KEGG ENZYME: 4.2.3.162

ENZYME: 4.2.3.162

Entry

EC 4.2.3.162                Enzyme

Name

(-)-alpha-amorphene synthase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (-)-alpha-amorphene-forming]

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate [RN:R11827]

Reaction(KEGG)

R11827

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

(-)-alpha-amorphene [CPD:C21679];
diphosphate [CPD:C00013]

Comment

The enzyme, found in the bacterium Streptomyces viridochromogenes, is specific for (2E,6E)-farnesyl diphosphate and produces only (-)-alpha-amorphene.

History

EC 4.2.3.162 created 2017

Orthology

K28675

(-)-alpha-amorphene synthase

Genes

SGU:	SGLAU_04155

STRT:

A8713_03740

SGS:	AVL59_27895

STSI:

A4E84_05595

SCAD:

DN051_33315

SPUN:

BFF78_38630

SCYA:

EJ357_44055

SHAW:

CEB94_06055

SCHA:

CP983_40410

SCOE:

CP976_06060

STUI:

GCM10017668_07460

SCHF:

IPT68_04790

SFEU:

IM697_26135

SLF:	JEQ17_05635

SJN:	RI060_37035

SCYN:

N8I84_05170

SKG:	KJK29_34280

SINN:

ABB07_34515

KBU:	Q4V64_48360

STSD:

HEP87_07795

SMOD:

POD33_31820

SFLU:

ACKTSN_41465

SSEC:

ABZO29_39275

» show all

Reference

1 [PMID:23307484]

Authors

Rabe P, Dickschat JS

Title

Rapid chemical characterization of bacterial terpene synthases.

Journal

Angew Chem Int Ed Engl 52:1810-2 (2013)
DOI:10.1002/anie.201209103

Sequence

[ag:WP_039931950]

Reference

2 [PMID:27666571]

Authors

Rinkel J, Rabe P, Garbeva P, Dickschat JS

Title

Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclizations.

Journal

Angew Chem Int Ed Engl 55:13593-13596 (2016)
DOI:10.1002/anie.201608042

Sequence

[ag:WP_039931950]

Reference

3 [PMID:27829890]

Authors

Rabe P, Schmitz T, Dickschat JS

Title

Mechanistic investigations on six bacterial terpene cyclases.

Journal

Beilstein J Org Chem 12:1839-1850 (2016)
DOI:10.3762/bjoc.12.173

Sequence

[ag:WP_039931950]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.162

IUBMB Enzyme Nomenclature:

4.2.3.162

ExPASy - ENZYME nomenclature database:

4.2.3.162

BRENDA, the Enzyme Database:

4.2.3.162

All links

Protein sequence (669)   
   UniProt (24)   
   SWISS-PROT (1)   
   RefSeq(pep) (644)   
DNA sequence (923)   
   RefSeq(nuc) (879)   
   GenBank (22)   
   EMBL (22)   
All databases (1592)   

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