KEGG   ENZYME: 4.2.3.151
Entry
EC 4.2.3.151                Enzyme                                 

Name
pentamethylcyclopentadecatrienol synthase;
DtcycB (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase [(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol-forming]
Reaction(IUBMB)
geranylgeranyl diphosphate + H2O = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate [RN:R10899]
Reaction(KEGG)
R10899
Substrate
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Product
(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol [CPD:C20924];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (R)-cembrene A. See EC 4.2.3.150, cembrene A synthase and EC 4.2.3.149, nephthenol synthase.
History
EC 4.2.3.151 created 2014
Orthology
K20505  nephthenol/cembrene A/pentamethylcyclopentadecatrienol synthase
Reference
1  [PMID:23386483]
  Authors
Meguro A, Tomita T, Nishiyama M, Kuzuyama T
  Title
Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton.
  Journal
Chembiochem 14:316-21 (2013)
DOI:10.1002/cbic.201200651
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.151
IUBMB Enzyme Nomenclature: 4.2.3.151
ExPASy - ENZYME nomenclature database: 4.2.3.151
BRENDA, the Enzyme Database: 4.2.3.151

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