KEGG ENZYME: 4.2.3.117

ENZYME: 4.2.3.117

Entry

EC 4.2.3.117                Enzyme

Name

(-)-camphene synthase;
CS

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-camphene-forming]

Reaction(IUBMB)

geranyl diphosphate = (-)-camphene + diphosphate [RN:R09972]

Reaction(KEGG)

R09972

Substrate

geranyl diphosphate [CPD:C00341]

Product

(-)-camphene [CPD:C06305];
diphosphate [CPD:C00013]

Comment

(-)-Camphene is the major product in Abies grandis (grand fir) with traces of other monoterpenoids [1]. In Pseudotsuga menziesii (Douglas-fir) there are about equal parts of (-)-camphene and (-)-alpha-pinene with traces of four other monoterpenoids [2,3]. In Solanum lycopersicum (tomato) tricyclene, beta-myrcene, limonene, and traces of several other monoterpenoids are also formed [4]. See also EC 4.2.3.15 myrcene synthase, EC 4.2.3.16 (4S)-limonene synthase, EC 4.2.3.119 (-)-alpha-pinene synthase and EC 4.2.3.105 tricyclene synthase.

History

EC 4.2.3.117 created 2012

Pathway

ec00902

Monoterpenoid biosynthesis

ec01100

Metabolic pathways

Orthology

K21925

(-)-camphene/tricyclene/(4S)-limonene/myrcene synthase

K22208

(-)-camphene synthase

Genes

SLY:	101245212(TPS3) 101249864

SPEN:

107012939 107012948

SOT:	102591915 102602070

SSTN:

125861389 125861571

CANN:

107840093

LBB:

132598839

NTA:	107785945 107787835

NSY:

104238653

NTO:

104090536

NAU:

109214608

SMIL:

131005775

SHIS:

125185612 125200997 125204274 125208619 125218604 125219856

» show all

Reference

1 [PMID:10441373]

Authors

Bohlmann J, Phillips M, Ramachandiran V, Katoh S, Croteau R

Title

cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis).

Journal

Arch Biochem Biophys 368:232-43 (1999)
DOI:10.1006/abbi.1999.1332

Sequence

[ag:AAB70707]

Reference

2 [PMID:15921711]

Authors

Huber DP, Philippe RN, Godard KA, Sturrock RN, Bohlmann J

Title

Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii.

Journal

Phytochemistry 66:1427-39 (2005)
DOI:10.1016/j.phytochem.2005.04.030

Reference

3 [PMID:15978541]

Authors

Hyatt DC, Croteau R

Title

Mutational analysis of a monoterpene synthase reaction: altered catalysis through directed mutagenesis of (-)-pinene synthase from Abies grandis.

Journal

Arch Biochem Biophys 439:222-33 (2005)
DOI:10.1016/j.abb.2005.05.017

Reference

4 [PMID:21813655]

Authors

Falara V, Akhtar TA, Nguyen TT, Spyropoulou EA, Bleeker PM, Schauvinhold I, Matsuba Y, Bonini ME, Schilmiller AL, Last RL, Schuurink RC, Pichersky E

Title

The tomato terpene synthase gene family.

Journal

Plant Physiol 157:770-89 (2011)
DOI:10.1104/pp.111.179648

Sequence

[sly:101245212]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.117

IUBMB Enzyme Nomenclature:

4.2.3.117

ExPASy - ENZYME nomenclature database:

4.2.3.117

BRENDA, the Enzyme Database:

4.2.3.117

All links

Protein sequence (7)   
   UniProt (3)   
   SWISS-PROT (3)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   InterPro (8)   
All databases (16)   

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