KEGG   ENZYME: 4.2.3.159
Entry
EC 4.2.3.159                Enzyme                                 
Name
tsukubadiene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, tsukubadiene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = tsukubadiene + diphosphate [RN:R11824]
Reaction(KEGG)
R11824
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
tsukubadiene [CPD:C21670];
diphosphate [CPD:C00013]
Comment
The synthesis of the diterpene tsukubadiene has been shown to occur in the Actinobacterium Streptomyces tsukubaensis.
History
EC 4.2.3.159 created 2017
Orthology
K25134  tsukubadiene synthase
Genes
STSU: B7R87_12705
Reference
1  [PMID:25605043]
  Authors
Yamada Y, Arima S, Nagamitsu T, Johmoto K, Uekusa H, Eguchi T, Shin-ya K, Cane DE, Ikeda H
  Title
Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host.
  Journal
J Antibiot (Tokyo) 68:385-94 (2015)
DOI:10.1038/ja.2014.171
Reference
2  [PMID:28146322]
  Authors
Rabe P, Rinkel J, Dolja E, Schmitz T, Nubbemeyer B, Luu TH, Dickschat JS
  Title
Mechanistic Investigations of Two Bacterial Diterpene Cyclases: Spiroviolene Synthase and Tsukubadiene Synthase.
  Journal
Angew Chem Int Ed Engl 56:2776-2779 (2017)
DOI:10.1002/anie.201612439
  Sequence
[stsu:B7R87_12705]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.159
IUBMB Enzyme Nomenclature: 4.2.3.159
ExPASy - ENZYME nomenclature database: 4.2.3.159
BRENDA, the Enzyme Database: 4.2.3.159

  All links  
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
All databases (9)   

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