KEGG   ENZYME: 4.2.3.187
Entry
EC 4.2.3.187                Enzyme                                 
Name
(2Z,6E)-hedycaryol synthase;
HcS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (2Z,6E)-hedycaryol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate [RN:R11852]
Reaction(KEGG)
R11852
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(2Z,6E)-hedycaryol [CPD:C21715];
diphosphate [CPD:C00013]
Comment
Isolated from the bacterium Kitasatospora setae. The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization. See also EC 4.2.3.174 (2E,6E)-hedycaryol synthase.
History
EC 4.2.3.187 created 2017
Orthology
K23046  (2Z,6E)-hedycaryol synthase
Genes
SROIIAG44_40725
KSKKSE_00200t KSE_76540t
Reference
1  [PMID:24399794]
  Authors
Baer P, Rabe P, Citron CA, de Oliveira Mann CC, Kaufmann N, Groll M, Dickschat JS
  Title
Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism.
  Journal
Chembiochem 15:213-6 (2014)
DOI:10.1002/cbic.201300708
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.187
IUBMB Enzyme Nomenclature: 4.2.3.187
ExPASy - ENZYME nomenclature database: 4.2.3.187
BRENDA, the Enzyme Database: 4.2.3.187

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