KEGG   ENZYME: 4.2.3.186
Entry
EC 4.2.3.186                Enzyme                                 
Name
ent-13-epi-manoyl oxide synthase;
SmKSL2;
ent-LDPP synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
ent-8alpha-hydroxylabd-13-en-15-yl-diphosphate diphosphate-lyase (cyclizing, ent-13-epi-manoyl-oxide-forming)
Reaction(IUBMB)
ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = ent-13-epi-manoyl oxide + diphosphate [RN:R11851]
Reaction(KEGG)
R11851
Substrate
ent-8alpha-hydroxylabd-13-en-15-yl diphosphate [CPD:C21656]
Product
ent-13-epi-manoyl oxide [CPD:C21714];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Salvia miltiorrhiza (red sage).
History
EC 4.2.3.186 created 2017
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22947  ent-13-epi-manoyl oxide synthase
Genes
SSPL121774692 121777194
Reference
1  [PMID:26077765]
  Authors
Cui G, Duan L, Jin B, Qian J, Xue Z, Shen G, Snyder JH, Song J, Chen S, Huang L, Peters RJ, Qi X
  Title
Functional Divergence of Diterpene Syntheses in the Medicinal Plant Salvia miltiorrhiza.
  Journal
Plant Physiol 169:1607-18 (2015)
DOI:10.1104/pp.15.00695
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.186
IUBMB Enzyme Nomenclature: 4.2.3.186
ExPASy - ENZYME nomenclature database: 4.2.3.186
BRENDA, the Enzyme Database: 4.2.3.186

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