KEGG   ENZYME: 4.2.3.155
Entry
EC 4.2.3.155                Enzyme                                 

Name
2-epi-valiolone synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
D-sedoheptulose-7-phosphate phosphate-lyase (cyclizing; 2-epi-valiolone-forming)
Reaction(IUBMB)
D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate [RN:R11327]
Reaction(KEGG)
R11327
Substrate
D-sedoheptulose 7-phosphate [CPD:C05382]
Product
2-epi-valiolone [CPD:C21282];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacteria Actinosynnema mirum and Stigmatella aurantiaca DW4/3-1, produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. cf. EC 4.2.3.152, 2-epi-5-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase.
History
EC 4.2.3.155 created 2016
Reference
1  [PMID:22741921]
  Authors
Asamizu S, Xie P, Brumsted CJ, Flatt PM, Mahmud T
  Title
Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products.
  Journal
J Am Chem Soc 134:12219-29 (2012)
DOI:10.1021/ja3041866
  Sequence
[ami:Amir_2000] [sur:STAUR_3140]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.155
IUBMB Enzyme Nomenclature: 4.2.3.155
ExPASy - ENZYME nomenclature database: 4.2.3.155
BRENDA, the Enzyme Database: 4.2.3.155

DBGET integrated database retrieval system