KEGG   ENZYME: 4.2.3.164Help
Entry
EC 4.2.3.164                Enzyme                                 

Name
(+)-eremophilene synthase;
STC3 (gene name);
geoA (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-eremophilene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate [RN:R11829]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-eremophilene [CPD:C21684];
diphosphate [CPD:C00013]
Comment
The enzyme has been identified in the myxobacterium Sorangium cellulosum and in the fungus Fusarium fujikuroi.
History
EC 4.2.3.164 created 2017
Orthology
K22978  (+)-eremophilene synthase
K22979  (+)-eremophilene synthase
Genes
FVR: FVEG_03771
FOX: FOXG_19140
SCL: sce8552(geoA)
SCU: SCE1572_49565
Taxonomy
Reference
1  [PMID:25504914]
  Authors
Schifrin A, Ly TT, Gunnewich N, Zapp J, Thiel V, Schulz S, Hannemann F, Khatri Y, Bernhardt R
  Title
Characterization of the gene cluster CYP264B1-geoA from Sorangium cellulosum So ce56: biosynthesis of (+)-eremophilene and its hydroxylation.
  Journal
Chembiochem 16:337-44 (2015)
DOI:10.1002/cbic.201402443
  Sequence
[scl:sce8552]
Reference
2  [PMID:27294564]
  Authors
Burkhardt I, Siemon T, Henrot M, Studt L, Rosler S, Tudzynski B, Christmann M, Dickschat JS
  Title
Mechanistic Characterisation of Two Sesquiterpene Cyclases from the Plant Pathogenic Fungus Fusarium fujikuroi.
  Journal
Angew Chem Int Ed Engl 55:8748-51 (2016)
DOI:10.1002/anie.201603782
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.164
IUBMB Enzyme Nomenclature: 4.2.3.164
ExPASy - ENZYME nomenclature database: 4.2.3.164
BRENDA, the Enzyme Database: 4.2.3.164

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