BAG12020]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.104

IUBMB Enzyme Nomenclature:

4.2.3.104

ExPASy - ENZYME nomenclature database:

4.2.3.104

BRENDA, the Enzyme Database:

4.2.3.104

DBGET integrated database retrieval system