(5-formylfuran-3-yl)methyl phosphate synthase;
mfnB (gene name);
4-(hydroxymethyl)-2-furaldehyde phosphate synthase
Acting on phosphates
D-glyceraldehyde-3-phosphate phosphate-lyase [D-glyceraldehyde-3-phosphate-adding; (5-formylfuran-3-yl)methyl-phosphate-forming]
2 D-glyceraldehyde 3-phosphate = (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O [RN:
D-glyceraldehyde 3-phosphate [CPD:
(5-formylfuran-3-yl)methyl phosphate [CPD:
The enzyme catalyses the reaction in the direction of producing (5-formylfuran-3-yl)methyl phosphate, an intermediate in the biosynthesis of methanofuran. The sequence of events starts with the removal of a phosphate group, followed by aldol condensation and cyclization. Methanofuran is a carbon-carrier cofactor involved in the first step of the methanogenic reduction of carbon dioxide by methanogenic archaea.
EC 18.104.22.168 created 2015 as EC 22.214.171.124, transferred 2015 to EC 126.96.36.199
K09733 (5-formylfuran-3-yl)methyl phosphate synthase
BCAI: K788_0001563 K788_0007396
PHS: C2L64_21780 C2L64_38215
PTER: C2L65_26215 C2L65_34210
ALI: AZOLI_p10712 AZOLI_p10905
SRW: TUE45_pSRc_0556(TUE45_pSRTUE45c_0556) » show all
Miller D, Wang Y, Xu H, Harich K, White RH
Biosynthesis of the 5-(Aminomethyl)-3-furanmethanol moiety of methanofuran.
Bobik TA, Morales EJ, Shin A, Cascio D, Sawaya MR, Arbing M, Yeates TO, Rasche ME
Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii.
Wang Y, Jones MK, Xu H, Ray WK, White RH
Mechanism of the Enzymatic Synthesis of 4-(Hydroxymethyl)-2- furancarboxaldehyde-phosphate (4-HFC-P) from Glyceraldehyde-3-phosphate Catalyzed by 4-HFC-P Synthase.
ExPASy - ENZYME nomenclature database: 188.8.131.52