KEGG   ENZYME: 4.2.3.161Help
Entry
EC 4.2.3.161                Enzyme                                 

Name
(3S)-(+)-asterisca-2(9),6-diene synthase;
TPS2 (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (3S)-(+)-asterisca-2(9),6-diene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate [RN:R11826]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(3S)-(+)-asterisca-2(9),6-diene [CPD:C21677];
diphosphate [CPD:C00013]
Comment
The sequiterpene (3S)-(+)-asterisca-2(9),6-diene has been shown to be synthezised in the slime-mould Dictyostelium discoideum. The enzyme is specific for (2E,6E)-farnesyl diphosphate.
History
EC 4.2.3.161 created 2017
Orthology
K23022  (3S)-(+)-asterisca-2(9),6-diene synthase
Genes
DDI: DDB_G0272510
Taxonomy
Reference
1  [PMID:27790999]
  Authors
Chen X, Kollner TG, Jia Q, Norris A, Santhanam B, Rabe P, Dickschat JS, Shaulsky G, Gershenzon J, Chen F
  Title
Terpene synthase genes in eukaryotes beyond plants and fungi: Occurrence in social amoebae.
  Journal
Proc Natl Acad Sci U S A 113:12132-12137 (2016)
DOI:10.1073/pnas.1610379113
Reference
2  [PMID:27862766]
  Authors
Rabe P, Rinkel J, Nubbemeyer B, Kollner TG, Chen F, Dickschat JS
  Title
Terpene Cyclases from Social Amoebae.
  Journal
Angew Chem Int Ed Engl 55:15420-15423 (2016)
DOI:10.1002/anie.201608971
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.161
IUBMB Enzyme Nomenclature: 4.2.3.161
ExPASy - ENZYME nomenclature database: 4.2.3.161
BRENDA, the Enzyme Database: 4.2.3.161

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