KEGG   ENZYME: 4.2.3.150Help
Entry
EC 4.2.3.150                Enzyme                                 

Name
cembrene A synthase;
DtcycB (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate diphosphate-lyase [(R)-cembrene-A-forming]
Reaction(IUBMB)
geranylgeranyl diphosphate = (R)-cembrene A + diphosphate [RN:R10898]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
(R)-cembrene A [CPD:C09140];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol. See EC 4.2.3.149, nephthenol synthase and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase.
History
EC 4.2.3.150 created 2014
Orthology
K20505  nephthenol/cembrene A/pentamethylcyclopentadecatrienol synthase
Reference
1  [PMID:23386483]
  Authors
Meguro A, Tomita T, Nishiyama M, Kuzuyama T
  Title
Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton.
  Journal
Chembiochem 14:316-21 (2013)
DOI:10.1002/cbic.201200651
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.150
IUBMB Enzyme Nomenclature: 4.2.3.150
ExPASy - ENZYME nomenclature database: 4.2.3.150
BRENDA, the Enzyme Database: 4.2.3.150

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