KEGG   ENZYME: 4.2.3.144
Entry
EC 4.2.3.144                Enzyme                                 

Name
geranyllinalool synthase;
TPS04/GES;
GES
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase [(E,E)-geranyllinalool-forming]
Reaction(IUBMB)
geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate [RN:R10533]
Reaction(KEGG)
R10533
Substrate
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Product
(6E,10E)-geranyllinalool [CPD:C20681];
diphosphate [CPD:C00013]
Comment
The enzyme is a component of the herbivore-induced indirect defense system. The product, (E,E)-geranyllinalool, is a precursor to the volatile compound 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT), which is released by many plants in response to damage.
History
EC 4.2.3.144 created 2013
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K17982  geranyllinalool synthase
Genes
ATH: AT1G61120(TPS04)
CRB: 17894892
CSAT: 104716016 104754111
EUS: EUTSA_v10023261mg
BNA: 106394830 106421978
BOE: 106317451
CIT: 102615273
CIC: CICLE_v10014262mg
PVY: 116145933
MINC: 123218154 123218155
GMX: 100801909(TPS17)
GSJ: 114375850
PDUL: 117621951
MNT: 21395364
SLY: 101262489
SPEN: 107015071
SOT: 102599238
ITR: 116028365
ECAD: 122582386
MING: 122075207
 » show all
Reference
1  [PMID:18398052]
  Authors
Herde M, Gartner K, Kollner TG, Fode B, Boland W, Gershenzon J, Gatz C, Tholl D
  Title
Identification and regulation of TPS04/GES, an Arabidopsis geranyllinalool synthase catalyzing the first step in the formation of the insect-induced volatile C16-homoterpene TMTT.
  Journal
Plant Cell 20:1152-68 (2008)
DOI:10.1105/tpc.106.049478
  Sequence
[ath:AT1G61120]
Reference
2  [PMID:18842097]
  Authors
Attaran E, Rostas M, Zeier J
  Title
Pseudomonas syringae elicits emission of the terpenoid (E,E)-4,8,12-trimethyl-1,3,7,11-tridecatetraene in Arabidopsis leaves via jasmonate signaling and expression of the terpene synthase TPS4.
  Journal
Mol Plant Microbe Interact 21:1482-97 (2008)
DOI:10.1094/MPMI-21-11-1482
  Sequence
[ath:AT1G61120]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.144
IUBMB Enzyme Nomenclature: 4.2.3.144
ExPASy - ENZYME nomenclature database: 4.2.3.144
BRENDA, the Enzyme Database: 4.2.3.144

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