KEGG   ENZYME: 4.2.3.163Help
Entry
EC 4.2.3.163                Enzyme                                 

Name
(+)-corvol ether B synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-corvol ether B-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate [RN:R11828]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(+)-corvol ether B [CPD:C21681];
diphosphate [CPD:C00013]
Comment
The enzyme, which forms the sesquiterpene (+)-corvol ether B, has been reported from the bacterium Kitasatospora setae.
History
EC 4.2.3.163 created 2017
Orthology
K23023  (+)-corvol ether B/A synthase
Genes
KSK: KSE_12950
Taxonomy
Reference
1  [PMID:25809275]
  Authors
Rabe P, Pahirulzaman KA, Dickschat JS
  Title
Structures and Biosynthesis of Corvol Ethers--Sesquiterpenes from the Actinomycete Kitasatospora setae.
  Journal
Angew Chem Int Ed Engl 54:6041-5 (2015)
DOI:10.1002/anie.201501119
  Sequence
[ksk:KSE_12950]
Reference
2  [PMID:26635093]
  Authors
Rabe P, Janusko A, Goldfuss B, Dickschat JS
  Title
Experimental and Theoretical Studies on Corvol Ether Biosynthesis.
  Journal
Chembiochem 17:146-9 (2016)
DOI:10.1002/cbic.201500543
  Sequence
[ksk:KSE_12950]
Reference
3  [PMID:27666571]
  Authors
Rinkel J, Rabe P, Garbeva P, Dickschat JS
  Title
Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclizations.
  Journal
Angew Chem Int Ed Engl 55:13593-13596 (2016)
DOI:10.1002/anie.201608042
  Sequence
[ksk:KSE_12950]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.163
IUBMB Enzyme Nomenclature: 4.2.3.163
ExPASy - ENZYME nomenclature database: 4.2.3.163
BRENDA, the Enzyme Database: 4.2.3.163

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