KEGG   ENZYME: 4.2.3.145
Entry
EC 4.2.3.145                Enzyme                                 
Name
ophiobolin F synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E,10E,14E)-geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, ophiobolin-F-forming)
Reaction(IUBMB)
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = ophiobolin F + diphosphate [RN:R10762]
Reaction(KEGG)
R10762
Substrate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate [CPD:C04217];
H2O [CPD:C00001]
Product
ophiobolin F [CPD:C16818];
diphosphate [CPD:C00013]
Comment
Isolated from the fungus Aspergillus clavatus. The product is a sesterterpenoid (C25 terpenoid).
History
EC 4.2.3.145 created 2014
Orthology
K18685  ophiobolin F synthase
Genes
FPOA: FPOAC1_001853
FVN: FVRRES_02082
AMUS: LMH87_007750
ACT: ACLA_076850
TMF: EYB26_002212
CIM: CIMG_09089
CPW: 9692537(D8B26_007495)
BZE: COCCADRAFT_107912
BSC: COCSADRAFT_130354
BOR: COCMIDRAFT_4383
Reference
1  [PMID:23324037]
  Authors
Chiba R, Minami A, Gomi K, Oikawa H
  Title
Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus.
  Journal
Org Lett 15:594-7 (2013)
DOI:10.1021/ol303408a
  Sequence
[act:ACLA_076850]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.145
IUBMB Enzyme Nomenclature: 4.2.3.145
ExPASy - ENZYME nomenclature database: 4.2.3.145
BRENDA, the Enzyme Database: 4.2.3.145

  All links  
Protein sequence (9)   
   UniProt (5)   
   SWISS-PROT (4)   
DNA sequence (3)   
   GenBank (2)   
   EMBL (1)   
All databases (12)   

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