KEGG   ENZYME: 4.2.3.162Help
Entry
EC 4.2.3.162                Enzyme                                 

Name
(-)-alpha-amorphene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (-)-alpha-amorphene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate [RN:R11827]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(-)-alpha-amorphene [CPD:C21679];
diphosphate [CPD:C00013]
Comment
The enzyme, found in the bacterium Streptomyces viridochromogenes, is specific for (2E,6E)-farnesyl diphosphate and produces only (-)-alpha-amorphene.
History
EC 4.2.3.162 created 2017
Reference
1  [PMID:23307484]
  Authors
Rabe P, Dickschat JS
  Title
Rapid chemical characterization of bacterial terpene synthases.
  Journal
Angew Chem Int Ed Engl 52:1810-2 (2013)
DOI:10.1002/anie.201209103
Reference
2  [PMID:27666571]
  Authors
Rinkel J, Rabe P, Garbeva P, Dickschat JS
  Title
Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclizations.
  Journal
Angew Chem Int Ed Engl 55:13593-13596 (2016)
DOI:10.1002/anie.201608042
Reference
3  [PMID:27829890]
  Authors
Rabe P, Schmitz T, Dickschat JS
  Title
Mechanistic investigations on six bacterial terpene cyclases.
  Journal
Beilstein J Org Chem 12:1839-1850 (2016)
DOI:10.3762/bjoc.12.173
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.162
IUBMB Enzyme Nomenclature: 4.2.3.162
ExPASy - ENZYME nomenclature database: 4.2.3.162
BRENDA, the Enzyme Database: 4.2.3.162

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