KEGG   ENZYME: 4.2.3.19
Entry
EC 4.2.3.19                 Enzyme                                 
Name
ent-kaurene synthase;
ent-kaurene synthase B;
ent-kaurene synthetase B, ent-copalyl-diphosphate diphosphate-lyase (cyclizing)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)
Reaction(IUBMB)
ent-copalyl diphosphate = ent-kaurene + diphosphate [RN:R05092]
Reaction(KEGG)
R05092
Substrate
ent-copalyl diphosphate [CPD:C06089]
Product
ent-kaurene [CPD:C06090];
diphosphate [CPD:C00013]
Comment
Part of a bifunctional enzyme involved in the biosynthesis of ent-kaurene. See also EC 5.5.1.13 (ent-copalyl diphosphate synthase)
History
EC 4.2.3.19 created 2002
Pathway
ec00904  Diterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04121  ent-kaurene synthase
K20657  ent-copalyl diphosphate/ent-kaurene synthase
Genes
ATHAT1G79460(GA2)
ALY9323851
CRB17894494
CSAT104703299 104714240 104752382
EUSEUTSA_v10018144mg
BRP103832422
BNA106354788 106430723
BOE106297063
RSZ108826853
THJ104812382
CPAP110817263
CIT102609462
CICCICLE_v10006575mg
PVY116142016 116142017 116142045 116142046
MINC123197853
TCC18594964
GRA105782971
GHI107916812 107921168
GAB108480537
DZI111287930
EGR104450546
GMX100793849(DW1)
GSJ114422065
PVUPHAVU_005G048500g
VRA106760976
VAR108332359
VUN114176685
CCAJ109816872
APRC113855184
MTRMTR_2g064295 MTR_3g058160
CAM101506236
LJALj0g3v0250739.2(Lj0g3v0250739.2) Lj3g3v0948400.1(Lj3g3v0948400.1) Lj3g3v0948400.2(Lj3g3v0948400.2) Lj3g3v0948400.4(Lj3g3v0948400.4)
ADU107458750
AIP107613546
AHF112702964 112771489
LANG109356576
FVE101301279 101301569
RCN112164573
PPER18778990
PMUM103325592 103325640 103343621
PAVI110745425 110767389 110770543 110770546
PDUL117625499 117626735
MDM103400427 103407925 103415767 103445924(KS)
PXB103932282 103932630 103937596
ZJU107424646
MNT21402193
CSV101217426
CMO103489622
BHJ120077990
MCHA111016726
CMAX111468079
CMOS111455458
CPEP111811232
RCU8259343 8259388 8277650 8282984 8282989 8282990
JCU105631138 105649262
HBR110633380 110633381 110646746 110660499 110660517 110662210 110667076 110671325 110672862
MESC110602995 110603473 110603522 110604205 110618412 110619742
POP18101433 7460670
PEU105118102
PALZ118055753
JRE108998981 108998982
QSU112027058 112027063 112027066
QLO115983925
TWL119988173 119988174 119988175
VVI100267397
VRI117909326
SLY101252605(TPS24)
SPEN107026218
SOT102602928
CANN107878924
NTA107795749(NtKS) 107825637
NSY104222495
NTO104102231
NAU109234174
INI109156386
ITR115998579
SIND105175114
EGT105968700 105968701 105971074
HAN110917813 110918013 110918028 110918153 110928588
ECAD122595277 122595279 122597925 122609084
LSV111876762 111876799
CCAV112522554 112522847
DCR108219753 108222343
CSIN114262481 114279873
BVG104904107
SOE110779336
CQI110682252 110718729
NNU104599747
MING122058922 122060619
TSS122651279
PSOM113336662
NCOL116254598
OSA4336960
DOSAOs04t0611800-00(Os04g0611800)
OBR102721543
BDI100827748 100828967 100829880
ATS109754648 109764882 109780574 109780577 109780593
TDC119323942 119356230 119358107 119358108 119358112 119358255 119358647 119361095 119361107 119361808 119365394 119365395 119365400
TAES100873131 100873134 100873147 123039360 123039367 123039521 123046477 123050317 123055900 123055901 123055905 123133218 123190211 123191848 123191853 123191952
SBI8063956
ZMA103645955 109943181
SITA101772220
SVS117844058 117864176
PVIR120641744 120658831 120666048 120666049 120666116 120666349 120666350 120667842 120682376 120699635 120701539
PHAI112886849 112887158 112899736
PDA103698812 103720937 103722282 120106536 120106542 120108804
EGU105059898 105059899 105059986
MUS103969833
DCT110092854
PEQ110024106 110030130 110039138
AOF109851541
ATR105421340 18443240
MGRMGG_01949
BZECOCCADRAFT_113213
BSCCOCSADRAFT_104215
BORCOCMIDRAFT_30863
 » show all
Reference
1  [PMID:4331199]
  Authors
Fall RR, West CA.
  Title
Purification and properties of kaurene synthetase from Fusarium moniliforme.
  Journal
J Biol Chem 246:6913-28 (1971)
Reference
2  [PMID:8771778]
  Authors
Yamaguchi S, Saito T, Abe H, Yamane H, Murofushi N, Kamiya Y.
  Title
Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.).
  Journal
Plant J 10:203-13 (1996)
DOI:10.1046/j.1365-313X.1996.10020203.x
Reference
3  [PMID:9268298]
  Authors
Kawaide H, Imai R, Sassa T, Kamiya Y
  Title
Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis.
  Journal
J Biol Chem 272:21706-12 (1997)
DOI:10.1074/jbc.272.35.21706
  Sequence
Reference
4  [PMID:10803977]
  Authors
Toyomasu T, Kawaide H, Ishizaki A, Shinoda S, Otsuka M, Mitsuhashi W, Sassa T
  Title
Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase.
  Journal
Biosci Biotechnol Biochem 64:660-4 (2000)
DOI:10.1271/bbb.64.660
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.19
IUBMB Enzyme Nomenclature: 4.2.3.19
ExPASy - ENZYME nomenclature database: 4.2.3.19
BRENDA, the Enzyme Database: 4.2.3.19
CAS: 9055-64-5

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