| Entry |
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| Name |
6-pyruvoyltetrahydropterin synthase;
2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase;
6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
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| Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
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| Sysname |
7,8-dihydroneopterin 3'-triphosphate triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
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| Reaction(IUBMB) |
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate [RN: R04286]
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| Reaction(KEGG) |
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| Substrate |
7,8-dihydroneopterin 3'-triphosphate [CPD: C04895]
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| Product |
6-pyruvoyl-5,6,7,8-tetrahydropterin [CPD: C03684];
triphosphate [CPD: C00536]
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| Comment |
Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 3.5.4.16 (GTP cyclohydrolase I) [3].
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| History |
EC 4.2.3.12 created 1999 as EC 4.6.1.10, transferred 2000 to EC 4.2.3.12, modified 2001
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| Pathway |
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| Orthology |
| K01737 | 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase |
| K22101 | dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Milstien S, Kaufman S. |
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| Title |
The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2'-oxo)reductase. |
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| Journal |
J Biol Chem 264:8066-73 (1989) |
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| Reference |
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| Authors |
Thony B, Leimbacher W, Burgisser D, Heizmann CW. |
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| Title |
Human 6-pyruvoyltetrahydropterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH. |
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| Title |
Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.3.12 |
| ExPASy - ENZYME nomenclature database: | 4.2.3.12 |
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